Clinical trials: Neoplasm, Ovarian
Polycystic Ovary Syndrome, Androgen Excess
The RolE oF Androgen Excess in MUscle Energy MetaboLism in Women With PolyCystic Ovary Syndrome (REFUEL PCOS) Study 2
Polycystic ovary syndrome (PCOS) affects 10% of all women, and it usually co-exists with high levels of sex hormones called androgens, such as testosterone.
- Conditions
- Polycystic Ovary Syndrome, Androgen Excess, Metabolic Disease
- Trial name
- REFUEL PCOS (NCT05647356)
- Testing
- Bicalutamide 50 mg
- Where
- Ireland
- Volunteers
- 16 people
- Sponsor
- Royal College of Surgeons, Ireland
Ovarian Cancer, Triple-negative Breast Cancer
A Study to Evaluate Rucaparib in Combination With Other Anticancer Agents in Participants With a Solid Tumor (SEASTAR)
This is an open label, Phase 1b/2 study with multiple treatment arms evaluating the safety, tolerability, pharmacokinetics (PK), and preliminary efficacy of rucaparib in combination with a second anticancer therapy in…
- Conditions
- Ovarian Cancer, Triple-negative Breast Cancer, Urothelial Carcinoma, Solid Tumor
- Trial name
- NCT03992131
- Testing
- Rucaparib, Lucitanib, Sacituzumab govitecan
- Where
- 3 sites in United States
- Volunteers
- 25 people
- Sponsor
- pharmaand GmbH
Locally Advanced Solid Tumor, Metastatic Cancer
ACE1702 in Subjects With Advanced or Metastatic HER2-expressing Solid Tumors
ACE1702 (anti-HER2 oNK cells) is an off-the-shelf Natural Killer (NK) cell product that targets human HER2-expressing solid tumors.
- Conditions
- Locally Advanced Solid Tumor, Metastatic Cancer, Solid Tumor, HER2-positive Gastric Cancer
- Trial name
- NCT04319757
- Testing
- ACE1702, Cyclophosphamide, Fludarabine
- Where
- 3 sites in United States, Taiwan
- Volunteers
- 12 people
- Sponsor
- Acepodia Biotech, Inc.
Ovarian Cancer, Peritoneal Cavity Cancer
Intraperitoneal Paclitaxel Albumin-Stabilized Nanoparticle Formulation in Treating Patients With Advanced Cancer of the Peritoneal Cavity
RATIONALE: Drugs used in chemotherapy, such as paclitaxel albumin-stabilized nanoparticle formulation, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing.
- Conditions
- Ovarian Cancer, Peritoneal Cavity Cancer, Unspecified Adult Solid Tumor, Protocol Specific
- Trial name
- NCT00825201
- Testing
- paclitaxel albumin-stabilized nanoparticle formulation, liquid chromatography, mass spectrometry
- Where
- 2 sites in United States
- Volunteers
- 27 people
- Sponsor
- City of Hope Medical Center
Ovarian Cancer, Fatigue
REVITALIZE: A Telehealth Intervention for Women With Advanced Ovarian Cancer and PARP Inhibitor-Related Fatigue
This study is testing whether a 6 week skills-based telehealth intervention can help ovarian cancer patients experiencing PARP inhibitor-related fatigue reduce the impact of fatigue on their daily life and activities.
- Conditions
- Ovarian Cancer, Fatigue, Coping Behavior, Coping Skills
- Trial name
- NCT04525183
- Testing
- Enhanced Usual Care (EOC), REVITALIZE ACT Intervention
- Where
- 2 sites in United States
- Volunteers
- 49 people
- Sponsor
- Dana-Farber Cancer Institute
Ovarian Cancer, Sexual Function
Advanced Ovarian Cancer and Sexuality Phase 1
Women with Advanced Ovarian Cancer (AOC) suffer from severe sexual side effects from treatment. The prevalence of the sexual issues is not known.
