Clinical trials: Neoplasms, completed
Lung Cancer
Telephone Support Program for Lung Cancer Patients and Their Family Caregivers
The goal of this project is to examine the physical and psychological health benefits of a novel, telephone-delivered symptom management intervention for advanced lung cancer patients and their family caregivers.
- Trial name
- NCT01993550
- Testing
- Telephone counseling, Education
- Where
- 3 sites in United States
- Volunteers
- 262 people
- Sponsor
- Indiana University
Childhood Solid Neoplasm, Recurrent Malignant Solid Neoplasm
Prexasertib in Treating Pediatric Patients With Recurrent or Refractory Solid Tumors
This phase I trial studies the side effects and best dose of prexasertib in treating pediatric patients with solid tumors that have come back after a period of time during which the tumor could not be detected or does not respond…
- Conditions
- Childhood Solid Neoplasm, Recurrent Malignant Solid Neoplasm, Recurrent Primary Central Nervous System Neoplasm, Refractory Malignant Solid Neoplasm
- Trial name
- NCT02808650
- Testing
- Laboratory Biomarker Analysis, Pharmacokinetic (PK) study, Prexasertib
- Where
- 21 sites in United States
- Volunteers
- 30 people
- Sponsor
- Children's Oncology Group
Non-small Cell Lung Cancer
Toripalimab Plus Pemetrexed+Platinus in Advanced Non-small-cell Lungcancer Patients Previsouly Treated EGFR-TKI
This is a Randomized, Double-Blind, Placebo-Controlled, Multicenter, Phase III Study to evaluate the efficacy and safety of Toripalimab injection (JS001) or placebo combined with chemotherapy in Advanced Non-small Cell Lung…
- Trial name
- NCT03924050
- Testing
- TORIPALIMAB INJECTION(JS001 )
- Where
- 2 sites in China
- Volunteers
- 440 people
- Sponsor
- Shanghai Junshi Bioscience Co., Ltd.
Glioblastoma, GBM
A Phase I Trial of High-Dose Ascorbate in Glioblastoma Multiforme
This is a phase 1 (first in man) study testing the safety of adding high dose ascorbate (vitamin C) to standard radiation and chemotherapy for initial treatment of glioblastoma multiforme (GBM).
- Conditions
- Glioblastoma, GBM, Glioblastoma Multiforme
- Trial name
- NCT01752491
- Testing
- Ascorbate, Temozolomide, Radiation therapy
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Joseph J. Cullen, MD, FACS
Hepatic Steatosis, Polycystic Ovarian Syndrome
Liver and Fat Regulation in Overweight Adolescent Girls
Women with polycystic ovarian syndrome (PCOS) have increased rates of hepatic steatosis compared to weight similar women with regular menses. It is unclear if this is related to high testosterone or insulin resistance.
- Conditions
- Hepatic Steatosis, Polycystic Ovarian Syndrome, Obesity
- Trial name
- APPLE (NCT02157974)
- Testing
- Byetta 5Mcg Pen Injection
- Where
- United States
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Polycystic Ovary Syndrome, Adolescent Behavior
Adolescent Polycystic Ovary Syndrome on a Low-carbohydrate Diet
The aim of the study was to investigate the changes in the clinical and biochemical parameters of adolescents on a low-carbohydrate diet in relation to their PCOS phenotype in the 3rd trimester.
- Conditions
- Polycystic Ovary Syndrome, Adolescent Behavior, Diet Habit
- Trial name
- PCOS (NCT06429618)
- Testing
- Low carbonhydrate diet
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Etlik Zubeyde Hanım Women's Health Care, Training and Research Hospital
No Disease State or Condition
Nutritional Language Model
Colorectal cancer survivors often face unique nutritional challenges and require support in their recovery and long0term health.
- Trial name
- NLM (NCT06661590)
- Testing
- Nutritional Messaging
- Where
- United States
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Acute Myeloid Leukemia, Acute Lymphoblastic Leukemia
Transplant-Related Mortality in Patients Undergoing a Peripheral Blood Stem Cell Transplantation or an Umbilical Cord Blood Transplantation
Study CR-AIR-006 is a part of the ATIR clinical development plan and will provide control data for patients treated with ATIR in clinical studies (e.g. study CR-AIR-007).
- Conditions
- Acute Myeloid Leukemia, Acute Lymphoblastic Leukemia, Myelodysplastic Syndrome
- Trial name
- NCT02188290
- Where
- 9 sites in United States, Belgium and 4 more
- Volunteers
- 178 people
- Sponsor
- Kiadis Pharma
Renal Cell Carcinoma
Study of GDC-0980 Versus Everolimus in Participants With Metastatic Renal Cell Carcinoma Who Have Progressed on or Following Vascular Endothelial Growth Factor- (VEGF) Targeted Therapy
Study PIM4973g is a multicenter, international, open-label Phase II trial. Participants with metastatic renal cell carcinoma who have progressed on or after VEGF targeted therapy will be randomized in 1:1 to two groups either to…
- Trial name
- NCT01442090
- Testing
- Everolimus, GDC-0980
- Where
- 22 sites in United States, France and 3 more
- Volunteers
- 85 people
- Sponsor
- Genentech, Inc.
