Clinical trials: Nerve Compression Syndrome
Amyotrophic Lateral Sclerosis, Hereditary Spastic Paraplegia
Phenotype, Genotype and Biomarkers 2
The purpose of this study is to learn more about amyotrophic lateral sclerosis (ALS) and other related neurodegenerative diseases, including frontotemporal dementia (FTD), primary lateral sclerosis (PLS), hereditary spastic…
- Conditions
- Amyotrophic Lateral Sclerosis, Hereditary Spastic Paraplegia, Primary Lateral Sclerosis, Progressive Muscular Atrophy
- Trial name
- PGB2 (NCT04875416)
- Where
- 4 sites in United States, South Africa
- Volunteers
- 217 people, healthy volunteers welcome
- Sponsor
- University of Miami
Carpal Tunnel Syndrome
Impact of a Conservative Treatment in the Waiting List for Carpal Tunnel Syndrome Surgery.
STC is considered one of the most prevalent peripheral neuropathy of the upper quadrant. Systematic review shows that conservative treatment is effective for treatment of CTS.
- Trial name
- NCT05130931
- Testing
- Multimodal conservative treatment
- Where
- Spain
- Volunteers
- 42 people
- Sponsor
- Universidad de Zaragoza
Carpal Tunnel Syndrome
The Treatment of Carpal Tunnel Syndrome Using Thumb Pressure Along the Median Nerve
The purpose of this study is to find the efficacy of treating the muscles in the inside (biceps,pronator teres) of the arm in order to eliminate the carpal tunnel syndrome .The authors hypothesise that eliminating the trigger…
- Trial name
- NCT00634699
- Testing
- Active Comparator, ischemic compressions
- Where
- Canada
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Guy Hains Chiropractor
Cubital Tunnel Syndrome
Comparing Surgical and Nonsurgical Outcomes of Cubital Tunnel Syndrome
Cubital tunnel syndrome is a condition that occurs when the ulnar nerve, which runs along the inside of the elbow, becomes irritated or compressed. It can cause pain, numbness, tingling, or weakness in the hand and arm.
- Trial name
- NCT07862543
- Testing
- Cubital tunnel release, Conservative Arm
- Where
- 7 sites in United States
- Volunteers
- 220 people
- Sponsor
- University of Pittsburgh
Hereditary Spastic Paraplegia
Identification of Modifying Factors in Hereditary Spastic Paraplegia
A first questionnaire - MODIFSPA conducted in 2014 - identified several environmental factors influencing spasticity in HSP: cold, fatigue, and especially physical activity.
- Trial name
- MODIFSPA2 (NCT05373082)
- Testing
- questionnaire completion
- Where
- France
- Volunteers
- 311 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Amyotrophic Lateral Sclerosis, Chronic Inflammatory Demyelinating Neuropathy
High-Tech Rehabilitation Pathway for Chronic Adult Neuromuscular Diseases - Fit4MedRob-Chronic MND Project
The primary objective is to demonstrate, in a population of chronic neuromuscular disease the non-inferiority of a rehabilitation treatment integrated with robotic and/or technological devices compared to traditional…
- Conditions
- Amyotrophic Lateral Sclerosis, Chronic Inflammatory Demyelinating Neuropathy, Charcot-Marie-Tooth Disease
- Trial name
- Fit4MR-ChrMND (NCT06881979)
- Testing
- High-tech rehabilitative treatment, Rehabilitation
- Where
- 7 sites in Italy
- Volunteers
- 60 people
- Sponsor
- Istituti Clinici Scientifici Maugeri SpA
Carpal Tunnel Syndrome
Effectiveness of Mirror Therapy in Patients With Carpal Tunnel Syndrome
Carpal tunnel syndrome (CTS) is the most prevalent entrapment neuropathy. CTS presents with motor and sensory disturbances, including pain, paraesthesia, and numbness in the fingers and hand.
