Clinical trials: Neoplasm Circulating Cells
Ductal Infiltrating Metastatic Breast Cancer, Hormone-receptors Positive Breast Cancer
Medico-economic Interest of Taking Into Account Circulating Tumor Cells (CTC) to Determine the Kind of First Line Treatment for Metastatic, Hormone-receptors Positive, Breast Cancers
The STIC CTC study is a randomized trial to evaluate the medico-economic interest of taking into account circulating tumor cells (CTC) to determine the kind of first line treatment for metastatic, hormone-receptors positive…
- Trial name
- NCT01710605
- Testing
- Circulating tumor cells counting at baseline
- Where
- 17 sites in France
- Volunteers
- 800 people
- Sponsor
- Institut Curie
Colorectal Cancer, Circulating Tumor Cell
Influence of Opioid Analgesia on Circulating Tumor Cells in Laparoscopic Colorectal Cancer Surgery
To compare the effects of three types of perioperative analgesia on the number of circulating tumor cells following radical colorectal cancer surgery.
- Trial name
- POACC-2 (NCT03700541)
- Testing
- Morphine, Piritramid
- Where
- 3 sites in Czechia
- Volunteers
- 71 people
- Sponsor
- The Institute of Molecular and Translational Medicine, Czech Republic
Cancer, Treatment-Related, Tumor of Breast
To Detect Cryoimmunologic Response Induced by Early Breast Cancer Ultrasound-guided Cryoablation (ICE-study)
The aim of our study is to examine the cryoimmunologic response and its mechanisms induced by US-guided cryoablation of small breast tumors (<2 cm) not eligible to neoadjuvant therapy.
- Conditions
- Cancer, Treatment-Related, Tumor of Breast, Systemic Inflammatory Response, Stage I Breast Cancer
- Trial name
- NCT05727813
- Testing
- cryoablation
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- University of Roma La Sapienza
Next-Generation-Sequencing
CIRculating Cell-free nUcLeic Acids in Cancer Therapy Monitoring -01
In cooperation with the molecular tumor board of the University Hospital Tübingen (UKT), a prospective collection of blood samples during the course of therapy is planned.
- Trial name
- CIRCULATING-01 (NCT05871593)
- Testing
- Molecular genetic diagnostic
- Volunteers
- 200 people
- Sponsor
- University Hospital Tuebingen
Bladder Cancer, Circulating Tumor Cells
Detection and Clinical Significance of Circulating Cancer Cells in Patient Undergoing Radical Cystectomy
Very few factors may be identified as prognostic for patients with bladder cancer undergoing radical cystectomy. Recently, detection of circulating tumor cells has shown to be very promising in anticipating both the likelyhood of…
- Trial name
- CirCanCell (NCT02345473)
- Testing
- Detection of circulating tumor cells in blood samples
- Where
- Italy
- Volunteers
- 59 people, healthy volunteers welcome
- Sponsor
- Azienda Ospedaliero-Universitaria Consorziale Policlinico di Bari
Melanoma
Serial Tumour Biopsies and Blood Biomarkers in Melanoma
Recent advances in understanding how cancer develops and spreads have led to effective new treatments and improved outcomes for patients with melanoma.
- Trial name
- NCT04493723
- Testing
- Surgery, Venepuncture
- Where
- United Kingdom
- Volunteers
- 300 people
- Sponsor
- The Christie NHS Foundation Trust
Locally Advanced Unresectable Uveal Melanoma
Neoadjuvant Tebentafusp for Uveal Melanoma
This is a prospective, single arm, phase II clinical trial of neoadjuvant Tebentafusp (KIMMTRAK®) in patients with locally advanced primary uveal melanoma.
- Trial name
- NCT06414590
- Testing
- Tebentafusp-Tebn
- Where
- 2 sites in United States
- Volunteers
- 19 people
- Sponsor
- Thomas Jefferson University
Carcinoma, Non-Small-Cell Lung, Brain Metastases
Circulating Tumor DNA and T Cell Repertoire Predict Radiotherapeutic Outcomes in NSCLC Patients With Brain Metastasis
Collection of ctDNA and TCR data to predict the efficacy and prognosis of brain radiotherapy in patients with brain metastases from non-small cell lung cancer (NSCLC) in a comprehensive manner
- Trial name
- NCT05737589
- Testing
- Whole-brain radiotherapy
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Xiaorong Dong
Cell Carcinoma
Establishment and Application of 3-Dimensional (3-D) Cell Culture Model of Clinical Circulating Tumor Cells (CTCs)
The goal of this observational study is to validate and evaluate the clinical feasibility of using a 3-D cell culture model for CTCs isolation/purification and their cell number expansion in cancer patient with transitional cell…
- Trial name
- NCT05623748
- Testing
- CTCs isolation/purification and cell number expansion
- Where
- Taiwan
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Chang Gung Memorial Hospital
Carcinoma, Pancreatic Ductal, Circulating Tumor Cells
According CTC to Compare the Influences of Different Methods to Remove the PDAC
Acccording circulating tumor cells to compare the differences of different methods(routine method、no-touch principle method、laparoscopy method) to remove the ductal adenocarcinoma of pancreatic body and tail.
