Clinical trials: Neoplasm, Gastrointestinal
Rectal Cancer
Effects of Different Treatment for Anorectal Function of Patients With Rectal Cancer
Background Neoadjuvant chemoradiotherapy (NCRT) and total mesorectal excision are standard treatments for patients with locally advanced rectal cancer.
- Trial name
- ARF-RC (NCT05671809)
- Testing
- NCRT with surgery, or NCT with surgery, or surgery
- Volunteers
- 402 people
- Sponsor
- Sixth Affiliated Hospital, Sun Yat-sen University
Cryptogenic Pyogenic Liver Abscess
Prevalence of Colon Cancer in Pyogenic Liver Abscess
Although a proportion of pyogenic liver abscess may originated from colonic mucosal lesions, the prevalence of colonic neoplasm in the patients with pyogenic liver abscess are still not evaluated yet.
- Trial name
- NCT02032914
- Where
- 2 sites in South Korea
- Volunteers
- 62 people
- Sponsor
- Inje University
Pancreas Cancer
Development of a Prediction Platform for Neoadjuvant Treatment and Prognosis in Pancreatic Cancer Using Organoid
The investigators create organoid from the pancreatic cancer tissue obtained via EUS-FNA and EUS-FNB within the pancreatic cancer diagnostic process.
- Trial name
- NCT04777604
- Testing
- Organoid
- Where
- South Korea
- Volunteers
- 300 people
- Sponsor
- Samsung Medical Center
Colo-rectal Cancer, Colon Cancer
Ellagic Acid, Urolithin and Colonic Microbial Communities Affected by Walnut Consumption
Briefly, this is a 28-day dietary intervention study participants will be asked to eat 2 ounces (52 grams) of walnuts every day for 3 weeks, and at the end of the study period they will come in for a colonoscopy.
- Conditions
- Colo-rectal Cancer, Colon Cancer, Diet Habit
- Trial name
- NCT04066816
- Testing
- Walnuts
- Where
- United States
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- UConn Health
Metastatic Colorectal Cancer
Safety, Tolerability and Pharmacokinetics of Oral Tablet of Irinotecan in Adult Patients With Solid Tumors
This study evaluates the safety, tolerability and pharmacokinetics of oral administration of irinotecan in adult patients. Oral irinotecan will be administered as monotherapy in a dose escalation trial to establish the Maximal…
- Trial name
- NCT03295084
- Testing
- Irinotecan, Capecitabine
- Where
- Denmark
- Volunteers
- 39 people
- Sponsor
- Dorte Nielsen
GastroEsophageal Cancer
Biobanking Upper Gastrointestinal Tumors to Evaluate Response (BURGER With BACON)
The goal of this observational study is to examine genetic changes that may contribute to immunotherapy resistance in gastroesophageal cancer.
- Trial name
- NCT06283238
- Testing
- Immune checkpoint inhibitor (ICI) or chemotherapy alone
- Where
- United States
- Sponsor
- Duke University
Liver Cancer
DEB-TACE Prior to Liver Transplantation in the Treatment of HCC
The goal of the study is to explore whether the usage of DEB-TACE (Drug-Eluting Bead Transarterial Chemoembolization) prior to living donor liver transplantation can prolong the recurrence-free survival in patients with…
- Trial name
- NCT06353126
- Testing
- DEB-TACE
- Where
- China
- Volunteers
- 40 people
- Sponsor
- RenJi Hospital
Metastatic Pancreatic Cancer, Unresectable Pancreatic Cancer
EL CENTRO: Engaging Latinos in the Center of Cancer Treatment Options
The objective of this study is to improve the chemotherapy decision making process for Latinos with advanced gastrointestinal cancers.
- Conditions
- Metastatic Pancreatic Cancer, Unresectable Pancreatic Cancer, Metastatic Colorectal Cancer
- Trial name
- NCT03602885
- Testing
- Usual chemotherapy education (CE), Chemotherapy education intervention (CEI)
- Where
- 5 sites in United States
- Volunteers
- 10 people
- Sponsor
- Dana-Farber Cancer Institute
Cancer of Pancreas, Cancer of Duodenum
Enteral Nutrition After Pancreaticoduodenectomy
Pancreaticoduodenectomy (PD) is the treatment of choice for resectable periampullary cancer. PD is still associated with a relatively a high incidence of delayed gastric emptying.
- Conditions
- Cancer of Pancreas, Cancer of Duodenum, Ampulla of Vater Cancer, Cholangiocarcinoma
- Trial name
- NCT03150615
- Testing
- Early enteral nutrition, Saline, nasojejunal tube insertion
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Nanjing Medical University
Pancreatic Cancer
BIOmarkers in Patients With Pancreatic Cancer ("BIOPAC")
No validated biomarkers to identify PC at an early stage and to predict treatment outcomes in the individual patient exist. The objective of the present study is to find diagnostic, prognostic and predictive biomarkers.
