Clinical trials: Neoplasm, Gastrointestinal
Rectal Cancer, Cancer of the Rectum
5-Fluorouracil, Bevacizumab, and Radiation Followed by Modified FOLFOX6 and Bevacizumab in Stage II/III Rectal Cancer
This phase II trial will investigate the combination of adjuvant 5-fluorouracil, radiation, and bevacizumab in patients with stage II and III rectal cancer, followed by FOLFOX6 and bevacizumab.
- Conditions
- Rectal Cancer, Cancer of the Rectum, Colorectal Cancer
- Trial name
- NCT00308516
- Testing
- 5-Fluorouracil, Bevacizumab, Radiation Therapy
- Where
- 14 sites in United States
- Volunteers
- 66 people
- Sponsor
- SCRI Development Innovations, LLC
Biliary Tract Cancer
Covered Versus Uncovered Biliary Stents for Biliary Malignancies
Patency duration of covered metal stents as compared with uncovered metal stents in the management of malignant strictures of the extra-hepatic biliary tree.
- Trial name
- NCT02102984
- Testing
- covered biliary stents, uncovered biliary stents
- Where
- Italy
- Volunteers
- 140 people
- Sponsor
- Nuovo Ospedale Civile S.Agostino Estense
Colorectal Cancer
Colorectal Cancer Screening in Familiar-Risk Population: Immunochemical Fecal Occult Blood Testing Versus Colonoscopy
This study is aimed: 1) to compare the accuracy of colonoscopy vs immunochemical faecal occult blood test (iFOBT) and colonoscopy when positive for colorectal cancer (CRC) screening in familiar-risk population and; 2) to…
- Trial name
- COLONFAM (NCT01075633)
- Testing
- Immunochemical fecal occult blood test And colonoscopy if test is positive, Colonoscopy with sedation
- Where
- Spain
- Volunteers
- 1,501 people
- Sponsor
- Enrique Quintero
Metastatic Colorectal Cancer
Intermittent Versus Continuous Tarceva Study
This is a randomized phase II study comprising of two treatment arms in patients who are previously untreated for metastatic or recurrent colorectal cancer.
- Trial name
- NCT01243047
- Testing
- Chemotherapy
- Where
- Hong Kong
- Volunteers
- 60 people
- Sponsor
- Chinese University of Hong Kong
Liver Cancer
Sorafenib Tosylate With or Without Pravastatin in Treating Patients With Liver Cancer and Cirrhosis
RATIONALE: Sorafenib tosylate and pravastatin may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth.
- Trial name
- NCT01075555
- Testing
- pravastatin sodium, sorafenib tosylate
- Where
- France
- Volunteers
- 323 people
- Sponsor
- Federation Francophone de Cancerologie Digestive
Fungal Infection, Acute Myelogenous Leukemia
Oral Posaconazole in High Risk Patients With Gastrointestinal Dysfunction (Study P05115)
The purpose of this study is: to explore the potential for different dosing strategies of posaconazole oral suspension (POS) to increase plasma levels and to profile the pharmacokinetics of these dosing strategies in patients…
- Conditions
- Fungal Infection, Acute Myelogenous Leukemia, Neutropenia
- Trial name
- NCT00686543
- Testing
- Posaconazole
- Volunteers
- 75 people
- Sponsor
- Merck Sharp & Dohme LLC
Pancreatic Cancer
Sequential Nutrition Intervention for Pancreatic Cancer Patients Undergoing CyberKnife Radiotherapy
This study aims to evaluate the clinical value of a structured nutritional support program for patients with pancreatic cancer undergoing CyberKnife radiotherapy.
- Trial name
- NCT07057843
- Testing
- Sequential Nutrition Intervention, Enteral Nutrition Emulsion, Routine Nutritional Intervention
- Where
- China
- Volunteers
- 100 people
- Sponsor
- The First Hospital of Hebei Medical University
H Pylori Infection, H Pylori Gastritis
Helicobacter Pylori Screening and Treatment in the At-risk South Florida Community- AIM 1
H. pylori is an infection of the stomach that can cause chronic gastritis, gastric cancer and peptic ulcer disease. The goal of this study is to screen people for this infection and offer treatment for those who test positive for…
- Conditions
- H Pylori Infection, H Pylori Gastritis, Gastric Cancer
- Trial name
- NCT07224035
- Testing
- PYTEST® 14C-Urea Breath Test, VOQUEZNA® Triple Pak®
- Where
- United States
- Volunteers
- 430 people, healthy volunteers welcome
- Sponsor
- University of Miami
Rectal Cancer
Reasons for Non-reversal of Temporary Stomas After Surgeries of Mid-low Rectal Cancer （NORESTO Study）
The goal of this observational study is to learn about in mid-low rectal patients who received temporary ostomies after surgery of the primary tumors.
- Trial name
- NCT06194708
- Where
- China
- Volunteers
- 235 people
- Sponsor
- Peking Union Medical College Hospital
CML, GIST
Distress, Medication Adherence and Care Needs in Patients With CML and GIST Receiving Oral Targeted Therapy
Background: Long-term or life-long oral targeted therapy might also increase patients' distress, influencing patients' cognitive and life activity function, medication adherence and related care needs.
