Clinical trials: Neoplasm, Gastrointestinal
Early Gastric Cancer, Gastric Dysplasia
Conventional Biopsies vs pCLE for Diagnosis of Superficial Gastric Neoplasia
Confocal endomicroscopy (CLE) allows real-time in-vivo high-resolution and high-magnification imaging of the gastrointestinal epithelium, which is comparable to histopathology.
- Trial name
- pCLE (NCT01688687)
- Testing
- Endoscopic submucosal dissection
- Where
- South Korea
- Volunteers
- 63 people
- Sponsor
- Soonchunhyang University Hospital
Gastric Cancer (GC)
Beta-Blockers on Neoadjuvant Immunochemotherapy for Hypertensive Patients With Gastric Cancer
Study Population: Patients with locally advanced gastric cancer complicated by primary hypertension, who received neoadjuvant immunochemotherapy followed by curative gastrectomy at Nanfang Hospital of Southern Medical University…
- Trial name
- BNIHGC (NCT07622693)
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Nanfang Hospital, Southern Medical University
Colorectal Neoplasms
Study of Narrow Band Imaging in the Characterization of Residual Neoplasia After Endoscopic Piecemeal Mucosal Resection
This study is designed to evaluate the diagnostic accuracy of Narrow Band Imaging (NBI) compared with High Definition White Light colonoscopy (WLE) for detection of residual neoplasia in subjects with piecemeal polypectomy scars.
- Trial name
- CROMOPIE (NCT02448693)
- Testing
- WLE, NBI
- Where
- Spain
- Volunteers
- 120 people
- Sponsor
- Parc de Salut Mar
Rectal Cancer
Phase II/III Study to Assess the Efficacy of Neoadjuvant Consolidation Chemotherapy in Rectal Cancer Patients.
This is a Phase II/III randomized study involving non-metastatic rectal cancer patients who are candidates for neoadjuvant chemoradiotherapy.
- Trial name
- NCT03957733
- Testing
- Chemotherapy
- Where
- Saudi Arabia
- Volunteers
- 338 people
- Sponsor
- King Abdullah Medical City
Diverticulosis, Colonic, Rectal Neoplasms
Concentration of Ertapenem in Colorectal Tissue
The purpose of this study is to determine the tissue kinetics of ertapenem in colonic tissue from three hours up to six hours (25% of dosing interval) after administration of ertapenem.
- Conditions
- Diverticulosis, Colonic, Rectal Neoplasms, Colonic Neoplasms
- Trial name
- NCT00535652
- Testing
- Ertapenem
- Where
- Germany
- Volunteers
- 23 people
- Sponsor
- University of Ulm
Locally Advanced Gastrointestinal Stromal Tumor, Locally Advanced Sarcoma
Testing the Anti-cancer Drug, Rogaratinib (BAY 1163877), for Treatment of Advanced Sarcoma With Alteration in Fibroblast Growth Factor Receptor (FGFR 1-4), and in Patients With SDH-deficient Gastrointestinal Stromal Tumor (GIST)
This phase II trial studies the effect of rogaratinib in treating patients with sarcoma with a change in a group of proteins called fibroblast growth factor receptors (FGFRs) or SDH-deficient gastrointestinal stromal tumor…
- Conditions
- Locally Advanced Gastrointestinal Stromal Tumor, Locally Advanced Sarcoma, Metastatic Gastrointestinal Stromal Tumor, Metastatic Sarcoma
- Trial name
- NCT04595747
- Testing
- Biopsy Procedure, Biospecimen Collection, Computed Tomography
- Where
- 18 sites in United States
- Volunteers
- 48 people
- Sponsor
- National Cancer Institute (NCI)
Hepatocellular Carcinoma
4SC-201 (Resminostat) and Sorafenib in Advanced Hepatocellular Carcinoma
The purpose of the study is to determine whether 4SC-201 alone or in combination with Sorafenib is effective and safe in the treatment of hepatocellular carcinoma in patients refractory to Sorafenib monotherapy.
- Trial name
- Shelter (NCT00943449)
- Testing
- 4SC-201, Sorafenib
- Where
- 15 sites in Germany, Italy
- Volunteers
- 57 people
- Sponsor
- 4SC AG
Colorectal Cancer, Colo-rectal Cancer
ctDNA-guided Surveillance for Stage III CRC, a Randomized Intervention Trial
IMPROVE-IT2 is a randomized multicenter trial comparing the outcomes of ctDNA guided post-operative surveillance and standard-of-care CT-scan surveillance.
- Conditions
- Colorectal Cancer, Colo-rectal Cancer, ctDNA, Gastro-Intestinal Disorder
- Trial name
- NCT04084249
- Testing
- ctDNA-analysis, Intensified Follow-up Schedule
- Where
- 10 sites in Denmark
- Volunteers
- 359 people
- Sponsor
- Claus Lindbjerg Andersen
Colon Adenocarcinoma
Study of the Immune Response in Colon Adenocarcinoma
Duration of each part of the study per patient: Screening: From 1 to 4 weeks Sampling period (blood and tissue): 1 day Follow-up by patient: 60 months Total study duration by patient: 84 months Total inclusion duration: 24 months…
- Trial name
- IMCO (NCT03015038)
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Colorectal Cancer
REINFORCEMENT ANASTOMOSIS WITH Modified Cyanacrylate IN Patients Undergoing to Oncologic Colorectal Surgery With Colorectal Anastomosis
In colorectal surgery about 30% of postoperative mortality is attributed to anastomotic leak, whit an incidence range between 1.8% and 15.9%.
