Clinical trials: Neoplasms, Thyroid
Tumor
Study of PXD101 Alone and in Combination With 5-Fluorouracil (5-FU) in Patients With Advanced Solid Tumors
This is a study to assess the combination of PXD101 and 5-Fluorouracil (5-FU)in patients with advanced solid tumors. The primary goal of the study is to understand the safety, anti-tumor activity, and how the study drug behaves…
- Trial name
- NCT00413322
- Testing
- belinostat, 5-Fluorouracil (5-FU)
- Where
- 3 sites in United States
- Volunteers
- 35 people
- Sponsor
- Valerio Therapeutics
Thyroid Gland Follicular Carcinoma, Thyroid Gland Papillary Carcinoma
Health and Wellness Coaching to Improve Adherence to Healthy Habits and Treatment Plans in Papillary and Follicular Thyroid Cancer Survivors
This clinical trial evaluates the impact of a patient-centered health and wellness coaching (HWC) intervention on adherence to treatment plans and healthy lifestyle practices in patients with papillary or follicular thyroid…
- Trial name
- NCT07545837
- Testing
- Counseling, Interview, Questionnaire Administration
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Mayo Clinic
Medullary Thyroid Cancer, Medullary Thyroid Carcinoma
Evaluation of the 18F-PSMA Positron Emission Tomography (PET)/CT in Patients With Medullary Thyroid Cancer
Rationale: In patients with medullary thyroid cancer (MTC), molecular imaging is used to assess the extent of disease in the primary diagnostic process and follow-up period to determine possible therapeutic options.
- Conditions
- Medullary Thyroid Cancer, Medullary Thyroid Carcinoma, Thyroid Carcinoma, Medullary, Thyroid Cancer, Medullary
- Trial name
- MIMETIC (NCT05534594)
- Testing
- 18F-PSMA-1007
- Where
- Netherlands
- Volunteers
- 8 people
- Sponsor
- University Medical Center Groningen
Metastatic Solid Tumor, Colorectal Cancer
Surufatinib in Combination With Tislelizumab in Subjects With Advanced Solid Tumors
This open-label, phase Ib/II study of surufatinib in combination with tislelizumab will evaluate the safety, tolerability, PK and efficacy in patients with advanced solid tumors.
- Conditions
- Metastatic Solid Tumor, Colorectal Cancer, Neuroendocrine Tumors, Small Cell Lung Cancer
- Trial name
- NCT04579757
- Testing
- Surufatinib and Tislelizumab _ Part 1, Surufatinib and Tislelizumab _ Part 2
- Where
- 18 sites in United States
- Volunteers
- 87 people
- Sponsor
- Hutchmed
Breast Cancer, Prostate Cancer
A Study of Meaning-Centered Therapy for Mexican Adults With Advanced Cancer
The purpose of this study is to find out if Meaning-Centered Psychotherapy for Latinos (MCP-L) helps reduce anxiety and depression and improves quality of life compared to cognitive behavioral therapy (CBT).
- Conditions
- Breast Cancer, Prostate Cancer, Colorectal Cancer, Thyroid Cancer
- Trial name
- NCT07225309
- Testing
- Meaning-Centered Psychotherapy for Latinos /MCP-L
- Where
- 2 sites in United States, Mexico
- Volunteers
- 300 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Depression, Thyroid Cancer
Study on the Mechanism of Ganoderma Lucidum Spore Powder in the Treatment of Depression
To clarify the clinical effect of Ganoderma lucidum spore powder intervention on postoperative depressive symptoms of papillary thyroid carcinoma ; to elucidate the antidepressant mechanism of Ganoderma lucidum spore powder.
- Trial name
- NCT06429514
- Testing
- Ganoderma lucidum spore powder
- Where
- China
- Volunteers
- 298 people
- Sponsor
- Ling Zhiqiang
Solid Tumor, Medullary Thyroid Cancer
A Study of Selpercatinib (LY3527723) in Participants With Advanced Solid Tumors Including RET Fusion-positive Solid Tumors, Medullary Thyroid Cancer and Other Tumors With RET Activation
The reason for this study is to see if the study drug selpercatinib is safe and effective in participants in China with rearranged during transfection (RET) fusion-positive solid tumors, medullary thyroid cancer (MTC) and other…
- Trial name
- LIBRETTO-321 (NCT04280081)
- Testing
- Selpercatinib
- Where
- 13 sites in China
- Volunteers
- 77 people
- Sponsor
- Eli Lilly and Company
Thyroid Nodule
Health-Related Quality of Life and Emotions in Patients with Thyroid Nodules
The purpose of this observational research is to evaluate and compare the health-related quality of life and emotional well-being of patients with thyroid nodules before and after treatment.
- Trial name
- NCT06610604
- Testing
- thermal ablation, thyroidectomy
- Where
- China
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Ming-an Yu
Anal Carcinoma, Bladder Carcinoma
Determining the Biodistribution of an Imaging Tracer (68Ga-FAPi-46) in Patients With Solid Tumors or Hematologic Cancers
This phase I trial is evaluating a new imaging tracer (68Ga-FAPi-46) with positron emission tomography (PET)/computed tomography (CT) to determine where and to which degree the tracer (68Ga-FAPi-46) accumulates in normal and…
- Conditions
- Anal Carcinoma, Bladder Carcinoma, Breast Carcinoma, Cervical Carcinoma
- Trial name
- NCT07118176
- Testing
- Computed Tomography, Fludeoxyglucose F-18, Gallium Ga 68 FAPi-46
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Jonsson Comprehensive Cancer Center
Advanced Solid Tumor, BRAF V600 Mutation
Safety and Tolerability of ABM-1310 in Patients With Advanced Solid Tumors
This is a Phase I, First-In-Human, open label, dose escalation and dose expansion study to evaluate the safety, tolerability, pharmacokinetics, and preliminary anti-cancer activity of ABM-1310 in adult patients with locally…
- Trial name
- NCT04190628
- Testing
- ABM-1310, Cobimetinib
- Where
- 8 sites in United States
- Volunteers
- 53 people
- Sponsor
- ABM Therapeutics Corporation
Cancer of Thyroid, Vertebral Fracture
Study of the Prevalence of Osteo-metabolic Complications in Patients With Thyroid Cancer
This is a multicenter retrospective observational study aimed to evaluate the prevalence of osteo-metabolic complications in patients with thyroid cancer.
