Clinical trials: Neoplasms, Thyroid
Thyroid Cancer
Study of Resistance to Thyroid Hormone After Long-term Exposure in People With Thyroid Cancer
The purpose of this study is to find out whether people who have had thyroid cancer develop resistance to treatment with thyroid hormones after having received high doses of thyroid drugs for many years.
- Trial name
- NCT04868045
- Testing
- Thyrotropin Releasing Hormone (TRH), levothyroxine, Hypothyroidism QOL questionnaire
- Sponsor
- Memorial Sloan Kettering Cancer Center
Huerthle Cell Carcinoma
Hürthle Cell Carcinoma and Follicular Thyroid Carcinoma
The goal of this retrospective study is to evaluate in patients with HCC and FTC who underwent lobectomy. The main questions it aims to answer are: The necessity of completion thyroidectomy based on the clinicopathological…
- Trial name
- HCC and FTC (NCT05968196)
- Volunteers
- 221 people
- Sponsor
- The Catholic University of Korea
Thyroid Cancer
Evaluating the Safety and Efficacy of Oral Lenvatinib in Medullary and Iodine-131 Refractory, Unresectable Differentiated Thyroid Cancers, Stratified by Histology
The purpose of this study is to determine the safety and efficacy of oral lenvatinib in participants with medullary thyroid cancer (MTC) or radioiodine (131 I)-refractory/resistant differentiated thyroid cancer (DTC)…
- Trial name
- NCT00784303
- Testing
- Lenvatinib (DTC Cohort), Lenvatinib (MTC Cohort)
- Where
- 42 sites in United States, Australia and 4 more
- Volunteers
- 117 people
- Sponsor
- Eisai Inc.
Thyroid Nodule
Benign Thyroid Nodules / Benign Goiter. What Subjective Problems Are Improved With an Operation and Can This be Predicted Preoperatively?
Nodules in the thyroid gland are common. Patients discover these lumps either because of their visible size increase or because of local discomforts such as difficulty swallowing, difficulty breathing or voice changes.
- Trial name
- NCT05526261
- Testing
- Hemithyroidectoy
- Where
- Sweden
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Linkoeping University
Non-Small Cell Lung Cancer, Medullary Thyroid Cancer
Pre-Approval Access Program (PAAP) for Pralsetinib (BLU-667) in Patients With Unresectable or Metastatic NSCLC or MTC
This is a global, multicenter, open-label pre-approval access program to provide access to pralsetinib (BLU-667) until such time that pralsetinib becomes available through other mechanisms or the Sponsor chooses to discontinue…
- Trial name
- NCT04204928
- Testing
- pralsetinib (BLU-667)
- Sponsor
- Blueprint Medicines Corporation
Thyroid Nodule
Comparison of the Vocal Cord Imaging Techniques After Thyroidectomy
Recurrent nerve palsy is a complication of thyroidectomy. Most surgeons want to visualize the vocal cords after tyroidectomy. The aim is to compare the direct laringoscopy, videolaringoscopy, fiberoptic laringoscopy and…
- Trial name
- NCT02410928
- Testing
- direct laringoscopy, fiberoptic nasal laringoscopy, ultrasonograph
- Where
- Turkey (Türkiye)
- Volunteers
- 75 people
- Sponsor
- Diskapi Teaching and Research Hospital
Advanced Solid Tumor
A Study of DB-1202 Monotherapy in Advanced Solid Tumors
This is a dose-escalation and dose-expansion Phase 1/2a trial to evaluate the safety and tolerability of DB-1201 in subjects with advanced solid tumors.
- Trial name
- NCT05785728
- Testing
- DB-1202
- Where
- China
- Volunteers
- 150 people
- Sponsor
- DualityBio Inc.
Thyroid Nodule
Clinical Study of Ultrasonic Artificial Intelligence and Fine Needle Aspiration in Qualitative Diagnosis of Thyroid Nodules
To study the value of thyroid artificial intelligence diagnosis system and fine needle puncture in the diagnosis of benign and malignant thyroid nodules, so as to provide evidence-based medical evidence for the diagnosis of…
- Trial name
- NCT05407506
- Testing
- THYROID AI
- Volunteers
- 1,000 people
- Sponsor
- Luo Dingcun
Thyroid Cancer
To Perform a Post-market Study of the Performance of the Idylla ThyroidPrint Assay Using Clinical Samples in Predicting the Nature of Indeterminate Thyroid Nodules (ITNs) Across Multiple Centers.
To perform a post-market study of the performance of the Idylla™ ThyroidPrint® Assay using clinical samples in predicting the nature of indeterminate thyroid nodules (ITNs) across multiple centers.
- Trial name
- NCT06849284
- Where
- United Kingdom
- Volunteers
- 100 people
- Sponsor
- Royal Cornwall Hospitals Trust
Thyroid Cancer
Selective Neck Dissection Versus Modified Neck Dissection in PTC
This study is a phase III, randomized controlled, open label non inferiority study. Patients who meet the inclusion criteria are randomly assigned 1:1 to either the experimental group (selective neck dissection) or the control…
- Trial name
- NCT06554652
- Testing
- Lymph node tracer navigated selective neck dissection, Modified neck dissection
- Where
- China
- Volunteers
- 250 people
- Sponsor
- Fudan University
Thyroid Nodule, Thyroid Dysfunction
Postoperative Hypocalcemia After Thyroidectomy
This retrospective cohort study investigates predictors of postoperative hypocalcemia following thyroidectomy procedures at Minia University Hospital over a 10-year period (2014-2024).