- Trial name
- BIOPAC (NCT03311776)
- Where
- Denmark
- Volunteers
- 5,000 people
- Sponsor
- Inna Chen, MD
Pancreatic Neoplasms
Surufatinib Combined With Sintilimab and AG in First-line Therapy of Patients With Locally Advanced or Metastatic Pancreatic Cancer
This is a single-center, single-arm, open-label, phase 2 clinical study, to explore the efficacy and safety of surufatinib combined with sintilimab and AG in first-line therapy of patients with locally advanced or metastatic…
- Trial name
- NCT05481476
- Testing
- Surufatinib, Sintilimab, AG
- Where
- China
- Volunteers
- 32 people
- Sponsor
- Sun Yat-sen University
Pancreatic Cancer, Liver Metastases
Simultaneous Resection of Pancreatic Cancer and Liver Oligometastasis After Induction Chemotherapy
This study is a multi-center phase 3 trial to evaluate a treatment strategy for selecting patients who can benefit from the synchronous resection of primary pancreatic cancer and liver oligometastasis after induction…
- Conditions
- Pancreatic Cancer, Liver Metastases, Surgery
- Trial name
- NCT03398291
- Testing
- Synchronous resection of primary pancreatic cancer and liver oligometastasis, Standard chemotherapy
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Fudan University
Gastric Cancer Patients Treated by Subtotal Gastrectomy
Obestatin Change in Distal Gastrectomy
According to Seoul cancer registry data (2000), cancer became the leading cause of death in Korea, accounting for 23.9% of all deaths and gastric cancer is the most prevalent malignant neoplasm, comprising 20.8% of all cancers.
- Trial name
- NCT00822718
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Samsung Medical Center
Colorectal Neoplasms, Colonic Polyp
Adenoma Detection Rate Using AI System in China
The primary aim of this study is to explore the usefulness of Artificial Intelligence system in colonoscopy on adenoma detection rate (ADR). Other aims include to explore the data below when Artificial Intelligence is used.
- Conditions
- Colorectal Neoplasms, Colonic Polyp, Adenoma
- Trial name
- SinoAIADR (NCT03840590)
- Testing
- CSK AI system, Standard Colonoscopy
- Where
- 4 sites in China
- Volunteers
- 743 people, healthy volunteers welcome
- Sponsor
- Changhai Hospital
Colorectal Cancer
Neoadjuvant Triplet Chemotherapy Regimen in Patients With Resectable Colorectal Cancer
Colorectal cancer is an aggressive malignancy with a poor overall outcome. The purpose of this study is to evaluate the feasibility, safety and efficacy of neoadjuvant oxaliplatin, irinotecan combined with…
- Trial name
- NCT02688023
- Testing
- oxaliplatin;irinotecan;leucovorin;5-fluorouracil;capecitabine;S-1
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Chinese Academy of Medical Sciences
Rectal Cancer
Phase II Trial of Preoperative High-dose-rate Endorectal Brachytherapy and FOLFOX Chemotherapy for Rectal Cancer
Standard treatment for rectum cancer is a pre-surgery course of external beam radiotherapy given with chemotherapy at the same time.
- Trial name
- HDRBT (NCT01659424)
- Testing
- High Dose Rate Endorectal Brachytherapy (HDR-ERBT)
- Where
- 2 sites in United States
- Sponsor
- Beth Israel Medical Center
Colorectal Neoplasms, Colonic Neoplasms
Study of Oxaliplatin/5-FU/Leucovorin Plus Vatalanib Versus Oxaliplatin/5-FU/Leucovorin in Patients With Metastatic Colorectal Cancer.
To compare treatment with oxaliplatin/5-FU/leucovorin plus vatalanib versus oxaliplatin/5-FU/leucovorin plus placebo in patients with colorectal cancer that has spread to other organs and are seeking first chemotherapy treatment
- Conditions
- Colorectal Neoplasms, Colonic Neoplasms, Rectal Neoplasms
- Trial name
- NCT00056459
- Testing
- Vatalanib
- Where
- 223 sites in United States, Australia and 17 more
- Volunteers
- 1,168 people
- Sponsor
- Novartis
Ileal Pouch-Anal Anastomosis
Ileal Pouch-Anal Anastomosis Registry
Little is known about the factors that predispose patients to complications after an ileal pouch-anal anastomosis procedure (IPAA).
- Trial name
- IPAA (NCT01026480)
- Where
- United States
- Volunteers
- 936 people
- Sponsor
- Boston Medical Center
Anal Cancer Patients
Patient Reported Outcomes (PROs) in Anal Cancer Patient Treated by Intensity Modulated Radiotherapy (IMRT).
Radiochemotherapy is the standard treatment for neoplasms of the anal canal with excellent rates of local control and preservation of the anal sphincter.
- Trial name
- PROACT (NCT06364579)
- Where
- Italy
- Volunteers
- 120 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Liver Cancer
TriNav Infusion System for the Evaluation of Fidelity Between 99mTc-MAA and Y90-Microspheres Hepatic Distribution for Dosimetry Treatment Planning
To learn if using the TriNav Infusion System (TriNav catheter) for the injection of the surrogate/test dose during the planning part of the radioembolization procedure and your actual treatment with the radioactive microspheres…
- Trial name
- NCT05743842
- Testing
- TriSalus™ TriNav™Infusion System, Angiogram, Y90-radioembolization procedure
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- M.D. Anderson Cancer Center
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