Clinical trials: Neoplasm, Ovarian
Polycystic Ovary Syndrome, Obstructive Sleep Apnea
The Impact of Obstructive Sleep Apnoea in Women With Polycystic Ovary Syndrome.
Women with PCOS and OSA, compared to women with PCOS only, have more severe clinical and biochemical features of PCOS and impaired QoL.
- Trial name
- NCT03065322
- Testing
- To assess risk of OSA
- Where
- United Kingdom
- Volunteers
- 38 people
- Sponsor
- University Hospitals Coventry and Warwickshire NHS Trust
Polycystic Ovary Syndrome, Insulin Resistance
Effects of Intermittent Fasting on Polycystic Ovary Syndrome (PCOS) Compared to Standard Treatment
The purpose of this study is to assess the effects of Time restricted eating in patients diagnosed with polycystic ovary syndrome, comparing it to the standard hormonal treatment.
- Trial name
- NCT06031753
- Testing
- Time restricted eating
- Where
- Mexico
- Volunteers
- 16 people
- Sponsor
- Instituto Superior de Investigación en Estética Médica, Nutrición y Anti-Envejecimiento
Platinum-sensitive Ovarian Cancer
Combination Therapy of AK112 With Chemotherapy and/or Olaparib in Platinum-sensitive Ovarian Cancer
An Exploratory, Multi-cohort Phase II Study of combination therapy of AK112 with chemotherapy and/or olaparib in platinum-sensitive ovarian cancer(PSOC)
- Trial name
- NCT06686030
- Testing
- AK112 low dose, Chemotherapy, Olaparib
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Akeso
Ovarian Sex Cord Stromal Tumor, Ovarian Neoplasms
TC or BEP in Treating Patients With Ovarian Malignant Sex Cord-Stromal Tumors
Investigators will conduct the trial to determine whether paclitaxel and cisplatin (PT) has the same curative effects and less adverse effects than bleomycin, etoposide and cisplatin(BEP) among newly diagnosed ovarian malignant…
- Conditions
- Ovarian Sex Cord Stromal Tumor, Ovarian Neoplasms, Ovarian Cancer
- Trial name
- SCST-01 (NCT02429700)
- Testing
- Paclitaxel, Carboplatin, Bleomycin
- Where
- China
- Volunteers
- 132 people
- Sponsor
- Beihua Kong
Fallopian Tube Cancer, Ovarian Cancer
Consolidation Therapy With Hu3S193 for Women With Ovarian, Primary Peritoneal or Fallopian Tube Cancer
RATIONALE: Monoclonal antibodies, such as Hu3S193, can block tumor growth in different ways. Some block the ability of tumor cells to grow and spread.
- Conditions
- Fallopian Tube Cancer, Ovarian Cancer, Peritoneal Cavity Cancer
- Trial name
- NCT01137071
- Testing
- Monoclonal antibody Hu3S193
- Where
- 8 sites in Brazil
- Volunteers
- 29 people
- Sponsor
- Recepta Biopharma
Breast Carcinoma, Colon Carcinoma
Clinical Outcomes for Offering Genetic Testing in a Tiered Approach
This clinical quality improvement study reviews and develops a clinical operations workflow to identify cancer patients who meet criteria for genetic counseling and testing.
- Conditions
- Breast Carcinoma, Colon Carcinoma, Malignant Solid Neoplasm, Ovarian Carcinoma
- Trial name
- NCT04902144
- Testing
- Electronic Health Record Review, Questionnaire Administration, Behavioral Intervention
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Fred Hutchinson Cancer Center
Childhood Germ Cell Tumor, Leydig Cell Tumor
Studying Genes in Samples From Younger Patients With Ovarian or Testicular Sex Cord Stromal Tumors
RATIONALE: Studying samples of tumor tissue from patients with cancer in the laboratory may help doctors identify biomarkers related to cancer.
