Clinical trials: Neoplasms, Thyroid
Advanced Solid Tumor
A First-in-Human Study of CDK-002 (exoSTING) in Subjects With Advanced/Metastatic, Recurrent, Injectable Solid Tumors
This is a first-in-human, Phase 1/2 open-label, multicenter, dose escalation, safety, pharmacodynamic, and PK study of CDK-002 in subjects with advanced/metastatic, recurrent, injectable solid tumors, whose disease has progressed…
- Trial name
- NCT04592484
- Testing
- CDK-002
- Where
- 8 sites in United States, United Kingdom
- Volunteers
- 27 people
- Sponsor
- Codiak BioSciences
Genomics, Thyroid Cancer
Integrating Tumor Genomics and Urinary Exosomal Proteomics to Establish a Multi-Layer Biomarker Framework for Early Risk Stratification and Post-Treatment Surveillance in Fresh Thyroid Cancer Patients
Thyroid cancer is the most common endocrine malignancy, and although differentiated thyroid cancer (DTC) generally confers favorable outcomes, 10-20% of patients still face substantial postoperative risks, including local…
- Conditions
- Genomics, Thyroid Cancer, NGS
- Trial name
- NCT07532356
- Volunteers
- 100 people
- Sponsor
- National Taiwan University Hospital
Thyroid Cancer
Association Between Cancer Cells and Normal Versus (Vs.) Low Levels of Thyroid Hormones in the Serum
Much experimental data has suggested that thyroid hormones (T3 and T4) may modulate neoplastic cells and that T3/T4 deprivation may remove this stimulus.
- Trial name
- NCT01153945
- Where
- Israel
- Sponsor
- Meir Medical Center
Thyroid Neoplasm Follicular, Bone Metastases
Efficacy of Sr-89 for Differentiated Thyroid Cancer With Bone Metastases
Using sensitive markers (such as thyroglobulin, etc) to evaluate the efficacy of strontium-89 chloride (Sr-89) in differentiated thyroid cancer with bone metastases with an aim to breaking out of its palliation effect for bone…
- Trial name
- NCT05466812
- Testing
- Sr-89
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Peking Union Medical College Hospital
Thyroid Nodule
HIFU Reapplication in Benign Nodules
High Intensity Focused Ultrasound (HIFU) is a new approach in treating benign thyroid nodule without surgery. It is proven effective and safe relative to traditional surgery.
- Trial name
- NCT03331172
- Testing
- Echopulse
- Where
- Hong Kong
- Volunteers
- 28 people
- Sponsor
- The University of Hong Kong
Thymic Epithelial Tumor, Teratoma
Establishing Prospective Mediastinal Tumor Database of PUMCH
This study aims to prospectively document the population characteristics, imaging findings, pathological features, prognostic factors, etc., of patients with mediastinal tumors.
- Conditions
- Thymic Epithelial Tumor, Teratoma, Thymic Cyst, Retrosternal Goitre
- Trial name
- MTDPUMCH (NCT06421805)
- Where
- China
- Volunteers
- 2,000 people
- Sponsor
- Peking Union Medical College Hospital
Papillary Thyroid Carcinoma, Thyroid Cancer
Pattern and Surgical Outcome of Papillary Thyroid Cancer at Sohag University Hospitals
The aim of this study is to evaluate the clinicopathological pattern and surgical outcome of papillary thyroid carcinoma (PTC) at Sohag University Hospitals.
- Trial name
- NCT07823439
- Volunteers
- 30 people
- Sponsor
- Sohag University
Thyroid Nodule
Accuracy of FNAC in Diagnosis of Thyroid Nodules
Detection of degree of accuracy of FNAC in diagnosis of thyroid nodules
- Trial name
- NCT06782828
- Testing
- observe results of FNAC
- Volunteers
- 100 people
- Sponsor
- Assiut University
Papillary Thyroid Cancer, Lymph Node Metastasis
Improvements in Thyroid Tumor Surgery and the Prognosis, Diagnosis, Recurrence and Metastasis of Patients
The objective of this research is to investigate the clinical outcomes of modified surgical techniques such as omitting the cervical linea alba suture in transthoracic endoscopic thyroidectomy.
- Conditions
- Papillary Thyroid Cancer, Lymph Node Metastasis, Carcinogenesis
- Trial name
- NCT06468696
- Testing
- Suturing the cervical linea alba during endoscopic thyroid surgery., Performing transcriptome sequencing
- Where
- China
- Volunteers
- 170 people
- Sponsor
- Second Affiliated Hospital of Xi'an Jiaotong University
Parathyroid Neoplasms
Using X-Ray Dye to Locate Hidden Parathyroid Tumors
Occasionally tumors of the parathyroid gland cannot be detected by standard x-ray diagnostic procedures (CT scans, MRIs, and ultrasounds). In order for the tumor to be removed surgically it must first be localized.
- Trial name
- NCT00001394
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Thyroid Gland Anaplastic Carcinoma, Thyroid Gland Squamous Cell Carcinoma
Pembrolizumab, Dabrafenib, and Trametinib Before Surgery for the Treatment of BRAF-Mutated Anaplastic Thyroid Cancer
This phase II trial studies the effect of pembrolizumab, dabrafenib, and trametinib before surgery in treating patients with BRAF V600E-mutated anaplastic thyroid cancer.
