Clinical trials: Nephritis, Interstitial, open to volunteers
Pyelonephritis
Population Pharmacokinetics of Temocillin in Acute Enterobacterial Pyelonephritis in Children
Temocillin, a 6-alpha-methoxypenicillin derivative of ticarcillin, is a narrow-spectrum antibiotic, primarily restricted to Enterobacterales.
- Trial name
- TEMOKID-POP (NCT07070102)
- Testing
- blood samples
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Intra Abdominal Infections, Appendicitis Acute
Diagnosis of Abdominal Pain Using RNA Levels: The NATURAL Study
The NATURAL Study is a prospective, observational, pragmatic study of RNA biomarkers of infections to aid in the diagnosis of abdominal pain.
- Conditions
- Intra Abdominal Infections, Appendicitis Acute, Pyelonephritis, Diverticulitis
- Trial name
- NATURAL (NCT07579312)
- Testing
- TruNAV, an RNA-based blood test for host immune activation by infections
- Where
- United States
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- True Bearing Diagnostics, Inc.
ANCA Associated Vasculitis, Extramembranous Glomerulopathy
Epithelial Dysmetabolism and Renal Fibrosis in ANCA Vasculitis
The project is to explore in humans the hypothesis of the link between the alteration of tubulo-interstitial metabolism and the rate of deterioration of renal function by comparing various nephropathies.
- Conditions
- ANCA Associated Vasculitis, Extramembranous Glomerulopathy, Nephrotic Syndrome, Minimal Change, Interstitial Nephritis
- Trial name
- PROTECT-Fi (NCT07010250)
- Where
- France
- Volunteers
- 146 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Pyelonephritis, Pyelonephritis Acute
The Validity of the Quick Renal MRI in Pediatric Kidney Disease
The investigators propose a new imaging method for children born with congenital anomalies of the urinary tract that is a rapid, injection-, sedation-, and radiation-free alternative: the quick renal MRI.
- Conditions
- Pyelonephritis, Pyelonephritis Acute, Renal Sclerosis
- Trial name
- NCT03959163
- Testing
- Quick MRI
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of Wisconsin, Madison
Acute Kidney Injury, Acute Interstitial Nephritis
Infliximab for Immune Checkpoint Inhibitor Associated AKI
This is a multi-center, 1:1 randomized pilot study examining the efficacy and safety of infliximab 5mg/kg x 1 paired with 2 weeks of prednisone 1mg/kg per day for 2 weeks versus standard-of-care glucocorticoid therapy (prednisone…
- Trial name
- NCT07683975
- Testing
- Infliximab, Prednisone, prednisone (oral)
- Where
- 3 sites in United States
- Volunteers
- 44 people
- Sponsor
- Massachusetts General Hospital
Anti-Glomerular Basement Membrane Disease
Anti-Glomerular Basement Membrane Disease
This study aims to clarify the prognosis of the rare but severe condition anti-glomerular basement membrane disease (anti-GBM disease also known as Goodpastures disease).
- Trial name
- PRAGMATIC (NCT07018024)
- Where
- Sweden
- Volunteers
- 300 people
- Sponsor
- Region Skane
Pyelonephritis in Pregnancy
Clinical Trial Comparing Oral Versus Intravenous Cefuroxime in Pregnant Women with Pyelonephritis
The goal of this clinical trial is to compare rates of cure in pregnant women with pyelonephritis. The main question aims to answer: Can we treat pyelonephritis in pregnancy with oral cefuroxime alone? Pregnant women with…
- Trial name
- CEFURO (NCT06527560)
- Testing
- Cefuroxime, Cefuroxime Axetil
- Where
- Brazil
- Volunteers
- 100 people
- Sponsor
- Hospital de Clinicas de Porto Alegre
Acute Kidney Injury, Acute Interstitial Nephritis
Biorepository to Support Research in Kidney Diseases
To support advances in the understanding of pathophysiology and therapies of kidney diseases by creating a BioBank of kidney tissue, DNA, plasma, and urine from patients with kidney diseases.
- Conditions
- Acute Kidney Injury, Acute Interstitial Nephritis, Kidney Diseases
- Trial name
- NCT04343417
- Where
- 2 sites in United States
- Volunteers
- 1,000 people
- Sponsor
- Yale University
SLE, LN
A Study of Anti-CD19/BCMA Universal CAR-T Cell Therapy RD06-05 in Patients With Autoimmune Diseases.
An Exploratory, Single-Arm, Open-Label, Dose-Escalation Study of the Safety, Tolerability, PK, PD, and Efficacy of Anti-CD19/BCMA Universal CAR-T Therapy RD06-05 in Autoimmune Diseases (including SLE/LN, AAV/AAGN, Anti-GBM, MN…
- Conditions
- SLE, LN, ANCA Associated Vasculitis, ANCA-Associated Glomerulonephritis
- Trial name
- NCT07203404
- Testing
- RD06-05 CART Cell Injection
- Where
- China
- Volunteers
- 96 people
- Sponsor
- Nanjing Bioheng Biotech Co., Ltd.
Systemic Lupus Erythematosus, Sjögren's Disease
A Study of BMS-986553 in Participants With Refractory Autoimmune Diseases
The purpose of this study is to evaluate the safety and tolerability of BMS-986553, CD19 in vivo Chimeric Antigen Receptor (CAR) T cells, in participants with refractory autoimmune diseases including systemic lupus erythematosus…
- Conditions
- Systemic Lupus Erythematosus, Sjögren's Disease, Rheumatoid Arthritis, Idiopathic Inflammatory Myopathies
- Trial name
- NCT07873931
- Testing
- BMS-986553
- Where
- 23 sites in United States, Belgium and 4 more
- Volunteers
- 60 people
- Sponsor
- Bristol-Myers Squibb
Acute Tubulo-Interstitial Nephritis
Prednisolone Treatment in Acute Interstitial Nephritis
A Prospective randomized trial with a primary objective to investigate the effect ofprdenisolone treatment in acute interstitial nephritis
- Trial name
- PRAISE (NCT04376216)
- Testing
- Prednisone
- Where
- Denmark
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Region MidtJylland Denmark