- Conditions
- Childhood Germ Cell Tumor, Leydig Cell Tumor, Ovarian Cancer
- Trial name
- NCT01572467
- Testing
- RNA analysis, gene expression analysis, mutation analysis
- Volunteers
- 50 people
- Sponsor
- Children's Oncology Group
Cancer
Chronic Graft-Versus-Host Disease in Patients Who Have Undergone Donor Stem Cell Transplant
RATIONALE: Studying samples of tissue from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to chronic graft-versus-host disease in patients who…
- Trial name
- NCT00957736
- Testing
- polymorphism analysis, laboratory biomarker analysis
- Where
- 3 sites in United States
- Volunteers
- 252 people
- Sponsor
- Vanderbilt-Ingram Cancer Center
Leukemia, Myeloid, Acute, Myeloid Dysplasia
Genetic Landscape in Women with Metastatic Ovarian Cancer Before and During Treatment with PARP Inhibitors
Therapy related acute myeloid leukemia and myelodysplasia (t-MN) is a potential late complication of cytotoxic therapy, and it is of particular concern in the treatment of patients with epithelial ovarian carcinoma (EOC) exposed…
- Conditions
- Leukemia, Myeloid, Acute, Myeloid Dysplasia, Ovarian Epithelial Cancer
- Trial name
- NCT06785077
- Testing
- buccal cells, bone marrow cells, peripheral blood cells
- Where
- Italy
- Volunteers
- 157 people
- Sponsor
- European Institute of Oncology
Ovarian Cancer
ChemoINTEL Assay Algorithm Development Study: In-Vitro Cytotoxic Drug Induced Apoptosis Correlation with Patient Clinical Response to Administered Chemotherapy in Patients
This is a prospective, non-randomized, observational, clinical development study. Pierian Biosciences is utilizing ChemoINTEL and ImmunoINTEL assay measurements in human tumour cells from patients with advanced stage epithelial…
- Trial name
- ChemoINtel (NCT06844136)
- Testing
- No intervention
- Where
- United Kingdom
- Volunteers
- 100 people
- Sponsor
- Pierian Biosciences
Advanced Cancer, Advanced Malignancies
Study of AB598 Monotherapy and Combination Therapy in Participants With Advanced Cancers
The primary purpose of this study is to assess the safety and tolerability of AB598 in participants with advanced malignancies.
- Conditions
- Advanced Cancer, Advanced Malignancies, Bladder Cancer, Cervical Cancer
- Trial name
- ARC-25 (NCT05891171)
- Testing
- AB598, Zimberelimab, Fluorouracil
- Where
- 19 sites in United States, Australia and 1 more
- Volunteers
- 40 people
- Sponsor
- Arcus Biosciences, Inc.
Comparison of US Bilateral Erector Spinae Plane Block, US Bilateral Quadratus Lumborum Block and Lumbar Epidural
Comparison of US Bilateral Erector Spinae Plane Block, US Bilateral Quadratus Lumborum Block and Lumbar Epidural for Postoperative Analgesia in Patients Undergoing Total Abdominal Hysterectomy
The investigators hypothesize that US Bilateral Erector Spinae Plane Block, US Bilateral Quadratus Lumborum Block and Lumbar Epidural for Postoperative Analgesia in Patients Undergoing Total Abdominal Hysterectomy resulting in…
- Trial name
- NCT06397300
- Testing
- bilateral Ultrasound guided erector spinae plane (ESP) block, quadratus lumborum block, lumbar epidural
- Where
- 2 sites in Egypt
- Volunteers
- 90 people
- Sponsor
- National Cancer Institute, Egypt
Advanced Gastric Cancer, Advanced Colorectal Cancer
SBRT-LDRT-Cadonilimab for Advanced Gastric, Colorectal and Ovarian Cancers With Peritoneal Metastases
The goal of this clinical trial is to see if high- and low-dose radiotherapy combined with immunotherapy can work in patients with advanced gastric, colorectal, and ovarian cancers with peritoneal metastases, and to learn about…
- Conditions
- Advanced Gastric Cancer, Advanced Colorectal Cancer, Advanced Ovarian Cancer, Peritoneal Metastasis
- Trial name
- NCT06940921
- Testing
- Low-Dose Radiation(LDRT) + Stereotactic body radiotherapy (SBRT), Cadonilimab
- Where
- China
- Volunteers
- 26 people
- Sponsor
- Zhang Tao
Pregnancy, Polycystic Ovary Syndrome
Acupuncture and Clomiphene Citrate on Live Birth in Anovulatory Women With Polycystic Ovary Syndrome