- Trial name
- NCT02451384
- Testing
- routine surgery, no-touch surgery, laparoscopic surgery
- Where
- 2 sites in China
- Volunteers
- 45 people
- Sponsor
- Shanghai Zhongshan Hospital
Colorectal Cancer Metastatic
Influence of BRAF and PIK3K Status on the Efficacy of 5-Fluorouracil/Leucovorin/Oxaliplatin (FOLFIRI) Plus Bevacizumab or Cetuximab in Patients With RAS Wild-type Metastatic Colorectal Carcinoma and < 3 Circulating Tumor Cells (CTC)
The purpose of the study is to explore the influence of BRAF and PIK3K status on the efficacy of FOLFIRI plus Bevacizumab or Cetuximab, as first line therapy of patients with RAS wild-type metastatic colorectal carcinoma and < 3…
- Trial name
- VISNU-2 (NCT01640444)
- Testing
- FOLFIRI + bevacizumab, FOLFIRI + cetuximab
- Where
- Spain
- Volunteers
- 240 people
- Sponsor
- Spanish Cooperative Group for the Treatment of Digestive Tumours (TTD)
Ovarian Neoplasms
Evaluation of Multiple Biomarkers to Estimate Risk of Ovarian Cancer in Patients With a Pelvic Mass.
ANGLE has developed the Parsortix™ Cell Separation System (Parsortix), an automated system capable of harvesting rare circulating cells for analysis from a sample of peripheral blood based on cellular size and deformability.
- Trial name
- NCT02785731
- Testing
- Pelvic imaging, Blood draw, laparotomy or laparoscopy
- Where
- 5 sites in Austria, Germany
- Volunteers
- 204 people
- Sponsor
- Angle plc
Glioma, miRNA
Monitoring of Patients With Low-grade Gliomas Using Circulating miRNA
With around 3,400 cases per year in France, diffuse gliomas are the most common primary tumours of the central nervous system. Their grade varies from 2 to 4.
- Conditions
- Glioma, miRNA, Low-grade Glioma, Biomarkers
- Trial name
- GLIBAMIR (NCT06610851)
- Testing
- Blood sample
- Where
- France
- Volunteers
- 20 people
- Sponsor
- University Hospital, Caen
Neuroendocrine Tumors
A Study to Evaluate the Value of Circulating Tumour DNA in Follow-up of Patients With an Advanced Gastroenteropancreatic or Lung Neuroendocrine Tumour Under Everolimus +- SSA Treatment (Liquid-NET 2.0)
Prospective, multicentric, single arm, POC study to evaluate the value of CtDNA in follow-up of patients treated with everolimus, with or without somatostatin analogues for advanced gastroenteropancreatic or lung neuroendocrine…
- Trial name
- NCT05268952
- Testing
- Liquid biopsies, Scans (CT, gallium-68 DOTATE/TOC/NOC PET-CT)
- Where
- 3 sites in Belgium, Cyprus
- Volunteers
- 100 people
- Sponsor
- University Hospital, Antwerp
Small Cell Lung Cancer
Circulating EV Long RNA Profiles in SCLC
To identify the circulating extracellular vesicle long RNA (exLR) profiles in small cell lung cancer (SCLC) and explore the potential of exLR as biomarkers to predict the therapeutic effect of SCLC.
- Trial name
- NCT05191849
- Testing
- Blood sample collection
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Fudan University
Peripheral T Cell Lymphoma
Circulating Tumor DNA Sequencing in Patients With Peripheral T-cell Lymphomas
The purpose of this study is to assess the feasibility of analyzing circulating tumor DNA (ctDNA) as a biomarker using the shallow whole genome sequencing (lpWGS) technique coupled with deep sequencing of a targeted panel of…
- Trial name
- PTCL-SEQ (NCT06089941)
- Testing
- circulating tumoral DNA detection
- Where
- France
- Volunteers
- 45 people
- Sponsor
- Centre Henri Becquerel
Breast Neoplasms
Early Detection of Breast Cancer
The TriNetra™ Breast test is intended for use as a breast cancer screening test that evaluates Circulating Tumor Cells (CTCs) associated with breast cancer.
- Trial name
- NCT06043661
- Where
- United States
- Volunteers
- 700 people, healthy volunteers welcome
- Sponsor
- Datar Cancer Genetics Inc
Circulating Tumor Cell
Circulating Tumor Cell Detection in Hepatocellular Carcinoma
The investigators examined circulating tumor cells (CTC) in the perioperative peripheral blood of hundreds of HCC patients undergoing liver cancer surgery using CellSearch technology between 2013 and 2016.
- Trial name
- NCT05297955
- Where
- China
- Volunteers
- 458 people
- Sponsor
- Tongji Hospital
Oropharynx Cancer, Oropharynx Cancer, Metastatic
Can Recurrence of Cancer in the Oropharynx be Detected by Blood Samples?
This study investigates if longitudinal analyses of cell-free HPV-DNA in blood samples can be utilized to detect recurrence in patients diagnosed and treated for HPV-positive oropharyngeal squamous cell carcinoma.
- Conditions
- Oropharynx Cancer, Oropharynx Cancer, Metastatic, Oropharynx Cancer, Recurrent, Oropharyngeal Carcinoma
- Trial name
- NCT06592716
- Testing
- Liquid biopsy
- Where
- Denmark
- Volunteers
- 200 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Diffuse Large B Cell Lymphoma
Molecular Monitoring With Circulating Tumor DNA and Nivolumab Maintenance
Patients suffering from diffuse large B-cell lymphoma (DLBCL) who relapse within 12 months of chemotherapy usually undergo salvage therapies, followed by autologous transplant with a low success rate.
- Trial name
- NCT03311958
- Testing
- Nivolumab, IV, 240 mg
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Fox Chase Cancer Center