- Trial name
- ANOVA1 (NCT00488202)
- Where
- 2 sites in Canada
- Volunteers
- 26 people
- Sponsor
- University of British Columbia
Oxidative Stress, Endocrine Disrupting Chemicals
Oxidative Stress and Bisphenol A (BPA) Impact With Polycystic Ovary Syndrome (PCOS)
Both oxidative stress and Bisphenol A (BPA) had been associated with polycystic ovary syndrome (PCOS). BPA, one of endocrine-disrupting chemicals (EDCs), is an environmental estrogen used in the synthesis of plastics, is a…
- Conditions
- Oxidative Stress, Endocrine Disrupting Chemicals, Polycystic Ovary Syndrome
- Trial name
- NCT01600872
- Where
- Taiwan
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Ming-I Hsu
Ovarian Cancer
Screening Women at High Genetic Risk for Ovarian Cancer
RATIONALE: Screening tests may help doctors detect cancer cells early and plan more effective treatment for ovarian cancer. PURPOSE: Screening trial to determine the best procedure to detect ovarian cancer in women who have a…
- Trial name
- NCT00033488
- Testing
- cytology specimen collection procedure, annual screening, comparison of screening methods
- Where
- 2 sites in United Kingdom
- Volunteers
- 5,000 people
- Sponsor
- University College London Hospitals
Polycystic Ovary Syndrome, Insulin Resistance
Acupuncture or Metformin for Insulin Resistance in Women With PCOS
The hypothesis is that acupuncture is equally effective as metformin (both treatments combined with lifestyle management) in improving whole body glucose homeostasis in insulin resistant women with polycystic ovary syndrome…
- Conditions
- Polycystic Ovary Syndrome, Insulin Resistance, Hyperandrogenism
- Trial name
- PIAII (NCT02647827)
- Testing
- Lifestyle management, Acupuncture, Metformin
- Where
- 2 sites in China, Sweden
- Volunteers
- 303 people, healthy volunteers welcome
- Sponsor
- Karolinska Institutet
Breast Cancer, Ovarian Cancer
Dermatological Effects and Quality of Life in Oncology Patients
This is a monocentric, low-risk interventional study designed to characterize established treatment-related dermatologic toxicity in patients receiving systemic anticancer therapies.
- Conditions
- Breast Cancer, Ovarian Cancer, NSCLC (Non-small Cell Lung Cancer), Melanoma (Skin Cancer)
- Trial name
- ReGenera (NCT07869186)
- Testing
- skin barrier assessment
- Where
- Italy
- Volunteers
- 300 people
- Sponsor
- European Institute of Oncology
Polycystic Ovary Syndrome
Use of Myo-inositol as Adjuvant Therapy in Patients With Polycystic Ovary Syndrome (PCOS) in Vitro Fertilization (IVF)
The original mechanism of action of myo-inositol and preliminary results available in the literature on its use in IVF suggest its value as adjuvant gonadotropin therapy to reduce the risk of OHSS in PCOS patients.
- Trial name
- FIV-INOPK (NCT02221154)
- Testing
- Inofolic®, Gonadotropins; Folic Acid
- Where
- 4 sites in France
- Volunteers
- 49 people
- Sponsor
- Centre Hospitalier Departemental Vendee
Polycystic Ovarian Syndrome, Hyperandrogenism
Hemocoagulation and Lipoperoxidation in Women Using Combined Oral Contraceptives, Correction by Antioxidants
We investigate parameters of hemocoagulation and lipoperoxidation in women using combined oral contraceptives with antiandrogenic activity (containing drospirenone with 20 or 30 mcg ethinylestradiol; or cyproterone acetate)…
- Conditions
- Polycystic Ovarian Syndrome, Hyperandrogenism, Menstrual Irregularities
- Trial name
- NCT02027337
- Testing
- 20 mcg ethinylestradiol /3 mg drospirenone, 20 mcg ethinylestradiol/3 mg drospirenone and Selmevit, 30 mcg ethinylestradiol/3 mg drospirenone
- Where
- Russia
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Tyumen State Medical University
Breast Neoplasms, Ovarian Neoplasms
Study of Motexafin Gadolinium and Docetaxel for Advanced Cancer
The primary purpose of this study is to evaluate the safety, side effects, and dosage for Motexafin Gadolinium given with the chemotherapy drug docetaxel to patients with advanced cancers.
- Conditions
- Breast Neoplasms, Ovarian Neoplasms, Prostatic Neoplasms, Lung Neoplasms
- Trial name
- NCT00120939
- Testing
- Motexafin Gadolinium
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Pharmacyclics LLC.