The objectives of the present trial are to test the following three hypotheses in anovulatory women with PCOS: 1. Acupuncture protocol 1 plus CC (Arm A) is more likely to result in live birth than acupuncture protocol 2 combined…
- Conditions
- Pregnancy, Polycystic Ovary Syndrome, Infertility
- Trial name
- PCOSAct (NCT01573858)
- Testing
- Acupuncture treatment 1, Acupuncture treatment 2, CC
- Where
- 25 sites in China
- Volunteers
- 1,000 people
- Sponsor
- Heilongjiang University of Chinese Medicine
Polycystic Ovary Syndrome, Abnormal Weight Gain
Go Girls! Fitness Support Group Intervention Effectiveness Study
The main purpose of this study is to determine if the Go Girls! program to take place at the Kluge Children's Rehabilitation Center Therapeutic Recreation Gymnasium, intended to introduce girls to a fun, non-threatening…
- Conditions
- Polycystic Ovary Syndrome, Abnormal Weight Gain, Excess Weight, Insulin Resistance
- Trial name
- CBS002 (NCT02117063)
- Testing
- Go Girls! Fitness Support Group
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- University of Virginia
Breast Cancer, Bladder Cancer
Germline Alterations of Tumor Susceptibility Genes in New York Cancer Patients
The basic premise of this research proposal is to determine whether there is any significant association between germline polymorphisms and cancers of colon, bladder, breast, testicular, prostate, ovaries, kidney, lung, lymphoid…
- Conditions
- Breast Cancer, Bladder Cancer, Kidney Cancer, Colon Cancer
- Trial name
- NCT00579514
- Testing
- PCR/PCR/LDR Strategy
- Where
- United States
- Volunteers
- 21,081 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Low Grade Fallopian Tube Serous Adenocarcinoma, Ovarian Low Grade Serous Adenocarcinoma
Letrozole With or Without Paclitaxel and Carboplatin in Treating Patients With Stage II-IV Ovarian, Fallopian Tube, or Primary Peritoneal Cancer
This phase III trial studies how well letrozole with or without paclitaxel and carboplatin works in treating patients with stage II-IV low-grade serous carcinoma of the ovary, fallopian tube, or peritoneum.
- Conditions
- Low Grade Fallopian Tube Serous Adenocarcinoma, Ovarian Low Grade Serous Adenocarcinoma, Primary Peritoneal Low Grade Serous Adenocarcinoma, Stage II Fallopian Tube Cancer AJCC v8
- Trial name
- NCT04095364
- Testing
- Biopsy Procedure, Biospecimen Collection, Carboplatin
- Where
- 909 sites in United States, Canada and 4 more
- Volunteers
- 450 people
- Sponsor
- NRG Oncology
Ovarian Cancer
Radiolabeled Folic Acid and Imaging to Detect Ovarian Cancer
RATIONALE: Diagnostic procedures using the drug radiolabeled folic acid and imaging may be effective in detecting ovarian cancer.
- Trial name
- NCT00003763
- Testing
- radionuclide imaging, indium In 111 folic acid
- Where
- 3 sites in United States
- Volunteers
- 35 people
- Sponsor
- Endocyte
Stage III Ovarian Carcinoma, Stage IV Ovarian Carcinoma
Autologous Dendritic Cells Loaded With Autologous Tumor Associated Antigens for Treatment of Advanced Epithelial Ovarian Carcinomas
This is a double-blind study in which approximately 99 study patients will be randomized in a 2:1 ratio to receive either AVOVA-1 or MC.
- Conditions
- Stage III Ovarian Carcinoma, Stage IV Ovarian Carcinoma, Fallopian Tube Carcinoma, Primary Peritoneal Carcinoma
- Trial name
- NCT02033616
- Testing
- AVOVA-1, MC
- Where
- 6 sites in United States
- Volunteers
- 99 people
- Sponsor
- Aivita Biomedical, Inc.
Epithelial Ovarian Cancer, Fallopian Tube Cancer
Study of IMNN-001 (Also Known as GEN-1) With NACT for Treatment of Ovarian Cancer (OVATION 2)
This is a randomized, open label, multicenter trial to evaluate the safety, dosing, efficacy and biological activity of intraperitoneal IMNN-001 plus NACT compared to NACT alone.
- Conditions
- Epithelial Ovarian Cancer, Fallopian Tube Cancer, Primary Peritoneal Cancer
- Trial name
- OVATION 2 (NCT03393884)
- Testing
- IMNN-001, Carboplatin, Paclitaxel
- Where
- 21 sites in United States, Canada
- Volunteers
- 130 people
- Sponsor
- Imunon
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