- Conditions
- Thyroid Nodule, Thyroid Dysfunction, Hypocalcemia, Thyroid Cancer
- Trial name
- NCT07428057
- Where
- Egypt
- Volunteers
- 600 people
- Sponsor
- Minia University
Lymph Node Metastases
the Dissection of Lymph Node Posterior to Right Recurrent Laryngeal Nerve for Papillary Thyroid Carcinoma
This study was completed in two stages. In the first stage, 2000 participants were enrolled according to the criteria. Following the principle of informed consent and voluntary consent of patients, the standard operation was…
- Trial name
- NCT03813706
- Testing
- lymph node dissection
- Volunteers
- 4,000 people
- Sponsor
- Zhejiang University
Thyroid Neoplasms
P53 in Differentiated Thyroid Cancer
In clinical practise patients with negative radioiodine scan with positive tyhroglobulin is considered as radioiodine resistant or in another words in the process of dedifferentiation.
- Trial name
- NCT01954134
- Where
- Turkey (Türkiye)
- Volunteers
- 199 people
- Sponsor
- Cumhuriyet University
Differentiated Thyroid Cancer
Efficacy of Apatinib in Radioactive Iodine-refractory Differentiated Thyroid Cancer
Radioactive iodine-refractory differentiated thyroid cancer (RAIR-DTC) is a great challenge in the treatment of thyroid cancer. Tyrosine kinase inhibitors (TKIs), like sorafenib and lenvatinib which have been approved by food and…
- Trial name
- NCT03048877
- Testing
- Apatinib Oral Tablet
- Where
- 2 sites in China
- Volunteers
- 118 people
- Sponsor
- Peking Union Medical College Hospital
Stomach Cancer, Colon Cancer
A Study With Health Educational Material on Health Promotion in Cancer Survivors
The purpose of this study is to provide educational material to promote screening for second primary cancer for the intervention group, or educational material to instruct appropriate use of dietary supplement for the control…
- Conditions
- Stomach Cancer, Colon Cancer, Thyroid Cancer, Breast Cancer
- Trial name
- NCT00948337
- Testing
- Brochure of Secondary Cancer Screening
- Where
- 2 sites in South Korea
- Volunteers
- 326 people
- Sponsor
- National Cancer Center, Korea
Thyroid Carcinoma, Hypothyroidism
The Effect of Coffee on the Absorption of Thyroid Hormone in Patients With Thyroid Carcinoma
The purpose of this study is to evaluate whether taking thyroid hormone medication with beverages other than water, decreases absorption of the medication by the intestine.
- Trial name
- NCT01707056
- Testing
- Black Coffee, Coffee with Milk, Black Tea
- Where
- 3 sites in United States
- Sponsor
- Medstar Health Research Institute
Hyperthyreosis and Goiter, Thyroid Cancer
The Incidence of Thyroid Cancer in 4474 Patients Treated for Hyperthyroidism or Goiter
Patients with hyperthyroidism and/or goiter are evaluated with blood samples and scintiscan before they are treated with radioiodine for their thyroid disease.
- Trial name
- NCT01384786
- Where
- Denmark
- Volunteers
- 4,474 people
- Sponsor
- Copenhagen University Hospital at Herlev
Microbiota
the Microbiota Are Associated With Iodine-131 Therapy and Hypothyroidism
Thyroid cancer is a common neck malignancy. Currently, total thyroidectomy or subtotal thyroidectomy is the main method for the treatment of thyroid cancer patients.
- Trial name
- NCT03574051
- Testing
- Probiotic
- Where
- China
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- First Affiliated Hospital of Harbin Medical University
Follicular Thyroid Cancer, Insular Thyroid Cancer
Dabrafenib With or Without Trametinib in Treating Patients With Advanced Differentiated Thyroid Cancer
This randomized phase II trial studies how well dabrafenib works with or without trametinib in treating patients with recurrent thyroid cancer.
- Conditions
- Follicular Thyroid Cancer, Insular Thyroid Cancer, Papillary Thyroid Cancer, Recurrent Thyroid Cancer
- Trial name
- NCT01723202
- Testing
- dabrafenib, trametinib
- Where
- 5 sites in United States
- Volunteers
- 53 people
- Sponsor
- Bhavana Konda
Anaplastic Thyroid Carcinoma, Thyroid Cancer
Pulsed Stereotactic Ablative Radiotherapy (PULSAR) With Systematic Therapy for Thyroid Cancer
This study is a single institution non-randomized phase 2 trial looking at the effect of Pulsed Stereotactic Ablative Radiotherapy (PULSAR) followed by neoadjuvant chemotherapy dabrafenib and trametinib (DT) with or without…
- Conditions
- Anaplastic Thyroid Carcinoma, Thyroid Cancer, Thyroid Carcinoma
- Trial name
- NCT07886905
- Testing
- Dabrafenib, Trametinib, Pembrolizumab
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Washington University School of Medicine
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