Clinical trials: Neoplastic Cells, Circulating
Lymphoma, Lymphoma, B-Cell
ctDNA-guided Therapy Optimization in Newly Diagnosed DLBCL
The purpose of this study is to 1) determine whether it is feasible to measure circulating tumor DNA (ctDNA) in real-time during standard treatment for newly diagnosed diffuse large B-cell lymphoma (DLBCL), and 2) evaluate the…
- Conditions
- Lymphoma, Lymphoma, B-Cell, Diffuse Large B Cell Lymphoma, Diffuse Large B-Cell Lymphoma, Not Otherwise Specified
- Trial name
- NCT06693830
- Testing
- Phased Variant Enrichment and Detection Sequencing (PhasED-seq), Standard of Care Treatment, De-escalated Treatment
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Hua-Jay J Cherng, MD
Breast Cancer, Prostate Cancer
Enumeration and Functional Analysis of Circulating Tumor Cells for Homologous Recombination: a Prospective Single-center Study on Advanced/Metastatic Solid Tumors
The goal of this clinical trial is to is to evaluate whether a correlation exists between functional HR status/CTC enumeration in expanded CTCs measured before treatment initiation, and Progression Free Survival (PFS) under PARPi…
- Conditions
- Breast Cancer, Prostate Cancer, Pancreatic Cancer, Ovarian Cancer
- Trial name
- E-FACTOR (NCT07555600)
- Testing
- blood sampling, Tumor sampling
- Volunteers
- 300 people
- Sponsor
- Centre Leon Berard
Circulating Tumor Cell, Gastrointestinal Cancer
EUS Guided HVA and PVA for Circulating Tumor DNA in Patients
The discovery of cell-free circulating tumor DNA (crDNA) in blood and the maturation of technologies for ctDNA analysis have presented an attractive opportunity for minimally invasive "liquid biopsy" genomic diagnostics.
- Trial name
- NCT04782557
- Testing
- EUS-guided portal vein and hepatic vein aspiration
- Where
- Hong Kong
- Volunteers
- 60 people
- Sponsor
- Chinese University of Hong Kong
Non Small Cell Lung Cancer
A2R and Ectonucleotidases Expression in Lung Cancer Circulating Tumor Cells
Early non-small cell lung cancer (NSCLC), treated by surgery or radiotherapy in the case of inoperability, relapses in almost 50% of cases.
- Trial name
- LUNGadenosine (NCT05648188)
- Testing
- Sample
- Where
- France
- Sponsor
- Centre Hospitalier Universitaire de Nice
Bladder Cancer, Circulating Tumor Cells
Detection and Clinical Significance of Circulating Cancer Cells in Patient Undergoing Radical Cystectomy
Very few factors may be identified as prognostic for patients with bladder cancer undergoing radical cystectomy. Recently, detection of circulating tumor cells has shown to be very promising in anticipating both the likelyhood of…
- Trial name
- CirCanCell (NCT02345473)
- Testing
- Detection of circulating tumor cells in blood samples
- Where
- Italy
- Volunteers
- 59 people, healthy volunteers welcome
- Sponsor
- Azienda Ospedaliero-Universitaria Consorziale Policlinico di Bari
Prostate Cancer, Metastatic Cancer
CTC, Free DNA, Stem Cells and EMT-related Antigens as Biomarkers of Activity of Cabazitaxel in CRPC.
Identification of biomarkers (Circulating Tumor Cells (CTC), free DNA, Stem Cells and EMT-related antigens) that may be predictive of outcome of activity of cabazitaxel treatment in castration-resistant prostate cancer.
