Clinical trials: Neoplasm, Liver
Hepatocellular Carcinoma
Laparoscopic Versus Open Major Hepatectomy for HCC Hepatectomy for Hepatocellular Carcinoma
Background: Hepatocellular carcinoma (HCC) is the sixth most common malignancy in the world. Major hepatectomy (resection of > 3 liver segments) is needed if tumor is close to major blood vessels within liver.
- Trial name
- AP-LAPO (NCT04852211)
- Testing
- Open or laparoscopic surgery
- Where
- Hong Kong
- Volunteers
- 212 people
- Sponsor
- Chinese University of Hong Kong
Hepatocellular Carcinoma (HCC)
A Phase 2 Study of Brivanib in Chinese Patients With Previously Treated Advanced HCC
This is a Phase 2, Open-label, Randomized, Multicenter Study to Investigate the Efficacy, Safety, and Pharmacokinetics of Brivanib in Patients with Previously Treated Advanced Hepatocellular Carcinoma.
- Trial name
- NCT03516071
- Testing
- Brivanib 800 mg, QD, Brivanib 400 mg, BID
- Where
- 15 sites in China
- Volunteers
- 90 people
- Sponsor
- Zai Lab (Shanghai) Co., Ltd.
Hepatic Impairment, Healthy Volunteers
Study to Assess Drug Levels and Safety of Golcadomide (BMS-986369) in Healthy Participants and Participants With Different Degrees of Hepatic Impairment
The purpose of this study is to assess the drug levels and safety of golcadomide (BMS-986369) in adult participants with moderate and severe Hepatic Impairment (HI), and in matched healthy control participants with normal hepatic…
- Trial name
- NCT06535399
- Testing
- BMS-986369
- Where
- 3 sites in United States
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Celgene
Hepatocellular Carcinoma, Face Cancer
Transcatheter Arterial Chemoembolization Combined With Sorafenib for Unresectable Hepatocellular Carcinoma
Hepatocellular carcinoma (HCC) is the 6th most common cancer and the third most frequent cause of cancer death worldwide. Hepatic resection (HR) has been the standard treatment modality for HCC aiming at clinical cure.
- Trial name
- NCT01833299
- Testing
- TACE-Sorafenib group, TACE
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Sun Yat-sen University
Liver Metastases, Recurrent Colon Cancer
Neoadjuvant and Adjuvant Capecitabine and Oxaliplatin in Treating Patients With Resectable Liver Metastases Secondary to Colorectal Cancer
Drugs used in chemotherapy, such as capecitabine and oxaliplatin, use different ways to stop tumor cells from dividing so they stop growing or die.
- Conditions
- Liver Metastases, Recurrent Colon Cancer, Recurrent Rectal Cancer, Stage IV Colon Cancer
- Trial name
- NCT00070265
- Testing
- oxaliplatin, capecitabine, therapeutic conventional surgery
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- National Cancer Institute (NCI)
Liver Cancer
A Real-world Study of Immunotherapy Combination Regimens for Treating Liver Cancer in Cold Regions
Hepatocellular carcinoma (HCC) is a common global malignancy. In China, the disease burden is substantial: HCC ranks fifth in cancer incidence and third in mortality, with a 5-year relative survival of only 14.4%.
- Trial name
- NCT07645209
- Testing
- Immune Checkpoint Inhibitors
- Where
- China
- Volunteers
- 1,000 people
- Sponsor
- Harbin Medical University
Hepatocellular Carcinoma
SHR-1210 Plus Apatinib in Patients With Advanced-Stage Hepatocellular Carcinoma
SHR-1210 is a humanized anti-PD-1 Immunoglobulin G4 (IgG4) monoclonal antibody. This is an open- label#single center #non-randomized #Single Arm Exploratory Study .
