Clinical trials: Neoplasms, Thyroid
Medullary Thyroid Cancer, Infantile Myofibromatosis
A Study of Oral LOXO-292 (Selpercatinib) in Pediatric Participants With Advanced Solid or Primary Central Nervous System (CNS) Tumors
This is an open-label, multi-center Phase 1/2 study of oral LOXO-292 in pediatric participants with an activating rearranged during transfection (RET) alteration and an advanced solid or primary CNS tumor.
- Conditions
- Medullary Thyroid Cancer, Infantile Myofibromatosis, Infantile Fibrosarcoma, Papillary Thyroid Cancer
- Trial name
- LIBRETTO-121 (NCT03899792)
- Testing
- Selpercatinib
- Where
- 26 sites in United States, Australia and 9 more
- Volunteers
- 36 people
- Sponsor
- Eli Lilly and Company
Metastic Thyroid Cancer
The Role of 68-Gallium-DOTATATE-PET/CT in the Imaging of Metastatic Thyroid Cancer
Background: About 5% to 10% of differentiated thyroid cancers become resistant to standard treatment with radioactive iodine. In these cases, treatment options are limited and generally not effective.
- Trial name
- NCT04927416
- Testing
- 68-Gallium-DOTATATE-PET/CT
- Where
- United States
- Volunteers
- 54 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Anaplastic Thyroid Cancer
Evaluating Trends in Anaplastic Thyroid Cancer Patients' Clinical Study Experiences
Clinical trials can sometimes favor certain demographic groups. Additionally, there is limited research that delves into the factors that influence participation in clinical study, both positive and negative.
- Trial name
- NCT05819593
- Volunteers
- 500 people
- Sponsor
- Power Life Sciences Inc.
Anaplastic Thyroid Cancer
Review of Multimodality Management of Anaplastic Thyroid Cancer
To describe the outcome of patients with anaplastic thyroid cancer treated with hyperfractionated radiotherapy and concomitant chemotherapy
- Trial name
- NCT00280852
- Where
- Canada
- Volunteers
- 5 people
- Sponsor
- Alberta Health services
Thyroid Neoplasms
Study of the Anti-angiogenesis Agent AG-013736 in Patients With Metastatic Thyroid Cancer
This is a Phase 2 study being conducted at multiple centers in the United States. Patients having thyroid cancer that has spread to other parts of the body (i.e., metastatic) are eligible to participate.
- Trial name
- NCT00094055
- Testing
- AG013736
- Where
- 9 sites in United States
- Volunteers
- 60 people
- Sponsor
- Pfizer
Papillary Thyroid Cancer
Ultrasound-guided Thermal Ablation for Papillary Thyroid Carcinoma
To evaluate long-term outcomes of ultrasound-guided thermal ablation for the treatment of papillary thyroid carcinoma
- Trial name
- NCT06733740
- Testing
- ultrasound-guided thermal ablation
- Where
- China
- Volunteers
- 3,000 people
- Sponsor
- Chinese PLA General Hospital
Thyroid Neoplasms
Prognostic Significance of Fine-Needle Aspiration Cytology Features in Papillary Thyroid Carcinoma
The purpose of this study is to investigate the relationship between prognosis and fine needle aspiration cytology character of papillary thyroid cancer.
- Trial name
- NCT00459459
- Testing
- Fine needle aspiration of the thyroid
- Where
- Taiwan
- Volunteers
- 100 people
- Sponsor
- National Taiwan University Hospital
Metastatic Cancer, Melanoma
Evaluation of Pathway Modulation by Raf, MEK, & Kinase Inhibitors
This is a pilot study designed to evaluate the cutaneous effect of systemic inhibition of the tyrosine kinase pathway in the presence or absence of solar simulated light exposure.
- Conditions
- Metastatic Cancer, Melanoma, Colon Cancer, Differentiated Thyroid Cancer
- Trial name
- NCT03176485
- Testing
- Solar Simulator
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- University of Arizona
Thyroid Neoplasms
Testing a Web-based Intervention for Radioactive Iodine Symptom Management to Improve Health-related Quality of Life Among Differentiated Thyroid Cancer Patients
The goal of this clinical trial is to learn if adult patients diagnosed with differentiated thyroid cancer can easily use and benefit from an online tool aimed to provide patients with educational resources and symptom management…
- Trial name
- NCT06853925
- Testing
- Radioactive Iodine Support (RAI Support), Treatment as Usual (TAU)
- Where
- United States
- Volunteers
- 88 people
- Sponsor
- Georgetown University
Galactin 3-thyroid Carcinoma
Galectin-3 in Papillary Thyroid Carcinoma
Thyroid cancer is a common head and neck malignancy. It is the most common endocrine tumor in the body accounting for 1% of all cancers worldwide. The incidence of thyroid cancer varies worldwide.
