Clinical trials: Nephrectomy
Nephrectomy
Comparing 3 Different Types of Pain Blocks After Laparoscopic Nephrectomy
All three methods of postoperative analgesia have been shown to decrease postoperative pain control in nephrectomy patients, the three methods have never been compared to each other.
- Trial name
- NCT03581539
- Testing
- Transverses Abdominis Plane (TAP) block, Quadratus Lumborum (QL) block, Surgeon Infiltration using Exparel
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Indiana University
Laparoscopic, Nephrectomy
Low-Thoracic Epidural Anesthesia For Laparoscopic Nephrectomy.
Laparoscopic nephrectomy is a surgical technique to excise a diseased kidney. It's a minimally invasive technique, so when compared to open surgery, it can mean significantly less post-operative pain, shorter hospital stay…
- Conditions
- Laparoscopic, Nephrectomy, Anesthesia, Epidural
- Trial name
- NCT04546230
- Testing
- Low-Thoracic Epidural Anesthesia, General Anesthesia
- Where
- Egypt
- Volunteers
- 80 people
- Sponsor
- Nazmy Edward Seif
Renal Cancer
Vaccination of Patients With Renal Cell Cancer With Dendritic Cell Tumor Fusions and GM-CSF
The main purpose of this study is to test the safety of the dendritic cell/tumor fusion study vaccine in combination with a laboratory-made agent called Granulocyte Macrophage Colony Stimulating Factor (GM-CSF).
- Trial name
- NCT00458536
- Testing
- Dendritic Cell Tumor Fusion Vaccine, Granulocyte Macrophage Colony Stimulating Factor (GM-CSF)
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- Beth Israel Deaconess Medical Center
Renal Tumors Less Than 4 cm
Study to Evaluate the Efficacy of Percutaneous Cryoablation for Renal Tumours < 4cm in Patients Who Are Not Candidates for Partial Nephrectomy
The main objective is to evaluate the oncologic efficacy of percutaneous cryoablation of renal tumors smaller than 4 cm in patients with renal cancer that cannot be offered a partial nephrectomy.
- Trial name
- CRYOREIN (NCT01471002)
- Testing
- Galil Medical patented 17G Cryoablation Needles
- Where
- France
- Volunteers
- 100 people
- Sponsor
- University Hospital, Strasbourg, France
General Anesthesia, Chronic Pain, Postoperative
Risk Factors for Chronic Postoperative Pain After Elective Nephrectomy
Chronic postoperative pain (CPP) is typically defined as pain persisting for 3 months or more after surgery[1]. CPP is a common and increasingly prevalent morbidity, leading to long-term psychological issues, reduced quality of…
- Conditions
- General Anesthesia, Chronic Pain, Postoperative, Acute Pain, Postoperative, Surgery
- Trial name
- NCT06673979
- Testing
- Numeric Rating Scale
- Where
- Turkey (Türkiye)
- Volunteers
- 204 people
- Sponsor
- Istanbul University - Cerrahpasa
Living Donor Nephrectomy
Scrotal Surgery After Laparoscopic Donor Nephrectomy
This study will examine whether laparoscopic nephrectomy is associated with a higher long-term risk of receiving scrotal surgery in male living kidney donors compared to male nondonors from the general population who have similar…
- Trial name
- NCT06716723
- Testing
- Nephrectomy
- Where
- Canada
- Volunteers
- 9,878 people, healthy volunteers welcome
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Metastatic Clear Cell Renal Cell Carcinoma, Metastatic Renal Cell Carcinoma
Comparing the Outcome of Immunotherapy-Based Drug Combination Therapy With or Without Surgery to Remove the Kidney in Metastatic Kidney Cancer, the PROBE Trial
This phase III trial compares the effect of adding surgery to a standard of care immunotherapy-based drug combination versus a standard of care immunotherapy-based drug combination alone in treating patients with kidney cancer…
- Conditions
- Metastatic Clear Cell Renal Cell Carcinoma, Metastatic Renal Cell Carcinoma, Stage IV Renal Cell Cancer AJCC v8
- Trial name
- PROBE (NCT04510597)
- Testing
- Cytoreductive Nephrectomy, Active Comparator
- Where
- 387 sites in United States
- Volunteers
- 364 people
- Sponsor
- SWOG Cancer Research Network
Surgery
Does Adding Spinal Anaesthesia to a General Anaesthetic Technique Influence Readiness for Discharge in Patients Having Hand Assisted Laparoscopic Live Donor Nephrectomy
About 1100 living donor nephrectomies are performed in the UK every year contributing to almost 35% of all the kidney transplants.
- Trial name
- NCT02700217
- Testing
- Bupivacaine and Diamorphine, Remifentanil, Propofol and Cistracurium, Bupivacaine and Rectus Sheath injection
- Where
- United Kingdom
- Volunteers
- 101 people
- Sponsor
- Manchester University NHS Foundation Trust
Nephrectomy
Systemic Effects of Lidocaine Infusion for TAP Block Catheter
Lidocaine is a local anesthetic that is usually used for nerve blocks to sensory/motor blockade. However, lidocaine can also been given intravenously, and it has been shown that this method can be used to help alleviate chronic…
- Trial name
- NCT03971708
- Testing
- Lidocaine, Ropivacaine
- Where
- Canada
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Alberta
Renal Cancer, Kidney Cancer
Does the Use of Hemostatic Clips During the Tumor Resection Step Reduce Blood Loss During Robot-assisted Partial Nephrectomy?
One challenge of robot-assisted partial nephrectomy (RAPN) is to reduce operative blood loss. Partial nephrectomy (PN) is a complex surgery that is being made easier by robotic assistance.