- Trial name
- SHR-1210 (NCT04014101)
- Testing
- SHR-1210, apatinib
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Shanghai Zhongshan Hospital
Hepatocellular Carcinoma, Hepatocellular Carcinoma by BCLC Stage
Brazilian Reality of Hepatocellular Carcinoma
National, multicenter, retrospective, non-randomized observational study (Real World Evidence-RWE) with the purpose of analyzing the epidemiological profile of Hepatocellular Carcinomas (BCLC A, B or C), clinical management…
- Conditions
- Hepatocellular Carcinoma, Hepatocellular Carcinoma by BCLC Stage, Hepatocellular Carcinoma Stage I, Hepatocellular Carcinoma Stage II
- Trial name
- BRA-HEP (NCT06230328)
- Where
- 11 sites in Brazil
- Volunteers
- 300 people
- Sponsor
- AstraZeneca
Colorectal Cancer, Depression
Studying Pain and Symptom Distress in Patients With Advanced Colon Cancer, Rectal Cancer, Pancreatic Cancer, or Liver Cancer
RATIONALE: Studying a patient's understanding of his or her illness, pain, symptoms, and quality-of-life may help the study of advanced cancer and may help patients live more comfortably.
- Conditions
- Colorectal Cancer, Depression, Fatigue, Liver Cancer
- Trial name
- NCT00950144
- Testing
- medical chart review, questionnaire administration, study of socioeconomic and demographic variables
- Where
- United States
- Volunteers
- 123 people
- Sponsor
- City of Hope Medical Center
Hepatitis C Virus Infection
Characterization of Immune Genotypes and Antibody Profiles to Foster the discoVERY of diagnosticbioMARKERS of Liver Cancer Development
Hepatitis C virus (HCV), which infects more than 185 million people, is a major risk factor. Direct-acting antiviral (DAA) therapy has significantly improved the eradication of the virus, but has not completely eliminated the…
- Trial name
- VERYMARKERS (NCT06718530)
- Where
- 4 sites in Italy
- Volunteers
- 1,000 people
- Sponsor
- Centro di Riferimento Oncologico - Aviano
Non-small Cell Lung Cancer, Esophageal Cancer
Tumor Cell and DNA Detection in the Blood, Urine and Bone Marrow of Patients With Solid Cancers
Patients with resectable solid primary cancers and even limited number of metastases are potentially curable. However, most patients develop recurrences despite surgery.
- Conditions
- Non-small Cell Lung Cancer, Esophageal Cancer, Gastric Cancer, Pancreatic Cancer
- Trial name
- NCT02838836
- Testing
- Study sample collection
- Where
- United States
- Volunteers
- 620 people, healthy volunteers welcome
- Sponsor
- University of Missouri-Columbia
Liver Tumour
Targeted Chemotherapy Using Focused Ultrasound for Liver Tumours
This proof of concept study proposes targeted delivery of a broad-spectrum cytotoxic agent (doxorubicin), via a specially formulated LTSL (ThermoDox®) activated by mild hyperthermia, by using focused ultrasound (FUS), to achieve…
- Trial name
- TARDOX (NCT02181075)
- Testing
- ThermoDox® (LTLD), Focused Ultrasound of Target Liver Tumour, Pre-LTLD Biopsy of Target Liver Tumour
- Where
- United Kingdom
- Volunteers
- 10 people
- Sponsor
- University of Oxford
Hepatocellular Carcinoma
Efficacy and Safety of Activated T Lymphocytes (ATL) in Hepatocellular Carcinoma
This is an open-label, single arm, multicenter, Phase II clinical study to investigate the efficacy and safety profiles of autologous ATL administration in HCC patients after curative treatment.
- Trial name
- NCT05304481
- Testing
- ATL administration
- Where
- 14 sites in Taiwan
- Volunteers
- 95 people
- Sponsor
- Lukas Biomedical Inc.