- Trial name
- NCT04675710
- Testing
- Conventional Surgery, Dabrafenib, Intensity-Modulated Radiation Therapy
- Where
- 6 sites in United States
- Volunteers
- 30 people
- Sponsor
- M.D. Anderson Cancer Center
Medullary Thyroid Cancer, Prositron Emission Tomography
68Ga-TCR-FAPI PET/CT Guided Precision Surgery for MTC
This is a phase II clinical trial to evaluate the capability of 68Ga-labeled targeted covalent radiopharmaceutical (TCR) fibroblast activation protein inhibitor (FAPI) PET/CT to guide the surgical treatment of medullary thyroid…
- Conditions
- Medullary Thyroid Cancer, Prositron Emission Tomography, Fibroblast Activation Protein Inhibitor, Surgery
- Trial name
- NCT06277180
- Testing
- Surgery
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Cancer Institute and Hospital, Chinese Academy of Medical Sciences
Columnar Cell Variant Thyroid Gland Papillary Carcinoma, Follicular Variant Thyroid Gland Papillary Carcinoma
Lenvatinib and Pembrolizumab in Differentiated Thyroid Cancers (DTC)
This phase II trial studies how well pembrolizumab and lenvatinib work in treating patients with differentiated thyroid cancer that has spread to other places in the body or has come back and cannot be removed by surgery.
- Conditions
- Columnar Cell Variant Thyroid Gland Papillary Carcinoma, Follicular Variant Thyroid Gland Papillary Carcinoma, Metastatic Thyroid Gland Follicular Carcinoma, Metastatic Thyroid Gland Papillary Carcinoma
- Trial name
- NCT02973997
- Testing
- Laboratory Biomarker Analysis, Lenvatinib, Lenvatinib Mesylate
- Where
- 7 sites in United States
- Volunteers
- 57 people
- Sponsor
- Academic and Community Cancer Research United
Thyroid Nodule, Diagnoses Disease
Diagnostic Significance of CTCs in Patients With Thyroid Nodules (Circulating Tumor Cells)
Thyroid nodule patients with suggestion of fine needle aspiration biopsy (FNAB) offered by ultrasound are enrolled in the study. CTCs tested by Optimizing method and FNAB will be performed simultaneously.
- Trial name
- CTCs (NCT03772496)
- Testing
- circulating tumor cells test, Fine needle aspiration biopsy
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Cancer Institute and Hospital, Chinese Academy of Medical Sciences
Thyroid Cancer
Psycho-oncological Intervention Through Counselling in Patients With Differentiated Thyroid Cancer in Treatment With Radioiodine
Diagnosis and treatment of differentiated thyroid carcinomas cause anxiety and depression. Additionally, these patients suffer hormonal alterations, associated with psychological symptoms (changes in mood, emotional instability…
- Trial name
- COUNTHY (NCT05054634)
- Testing
- Psycho-oncological Intervention Based on Counselling (PIBC)
- Where
- Spain
- Volunteers
- 75 people
- Sponsor
- Quironsalud
Quality of Life
A Follow-up Study on Total Endoscopic Thyroidectomy Bilateral Areola Approach
Endoscopic thyroidectomy bilateral areola approach (ETBAA) is one of the most widely applied approach in China, meanwhile its safety and effectiveness has been broadly discussed since being introduced.
- Trial name
- NCT05315219
- Testing
- Endoscopic Thyroidectomy Bilateral Areola Approach
- Volunteers
- 295 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Thyroid Cancer
RW Study of Adjuvant Radiotherapy in Locally Advanced Thyroid Cancer
This study is a real-world study to observe the role of adjuvant radiotherapy in locally advanced recurrent high-risk thyroid cancer.
- Trial name
- NCT06524167
- Testing
- adjuvant radiotherapy
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Fudan University
Solid Tumors
Study of SNH-118110 in Advanced Solid Tumors
This is a multicenter, open-label, Phase I clinical study to evaluate the safety, tolerability, pharmacokinetics, and efficacy of SNH-118110 administered orally.
- Trial name
- SNH-118110 (NCT07649200)
- Testing
- SNH-118110 Soft Capsules
- Where
- China
- Volunteers
- 240 people
- Sponsor
- ScinnoHub Pharmaceutical Co., Ltd.
Thyroid Nodule, Thyroid Cancer
Shared Decision Making in Patients With Thyroid Nodules
The objective of this project is to evaluate a treatment decision aid for patients with low risk thyroid cancer.
- Trial name
- NCT02878044
- Testing
- Thyroid Decision Aid
- Where
- 2 sites in United States
- Volunteers
- 21 people
- Sponsor
- Mayo Clinic
Incidence of Thyroid Cancer in Long Standing MNG
Risk of Malignancy in Endemic Long Standing Nodular Goitres: a Prospective Cohort Study
To determine the incidence of thyroid cancer in patients with long standing goitres presenting for surgery.
- Trial name
- NCT06405919
- Testing
- Histopathology
- Where
- Sudan
- Volunteers
- 160 people
- Sponsor
- University of Khartoum
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