- Conditions
- Renal Cancer, Kidney Cancer, Blood Loss
- Trial name
- NCT04388917
- Testing
- Patial nephrectomy
- Volunteers
- 53 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Ischemia Reperfusion Injury
Pneumoperitoneum Preconditioning for the Prevention of Renal Function After Laparoscopic Partial Nephrectomy
The present study is designed to investigate the short-term and long-term renoprotective role of pneumoperitoneum preconditioning in patients undergoing laparoscopic partial nephrectomy.
- Trial name
- NCT03822338
- Testing
- Pneumoperitoneum preconditioning
- Where
- China
- Volunteers
- 86 people
- Sponsor
- Nanjing First Hospital, Nanjing Medical University
External Oblique Intercostal Plane Block, Transversus Abdominis Plane Block
External Oblique Intercostal Plane Block Versus Transversus Abdominis Plane Block for Postoperative Analgesia in Adult Patients Undergoing Open Nephrectomy
The aim of this study is to compare external oblique intercostal plane (EOIP) block and ultrasound guided transversus abdominis plane (TAP) Block for postoperative analgesia in adult patients undergoing open nephrectomy.
- Conditions
- External Oblique Intercostal Plane Block, Transversus Abdominis Plane Block, Postoperative Analgesia, Nephrectomy
- Trial name
- NCT06452238
- Testing
- External Oblique Intercostal Plane Block, Transversus Abdominis Plane Block
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Tanta University
Kidney Transplantation
Donor Recipient Kidney Function Following Open Surgical vs. Laparoscopic Kidney Donation
This study will evaluate the differences between open surgical kidney donation and laparoscopic kidney donation on kidney donors and recipients.
- Trial name
- NCT00100516
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Metastatic Clear Cell Renal Cell Carcinoma, Recurrent Clear Cell Renal Cell Carcinoma
Pembrolizumab With or Without Axitinib for Clear Cell Kidney Cancer in Patients Undergoing Surgery
This phase II trial studies how well pembrolizumab with or without standard of care axitinib works in treating patients with clear cell kidney cancer that has spread to nearby tissues or lymph nodes (locally advanced) or other…
- Conditions
- Metastatic Clear Cell Renal Cell Carcinoma, Recurrent Clear Cell Renal Cell Carcinoma, Stage III Renal Cell Cancer AJCC v8, Stage IV Renal Cell Cancer AJCC v8
- Trial name
- NCT04370509
- Testing
- Axitinib (VEGF-TKI), Cytoreductive Nephrectomy (CN), Metastasectomy (MET)
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- University of California, San Francisco
Nephrectomy / Methods, Intraoperative Hypothermia
Effect of Preoperative Prewarming on Serum Lactate Levels in Patients Undergoing Elective Nephrectomy
The goal of this observational study is to learn whether warming patients before surgery, called "prewarming," affects blood lactate levels (a marker of how well tissues are getting oxygen) and recovery in adults having planned…
- Conditions
- Nephrectomy / Methods, Intraoperative Hypothermia, Hyperlactatemia
- Trial name
- NCT07702487
- Testing
- Preoperative active warming (prewarming)
- Where
- Turkey (Türkiye)
- Volunteers
- 128 people
- Sponsor
- Beyzanur Aydoğdu
Urological Surgeries
A Real-World Study to Evaluate the Clinical Performance and Safety of da Vinci SP Surgical System for Single-Port Urological Surgeries
Study name：A Real-World Study to Evaluate the Clinical Performance and Safety of da Vinci SP Surgical System for Single-Port Urological Surgeries； Study purpose：This clinical trial is a real-world study to evaluate the clinical…
- Trial name
- SPiM-RWS-URO (NCT06181942)
- Testing
- SP
- Where
- China
- Volunteers
- 15 people
- Sponsor
- Ruijin Hospital
Renal Cell Carcinoma
Primary Metastatic Renal Cell Carcinoma Treated With Immunecheckpoint Inhibitors and Cytoreductive Nephrectomy
The benefit of deferred Cytoreductive Nephrectomy (CN) has to be re-assessed in the context of IO +IO and IO + TKI systemic treatment.
- Trial name
- PrimerX (NCT05941169)
- Testing
- Cytoreductive Nephrectomy
- Volunteers
- 750 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Patients Undergoing Laparoscopic Nephrectomy
Study on Efficacy of iv PCA With Fentanyl or Sufentanil in Patients Undergoing Laparoscopic Nephrectomy
The purpose of this study is to compare the efficacy of iv PCA with fentanyl or sufentanil in patients undergoing laparoscopic nephrectomy
- Trial name
- NCT03171610
- Testing
- Sufentanil group, Fentanyl group
- Where
- South Korea
- Volunteers
- 82 people
- Sponsor
- Yonsei University
Nephrectomy, Acute Kidney Injury
Effect of Fluid Regimen on Acute Kidney Injury
Postoperative acute kidney injury (AKI) is an important surgical complication that increases hospital stay and mortality when it occurs after kidney surgery.
- Conditions
- Nephrectomy, Acute Kidney Injury, Fluid Therapy
- Trial name
- NCT06256120
- Testing
- Restrictive, Liberal
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Muğla Sıtkı Koçman University
Quadratus Lumborum Block, Surgical Wound Infiltration
Surgeon Infiltration QL Block Comparison
The purpose of this study is to learn if using a Quadratus Lumborum (QL) plane injection technique (also called a "nerve block") that numbs the nerves going to the abdominal area improve pain control after surgery compared to…
- Trial name
- NCT03496610
- Testing
- Liposomal Bupivicaine, QL Block
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- Duke University