Clinical trials: Neoplasm of Breast (Disorder)
Breast Cancer, Depression
Intervention Study of Depression in Breast Cancer Patients
The purpose of this study is to evaluate the efficacy of cognitive-behavioral therapy on depression and anxiety in breast cancer patients.
- Conditions
- Breast Cancer, Depression, Anxiety
- Trial name
- NCT01256008
- Testing
- CBT, Clinical Management
- Where
- China
- Volunteers
- 392 people
- Sponsor
- Wenzhou Medical University
Breast Cancer
Adjuvant Albumin-bound Paclitaxel Versus Taxanes in Breast Cancer: a Real-world Study
This is a prospective, multi-center, real-world study designed to evaluate the efficacy and safety of albumin-bound paclitaxel versus paclitaxel or docetaxel in adjuvant treatment of breast cancer.
- Trial name
- NCT05287308
- Testing
- doxorubicin, epirubicin, pirarubicin
- Where
- China
- Volunteers
- 500 people
- Sponsor
- Chinese Academy of Medical Sciences
Breast Cancer, Lung Cancer
Metabolic Changes as a Diagnostic Indicator for Cancer
This study aims to determine whether metabolic changes occur in blood plasma of cancer patients, and whether these changes can be used as a biomarker to detect cancer.
- Trial name
- NCT02362776
- Testing
- Venous blood sample
- Where
- 2 sites in Belgium
- Volunteers
- 426 people, healthy volunteers welcome
- Sponsor
- Hasselt University
Metabolic Syndrome, Obesity
An Exercise RCT Targeting African-American Women With Metabolic Syndrome and High Risk for Breast Cancer
Among African-American women, in whom metabolic syndrome (MetS) is very prevalent and breast cancer mortality rates are high, it is hypothesized that intervening on MetS to improve the MetS profile may prove to be a means to…
- Trial name
- NCT02103140
- Testing
- Facility-based Exercise, Home-based Exercise
- Where
- United States
- Volunteers
- 213 people, healthy volunteers welcome
- Sponsor
- Georgetown University
Breast Cancer
Increasing Oral Medication Adherence for Metastatic Breast Cancer Patients
Aim of this study is to optimize an adherence increasing intervention designed for metastatic Breast Cancer (BC) patients by applying a full factorial design in order to evaluate the optimal combination of three different…
- Trial name
- NCT06726889
- Testing
- Standard care, Decision Support System (DSS), Reminders
- Where
- Italy
- Volunteers
- 104 people
- Sponsor
- European Institute of Oncology
Breast Cancer
Tumor Integrating Gut Microbiota in bREast Cancer
Study on patients undergoing surgery for breast cancer. Objective: to characterize the intratumoral microbiota and integrate these findings with clinicopathologic data, the estrobolome, and gut microbiota, with analyses…
- Trial name
- TIGER-BC (NCT07253168)
- Testing
- Surgery for breast cancer
- Volunteers
- 240 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Breast Cancer
Evaluation of Safety and Efficacy of TOCOSOL(R) Paclitaxel as Initial Treatment for Metastatic Breast Cancer
This is an open label study where each patient will receive TOCOSOL(R) Paclitaxel 120mg/m2 every week for first line treatment of metastatic breast cancer.
- Trial name
- NCT00096668
- Testing
- TOCOSOL(R) Paclitaxel
- Where
- 7 sites in Russia
- Volunteers
- 47 people
- Sponsor
- Achieve Life Sciences
Breast Cancer, Upper Extremity
Combined Upper Extremity Resistance and Aerobic Exercise Training in Patients With Breast Cancer
According to updated data from the International Agency for Research on Cancer (IARC) for 2022, breast cancer in women is responsible for one in four cancer cases and one in six cancer deaths worldwide and is the second leading…
- Conditions
- Breast Cancer, Upper Extremity, Resistance Exercise, Aerobic Exercise
- Trial name
- NCT07070791
- Testing
- Upper Extremity Aerobic Exercise Training, Upper Extremity Progressive Resistance Exercise Training
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Hacettepe University
Metastatic Breast Cancer
Combination Weekly Taxotere™ With Iressa™ /Placebo in Metastatic Breast Cancer
The purpose of this study is to determine if combination therapy of weekly Taxotere™ with Iressa™ will increase the objective responses in measurable leasions in metastatic breast cancer
- Trial name
- NCT00319618
- Testing
- Gefitinib, Docetaxel
- Where
- Norway
- Volunteers
- 66 people
- Sponsor
- AstraZeneca
Breast Neoplasms
Study of Tumor RNA Disruption Assay™ (RDA)
The purpose of this study is to find out if the pathological complete response (pCR) to chemotherapy given before surgery (neoadjuvant chemotherapy) could be predicted by the evaluation of the RNA (ribonucleic acids) disruption…
- Trial name
- RnaDx (NCT02239315)
- Testing
- Tumor RNA Disruption Assay™ (RDA)
- Where
- 4 sites in Canada
- Volunteers
- 1 people
- Sponsor
- University of Toronto
Breast Cancer
Community-led Navigation to Address Disparities in Mammography Among Native American Women
The goal of this study is to evaluate the effectiveness of an intervention to promote breast cancer screening mammography among women in one community on the Navajo Nation.