- Trial name
- NCT03880617
- Where
- Taiwan
- Volunteers
- 297 people
- Sponsor
- National Taiwan University Hospital
Colorectal Neoplasms
The Magnitude of Effect of PCP Counseling on Participation Rate and Sedation Rate in Colonoscopy-based Screening Program
The purpose of this study is to assess the impact of physician's counseling on participation and utilization of sedation in a primary colonoscopy-based colorectal cancer (CRC) screening program
- Trial name
- NCT01688817
- Testing
- Physician's counseling, Information leaflet
- Volunteers
- 600 people
- Sponsor
- Maria Sklodowska-Curie National Research Institute of Oncology
Colorectal Cancer, Metastatic Colorectal Adenocarcinoma
Dual-Targeting CAR-NK Cells in Biomarker-Selected Advanced Colorectal Cancer
This Phase 1/2 study evaluates the safety, tolerability, and preliminary anti-tumor activity of an allogeneic dual-target chimeric antigen receptor natural killer (CAR-NK) cell product in adults with advanced or metastatic…
- Conditions
- Colorectal Cancer, Metastatic Colorectal Adenocarcinoma, Unresectable Colorectal Cancer
- Trial name
- DUO-CRC-NK-111 (NCT07589517)
- Testing
- EB-DUO-CAR-NK-CEA/GCC, Lymphodepletion
- Where
- China
- Volunteers
- 48 people
- Sponsor
- Beijing Biotech
Tuberculosis, Tuberculosis, Pulmonary
Pharmacokinetics of Anti-tuberculosis Drugs in Gastrectomized Patients
The purpose of this study is to evaluate the effect of gastrectomy on pharmacokinetic profile of first-line anti-tuberculosis drugs in patients with pulmonary tuberculosis (TB).
- Conditions
- Tuberculosis, Tuberculosis, Pulmonary, Early Gastric Cancer
- Trial name
- NCT01364324
- Testing
- standard first line anti-TB drugs
- Where
- South Korea
- Volunteers
- 40 people
- Sponsor
- National Cancer Center, Korea
Surgery of Upper Gastrointestinal Tract Cancer
Prehabilitation for Upper Gastrointestinal Tract Cancer Surgery
Patients receiving surgery of upper gastrointestinal tract are often elderly, frail, malnourished, with poor functional reserve. They are associated with poor post-operative outcomes.
- Trial name
- NCT07713888
- Testing
- Prehabilitation
- Where
- Taiwan
- Volunteers
- 40 people
- Sponsor
- Taichung Tzu Chi Hospital
Esophageal Cancer, Cancer of the Esophagus
Irinotecan and Taxotere With Radiotherapy as Preoperative Treatment in Resectable Esophageal Cancer
There is a need for more effective therapy for patients following surgery for esophageal carcinoma. Docetaxel and Irinotecan, independent of each other, have demonstrated activity in this disease.
- Conditions
- Esophageal Cancer, Cancer of the Esophagus, Esophagus Cancer, Esophageal Neoplasm
- Trial name
- NCT00318903
- Testing
- Irinotecan (drug), Taxotere (drug), Radiotherapy (procedure)
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- University of Alabama at Birmingham
Pancreatic Cancer
Combination Chemotherapy Plus Radiation Therapy in Treating Patients With Advanced Pancreatic Cancer
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining radiation therapy with chemotherapy may kill more tumor cells.
- Trial name
- NCT00026403
- Testing
- cisplatin, gemcitabine hydrochloride, radiation therapy
- Where
- 26 sites in United States, Canada
- Volunteers
- 48 people
- Sponsor
- Alliance for Clinical Trials in Oncology
Gastric Cancer
Cyclooxygenase-2-Associated Factors and Gastric Carcinogenesis Mechanisms-Clinical Association and Genomic Investigation
Background: Gastric carcinoma (GC) remains among the most frequent malignancies in Taiwan as well as in the world and also one of leading causes of cancer-related death.
- Trial name
- NCT00172861
- Where
- Taiwan
- Volunteers
- 20 people
- Sponsor
- National Taiwan University Hospital
Gastrointestinal Malignancy, Pain Control
The Erector Spinae Plane Block For Gastrointestinal Malignancy Pain Treatment (EGIPT)
This study will target patients with gastrointestinal (GI) malignancy who present to any of 4 Penn Medicine emergency departments (EDs) with intractable abdominal pain.
- Trial name
- EGIPT (NCT07211386)
- Testing
- Erector Spinae Plane Block
- Where
- 4 sites in United States
- Volunteers
- 25 people
- Sponsor
- Abramson Cancer Center at Penn Medicine
Hepatocellular Cancer, Liver Cirrhoses
Comparing the Diagnostic Efficiencies of CEUS and EOB-MRI in Patients With High Risk of HCC
HCC is a serious threat to the health of people. Accurate diagnosis of early HCC by imaging allows patients to obtain proper treatment.
- Conditions
- Hepatocellular Cancer, Liver Cirrhoses, Diagnoses Disease
- Trial name
- NCT04212286
- Testing
- Diagnostic CEUS and EOB-MRI
- Where
- China
- Volunteers
- 115 people
- Sponsor
- Tianjin Third Central Hospital
Colorectal Cancer
Gefitinib and Combination Chemotherapy in Treating Patients With Advanced Solid Tumors or Colorectal Cancer
RATIONALE: Biological therapies such as gefitinib may interfere with the growth of tumor cells and slow the growth of the tumor.
- Trial name
- NCT00025142
- Testing
- FOLFOX regimen, fluorouracil, gefitinib
- Where
- United States
- Sponsor
- Stanford University
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