Clinical trials: Neostigmine
Anesthesia, General
Comparison of Sugammadex With Neostigmine During Laparoscopic Cholecystectomy or Appendectomy (P05699)
The current trial was designed to demonstrate faster recovery from a neuromuscular blockade (NMB) induced by rocuronium after reversal at 1-2 Post Tetanic Count (PTC) by 4.0 mg.kg-1 sugammadex compared to 50 µg.kg-1 neostigmine…
- Trial name
- NCT00724932
- Testing
- Rocuronium, Sugammadex, Neostigmine
- Volunteers
- 140 people
- Sponsor
- Merck Sharp & Dohme LLC
Neuromuscular Blockade
Postoperative Urinary Retention in Patients After Noncardiac Surgery and Reversal of Neuromuscular Block
The investigators propose a randomized trial comparing sugammadex and neostigmine for the reversal of neuromuscular blocks induced by rocuronium or vecuronium in adults having general anesthesia with muscular block for noncardiac…
- Trial name
- NCT05545280
- Testing
- Neostigmine with glycopyrrolate, Sugammadex
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- The Cleveland Clinic
Acute Pancreatitis, Intra-abdominal Hypertension
Neostigmine Treatment of Acute Pancreatitis Combined With Intra-abdominal Hypertension
Acute pancreatitis(A) often complicated with Intra-abdominal Hypertension. After the onset of acute pancreatitis, capillary leakage causing ascites,upper gastrointestinal tract obstruction and paralytic ileus leading to an…
- Trial name
- NCT02543658
- Testing
- Neostigmine Methylsulfate 1 MG/ML, Conservative treatment
- Where
- China
- Volunteers
- 80 people
- Sponsor
- The First Affiliated Hospital of Nanchang University
Surgery
Study of Recovery of Strength After Surgery Comparing Two Different Medications for Reversal of Muscle Relaxant
The purpose of this study is to compare two different medications (neostigmine/glycopyrrolate and sugammadex) to see if one drug improves patient comfort regarding the return of muscle strength after surgery.
- Trial name
- NCT03116997
- Testing
- Neostigmine+glycopyrrolate, Sugammadex
- Where
- 4 sites in United States
- Volunteers
- 201 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Labor Pain
Epidural Neostigmine for Labor Pain
The purpose of this study is to see which dose of epidural neostigmine is the best additive to use with the numbing medication used in an epidural during labor.
- Trial name
- NCT00779467
- Testing
- Neostigmine, Bupivacaine, fentanyl
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Wake Forest University
Anesthesia
Optimizing Post-operative Recovery in Bariatric Patients With Obstructive Sleep Apnea Undergoing Outpatient Surgery: A Comparison of Sugammadex and Neostigmine
This study assesses the efficacy of sugammadex against neostigmine for hastening recovery from neuromuscular blockade and optimizing pulmonary function in obese patients with obstructive sleep apnea presenting for outpatient…
- Trial name
- NCT04570150
- Testing
- Sugammadex, Neostigmine
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- University of California, San Diego
Spine Surgery, Reversal of Neuromuscular Blockade
Sugammadex vs Neostigmine/Glycopyrrolate on Urinary Retention After Spine Surgery
This is an active-comparator controlled study to evaluate the effect of sugammadex compared to neostigmine/glycopyrrolate for reversal of rocuronium on the incidence of urinary retention after subjects undergo elective ambulatory…
- Conditions
- Spine Surgery, Reversal of Neuromuscular Blockade, Urinary Retention Postoperative
- Trial name
- NCT05887375
- Testing
- Sugammadex, Neostigmine, Glycopyrrolate
- Where
- United States
- Volunteers
- 118 people
- Sponsor
- University of Missouri-Columbia
Laparoscopy, Anesthesia Recovery Period
Deep Neuromuscular Block for Laparoscopic Surgery
Trial summary: deep neuromuscular block is proposed as a technique to improve operative conditions for laparoscopy. Early clinical data would suggest that there may also be patient benefits beyond the operative period related to…
- Trial name
- DEEPBLOCK (NCT03034577)
- Testing
- Sugammadex, Neostigmine
- Where
- 4 sites in Australia
- Volunteers
- 350 people
- Sponsor
- University of Melbourne
Anesthesia
Comparision of Different Dose of Neostigmine at Advanced Decurarization
Neuromuscular blockers (NMB) are currently used in anesthesia. Residual paralysis (RP) due to NMB is responsible for respiratory disorders after extubation.
- Trial name
- NEODEC (NCT00847938)
- Testing
- neostigmine
- Where
- France
- Volunteers
- 62 people
- Sponsor
- Centre Hospitalier Departemental Vendee
Neuromuscular Blockade
Sugammadex as Rescue Therapy
Neuromuscular blocking agents (NMBAs) are commonly used in the practice of anesthesiology for skeletal muscle relaxation to facilitate tracheal intubation, mechanical ventilation, and to provide optimal surgical conditions.