- Trial name
- NCT06957535
- Testing
- Navigation, TEAM
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Johns Hopkins Bloomberg School of Public Health
Breast Cancer
Phase II Study of Pembrolizumab and Nab-paclitaxel in HER-2 Negative Metastatic Breast Cancer
This is a single-arm open-label multi-cohort Phase II study evaluating the safety/tolerability and clinical activity of the combination of nab-paclitaxel and the antibody against programmed cell death 1 (PD-1), pembrolizumab, in…
- Trial name
- NCT02752685
- Testing
- Pembrolizumab, Nab-Paclitaxel
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- NYU Langone Health
Breast Cancer Female
Evaluating and Following Breast Cancer Patients in a Better Way
The current observational study aims at analysing current semiology on breast cancer patients aiming at noting indicators and signs with significant relationship with the disease outcomes.
- Trial name
- EFBCancer (NCT03831308)
- Testing
- clinical and physical assessment
- Volunteers
- 200 people
- Sponsor
- Centro Hospitalar Lisboa Ocidental
Breast Cancer, Brain Metastases
FSRT in Breast Cancer Patients With Brain Metastases
Brain metastasis accounted for 10-15% of all breast cancer patients and even higher in patients with triple negative and HER2 overexpressed subtype.
- Trial name
- NCT04061408
- Testing
- Fractionated stereotactic radiotherapy(FSRT)
- Where
- China
- Volunteers
- 170 people
- Sponsor
- Fudan University
Breast Cancer, Post Mastectomy
Breast Fractionation Study - Standard Versus Investigational Fractionation Trial - Nodal Radiation
The purpose of this study is to investigate the difference in fatigue, quality of life and radiation morbidity between hypofractionated and conventional radiation to the breast, chest wall and regional lymph nodes post mastectomy…
- Trial name
- NCT04909125
- Testing
- Hypofractionated radiotherapy VS Standard/Conventional fractionation radiotherapy
- Where
- Australia
- Volunteers
- 132 people
- Sponsor
- Royal North Shore Hospital
Breast Cancer Patients
Efficacy and Safety of Prepectoral Prosthesis Immediate One-Stage Breast Reconstruction Versus Two-Stage Expander/Prosthesis Reconstruction in Postoperative Adjuvant Radiotherapy Breast Cancer Patients: A Prospective, Single-Center, Cohort Study
Prospective Evaluation of the Efficacy and Safety of Prepectoral Immediate One-Stage Prosthetic Breast Reconstruction Versus Two-Stage Expander/Prosthesis Reconstruction in Postoperative Adjuvant Radiotherapy Breast Cancer…
- Trial name
- NCT07037576
- Testing
- Breast Reconstruction Surgery
- Where
- China
- Volunteers
- 104 people
- Sponsor
- Henan Cancer Hospital
Breast Cancer, Chemotherapy Effect
Evaluation of Recurrence Risk Factors in Locally Advanced Breast Cancer Patients Underwent Neoadjuvant Chemotherapy.
INTRODUCTION Breast cancer (BC) is the leading cause of cancer-related death in women. Since the early 1980s, the implementation of screening programs has reduced the number of patients diagnosed with locally advanced breast…
- Conditions
- Breast Cancer, Chemotherapy Effect, Triple Negative Breast Cancer, Recurrence, Local Neoplasm
- Trial name
- NEORISK (NCT06441240)
- Testing
- MRI
- Where
- Italy
- Volunteers
- 933 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Breast Neoplasms, Radiotherapy
Hypofractionated LocoRegional Radiotherapy in Breast Cancer
The primary objective of this study is to determine if hypofractionated RT delivered over 1 week to the breast or chest wall and regional nodes (26Gy in 5 daily fractions) following BCS or mastectomy, is non-inferior to…
- Conditions
- Breast Neoplasms, Radiotherapy, Lymphedema
- Trial name
- RHEAL (NCT04228991)
- Testing
- Locoregional radiation treatment - Conventional fractionation, Locoregional radiation treatment - Hypofractionation
- Where
- 20 sites in Canada
- Volunteers
- 588 people
- Sponsor
- Ontario Clinical Oncology Group (OCOG)
Breast Cancer, Molecular Typing
Clinical Study of Imaging Genomics Based on Machine Learning for BCIG
1. Identify the imaging features of breast cancer with different molecular types 2. Reveal the association between hormone receptor positive/HER2 negative breast cancer and imaging histology, Oncotype Dx recurrence score 3.
- Conditions
- Breast Cancer, Molecular Typing, Pathology, Image, Body
- Trial name
- NCT04461990
- Testing
- Multidisciplinary cooperative comprehensive treatment
- Where
- China
- Volunteers
- 1,500 people
- Sponsor
- Fudan University
Carcinoma Breast Stage IV
Steroid Aromatase Inhibitors Versus Progestogens for nSAID-resistanced Late Stage Breast Cancer
Steroid Aromatase Inhibitors and Non-Steroid Aromatase Inhibitors in Late Stage Breast Cancer is the recommended scheme in National Comprehensive Cancer Network (NCCN) guideline.
- Trial name
- NCT02161315
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Tianjin Medical University Cancer Institute and Hospital