Clinical trials: Nephrotoxicity
Cystic Fibrosis
Antibiotic Nephrotoxicity in Adult Patients With Cystic Fibrosis
Adult patients with cystic fibrosis (CF) are treated with high dose antibiotics to reduce the long term damage to their lungs from infection.
- Trial name
- NCT02489955
- Testing
- Amikacin, Tobramycin, Colomycin
- Where
- United Kingdom
- Sponsor
- The Leeds Teaching Hospitals NHS Trust
Acute Kidney Injury
Impact of Ascorbic Acid in the Prevention of Vancomycin Induced Nephrotoxicty
A Randomized controlled trial aiming to investigate whether ascorbic acid has a role in preventing vancomycin induced nephrotoxicity or not in critically ill patients.
- Trial name
- NCT03921099
- Testing
- Ascorbic Acid
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Ain Shams University
Kidney Injury, Contrast-induced Nephropathy
Early Diagnosis as Strategy in Reducing the Incidence of Contrast-induced Nephropathy
Renal damage due to contrast media (CM) administration is one of the main complications of cardiac intervention and is called contrast-induced nephropathy (CIN).
- Trial name
- NCT04225013
- Testing
- Early kidney damage biomarkers, Predisposition to kidney injury biomarkers
- Where
- Spain
- Volunteers
- 150 people
- Sponsor
- R. Laura Vicente Vicente
Contrast Induced Acute Kidney Injury
Contrast-inDuced nephRotoxicity as Assessed by the KIdney Load-to-DAmage RElationship
We previously demonstrated that the slope of the relationship plotting individual iodine loads against contrast-induced serum creatinine changes ( the load-to-damage relationship, LDR) characterizes the intrinsic nephrotoxicity…
- Trial name
- DrKILDARE (NCT01908309)
- Testing
- Iobitridol 350, Iodixanol 320
- Where
- Italy
- Volunteers
- 150 people
- Sponsor
- Azienda Sanitaria Locale 9, Grosseto
Drug Induced Nephrotoxicity
N-acetylcysteine Protects From Aminoglycosides Induced Nephrotoxicity
This randomized, double-blind, placebo-controlled clinical trial will be performed to assess the effect of N-acetylcysteine therapy on the incidence of nephrotoxicity among patients hospitalized with an infection and treated with…
- Trial name
- NCT00267384
- Testing
- Oral N-Acetylcysteine
- Where
- Israel
- Sponsor
- Soroka University Medical Center
Staphylococcus Aureus, Bacteremia
Comparison of Nephrotoxicity and Hospital Costs in Patients With Methicillin-Resistant Staphylococcus Aureus Bacteremia Who Received Vancomycin Versus Teicoplanin Therapy
Staphylococcus aureus, the most virulent of the many staphylococcal species, has been recognized as one of the most important and lethal human bacterial pathogens.
- Trial name
- NCT01352936
- Where
- Taiwan
- Volunteers
- 190 people
- Sponsor
- Taipei Medical University WanFang Hospital
Kidney Diseases
The Correlation Between Oxidative Stress and Indinated Contrast-Media Nephrotoxicity
Clinically, iodinated contrast-medium (CM) is widely used in angiography and computerized tomography. CM-induced nephropathy (CMIN) is one major complication after application of CM.
- Trial name
- NCT00632892
- Where
- Taiwan
- Volunteers
- 80 people
- Sponsor
- Far Eastern Memorial Hospital
Nephrotoxicity
0,9% NaCl Effect on Kidney Function and Glycocalyx in Patients Operated on for Primary Hiparthrosis
The purpose of this study is to determine if chloride is nephrotoxic using 0,9% saline versus Plasma-Lytein in patients having primary hip replacement surgery.
- Trial name
- KIPA (NCT02528448)
- Testing
- Plasma-lyte, 0,9% saline
- Where
- Denmark
- Volunteers
- 40 people
- Sponsor
- Regional Hospital Holstebro
Renal Toxicity
Frequency and Clinical Significance of Renal and Bone Toxicity in HIV-infected Patients
The purpose of this study is to determine the frequency of renal and bone toxicity in HIV infected patients receiving antiretroviral therapy, and the outcome in terms of treatment change or/and virological failure, in relation…
- Trial name
- ComorVIH (NCT02116751)
- Where
- Spain
- Volunteers
- 306 people
- Sponsor
- Asociacion para el Estudio de las Enfermedades Infecciosas
Mortality, Surgical Complication
Clinical Outcomes in Adult Patients Undergoing Laparoscopic Surgery Under Neuraxial Anesthesia
The goal of this observational study is to learn about postoperative mortality and postoperative length of stay outcomes after abdominal laparoscopic major surgery.
