Clinical trials: Nephritis
Systemic Lupus Erythematosus
Study of TRU-015 in Subjects With Membranous Nephropathy Secondary to Systemic Lupus Erythematosus
The purpose of this study is to determine how the body absorbs and chemically changes a single infusion of TRU-015 in subjects with kidney disease caused by lupus.
- Trial name
- NCT00479622
- Testing
- TRU-015
- Where
- 6 sites in United States
- Volunteers
- 20 people
- Sponsor
- Wyeth is now a wholly owned subsidiary of Pfizer
Lupus Nephritis, ANCA Associated Vasculitis
Refractory ANCA Associated Vasculitis and Lupus Nephritis Treated With BCMA-targeting CAR-T Cells
Lupus nephritis (LN) and ANCA-associated vasculitis are severe autoimmune diseases, which may lead to the death of patients, particularly when they are refractory to the conventional therapeutic agents.
- Trial name
- NCT06277427
- Testing
- PRG-1801 （CAR-T against BCMA）
- Where
- China
- Volunteers
- 24 people
- Sponsor
- Lingli Dong
Focal Segmental Glomerulosclerosis
AMPK-activation by Metformin in FSGS: AMP-FSGS
The primary objective of this study is to determine whether extended-release MF (in addition to standard of care (S-o-C)) is superior to placebo in reducing podocyte injury and promoting podocyte survival by 6-months in Focal…
- Trial name
- AMP-FSGS (NCT06090227)
- Testing
- Metformin + Standard of Care
- Where
- 2 sites in United States
- Volunteers
- 30 people
- Sponsor
- Yale University
Primary IgA Nephropathy
Efficacy and Safety in Patients With Primary IgA Nephropathy Who Have Completed Study Nef-301 (Nefigard-OLE)
This is a Phase 3b, multicenter, open-label extension (OLE) study to evaluate the efficacy and safety of Nefecon treatment in patients with IgAN who have completed the Phase 3 Study Nef-301 and continue to be treated with a…
- Trial name
- Nefigard-OLE (NCT04541043)
- Testing
- Nefecon 16mg daily
- Where
- 18 sites in United States, Argentina and 16 more
- Volunteers
- 119 people
- Sponsor
- Calliditas Therapeutics AB
Pyelonephritis in Pregnancy
Clinical Trial Comparing Oral Versus Intravenous Cefuroxime in Pregnant Women with Pyelonephritis
The goal of this clinical trial is to compare rates of cure in pregnant women with pyelonephritis. The main question aims to answer: Can we treat pyelonephritis in pregnancy with oral cefuroxime alone? Pregnant women with…
- Trial name
- CEFURO (NCT06527560)
- Testing
- Cefuroxime, Cefuroxime Axetil
- Where
- Brazil
- Volunteers
- 100 people
- Sponsor
- Hospital de Clinicas de Porto Alegre
Alport Syndrome
A Phase 2/3 Trial of the Efficacy and Safety of Bardoxolone Methyl in Patients With Alport Syndrome - CARDINAL
This international, multi-center, Phase 2/3 trial will study the safety, tolerability, and efficacy of bardoxolone methyl in qualified patients with Alport syndrome.
- Trial name
- CARDINAL (NCT03019185)
- Testing
- Bardoxolone Methyl
- Where
- 63 sites in United States, Australia and 6 more
- Volunteers
- 187 people
- Sponsor
- Biogen
Idiopathic Membranous Nephropathy
Prognostic Model of GC/TAC in the Treatment of MN
The goal of this observational study is to explore the factors that can predict the prognosis difference in patients with idiopathic membranous nephropathy (IMN) under the treatment of glucocorticoid + tacrolimus.
- Trial name
- NCT05667896
- Testing
- glucocorticoid + tacrolimus
- Volunteers
- 50 people
- Sponsor
- Qianfoshan Hospital
Lupus Erythematosus, Systemic, Lupus Glomerulonephritis
Mesenchymal Stromal Cells (MSC´s) in Renal Lupus
Phase II Clinical Trial to Assess the dose-response and Efficacy of Umbilical Cord-derived Mesenchymal Stromal Cells (MSCs) in Severe Renal Systemic Lupus Erythematosus (SLE).
- Trial name
- MSC-ROLE (NCT03917797)
- Testing
- MSC treatment, Standard of Care
- Where
- 2 sites in Chile
- Volunteers
- 39 people
- Sponsor
- Universidad de los Andes, Chile