- Trial name
- NCT05661409
- Testing
- Sugammadex
- Where
- United States
- Volunteers
- 46 people
- Sponsor
- Emory University
Incomplete Reversal of Neuromuscular Block
Quality of Recovery After Reversal With Neostigmine or Sugammadex.
This study will compare patient recovery measures after reversal of neuromuscular blockade with neostigmine or sugammadex after surgery.
- Trial name
- NCT02909439
- Testing
- Sugammadex, Neostigmine
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Stony Brook University
Obstructive Sleep Apnea
Impact of Sugammadex vs. Neostigmine Reversal on Post-Operative Recovery and Complications
Sugammadex or neostigmine are given at the end of the surgery to reverse neuro muscular blocking drugs (NMBD). This study will evaluate whether reversal of NMBD with sugammadex is associated with faster recovery than neostigmine…
- Trial name
- Sugammadex (NCT03679611)
- Testing
- Sugammadex Sodium, Neostigmine
- Where
- Canada
- Volunteers
- 120 people
- Sponsor
- University Health Network, Toronto
Neuromuscular Blockade
Sugammadex Provide Better Surgical Condition Compared With Neostigmine in Laryngeal Microsurgery.
This study aims to make a comparison of surgical condition and recovery time between rocuronium 0.45 mg/kg and neostigmine group and rocuronium 0.9 mg/kg and sugammadex group.
- Trial name
- NCT02330172
- Testing
- Injection of neostigmine or sugammadex
- Where
- South Korea
- Volunteers
- 44 people
- Sponsor
- Seoul National University Hospital
Muscle Weakness
Best Practice Using Rocuronium and Reversal With Neostigmine or Sugammadex
This is an estimation study, prospectively evaluating the incidence of postoperative residual neuromuscular blockade (PRNB) when a best practice protocol is implemented for a cohort of abdominal surgery and orthopedic surgery…
- Trial name
- NCT03543826
- Testing
- Protocol for rocuronium neuromuscular block
- Where
- United States
- Volunteers
- 201 people
- Sponsor
- University of Washington
Neuromuscular Blockade, Anesthesia
Sugammadex Versus Neostigmine for Reversal of Rocuronium Neuromuscular
The aim of this study is to evaluate whether the use of Sugammadex for reversing the neuromuscular blocking effects of rocuronium during neurointerventional procedures can speed recovery of neuromuscular function.
- Trial name
- NCT03322657
- Testing
- Neostigmine, Glycopyrrolate, Sugammadex
- Where
- United States
- Volunteers
- 69 people
- Sponsor
- The Cleveland Clinic
Respiratory Insufficiency
Effect of Neuromuscular Blockade and Reversal on Breathing
In this study the investigators will assess (i) the effect of partial neuromuscular blockade (NMB; TOF ratio 0.8 and 0.6) induced by low-dose rocuronium on the ventilatory response to isocapnic hypoxia and (ii) the effect over…
- Trial name
- BREATH (NCT02845375)
- Testing
- Sugammadex, Neostigmine
- Where
- Netherlands
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Leiden University Medical Center
Anesthesia
Comparison of Sugammadex Administered at 1-2 Post Tetanic Counts (PTCs) or Better With Neostigmine Administered as Per Standard of Care to Reverse Rocuronium-Induced Neuromuscular Blockade in Adults Undergoing Elective Open Abdominal Procedure (19.4.334) (P05774)
The primary purpose of this study is to compare the incidence of residual neuromuscular blockade at the time of tracheal extubation after reversal of rocuronium bromide-induced neuromuscular blockade by 4 mg/kg sugammadex with…
- Trial name
- NCT00675792
- Testing
- Sugammadex, Neostigmine, Rocuronium
- Volunteers
- 100 people
- Sponsor
- Merck Sharp & Dohme LLC
Bowel Dysfunction, Postoperative Complications
Sugammadex To IMprove Bowel Function
Colon and rectal surgery is associated with high cost, long length of stay, high postoperative surgical site infection rate, high incidence of postoperative nausea and vomiting, and a high rate of hospital readmission.
- Conditions
- Bowel Dysfunction, Postoperative Complications, Neuromuscular Blockade
- Trial name
- STIM_Bowel (NCT04546672)
- Testing
- Sugammadex, Neostigmine
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Oregon Health and Science University
Muscle Relaxation
Effectiveness of Sugammadex in LMS Surgery
This study is comparing of rocuronium-sugammadex and succinylcholine during LMS surgery that is characterized by short operation time, required intense paralysis and ambulatory setting, has not been investigated.
- Trial name
- NCT02329964
- Testing
- Sugammadex, Neostigmine
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Korea University Anam Hospital
Neuromuscular Blockade
Sugammadex vs. Neostigmine for Neuromuscular Blockade Reversal in Thoracic Surgical Patients
This prospective, randomized, double blinded study is intended to enroll a total of 92 patients undergoing thoracic surgery with general endotracheal anesthesia at Parkland Hospital.
- Trial name
- NCT03168308
- Testing
- Sugammadex, Neostigmine w/ Glycopyrrolate
- Where
- United States
- Volunteers
- 92 people
- Sponsor
- University of Texas Southwestern Medical Center