- Conditions
- Prostate Cancer, Metastatic Cancer, Castration-resistant Prostate Cancer, Circulating Tumor Cells
- Trial name
- IRSTB030 (NCT03381326)
- Testing
- blood and FFPE sample collection
- Where
- 9 sites in Italy
- Volunteers
- 104 people
- Sponsor
- Istituto Romagnolo per lo Studio dei Tumori Dino Amadori IRST S.r.l. IRCCS
Stage II Bladder Urothelial Carcinoma
Circulating Tumor Cells in Operative Blood in Patients With Bladder Cancer
This pilot clinical trial studies the impact of radical cystectomy (surgery) on the expulsion (release) of circulating tumor cells into the blood stream in patients with bladder cancer.
- Trial name
- NCT02514408
- Testing
- Catheter Management, Cytology Specimen Collection Procedure, Laboratory Biomarker Analysis
- Sponsor
- University of Southern California
Metastatic Colorectal Cancer
Circulating Tumor Cells and Neutrophils Count for Colorectal Metastatic Cancer
Colorectal cancer represents a major public health problem in France because of its high incidence and severe prognosis. Early stages of the disease are well know and have justified the establishment of a mass screening strategy.
- Trial name
- NCT05793775
- Where
- 2 sites in France
- Volunteers
- 30 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Breast Neoplasms
Sweden Cancerome Analysis Network - Breast : Genomic Profiling of Breast Cancer
This study evaluates the genomic profiles of breast cancer in a prospective and population-based manner. In the first phase, breast tumors are analyzed by whole transcriptome RNA-sequencing.
- Trial name
- SCAN-B (NCT02306096)
- Where
- 10 sites in Sweden
- Volunteers
- 20,000 people
- Sponsor
- Lund University
Circulating Tumor Cell, Metastatic Prostate Cancer
Cabazitaxel in mCRPC Patients With AR-V7 Positive Circulating Tumor Cells (CTCs)
After failure on docetaxel, which has been the standard first line therapy for patients with metastatic castration-resistant prostate cancer (mCRPC), several treatment options are currently available.
- Trial name
- CABA-V7 (NCT03050866)
- Testing
- Cabazitaxel, Antihistamine, Corticosteroid
- Where
- 9 sites in Netherlands
- Volunteers
- 140 people
- Sponsor
- Erasmus Medical Center
Breast Carcinoma Metastatic in the Bone, Circulating Tumor Cell Count
Denosumab in Treating Patients With ER and/or PR Positive, HER2 Negative Metastatic Breast Cancer With Bone Metastases and Detectable Circulating Tumor Cells
The purpose of this study is to look at the amount of cancer cells in the blood of participants who are being treated with denosumab.
- Conditions
- Breast Carcinoma Metastatic in the Bone, Circulating Tumor Cell Count, Estrogen Receptor Positive, HER2/Neu Negative
- Trial name
- NCT03070002
- Testing
- Denosumab, Laboratory Biomarker Analysis
- Where
- 2 sites in United States
- Volunteers
- 1 people
- Sponsor
- Northwestern University
Neoplastic Cells, Circulating
The Detection of Circulating Tumor Cells (CTCs) in Patients With Breast Cancer Undergoing Cryosurgery Combined With DC-CIK Treatment
Circulating tumor cells (CTCs) have the potential to provide a surrogate for'real-time biopsy' of tumor biological activity. Enumeration and molecular characterization of CTCs in breast cancer could play an important role in…
- Trial name
- NCT02450357
- Testing
- Flow cytometry (FCM), RT-PCR
- Where
- China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Fuda Cancer Hospital, Guangzhou
Resectable Esophageal Cancer
Circulating Tumor Cells as a Biomarker for Preoperative Prognostic Staging in Patients With Esophageal Cancer
Despite the availability of several preoperative diagnostic techniques, accurate pretreatment staging of esophageal cancer (EC) remains challenging.
- Trial name
- NCT01858805
- Testing
- esophagectomy
- Where
- Germany
- Volunteers
- 123 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Colorectal Cancer, Circulating Tumor Cell
Influence of Opioid Analgesia on Circulating Tumor Cells in Laparoscopic Colorectal Cancer Surgery
To compare the effects of three types of perioperative analgesia on the number of circulating tumor cells following radical colorectal cancer surgery.
