Clinical trials: Neoplasm, Gastrointestinal
Esophageal Cancer, Intensity-modulated Radiation Therapy
The Effect of Prophylactic TPO Combined with BMS-IMRT to Esophageal Cancer Patients
The goal of this interventional study is to explore the protective effect of prophylactic TPO combined with bone marrow sparing (BMS)-IMRT in patients with esophageal cancer undergoing concurrent chemoradiotherapy.
- Conditions
- Esophageal Cancer, Intensity-modulated Radiation Therapy, Concurrent Chemoradiotherapy, Thrombocytopenia
- Trial name
- NCT05944809
- Testing
- rhTPO
- Where
- China
- Volunteers
- 32 people
- Sponsor
- JIANYANG WANG
Colorectal Neoplasms, Colonic Polyps
Study of Flat Polyp Detection Using New Narrow Band Imaging (NBI) Compared to White Light Colonoscopy - The FIND FLAT Colonoscopy Study
We hypothesize that high definition narrow band imaging (NBI) colonoscopy compared to high definition white light colonoscopy will detect an increased number of nonpolypoid (flat and depressed) colorectal neoplasm.
- Conditions
- Colorectal Neoplasms, Colonic Polyps, Colorectal Cancer
- Trial name
- NBI (NCT01310699)
- Testing
- Olympus Colonoscope CFHQ190AL
- Where
- 3 sites in United States
- Volunteers
- 281 people, healthy volunteers welcome
- Sponsor
- VA Palo Alto Health Care System
Pancreatic Neoplasms
A Study for Participants With Pancreatic Cancer
The purpose of the Phase 1 portion of this study was to determine the dose of LY2603618 that can be safely administered 24 hours after gemcitabine treatment. This dose was then used for the Phase 2 portion of the study.
- Trial name
- NCT00839332
- Testing
- LY2603618, Gemcitabine
- Where
- 30 sites in United States, Germany and 4 more
- Volunteers
- 157 people
- Sponsor
- Eli Lilly and Company
Gastric Cancer
Phase 1/2 Study of S-1 and Cisplatin in Advanced Gastric Cancer
The purpose of the phase 1 portion of the study is to determine the safe dose of S-1 and cisplatin that can be administered in gastric cancer patients.
- Trial name
- NCT00072787
- Testing
- S-1, cisplatin
- Where
- 11 sites in United States
- Volunteers
- 41 people
- Sponsor
- Taiho Oncology, Inc.
Endoscopic Mucosal Resection, Colonic Neoplasms
Efficacy and Safety of a Solution for Endoscopic Mucosal Resection of Colonic Lesions
The objetive of this clinical trial is to evaluate the efficacy and safety of a solution for endoscopic mucosal resection of colonic lesions in patients undergoing endoscopic resection procedures.
- Conditions
- Endoscopic Mucosal Resection, Colonic Neoplasms, Therapeutic Irrigation, Treatment Outcome
- Trial name
- NCT06910514
- Testing
- Mucopolysaccharide saline solution 0.9%, Saline solution 0.9%
- Where
- Spain
- Volunteers
- 52 people
- Sponsor
- Nakafarma S.L.
Hepatocellular Carcinoma, Liver Cirrhosis
Safety and Efficacy of Atezolizumab-Bevacizumab Versus Tyrosin Kinase Inhibitors in Patients With Liver Cirrhosis
Following the results of the randomized clinical trial IMbrave150, the combination of Atezolizumab with Bevacizumab became the first line regimen for patients with advanced hepatocellular carcinoma and it was approved by the FDA…
- Trial name
- SEEK (NCT07193316)
- Testing
- no intervention
- Where
- Italy
- Volunteers
- 38 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Locally Advanced Colorectal Cancer, Metastatic Colorectal Cancer
CapeOx Combined With Anti-PD1 Antibody Plus Dihydroartemisinin as Neoadjuvant or Conversion Therapy for Microsatellite Stable Locally Advanced and Metastatic Colorectal Cancer
This prospective, single-arm study aims to investigate the efficacy and safety of CapeOX combined with anti-PD1 antibody plus dihydroartemisinin as neoadjuvant or conversion therapy for pMMR/MSS locally advanced and metastatic…
- Trial name
- NCT07801352
- Testing
- Capecitabine, Oxaliplatin, Dihydroartemisinin
- Where
- China
- Volunteers
- 15 people
- Sponsor
- Shanghai Changzheng Hospital
Primary Rectal Cancer
Preoperative Chemoradiation Versus Short Term Radiation Alone With Delayed Surgery for Stage II and III Resectable Rectal Cancer
Trial compares two preoperative stage II and III rectal cancer treatment strategies: short term radiotherapy 5x5 Gy and delayed surgery after 6 weeks versus conventional chemoradiotherapy 50 Gy + 5Fu/Lv and surgery also after 6…
- Trial name
- NCT00597311
- Testing
- radiotherapy
- Where
- Lithuania
- Volunteers
- 150 people
- Sponsor
- Kaunas University of Medicine
Colorectal Cancer, Colorectal Cancer Stage III
Multimodal Prehabilitation for Colorectal Surgery
Despite advances in surgical care, the incidence of postoperative complications and prolonged recovery following colorectal surgery remains high.
- Trial name
- NCT01356264
- Testing
- multimodal prehabilitation
- Where
- Canada
- Volunteers
- 89 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Pancreatic Cancer
Assessment of the Cytotoxic Immune Status of Pancreatic Cancer Patients and the Severity of the Cancer Using Measurement of Natural Killer Cell Activities
Pancreatic cancer is the 5th leading cause of cancer death and the worst prognostic cancer in the world. This is due to high recurrent rate after surgical resection and poor response to chemotherapy and radiotherapy.