- Conditions
- Cancer of Thyroid, Vertebral Fracture, Osteoporosis
- Trial name
- NCT06627998
- Testing
- Diagnostic (chest x-ray /DXA)and clinical data collected for clinical practice
- Where
- Italy
- Volunteers
- 82 people
- Sponsor
- IRCCS San Raffaele
Medullary Thyroid Carcinoma
Radiolabelled CCK-2/Gastrin Receptor Analogue for Personalized Theranostic Strategy in Advanced MTC
The study is a phase I multicentre randomized, open, parallel-arm clinical trial conducted to investigate the IMP, namely 111In-CP04.
- Trial name
- GRAN-T-MTC (NCT03246659)
- Testing
- 111In-CP04, 111In-CP04 with co-administration of gelofusine/gelaspan
- Where
- 5 sites in Austria, Germany and 3 more
- Volunteers
- 16 people
- Sponsor
- Paola Anna Erba
Thyroid
Metformin to Mitigate Sequelae of Radioactive Iodine Treatment for Thyroid Cancers
This pilot clinical trial studies how will metformin hydrochloride works in mitigating the side effects of radioactive iodine treatment in patients with differentiated thyroid cancer.
- Trial name
- NCT03109847
- Testing
- Metformin Hydrochloride, Radioactive Iodine
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University
Hypopituitarism, Hypogonadism
Detection and Treatment of Endocrine Abnormalities in Childhood Cancer Survivors and Hematopoietic Stem Cell Transplant Recipients
This study will determine the prevalence of endocrine-related side effects in children who have been treated for cancer and establish a database and registry organized according to cancer diagnosis, treatments and endocrine side…
- Conditions
- Hypopituitarism, Hypogonadism, Thyroid Dysfunction, Bone Diseases, Metabolic
- Trial name
- NCT00504218
- Where
- United States
- Volunteers
- 62 people
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Thyroid Neoplasm
Dose-dependent Effect of Fentanyl on Cough Attenuation During Emergence From General Anaesthesia
Fentanyl is expected to suppress tracheal tube-induced cough during emergence from general anaesthesia through binding to its receptors in the brainstem.
- Trial name
- NCT01308320
- Testing
- fentanyl citrate, saline
- Where
- South Korea
- Volunteers
- 42 people
- Sponsor
- Yonsei University
Thyroid Cancer
99mTc Sestamibi Scans In Thyroglobulin Positive Scan Negative Differentiated Thyroid Cancer (DTC) Patients
This study is being done to see if the radioisotope 99mTc sestamibi scans can locate what is causing the elevated serum thyroglobulin in persons with differentiated thyroid cancer who have elevated serum thyroglobulin levels and…
- Trial name
- NCT03065218
- Testing
- 99mTc sestamibi
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Medstar Health Research Institute
Hypothyroidism, Complications
Post-radiation Hypothyroidism After IMRT for Nasopharyngeal Carcinoma
The investigators evaluate if there are radiation dosimetric parameters for the prediction of biochemical and clinical hypothyroidism after intensity-modulated radiation therapy (IMRT) for non-metastatic nasopharyngeal carcinoma…
- Trial name
- NCT02689609
- Testing
- Intensity-modulated radiation therapy
- Volunteers
- 149 people
- Sponsor
- The University of Hong Kong
Differentiated Thyroid Cancer (DTC), Papillary Thyroid Carcinoma
Serum Treg/Th17-Related Cytokines and Systemic Inflammatory Indices in Differentiated Thyroid Cancer
This study measures circulating immune-signalling molecules before thyroid surgery to determine whether they differ between patients whose thyroid nodule proves to be a differentiated thyroid carcinoma and patients whose nodule…
- Conditions
- Differentiated Thyroid Cancer (DTC), Papillary Thyroid Carcinoma, Thyroid Cancer, Thyroid Nodule
- Trial name
- THINC (NCT07907432)
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people
- Sponsor
- Marmara University
Thyroid Cancer Stage IV, Radiation Toxicity
To Study the Impact of Radiation Treatment After Surgery in Patient With Locally Advanced Thyroid Cancer.
This trial deals with cancers of the thyroid gland which are advanced at the local site of thyroid. These cancers are treated with surgery and complete removal of the thyroid gland.
- Trial name
- THYRO-RT (NCT03669432)
- Testing
- Intensity Modulated Radiotherapy, Surgery alone
- Where
- India
- Volunteers
- 72 people
- Sponsor
- Tata Memorial Hospital
Thyroid Cancer
Trail Evaluating Apatinib With IMRT for Inoperable or Iodine Refractory Thyroid Cancer
To determine the efficacy and safety of intensity modulated radiation therapy combined with apatinib for inoperable or iodine refractory thyroid cancer.
- Trial name
- NCT03300765
- Testing
- Apatinib, Intensity modulated radiation therapy
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Xiayun He, MD
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