Clinical trials: Neostigmine
Muscle Relaxation
Effectiveness of Sugammadex in LMS Surgery
This study is comparing of rocuronium-sugammadex and succinylcholine during LMS surgery that is characterized by short operation time, required intense paralysis and ambulatory setting, has not been investigated.
- Trial name
- NCT02329964
- Testing
- Sugammadex, Neostigmine
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Korea University Anam Hospital
Acute Pain
Clinical Efficacy of Prophylactic Intravenous Neostigmine and Atropine in Preventing Post-Dural Puncture Headache Among Parturient Undergoing Spinal Anesthesia for Cesarean Section: A Double-blind Randomized Placebo-controlled Trial
Post dural puncture headache is a distressing issue, many measures tried to treat symptoms but few delt with prevention.
- Trial name
- NCT06493838
- Testing
- intravenous 50 mL of saline injection of 0.9% after umbilical cord clamping., Neostigmine 20μg/kg (Neostigmine Methylsulphate 0.5 mg, Amriya Pharm.Ind.) and atropine 0.01 mg/kg (diluted in 50 ml saline; 0.9% for 10 min) following umbilical cord clamping.
- Volunteers
- 180 people
- Sponsor
- Minia University
Anesthesia, General, Neuromuscular Blockade
Comparison of 2.0 mg/kg Sugammadex and Neostigmine at Reappearance of T2 in Chinese and European Subjects (Study 19.4.324)(P05768AM1)(COMPLETED)
The present trial was set up to evaluate the efficacy and safety of 2.0 mg.kg-1 sugammadex compared to neostigmine administered at reappearance of T2 in Chinese and Caucasian subjects for registration purposes in China.
- Trial name
- NCT00825812
- Testing
- Sugammadex, neostigmine
- Volunteers
- 308 people
- Sponsor
- Merck Sharp & Dohme LLC
Labor Pain
Epidural Neostigmine for Labor Pain
The purpose of this study is to see which dose of epidural neostigmine is the best additive to use with the numbing medication used in an epidural during labor.
- Trial name
- NCT00779467
- Testing
- Neostigmine, Bupivacaine, fentanyl
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Wake Forest University
Postoperative Urinary Retention
The Role of Sugammadex in Posotoperative Urinary Retention in Patients Undergoing Pelvic Floor Reconstructive Procedures
The Investigator will perform a single-institution randomized double-blinded controlled trial comparing intraoperative Sugammadex vs.
- Trial name
- NCT05664633
- Testing
- Sugammadex
- Sponsor
- West Virginia University
Nasal Septum Deviation
Sugammadex Versus Neostigmine Use in Patients Undergoing Septoplasty Operations
The purpose of this study to determine the effectiveness of sugammadex in septoplasty patients whose mask ventilation would be difficult after extubation.
- Trial name
- NCT02026999
- Where
- Turkey (Türkiye)
- Volunteers
- 88 people
- Sponsor
- Ankara University
Morbid Obesity, Neuromuscular Blockade
Comparative Study of Sugammadex Versus Neostigmine for Reversal of Neuromuscular Blockade in Morbidly Obese Patients
Postoperative residual curarization in the post anaesthesia unit has been associated to complications involving respiratory function and impaired laryngeal and pharyngeal muscles' function.
- Trial name
- NCT01629394
- Testing
- Sugammadex, Neostigmine
- Where
- Greece
- Volunteers
- 120 people
- Sponsor
- University of Patras
Anesthesia
Optimizing Post-operative Recovery in Bariatric Patients With Obstructive Sleep Apnea Undergoing Outpatient Surgery: A Comparison of Sugammadex and Neostigmine
This study assesses the efficacy of sugammadex against neostigmine for hastening recovery from neuromuscular blockade and optimizing pulmonary function in obese patients with obstructive sleep apnea presenting for outpatient…
- Trial name
- NCT04570150
- Testing
- Sugammadex, Neostigmine
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- University of California, San Diego
Postoperative Vomiting, Postoperative Nausea
Sugammadex and Neostigmine in Pediatric Patients
In this study, it was aimed to compare the use of sugammadex instead of neostigmine + atropine in the reversal of NMB in children undergoing lower abdominal surgery or urogenital surgery, and to compare the rates of postoperative…
- Conditions
- Postoperative Vomiting, Postoperative Nausea, Postoperative Delirium
- Trial name
- NCT05618236
- Testing
- Group N; neostigmine+atropine, GROUP S; decurarized with sugammadex.
- Where
- Turkey (Türkiye)
- Volunteers
- 130 people
- Sponsor
- Marmara University
Obstructive Sleep Apnea
Impact of Sugammadex vs. Neostigmine Reversal on Post-Operative Recovery and Complications
Sugammadex or neostigmine are given at the end of the surgery to reverse neuro muscular blocking drugs (NMBD). This study will evaluate whether reversal of NMBD with sugammadex is associated with faster recovery than neostigmine…
- Trial name
- Sugammadex (NCT03679611)
- Testing
- Sugammadex Sodium, Neostigmine
- Where
- Canada
- Volunteers
- 120 people
- Sponsor
- University Health Network, Toronto
Residual Neuromuscular Blockade
Incidence and Severity of Residual Neuromuscular Blockade
This prospective study will take place at Harborview Medical Center (HMC) and the University of Washington Medical Center (UWMC), and will enroll adult patients undergoing abdominal surgery.