- Trial name
- POACC-2 (NCT03700541)
- Testing
- Morphine, Piritramid
- Where
- 3 sites in Czechia
- Volunteers
- 71 people
- Sponsor
- The Institute of Molecular and Translational Medicine, Czech Republic
NSCLC
Postoperative NSCLC Treated With Integrated Medicine Base on Circulating Tumor Cell Detection
Objective: To study the effect of Jinfukang Koufuye combined with chemotherapy on preventing relapse and metastasis of early postoperative NSCLC patients.
- Trial name
- NCT03269162
- Testing
- Jinfukang Koufuye, Docetaxel, Pemetrexed
- Volunteers
- 144 people
- Sponsor
- lihegen
Breast Cancer Females, Circulating Tumor Cells.Breast
Does Anesthesia Technique Impact on the Long-term Outcome 5 and 10 Years After the First Intervention in Primary Breast Cancer Surgery? A Follow-up Analysis.
Goal of this observational study is to analyze data about cancer recurrence rates 5 and 10 years after primary breast cancer surgery with propofol or sevoflurane anesthesia.
- Conditions
- Breast Cancer Females, Circulating Tumor Cells.Breast, Follow Up Analysis
- Trial name
- CTC follow up (NCT07689253)
- Where
- Switzerland
- Volunteers
- 161 people
- Sponsor
- University of Zurich
Locally Advanced Rectal Carcinoma, Neoadjuvant Treatment
Longitudinal Multimodal Response Assessment During Neoadjuvant Treatment of Rectal Cancer
This pilot study aims to trial multimodal early response assessment to enable therapy adaptions in the context of non-operative therapy strategies of locally advanced rectal cancer (LARC) for development of a non-invasive…
- Conditions
- Locally Advanced Rectal Carcinoma, Neoadjuvant Treatment, Radiotherapy, Adaptive Treatment
- Trial name
- PRIMO (NCT05524012)
- Testing
- Blood sample, MRI scan
- Where
- Germany
- Volunteers
- 40 people
- Sponsor
- Jena University Hospital
Ethmoid Sinus Tumor, Adenocarcinoma
Liquid Biopsy for the Diagnosis of Intestinal-type Adenocarcinoma of the Ethmoid (BLADE)
The role of this transversal study is to assess the specificity and sensitivity of liquid biopsy to detect circulating cells tumor of adenocarcinoma of the ethmoid.
- Conditions
- Ethmoid Sinus Tumor, Adenocarcinoma, Circulating Tumor Cell
- Trial name
- BLADE (NCT06090214)
- Testing
- Liquid biopsy
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- University Hospital, Montpellier
Minimal Residual Disease, KRAS G12D
A Study of ELI-002 in Subjects With KRAS Mutated Pancreatic Ductal Adenocarcinoma (PDAC) and Other Solid Tumors
This is a Phase 1 study to assess the safety and efficacy of ELI-002 immunotherapy (a lipid-conjugated immune-stimulatory oligonucleotide [Amph-CpG-7909] plus a mixture of lipid-conjugated peptide-based antigens [Amph-Peptides])…
- Conditions
- Minimal Residual Disease, KRAS G12D, KRAS G12R, NRAS G12D
- Trial name
- AMPLIFY-201 (NCT04853017)
- Testing
- ELI-002 2P
- Where
- 10 sites in United States
- Volunteers
- 25 people
- Sponsor
- Elicio Therapeutics
Cancer
Clinical Validation of a Microfluidic Device for Isolation and Molecular Characterization of Circulating Tumor Cells
To evaluate the efficiency of a microdevice for circulating tumor cells isolation and to correlate the circulating titre with response and progression.
- Trial name
- CTC (NCT01022723)
- Where
- Singapore
- Volunteers
- 817 people
- Sponsor
- National Cancer Centre, Singapore