- Trial name
- NCT02887599
- Testing
- Blood collection
- Where
- South Korea
- Volunteers
- 203 people, healthy volunteers welcome
- Sponsor
- Yonsei University
Metastatic Cancer, Solid Tumors
Arginase Inhibitor INCB001158 as a Single Agent and in Combination With Immune Checkpoint Therapy in Patients With Advanced/Metastatic Solid Tumors
This study is an open-label Phase 1/Phase 2 evaluation of INCB001158 as a single agent and in combination with immune checkpoint therapy in patients with advanced/metastatic solid tumors.
- Conditions
- Metastatic Cancer, Solid Tumors, Colorectal Cancer (CRC), Gastric Cancer
- Trial name
- NCT02903914
- Testing
- INCB001158, Pembrolizumab
- Where
- 20 sites in United States, Italy and 2 more
- Volunteers
- 260 people
- Sponsor
- Incyte Corporation
Barrett's Esophagus
Application of hybridAPC in the Treatment of Barrett
The purpose of this study is to evaluate the efficacy and safety of the new technique of HybridAPC in the treatment of Barrett.
- Trial name
- NCT03418584
- Testing
- HybridAPC
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Changhai Hospital
Colorectal Cancer, Early Detection of Cancer
ASPIRES (Activating Cancer Survivors and Their Primary Care Providers to Increase Colorectal Cancer Screening) Study
The primary purpose of this study is to assess the best method for encouraging high-risk cancer survivors to get screened for colorectal cancer at the recommended age.
- Trial name
- ASPIRES (NCT05084833)
- Testing
- Control, Patient activation, Primary care provider activation
- Where
- 4 sites in United States
- Volunteers
- 300 people
- Sponsor
- Ann & Robert H Lurie Children's Hospital of Chicago
Liver Metastases, Hepatocellular Carcinoma
Stereotactic Body Radiotherapy for Liver Tumors
This study will evaluate the local control rate as well as acute and late toxicity rates of stereotactic body radiotherapy for the treatment of liver metastases and unresectable primary liver tumors such as hepatocellular…
- Conditions
- Liver Metastases, Hepatocellular Carcinoma, Intrahepatic Cholangiocarcinoma
- Trial name
- NCT01347333
- Testing
- Stereotactic body radiosurgery, Stereotactic Body Radiotherapy
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- Mercy Research
Gallbladder Cancer
Envafolimab Combined With GEMOX in First-line Treatment of Advanced GBC
The TOPAZ-1 study compared the advantages and disadvantages of immune checkpoint inhibitor anti-PD-L1 antibody combined with Gem/Cis chemotherapy (Gemcitabine and Cisplatin) and Gem/Cis chemotherapy alone in first-line treatment…
- Trial name
- NCT06013943
- Testing
- Envafolimab+Gemox
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Eastern Hepatobiliary Surgery Hospital
Cancer, Mucositis
Effect of Topical Morphine (Mouthwash) on Oral Pain Due to Chemo- and/or Radiotherapy Induced Mucositis
Introduction: Oral pain due to mucosal lesion is quite frequent in oncology, geriatric as well as palliative care settings. The oncology patient is mainly suffering from radio- and/or chemotherapy induced oral mucositis.
- Trial name
- NCT00613743
- Testing
- mouth wash with morphine
- Where
- Switzerland
- Volunteers
- 30 people
- Sponsor
- University Hospital, Geneva
Esophageal Cancer
Rehabilitative Strategies Following Oesophageal Cancer
The ReStOre trial is a multi-disciplinary intervention of exercise, diet and education for patients who have completed treatment for oesophageal cancer.
- Trial name
- ReStOre (NCT03314311)
- Testing
- Rehabilitation programme
- Where
- Ireland
- Volunteers
- 44 people
- Sponsor
- University of Dublin, Trinity College
Gastric Cancer
Pepsinogen II and Helicobacter Pylori Test in Gastric Cancer
The aim of this study to validate the role of pepsinogens in gastric cancer screening.
- Trial name
- NCT06301464
- Where
- South Korea
- Volunteers
- 24,000 people, healthy volunteers welcome
- Sponsor
- Seoul National University Bundang Hospital
Anal Cancer
Shortening Radiation Course Duration Using Simultaneous Integrated Boost With Lower Intensity Elective Nodal Dosing and Concurrent Chemotherapy for High-Risk Anal Squamous Cell Carcinoma
This phase 2 single-arm study will evaluate whether a shortened course of mildly hypofractionated radiation therapy given with standard concurrent chemotherapy (mitomycin C and capecitabine) can provide acceptable tumor control…
- Trial name
- SSIBLING (NCT07775209)
- Testing
- Hypofractionated Radiation Therapy
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- University of Vermont Medical Center
Esophageal Squamous Cell Carcinoma
Neoadjuvant Adebrelimab Plus Chemotherapy for Esophageal Cancer: A Clinical Study
This is a domestic exploratory, single-arm clinical study enrolling patients with histologically or cytologically confirmed locally advanced esophageal squamous cell carcinoma (ESCC), aiming to evaluate the efficacy and safety of…
- Trial name
- NCT07437898
- Testing
- Adebrelimab, chemotherapy
- Where
- China
- Volunteers
- 42 people
- Sponsor
- The Affiliated Hospital of Putian University
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