- Trial name
- ANASTOSEAL (NCT03380858)
- Testing
- colectomy
- Where
- Italy
- Volunteers
- 390 people, healthy volunteers welcome
- Sponsor
- National Cancer Institute, Naples
Gastric Cancer
Prospective Randomized Trial Comparing Gastrectomy, Metastasectomy Plus Systemic Therapy Versus Systemic Therapy Alone: GYMSSA Trial
Background: Gastric (stomach) cancer is a rare cancer. In most cases, by the time it has been diagnosed it has spread to other organs in the body and the chance of a cure is very small.
- Trial name
- NCT00941655
- Testing
- Oxaliplatin, Irinotecan, 5-Fluorouracil
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- National Cancer Institute (NCI)
Colorectal Cancer, Neoplasm of Uncertain Malignant Potential
Fludeoxyglucose F 18 PET Imaging in Determining Protein and Gene Expression Signatures in Patients With Premalignant Polyps or Colon Cancer
RATIONALE: Diagnostic imaging procedures, such as fludeoxyglucose F 18 PET, may be effective in detecting cancer or recurrence of cancer, or premalignant polyps.
- Trial name
- NCT00550628
- Testing
- DNA methylation analysis, fluorescence in situ hybridization, gene expression analysis
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Ulcerative Colitis
Endomicroscopy in Ulcerative Colitis
This is a confirmatory, multicentric, prospective, randomized, controlled, single-blind study in subjects with long standing ulcerative colitis in clinical remission with indication for surveillance colonoscopy.
- Trial name
- NCT00659867
- Testing
- PENTAX EC-3870CIFK / EC-3870CILK confocal colonoscopes
- Where
- 5 sites in Germany, Italy
- Volunteers
- 182 people
- Sponsor
- PENTAX Europe GmbH
Gum Chewing
Effect of Chewing Gum on Gastrointestinal Function Recovery After Surgery of Gynecological Cancer Patients
A total patients undergoing abdominal complete surgical staging for various gynecological cancers were randomized into a gum-chewing group or a control group.
- Trial name
- NCT03669107
- Testing
- Gum
- Where
- Thailand
- Volunteers
- 80 people
- Sponsor
- Department of Medical Services Ministry of Public Health of Thailand
Metastatic Colorectal Cancer
Phase II Trial of Lapatinib & Capecitabine for Patients With Refractory Advanced Colorectal Adenocarcinoma
The purpose of this study is to find out how effective this combination is as a second line treatment for colorectal cancer that has spread from one part of the body to another (metastasized) or has not metastasized but is…
- Trial name
- NCT00574171
- Testing
- lapatinib, Capecitabine
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- University of Wisconsin, Madison
Pancreatic Cysts
Registry and Fluid Banking of Pancreatic Cystic Lesions
The purpose of this study is to follow patients, who have small mucinous cysts in the pancreas, prospectively over a 5-year period.
- Trial name
- NCT01769534
- Where
- United States
- Volunteers
- 107 people, healthy volunteers welcome
- Sponsor
- University of Oklahoma
Carcinoma of Esophagus
Pre-op Chemo-RT w/CDDP/5FU vs Chemo w/ Docetaxel/Irinotecan in PET Non Responder Resectable Esophagus Cancer
The purpose of this study is to improve their outcome by either changing the chemotherapy drugs or giving them radiation therapy with concurrent chemotherapy, hoping that this will improve their outcome.
- Trial name
- NCT01608464
- Testing
- irinotecan and docetaxel, Cisplatin, fluorouracil and concurrent radiation therapy
- Where
- Saudi Arabia
- Volunteers
- 170 people
- Sponsor
- King Faisal Specialist Hospital & Research Center
Biliary Tract Cancer
A Post-marketing Observational Study of Tasfygo in Participants With Unresectable Biliary Tract Cancer With Fibroblast Growth Factor Receptor 2 (FGFR2) Fusion Gene Positivity Who Progressed After Chemotherapy
The primary purpose of this study is to investigate the safety of Tasfygo.
- Trial name
- NCT06793709
- Testing
- No Intervention
- Where
- Japan
- Volunteers
- 60 people
- Sponsor
- Eisai Co., Ltd.
BRAF V600E, Colorectal Cancer
A Phase II Study of Sintilimab Combined With Ipilimumab N01, Cetuximab and Dabrafenib in Patients With Microsatellite-Stable, BRAF V600E-Mutated Metastatic Colorectal Cancer
Colorectal cancer (CRC) is the second leading cause of cancer-related death globally. BRAF V600E mutations occur in approximately 12% of metastatic CRC (mCRC) patients, conferring an extremely poor prognosis with a median overall…
- Conditions
- BRAF V600E, Colorectal Cancer, Sintilimab, MSS (Microsatellite Stable)
- Trial name
- NCT07506109
- Testing
- Ipilimumab N01, Sintilimab, Cetuximab
- Where
- 4 sites in China
- Volunteers
- 49 people
- Sponsor
- Tianjin Medical University Cancer Institute and Hospital
Pancreatic Cancer
Low-dose Radiotherapy Plus Chemotherapy With Gem-based Doublets and Stereotactic Radiotherapy for Advanced Pancreatic Cancer
Aim of this study is to evaluate if low-dose radiotherapy (LDR) can intensify local effect of a chemotherapy regimen with Gem-based doublets administered sequentially with stereotactic body radiotherapy (SBRT) and to assess the…
- Trial name
- ORCHESTRATE (NCT02416609)
- Testing
- LDR, Gem-based doublets, SBRT
- Where
- Italy
- Volunteers
- 44 people
- Sponsor
- Azienda Ospedaliero-Universitaria di Modena
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