- Trial name
- NCT05115396
- Testing
- Mirror therapy, Cross-education treatment
- Where
- 2 sites in Spain
- Volunteers
- 40 people
- Sponsor
- University of Valencia
Muscle Spasticity, Hypertonia, Muscle
Single and Multiple Ascending Dose Study of MTR-601 in Healthy Individuals
To assess the safety and tolerability of single and multiple doses of MTR-601 in normal healthy volunteers under fed and fasted conditions. To evaluate the plasma and urine pharmacokinetics (PK) of MTR-601.
- Conditions
- Muscle Spasticity, Hypertonia, Muscle, Cerebral Palsy, Multiple Sclerosis
- Trial name
- NCT06117020
- Testing
- MTR-601
- Where
- United States
- Volunteers
- 89 people, healthy volunteers welcome
- Sponsor
- Motric Bio
Carpal Tunnel Syndrome, Pain, Chronic
Dexmedetomidine Versus Hyalase Treatment of Carpal Tunnel Syndrome
Carpal tunnel syndrome (CTS) is a common peripheral entrapment neuropathy, this study aims to investigate if, and to what extent hydro-dissection hyalase and saline versus dexmedetomidine upon the median nerve could offer…
- Trial name
- NCT05280223
- Testing
- Dexmedetomidine, Hyalase
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Assiut University
Carpal Tunnel Syndrome
A Study of Fisetin to Treat Carpal Tunnel Syndrome
This research study is being conducted to investigate the safety and effectiveness of the drug Fisetin for mild or moderate carpal tunnel syndrome (CTS).
- Trial name
- NCT05416515
- Testing
- Fisetin
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Peter C. Amadio, M.D.
Charcot-Marie-Tooth Disease
Irisin Levels in Patients With Charcot-Marie-Tooth (CMT) Disease
Irisin is an exercise-mimetic myokine secreted by skeletal muscle. Compelling evidence in animal models and humans showed that Irisin prevents onset of musculoskeletal atrophy and its low serum levels are predictive of…
- Trial name
- IRICDE (NCT04786522)
- Testing
- Bioimpedenziometry, Handgrip strenght evaluation, Evaluation on blood specimens
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- University of Bari
Carpal Tunnel, Carpal Tunnel Syndrome
Testing of a Tool to Elicit Patient Preferences for CTS
This study will complete a randomized controlled trial to quantitatively measure patient decisional conflict (Decisional Conflict Scale) in 150 patients treated for CTS with the tool compared to 150 patients treated with standard…
- Conditions
- Carpal Tunnel, Carpal Tunnel Syndrome, Carpal Tunnel Syndrome Left, Carpal Tunnel Syndrome Right
- Trial name
- NCT03532373
- Testing
- Preference Elicitation tool
- Where
- United States
- Volunteers
- 49 people
- Sponsor
- Stanford University
Charcot-Marie-Tooth Disease, Type IA, Peripheral Neuropathy Hereditary
Physical Activity Level at Home in CMT1A Patients: Wearable Sensor Assessment
Charcot-Marie-Tooth disease type 1A (CMT1A) is the most common hereditary peripheral neuropathy, affecting approximately 26,000 patients in France.
- Conditions
- Charcot-Marie-Tooth Disease, Type IA, Peripheral Neuropathy Hereditary, Motor Activity, Walking, Difficulty
- Trial name
- CMT1A-HOME (NCT07591779)
- Where
- France
- Volunteers
- 60 people
- Sponsor
- University Hospital, Limoges
Pudendal Neuralgia, Chronic Pelvic Pain Syndrome
Transvaginal Versus Fluoroscopy-guided Trans Gluteal Pudendal Nerve Block for Pudendal Neuralgia
Chronic pain affecting the pelvic and urogenital area is a major clinical problem and can have a profound impact on quality of life and health care costs.
- Trial name
- NCT06644261
- Testing
- Bupivacaine injection
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Louisville