Clinical trials: Neonatal Surgery
Choledochal Cyst
A Longitudinal Cohort Study on the Changes of Physiological Mechanisms in Children After Biliary Tract Reconstruction
Through observational studies, the long-term changes in liver function, metabolic state, immune response and other aspects of children after biliary tract reconstruction during their growth process were systematically explored.
- Trial name
- NCT07530354
- Where
- 3 sites in China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Wuhan Children's Hospital
Heart-lung Interaction, Right Ventricular Hypertrophy
Cardiopulmonary Effect of Mechanical Ventilation in Children With Right Ventricular Hypertrophy
Neurally adjusted ventilatory assist (NAVA) is a new mode of mechanical ventilation that delivers ventilatory assist in proportion to neural effort.
- Conditions
- Heart-lung Interaction, Right Ventricular Hypertrophy, Postoperative Care, Congenital Heart Disease
- Trial name
- NCT04825054
- Testing
- Mechanical ventilation with NAVA mode, Mechanical ventilation with PCV mode, Mechanical ventilation with PSV mode
- Where
- 2 sites in China
- Volunteers
- 30 people
- Sponsor
- Limin Zhu
Organ Protection
The Effect of Intravenous Lidocaine on Postoperative Cognitive Function in Elderly Patients
The purpose of this study is to investigate the efficacy of intravenous lidocaine on BDNF, NGF, miRNA-206 and miRNA-98 in serum in elderly patients undergoing abdominal surgery under general anesthesia.
- Trial name
- NCT05502705
- Testing
- Lidocaine, Normal saline (NS)
- Volunteers
- 50 people
- Sponsor
- General Hospital of Ningxia Medical University
Delirium - Postoperative, Sleep Problems
Preoperative Sleep Intervention on Postoperative Delirium in Infants and Toddlers Undergoing Congenital Heart Surgery
This is a multicenter, randomized, controlled clinical trial aimed to determine whether preoperative sleep interventions could reduce the incidence of adverse outcomes, such as postoperative delirium, in sleep-disordered infants…
- Conditions
- Delirium - Postoperative, Sleep Problems, Congenital Heart Disease (CHD)
- Trial name
- NCT06861998
- Testing
- Message-based bedtime routine, sleep hygiene education
- Where
- China
- Volunteers
- 452 people
- Sponsor
- Yan Fuxia
Maxillary Hypoplasia
Effectiveness of SARPE With 3 and 2-Segment Technique: A Randomized Clinical Trial
A few studies state that 3-segment SARPE has the following advantages: a) higher level of expansion symmetry; b) higher level of stability of the expansion achieved; and c) faster bone healing.
- Trial name
- 3S/2S_SARPE (NCT02179593)
- Testing
- 2-Segment SARPE, 3-Segment SARPE
- Where
- Brazil
- Volunteers
- 50 people
- Sponsor
- Federal University of São Paulo
Hirschsprung Disease, Febrile Urinary Tract Infection (Disorder)
Does Hirschsprung Disease Increase the Risk of Febrile Urinary Tract Infection in Children
Febrile urinary tract infection (FUTIs) are the most common bacterial infections in children under the age of 2 years. They represent 7% of children presenting with fever without a source.
- Trial name
- NCT04837963
- Where
- France
- Volunteers
- 630 people
- Sponsor
- University Hospital, Montpellier
Dilated Cardiomyopathy
Safety and Feasibility of Algisyl-LVR™ as a Method of Left Ventricular Restoration in Patients With DCM Undergoing Open-heart Surgery
This is a pilot study to evaluate the feasibility and safety of the Algisyl-LVR™ device. The purpose of this study is to investigate Algisyl-LVR™ employed as a method of left ventricular restoration in patients with dilated…
- Trial name
- NCT00847964
- Testing
- Algisyl-LVR
- Where
- 3 sites in Germany, Poland
- Volunteers
- 11 people
- Sponsor
- LoneStar Heart, Inc.