- Trial name
- NCT05699590
- Volunteers
- 60 people
- Sponsor
- Sohag University
Lung Cancer, Head and Neck Cancer
Improving Care for Rural Patients With Solid Tumors
This study will assess if the CARES (Cancer Advocacy, Resources, Education and Support) intervention improves time to start of treatment after diagnosis and time to treatment completion for solid tumors (ex: lung, head, neck…
- Conditions
- Lung Cancer, Head and Neck Cancer, Thyroid Cancer, Cervical Cancer
- Trial name
- NCT04916990
- Testing
- CARES Intervention
- Where
- 14 sites in United States
- Volunteers
- 320 people
- Sponsor
- University of Colorado, Denver
Thyroid Gland Anaplastic Carcinoma, Poorly Differentiated Thyroid Carcinoma
[177Lu]Lu-AKIR001 First-in-human Study
The goal of this clinical trial is to evaluate the safety and tolerability of increasing doses of [177Lu]Lu-AKIR001, both in relation to tolerable activity of lutetium-177 and the absorbed protein mass dose of AKIR-001 in…
- Conditions
- Thyroid Gland Anaplastic Carcinoma, Poorly Differentiated Thyroid Carcinoma, Cancer Head and Neck, Cervix Carcinoma
- Trial name
- AKIR001 (NCT06639191)
- Testing
- [177Lu]Lu-AKIR001
- Where
- Sweden
- Volunteers
- 15 people
- Sponsor
- Karolinska University Hospital
Anaplastic Thyroid Cancer
Nivolumab Plus Lenvatinib Against Anaplastic Thyroid Cancer (NAVIGATION)
This study is an open-label phase 2 study to evaluate the safety and efficacy of Nivolumab plus Lenvatinib in patients with unresectable anaplastic thyroid cancer.
- Trial name
- NCT05696548
- Testing
- Lenvatinib, Nivolumab
- Where
- 10 sites in Japan
- Volunteers
- 51 people
- Sponsor
- National Cancer Center Hospital East
Renal Cell Carcinoma Metastatic, Breast Cancer
Pilot Study of the eHealth Application "Cancer Patients Better Life Experience" (CAPABLE) - Italy
The purpose of the CAPABLE study is to compare health-related quality of life in renal cell carcinoma patients who use or do not use a mobile-based application to monitor adverse events for cancer treatment at home.
- Conditions
- Renal Cell Carcinoma Metastatic, Breast Cancer, Head and Neck Cancer, Thyroid Cancer
- Trial name
- CAPABLE-IT (NCT06161233)
- Testing
- CAPABLE cohort
- Where
- Italy
- Volunteers
- 56 people
- Sponsor
- Istituti Clinici Scientifici Maugeri SpA
Thyroid Cancer
Toripalimab Combined With Surufatinib for Locally Advanced Thyroid Cancer: a Phase II Study
This study is designed to evaluate the efficacy and safety of the combination of Toripalimab and Surufatinib for Locally Advanced Thyroid Cancer.
- Trial name
- NCT04524884
- Testing
- Surufatinib, Toripalimab
- Where
- China
- Volunteers
- 10 people
- Sponsor
- Fudan University
Well Differentiated Thyroid Carcinoma, Papillary Thyroid Cancer
The Incidence of Postoperative Re-stratification for Recurrence in Well-differentiated Thyroid Cancer - A Single Tertiary Israeli Center Experience
Background After diagnosing well-differentiated thyroid cancer (WDTC), careful assessment of the risk for disease-specific recurrence is essential for deciding between partial (low risk) and completion (high risk)…
- Trial name
- NCT04500925
- Testing
- UNILATERAL THYROIDECTOMY
- Volunteers
- 301 people
- Sponsor
- Tel-Aviv Sourasky Medical Center
Thyroid Neoplasm
Routine Calcium for Preventing Hypocalcemia
The present study investigated the effect of routine calcium and vitamin D supplementation and tried to find the predictors for postoperative hypocalcemia in patients with thyroid cancer.
- Trial name
- NCT03484416
- Testing
- Calcium Carbonate 1500 Mg with Vitamin D
- Where
- South Korea
- Volunteers
- 138 people
- Sponsor
- Ewha Womans University Mokdong Hospital
Head and Neck Cancer
SU5416 and Paclitaxel in Treating Patients With Recurrent, Locally Advanced or Metastatic Cancer of the Head and Neck
RATIONALE: SU5416 may stop the growth of head and neck cancer by stopping blood flow to the tumor. Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die.
- Trial name
- NCT00005647
- Testing
- paclitaxel, semaxanib
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Case Comprehensive Cancer Center
Papillary Thyroid Carcinoma
A Comparative Study of Robotic Thyroidectomy Using Transaxillary Approach Versus Conventional Open Thyroidectomy
Most patients with thyroid tumors are effectively treated surgically by practitioners experienced in the techniques of thyroidectomy.
- Trial name
- NCT01311089
- Where
- South Korea
- Volunteers
- 169 people
- Sponsor
- Yonsei University
Locally Advanced Larynx, Hypopharyngeal Squamous Cell Cancers, Locally Advanced Thyroid Cancers
A Phase I/II Study of the Use of Intensity Modulated Radiotherapy (IMRT) in Cancer of the Thyroid, Larynx and Hypopharynx
This study is a phase I/II dose escalation trial designed to test the feasibility of delivering IMRT to thyroid, larynx and hypopharynx cancer patients, and to assess the safety and possible improvement in outcome when the dose…
- Trial name
- NCT02055989
- Testing
- Dose-escalated radiotherapy level 1, Sequential dose-escalated radiotherapy level 2
- Where
- United Kingdom
- Volunteers
- 105 people
- Sponsor
- Royal Marsden NHS Foundation Trust
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