Polycystic Ovary Disease
"KETOGENIC MEDITERRANEAN VERSUS HYPOCALORIC BALANCED DIET ON POLYCYSTIC OVARIAN ADOLESCENTS"
study was designed to determine the effect of ketogenic Mediterranean diet versus hypocaloric balanced diet on adolescent female with polycystic ovary disease.
- Trial name
- keto- MEDITERR (NCT06610812)
- Testing
- KETOGENIC MEDITERRANEAN diet, hypo-caloric diet:, moderate aerobic exercises
- Where
- Egypt
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- MTI University
Cervical Cancer, Endometrial Cancer
Capecitabine and Radiation Therapy in Treating Patients With Locally Advanced Cervical Cancer or Other Pelvic Cancer
RATIONALE: Drugs used in chemotherapy, such as capecitabine, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing.
- Conditions
- Cervical Cancer, Endometrial Cancer, Ovarian Cancer, Vaginal Cancer
- Trial name
- NCT00118300
- Testing
- capecitabine, brachytherapy, radiation therapy
- Where
- 2 sites in United States
- Sponsor
- Case Comprehensive Cancer Center
Epithelial Ovarian Cancer, Primary Peritoneal Cancer
Study of Paclitaxel in Patients With Ovarian Cancer
RATIONALE: Paclitaxel is one of the most widely used human anticancer agents. Paclitaxel has a low degree of solubility and Cremophor EL is typically used as the solubiliser.
- Conditions
- Epithelial Ovarian Cancer, Primary Peritoneal Cancer, Fallopian Tube Cancer
- Trial name
- NCT00989131
- Testing
- Paclical®, Taxol®
- Where
- 84 sites in Belarus, Belgium and 14 more
- Volunteers
- 789 people
- Sponsor
- Oasmia Pharmaceutical AB
Cancer
Caspofungin Acetate in Treating Aspergillosis in Patients With Hematologic Cancer or in Patients Who Have Undergone a Stem Cell Transplant
RATIONALE: Antifungals, such as caspofungin acetate, may be effective in treating fungal infections caused by chemotherapy or stem cell transplant.
- Trial name
- NCT00110045
- Testing
- caspofungin acetate
- Where
- 13 sites in Belgium, France and 5 more
- Volunteers
- 171 people
- Sponsor
- European Organisation for Research and Treatment of Cancer - EORTC
Recurrent Malignant Solid Neoplasm, Stage IV Breast Cancer
Canady Helios Cold Plasma Scalpel Treatment at the Surgical Margin and Macroscopic Tumor Sites
The study designed is to evaluate the safety of Canady Helios™ Cold Plasma Scalpel (CHCPS) in patients with solid tumors with carcinomatosis scheduled to undergo surgical resection for cytoreduction.
- Conditions
- Recurrent Malignant Solid Neoplasm, Stage IV Breast Cancer, Stage IV Prostate Cancer, Stage IV Pancreatic Cancer
- Trial name
- NCT04267575
- Testing
- Canady Helios Cold Plasma Scalpel
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Jerome Canady, M.D.
Polycystic Ovary Syndrome
Ovary Syndrome for Efficient Diagnosis and Targeted Therapy
OBJECTIVES: 1. Analysis of DNA methyl transferases (DNMT1, DNMT3A and DNMT3B) and Histone deacetylases (HDAC 1,2,3 and SIRTs) polymorphisms (Somatic and germ line variations). 2.
- Trial name
- PCOS-01 (NCT06102629)
- Testing
- laparoscopy / laparotomy, NO INTERVENTION
- Where
- India
- Volunteers
- 200 people
- Sponsor
- Asian Institute of Gastroenterology, India
Ovarian Neoplasms, Ovarian Cancer
Improved Diagnosis of Ovarian Cancer
After implementation of systematic image description of adnexal masses, we aim to improve and evaluate our use of available imaging methods and biomarkers for classifying adnexal masses and distinguishing between benign and…
- Conditions
- Ovarian Neoplasms, Ovarian Cancer, Ovarian Cysts, Adnexal Mass
- Trial name
- NCT05842629
- Where
- Denmark
- Volunteers
- 1,700 people
- Sponsor
- University of Aarhus
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