- Trial name
- NCT02660398
- Testing
- Standardized NMBD Management
- Where
- United States
- Volunteers
- 78 people
- Sponsor
- University of Washington
Anesthesia
Role of Sugammadex and Neostigmine for Recovery From Rocuronium
evaluation the reversal of neuromuscular blocking by sugammadex versus neostigmine through assessing the residual neuromuscular blocking effect by ultrasound imaging of expiratory muscle strength and diaphragmatic excursion.
- Trial name
- NCT06432621
- Testing
- using of sugammadex and neostigmine for reversal from rocuronium and assessment of response using ultrasound and nerve stimulation
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Ain Shams University
Neuromuscular Blockade
Reversal of Neuromuscular Blockade During the General Anaesthesia
There are individual reports indicating that after the reversal of nondepolarizing neuromuscular blockade with neostigmine, some patients starts to relax spontaneously again after the tof ratio has already recovered to the safe…
- Trial name
- NCT04048655
- Testing
- Neostigmine, Combinations
- Where
- Finland
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Tampere University Hospital
Neostigmine, Neuromuscular Blocking Agents
Reversal of Moderate or Superficial Neuromuscular Blockade Induced by Cisatracurium
The administration of acetylcholinesterase inhibiting agents (such as neostigmine) has been used to reverse the muscle paralysis induced by non-depolarizing neuromuscular blocking agents.
- Conditions
- Neostigmine, Neuromuscular Blocking Agents, Muscle Weakness
- Trial name
- NCT04920682
- Testing
- Reversal of moderate neuromuscular blockade, Reversal of superficial neuromuscular blockade, Two-step reversal
- Where
- Brazil
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Pontificia Universidade Catolica de Sao Paulo
Neuromuscular Blockade, Neuromuscular Block, Residual
Different Doses of Neostigmine for Reversal of Moderate Neuromuscular Blockade in Children
There is no recent information on the required dose of neostigmine for the reversal of cisatracurium-induced moderate neuromuscular blockade (NMB) [Train-of-four (TOF) count = 1-3)] in children.
- Conditions
- Neuromuscular Blockade, Neuromuscular Block, Residual, Neuromuscular Block Prolonged
- Trial name
- NCT05053594
- Testing
- Neostigmine 10 mcg/kg, Neostigmine 20 mcg/kg, Neostigmine 30 mcg/kg
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Pontificia Universidade Catolica de Sao Paulo
Spine Surgery, Reversal of Neuromuscular Blockade
Sugammadex vs Neostigmine/Glycopyrrolate on Urinary Retention After Spine Surgery
This is an active-comparator controlled study to evaluate the effect of sugammadex compared to neostigmine/glycopyrrolate for reversal of rocuronium on the incidence of urinary retention after subjects undergo elective ambulatory…
- Conditions
- Spine Surgery, Reversal of Neuromuscular Blockade, Urinary Retention Postoperative
- Trial name
- NCT05887375
- Testing
- Sugammadex, Neostigmine, Glycopyrrolate
- Where
- United States
- Volunteers
- 118 people
- Sponsor
- University of Missouri-Columbia
Cesarean Section
MgSO4 as Adjuvants to Bupivacaine vs Neostigmine in TAP Block in Cesarean Section
The aim of this study is to compare the duration of analgesia obtained by addition of Neostigmine versus MgSO4 as adjuvants to bupivacaine in TAP block in patients undergoing Cesarean Section and to evaluate postoperative…
- Trial name
- NCT06513013
- Testing
- transversus abdominis plane (TAP) block in cesarean section, Magnesium sulfate, Neostigmine
- Where
- Egypt
- Volunteers
- 68 people
- Sponsor
- Assiut University
Adjuvants, Anesthesia
Neostigmine Versus Dexamethasone as Adjuvants to Lidocaine During Intravenous Local Anesthesia
Intravenous regional anesthesia (IVRA) is described firstly in 1908 by August Bier. It is simple, safe, reliable, less cost, efficient method in forearm surgery.
- Trial name
- NCT03021772
- Testing
- Neostigmine, Dexamethasone
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Assiut University
Obstructive Sleep Apnea
Sugammadex Compared With Neostigmin/Atropin for Neuromuscular Block Reversal in Patients With Obstructive Sleep Apnea
Incomplete recovery of neuromuscular function after surgery can lead to respiratory complications. Patients with obstructive sleep apnea (OSA) are prone to respiratory complications after surgery.
- Trial name
- NCT02160223
- Testing
- Sugammadex, Neostigmine
- Where
- Turkey (Türkiye)
- Volunteers
- 74 people
- Sponsor
- Diskapi Teaching and Research Hospital
Sepsis, Septic Shock
Adjuvant Use of Neostigmine in Sepsis and Septic Shock.
The inflammatory response represents an important, central component of sepsis. Therefore, it is believed that blunting inflammation will decrease mortality.
- Trial name
- NCT04130230
- Testing
- Neostigmine, Standard therapy
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Mansoura University