- Conditions
- Mortality, Surgical Complication, Neurological Complication, Respiratory Complication
- Trial name
- NEURAX (NCT06360666)
- Where
- Italy
- Volunteers
- 70 people
- Sponsor
- Asst Melegnano e Martesana
Drug-Induced Nephropathy
Drug Nephrotoxicity Amelioration by N-acetylcysteine
When treating individuals with febrile neutropenia, amphotericin B (AmB-d) is one of the most effective treatments against often fatal systemic fungal infections.Nephrotoxicity from amphotericin B can develop with an incidence of…
- Trial name
- NCT06122311
- Testing
- N Acetylcysteine
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Helwan University
Herpes Simplex
Acyclovir in Preventing Herpes Simplex Virus Infection in Patients With Neutropenia
RATIONALE: Acyclovir may be effective in preventing herpes simplex virus infection in patients with neutropenia. PURPOSE: This randomized phase III trial is studying the side effects of acyclovir and is comparing two doses of…
- Trial name
- NCT00855309
- Testing
- acyclovir sodium
- Where
- United States
- Volunteers
- 112 people
- Sponsor
- Wake Forest University Health Sciences
Cisplatin Nephrotoxicity, Cisplatin Adverse Reaction
Safety Study of GMDTC Injection in Participants With Solid Tumors and Cisplatin-Induced Renal Dysfunction
This trial is a multicenter, combined hydration, multiple-dose, dose-escalation phase Ib clinical study, designed to evaluate the safety, tolerability, pharmacokinetic and pharmacodynamic characteristics of the injection product…
- Trial name
- NCT07824843
- Testing
- GMDTC 1 mg/ml, GMDTC 2mg/ml, GMDTC 3mg/ml
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Guangdong Jianersheng Pharmaceutical Technology Co., Ltd.
Sepsis, Septic Shock
Specific miRNAs in Sepsis and Nephrotoxic Antibiotic Treatment
Critically ill patients are prone to develop acute kidney injury due to sepsis itself and by administration of potentially nephrotoxic antibiotic treatment (vancomycin or gentamicin).
- Conditions
- Sepsis, Septic Shock, Acute Kidney Injury
- Trial name
- NCT04991376
- Testing
- Blood-specific miRNA levels
- Where
- Czechia
- Volunteers
- 53 people
- Sponsor
- University Hospital Ostrava
Contrast-Associated Acute Kidney Injury, Acute Kidney Injury
Contrast Volume as a Predictor of Kidney Injury Following Contrast-Enhanced CT
Iodinated contrast dye used during computed tomography (CT) scans can sometimes cause kidney stress or damage, known as contrast-associated acute kidney injury (CA-AKI).
- Conditions
- Contrast-Associated Acute Kidney Injury, Acute Kidney Injury, Contrast-Induced Nephropathy, Acute Renal Failure
- Trial name
- NCT07813819
- Volunteers
- 1,112 people
- Sponsor
- Assiut University
Nephrectomy, Kidney Cancer
Nephrotoxicity Associated to Parenchymal Clamping During Partial Nephrectomy Using a Microdialysis Technique
Surgery plays a central role in kidney cancer management being the only therapy that offers the possibility of healing the patients.
- Conditions
- Nephrectomy, Kidney Cancer, Microdialysis
- Trial name
- NECPAR (NCT02511275)
- Testing
- Renal microdialysis
- Where
- France
- Volunteers
- 4 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Myocardial Infarction
Evaluation of the Predictive Effect of Inflammatory Markers in MI Patients
Acute myocardial infarction (AMI), triggered by myocardial ischemia and reperfusion injury, is a disease with high morbidity and mortality, and there is a tendency for its incidence to increase at younger ages.
- Trial name
- NCT05479838
- Testing
- Percutaneous coronary intervention
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Abant Izzet Baysal University
Acute Kidney Injury, Nephrotoxicity
Assessment of Urinary NGAL to Predict AKI in Children Receiving Multiple Nephrotoxic Medications
Nephrotoxic medication (NTMx) exposure is one of the most commonly cited causes of acute kidney injury (AKI) in hospitalized children, and is the primary cause of AKI in 16% of cases.
- Trial name
- NINJA NGAL (NCT03527160)
- Where
- 2 sites in United States
- Volunteers
- 134 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Cisplatin-induced Nephrotoxicity
Magnesium Supplementation for the Prevention of Cisplatin-Induced Nephrotoxicity
This prospective, randomized, open-label study evaluated whether intravenous magnesium sulphate added to standard hydration could reduce cisplatin-associated renal toxicity in adult patients with solid tumors receiving weekly…
- Trial name
- NCT07874373
- Testing
- Magnesium sulphate, Furosemide, Saline (0.9% NaCl)
- Where
- Romania
- Volunteers
- 43 people
- Sponsor
- Grigore T. Popa University of Medicine and Pharmacy
Nephrotoxicity
Switch From Calcineurin Inhibitor to Belatacept in Pancreas Transplant Recipients
Kidney damage is a major complication of current antirejection medicines used in transplantation. An increasing number of brittle diabetics are successfully receiving a pancreas transplant.
- Trial name
- NCT02103855
- Testing
- Belatacept
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Indiana University