Hypofibrinogenemia
A Point-of-care Electrochemical-based Device for Rapid Detection of Fibrinogen on Type A Aortic Dissection Surgery
This study compares the results of the existing fibrinogen concentration monitoring technology to the Electrochemical-based device, a point-of-care and rapid method,using a small amount of extra blood obtained in Type A Aortic…
- Trial name
- NCT06434389
- Testing
- the Electrochemical-based device
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Dysplasia; Hip
Biomechanical Reconstruction of Three Different Hip Stem Designs in Hip Dysplasia Using a 3D CT-based Planning Software
A random population of 200 CT scans of pelvis and thigh in an adult population affected by hip dysplasia will be selected. The aim of this study is to evaluate the biomechanical reconstruction of the hip anatomy provided by three…
- Trial name
- CTdevice (NCT04904640)
- Testing
- Hip stem
- Where
- Italy
- Volunteers
- 150 people
- Sponsor
- Istituto Ortopedico Rizzoli
Total Anomalous Pulmonary Venous Connection
Anticoagulation Medicine in Surgical Repair for Total Anomalous Pulmonary Venous Connection
Total anomalous pulmonary venous connection (TAPVC) is a complex congenital heart disease, requiring surgical repair. Pulmonary venous obstruction (PVO) is the major complication, with limited effective reinterventions and poor…
- Trial name
- NCT04241380
- Testing
- Anticoagulant Solutions, No anticoagulant solutions, Anticoagulant management
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Guangdong Provincial People's Hospital
Transposition of Great Vessels
Late Function After Surgery for Transposition of the Great Arteries
The investigators proposed to review the exercise tolerance, cardiac function, and quality of life in patients born with transposition of the great arteries that have undergone surgery with either the Mustard or Senning…
- Trial name
- NCT03078413
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- Indiana University
Hemophilia A
Study Evaluating B-Domain Deleted Recombinant Factor VIII (BDDrFVIII, ReFacto AF) in Patients With Hemophilia A Undergoing Elective Major Surgery
This study will examine the efficacy and safety of ReFacto AF in patients with severe and moderately severe hemophilia A undergoing elective major surgery when administered by either bolus injections (BI) or continuous infusion…
- Trial name
- NCT00243659
- Testing
- ReFacto AF
- Where
- 17 sites in United States, Australia and 6 more
- Volunteers
- 30 people
- Sponsor
- Wyeth is now a wholly owned subsidiary of Pfizer
Congenital Heart Disease (CHD), Chest Tube Removal
The Effect of Music and Musical Mobile Interventions on Pain and Physiological Parameters
Chest tube removal in infants undergoing surgery for congenital heart disease is an invasive procedure associated with significant pain and physiological stress responses.
- Trial name
- Music Pain Inf (NCT07564882)
- Testing
- Music Group, Musical Mobile Group
- Where
- Turkey (Türkiye)
- Volunteers
- 54 people
- Sponsor
- Baskent University
Hypofibrinogenemia, Surgical Blood Loss
Effectiveness of Different Fibrinogen Preparations in Restoring Clot Firmness
Fibrinogen concentrate is produced by different manufacturers using different purification technologies. The products available in Italy are three: RiaSTAP (CSL Behring), FIBRYGA (Octapharma), and FibCLOT (LFB).
- Conditions
- Hypofibrinogenemia, Surgical Blood Loss, Bleeding, Cardiac Disease
- Trial name
- EDIPORE (NCT05780125)
- Testing
- FibCLOT, RiaSTAP
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- IRCCS Policlinico S. Donato
Congenital Heart Disease, Coarctation of Aorta
An Integrated Prenatal and Postnatal Treatment Model for the Treatment of Newborns With Critical Congenital Heart Disease
The purpose of this two-way cohort study was to explore whether an integrated prenatal and postnatal treatment model for neonates with critical congenital heart disease (CCHD) could be effective in avoiding preoperative…
- Conditions
- Congenital Heart Disease, Coarctation of Aorta, Aortic Stenosis, Pulmonary Atresia
- Trial name
- NCT06768008
- Where
- China
- Volunteers
- 10,000 people
- Sponsor
- Beijing Anzhen Hospital
Pectus Excavatum, Autonomic Dysfunction
Autonomic Dysfunction in Patients With Pectus Excavatum.
Investigators conducted a pilot study to to evaluate the autonomic function in participants with pectus excavatum before and after Nuss surgery.
- Conditions
- Pectus Excavatum, Autonomic Dysfunction, Surgery
- Trial name
- ADPE (NCT03346876)
- Testing
- Nuss surgery
- Where
- Taiwan
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation
Hyponatremia, Hypernatremia
Comparison of Isotonic Versus Hypotonic Fluids in Neonates for Maintenance Fluid Therapy After Surgery
The goal of this clinical trial is to determine if isotonic or hypotonic fluids are more effective in maintaining serum sodium levels in neonates undergoing maintenance fluid therapy post-surgery.
- Conditions
- Hyponatremia, Hypernatremia, Postoperative Care in Neonates, Edema
- Trial name
- NCT06484608
- Testing
- Isotonic Saline with Dextrose
- Where
- Pakistan
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Rawalpindi Medical College
Obstructive Sleep Apnea of Child
Surgical Treatment of Children With OSA and Small Tonsils or Down Syndrome
The purpose of this study is to prospectively compare the effectiveness of a novel personalized approach to the surgical treatment of obstructive sleep apnea (OSA) in children, drug induced sleep endoscopy (DISE) directed surgery…
- Trial name
- NCT05154214
- Testing
- Adenotonsillectomy, Drug-induced sleep endoscopy directed surgery
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Oregon Health and Science University
Biliary Atresia
Kasai Portoenterostomy Timing and Outcomes in Biliary Atresia
What is this study about? This study aims to find out the best timing for a major surgery called Kasai portoenterostomy (Kasai surgery) in infants with a liver disease called biliary atresia.
- Trial name
- NCT07328204
- Testing
- Kasai portoenterostomy
- Where
- China
- Volunteers
- 200 people
- Sponsor
- The Children's Hospital of Zhejiang University School of Medicine
Malnutrition
Pilot Study of the Safety and Efficacy of Oxandrolone in the Prevention and Treatment of Malnutrition in Infants
Oxandrolone is an anabolic steroid, marketed in the United States as an adjunctive therapy to combat weight loss resulting from chronic infection, extensive surgery, severe trauma, protein catabolism associated with prolonged…
- Trial name
- NCT01048632
- Testing
- Oxandrolone
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Utah
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