Prostate Cancer
Radium Ra 223 With Enzalutamide Compared to Enzalutamide Alone in Men With Metastatic Castration Refractory Prostate Cancer
Study of Radium Ra 223 dichloride with enzalutamide compared to enzalutamide alone in men with metastatic castration refractory prostate cancer
- Trial name
- NCT02199197
- Testing
- Radium Ra 223 Dichloride, Enzalutamide
- Where
- United States
- Volunteers
- 49 people
- Sponsor
- University of Utah
Small Cell Lung Cancer, Carcinoma, Small Cell
Higher Dose Weekly Topotecan In The Treatment Of Patients With Extensive Stage Small-Cell Lung Cancer
This proposed phase II trial will investigate weekly topotecan at a higher dose than was used in the previous trials in an attempt to achieve improved response rates and disease control without added toxicity.
- Trial name
- NCT00294190
- Testing
- Topotecan
- Where
- 13 sites in United States
- Volunteers
- 38 people
- Sponsor
- SCRI Development Innovations, LLC
Prostatic Neoplasms
Standard Dose Versus High Dose and Versus Extended Standard Dose Radium-223 Dichloride in Castration-resistant Prostate Cancer Metastatic to the Bone
This study will assess different doses and regimens of radium-223 dichloride on the incidence of symptomatic skeletal events. Eligible subjects must have castration resistant prostate cancer with 2 or more skeletal metastases…
- Trial name
- NCT02023697
- Testing
- Radium-223 dichloride (Xofigo, BAY88-8223)
- Where
- 68 sites in United States, Australia and 13 more
- Volunteers
- 391 people
- Sponsor
- Bayer
Colonic Cancer, Postoperative Care
Rehabilitation Following Laparoscopic Colonic Surgery
The standard procedure for treating colonic cancer is changing from open surgery to laparoscopic surgery. Following open colonic surgery patients are fatigued and loss body mass and have a reduction in physical function, but the…
- Conditions
- Colonic Cancer, Postoperative Care, Fatigue
- Trial name
- NCT00938210
- Testing
- Laparoscopic colonic surgery
- Where
- 2 sites in Denmark
- Volunteers
- 50 people
- Sponsor
- Aarhus University Hospital
Chronic Myeloid Leukemia, Philadelphia-Positive Myeloid Leukemia
Study of BMS-354825 (Dasatinib) in Patients With Chronic Myeloid Leukemia Who Are Either Resistant or Intolerant to Imatinib
The purpose of this study is assess the effects of the investigational drug dasatinib on participants who are in chronic phase Philadelphia chromosome chronic myeloid leukemia and who are either resistant to or intolerant of…
- Trial name
- NCT00101660
- Testing
- Dasatinib
- Where
- 85 sites in United States, Australia and 20 more
- Volunteers
- 387 people
- Sponsor
- Bristol-Myers Squibb
Multiple Myeloma
Carfilzomib, Lenalidomide, and Dexamethasone in New Multiple Myeloma Patients
Background: Carfilzomib is an experimental anti-cancer drug that has not yet been approved for treating multiple myeloma. Lenalidomide is a drug that may stop tumor growth and help the immune system kill cancer cells.
- Trial name
- NCT01402284
- Testing
- Carfilzomib, Lenalidomide, Dexamethasone
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- National Cancer Institute (NCI)
Tumors
Randomized, Double Blind, Placebo-controlled Topical Resiquimod Adjuvant for NY-ESO-1 Protein Vaccination
The study is designed to see if a course of injections containing the NY-ESO-1 protein (a tumor antigen, marker expressed by tumors); in combination with an immune stimulant (adjuvant) Montanide, with or without resiquimod…
- Trial name
- NCT00821652
- Testing
- NY-ESO-1 protein; Montanide ISA®-51 VG; Resiquimod
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- Nina Bhardwaj
Breast Cancer
Anesthetic Effect on Immune Cell in Patients With Cancer
Anesthetics agents has an effect on immune response during the cancer surgery.This influence can regulatory to immune activity or cancer cell survival.
- Trial name
- NCT02758249
- Testing
- Sevoflurane, propofol
- Where
- South Korea
- Volunteers
- 47 people
- Sponsor
- Konkuk University Medical Center
Fallopian Tube Cancer, Ovarian Cancer
Laparoscopic Staging in Patients With Ovarian, Fallopian Tube, or Other Primary Abdominal Cancers
RATIONALE: Laparoscopic staging may help doctors plan more effective treatment for ovarian, primary fallopian tube, and primary abdominal cancers.
- Conditions
- Fallopian Tube Cancer, Ovarian Cancer, Primary Peritoneal Cavity Cancer
- Trial name
- NCT00002538
- Testing
- laparoscopic surgery
- Where
- 11 sites in United States
- Sponsor
- Gynecologic Oncology Group
Colorectal Cancer
Focusing Implementation to Bring Effective Reminders (FIBER)
FIBER is 4-year study that will evaluate the implementation of a large-scale population-based colorectal cancer screening patient reminder and coordinated follow-up program.
- Trial name
- FIBER (NCT00656838)
- Testing
- Patients receives letter, phone call, office visit, educational materials
- Where
- United States
- Volunteers
- 85,289 people, healthy volunteers welcome
- Sponsor
- Kaiser Permanente
Colorectal Cancer, Surgery--Complications
Effect of the Nutraceutical "MICODIGEST 2.0" on the Complications After Surgery for Colorectal Cancer
Most of Colorectal cancer (CRC) diagnosed are candidates for surgical resection with curative intent, although colorectal surgery is associated with some complications that could be life-threatening.
- Trial name
- NCT04821258
- Testing
- MICODIGEST 2.0 supplement
- Where
- Spain
- Volunteers
- 48 people
- Sponsor
- Fundacin Biomedica Galicia Sur