Liver Cancer, Sarcopenia
Relationship Between Liver Cancer and Sarcopenia
By tracking the short-term and long-term results of patients after hepatectomy, the difference of short-term results between patients with sarcopenia and patients without sarcopenia was analyzed, and the correlation between…
- Trial name
- NCT05339919
- Testing
- gait speed; ct scan;grip strength and chair stand test
- Where
- China
- Volunteers
- 1,200 people
- Sponsor
- First Affiliated Hospital of Wenzhou Medical University
Pancreatic Steatosis, Pancreatic Cyst
Prevalence of Pancreatic Steatosis in Pancreatic Cystic Neoplasms and Pancreatic Adenocarcinoma
Several pancreatic neoplastic cystic lesions, such as IPMN (intrapapilary mucinous neoplasia), cystic neuroendocrine tumors (NET) and mucinous neoplasms, present a carcinogenetic risk, though it is yet unknown if this risk is…
- Conditions
- Pancreatic Steatosis, Pancreatic Cyst, Pancreatic Adenocarcinoma
- Trial name
- SPACE (NCT06867172)
- Testing
- computerized tomography, Endosonography (EUS)
- Where
- Romania
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Carol Davila University of Medicine and Pharmacy
Carcinoma, Hepatocellular
Comparison Between Radiofrequency Versus Ethanol Injection for the Treatment of Hepatocellular Carcinoma
Ethanol injection has been for many years the standard approach as percutaneous treatment of non-surgical early hepatocellular carcinoma in cirrhotic patients.
- Trial name
- NCT00355212
- Testing
- percutaneous ablation of hepatocellular carcinoma
- Where
- Italy
- Volunteers
- 240 people
- Sponsor
- Azienda Ospedaliera San Giovanni Battista
Adenocarcinoma (NOS), Anal Cancer
DESTINY-PANTUMOUR04
This study will evaluate the effectiveness of T-DXd in patients with HER2-positive (IHC 3+) locally advanced, unresectable, or metastatic solid tumors who have received prior systemic treatment for metastatic or advanced disease…
- Conditions
- Adenocarcinoma (NOS), Anal Cancer, Bladder Cancer, Cervical Cancer
- Trial name
- DP-04 (NCT07124000)
- Testing
- Trastuzumab deruxtecan
- Where
- 18 sites in United States
- Volunteers
- 100 people
- Sponsor
- AstraZeneca
Hepatocellular Carcinoma (HCC)
Nivolumab Plus Ipilimumab as Neoadjuvant Therapy for Hepatocellular Carcinoma (HCC)
Objectives: 1. To evaluate the efficacy, in terms of tumor shrinkage, objective response rate, and down-stage rate, of nivolumab + ipilimumab as neoadjuvant therapy for patients with HCC; 2.
- Trial name
- NCT03510871
- Testing
- nivolumab, ipilimumab
- Where
- 8 sites in Taiwan
- Volunteers
- 43 people
- Sponsor
- National Health Research Institutes, Taiwan
Liver and Intrahepatic Bile Duct Carcinoma
Surveys, Blood Testing, and Fibroscan in Screening for Liver Fibrosis and Liver Cirrhosis
This clinical trial studies the use of surveys, blood testing, and fibroscan in screening for liver fibrosis and liver cirrhosis in new or existing patients of the HOPE clinic seeking usual clinical care.
- Trial name
- NCT04785534
- Testing
- Clinical Evaluation, Laboratory Biomarker Analysis, Liver Ultrasonographic Elastography
- Where
- United States
- Volunteers
- 1,000 people
- Sponsor
- M.D. Anderson Cancer Center
HepatoCellular Carcinoma
Radiotherapy in Hepatocellular Carcinomas After Hepatectomy With Narrow Margin (<1 cm) and / or Microvascular Invasion
Hepatocellular carcinoma is one of ten leading cancer types worldwide and also in Asia, but the five-year relative survival rate is relatively quite low1-3.
- Trial name
- RHCC:BCLC-A (NCT02678806)
- Testing
- Postoperative radiotherapy, Postoperative TACE
- Where
- China
- Volunteers
- 620 people
- Sponsor
- Guangxi Medical University