Clinical trials: Nerve Palsy
Radial Palsy
Tendon Transfer for Irreversible Radial Nerve Palsy, Does it Help?Retrospective Cohort From Level-1 Trauma Center.
Radial nerve palsy is associated with serious disability jeopardizing the grasp and power grip accountable to the loss of thumb and fingers extension and loss of active wrist extension respectively.
- Trial name
- NCT03936868
- Testing
- Tendon transfer
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- Aga Khan University
Gastroparesis, Functional Dyspepsia
Transauricular Vagal Nerve Stimulation; Functional Dyspepsia and Gastroparesis
The goal of this study is to establish parameters of gastric myoelectrical activity and heart rate variability in healthy human subjects and compare and contrast them to those with gastroparesis and functional dyspepsia, at…
- Conditions
- Gastroparesis, Functional Dyspepsia, Healthy, Digestive System Disease
- Trial name
- AVNS (NCT05405842)
- Testing
- Transauricular Vagal Nerve Stimulation
- Volunteers
- healthy volunteers welcome
- Sponsor
- Stanford University
Unilateral Vocal Cord Paralysis
Surgery for Vocal Cord Paralysis
Unilateral vocal fold paralysis (UVFP) is caused by injury to the nerve to the affected vocal fold. The injury to the vocal fold makes the affected person's voice sound "breathy".
- Trial name
- NCT00064571
- Testing
- vocal fold medialization, vocal fold reinnervation
- Where
- 12 sites in United States
- Volunteers
- 300 people
- Sponsor
- National Institute on Deafness and Other Communication Disorders (NIDCD)
Chronic Nausea, Chronic Nausea and Vomiting Syndrome
Evaluating Whether a Nausea Band Reduces Symptoms in Those With Chronic Nausea Vomiting
The goal of this clinical trial is to learn whether a wearable transcutaneous electrical nerve stimulation (TENS) device called EmeTerm can help reduce nausea in adults who have had nausea for 2 months or longer and who receive…
- Trial name
- WINNER (NCT07720323)
- Testing
- EmeTerm wearable TENS device
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Ohio State University
Stridor, Vocal Cord Paralysis
The Yield of Laryngeal Ultrasound in the Evaluation of Stridor and Dysphonia in Children
Stridor is a respiratory noise caused by partial obstruction of the large airways at the level of the pharynx, larynx and/or trachea. The second most common cause of stridor is vocal cord paralysis.
- Trial name
- NCT02244697
- Where
- Israel
- Volunteers
- 100 people
- Sponsor
- Tel-Aviv Sourasky Medical Center
Stroke, Ischemic, Hemiplegia
Evaluation of Noninvasive Vagus Nerve Stimulation on Functional Status in Ischemic Stroke
In this study, the effectiveness of vagus nerve stimulation in patients with right and left hemiparesis will be compared with each other and with the sham application.
- Conditions
- Stroke, Ischemic, Hemiplegia, Hemiparesis;Poststroke/CVA
- Trial name
- NCT05809037
- Testing
- transcutaneous auricular vagus nerve stimulation
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Istanbul Physical Medicine Rehabilitation Training and Research Hospital
Facial Palsy, Facial Nerve Diseases
Evaluation of Cortisone Treatment in Children With Acute Facial Nerve Palsy
Acute facial nerve palsy occur in 10-20/100 000 children/year in Sweden. About 20 % of these children will have persistent symptoms with excessive tear secretion, drooling and social problems due to asymmetry in the face.
- Conditions
- Facial Palsy, Facial Nerve Diseases, Borrelia Infection of Central Nervous System, Bell Palsy
- Trial name
- FACE (NCT03781700)
- Testing
- Prednisolone
- Where
- 15 sites in Sweden
- Volunteers
- 343 people
- Sponsor
- Dalarna County Council, Sweden
PARKINSON DISEASE (Disorder), Atypical Parkinsonism
Early Molecular Biomarkers for Differentiating Parkinsonian Syndromes
This prospective observational study aims to identify and preliminarily validate molecular biomarkers, including microRNAs and metabolites, for the early differentiation of Parkinson's disease (PD) from atypical parkinsonian…
- Conditions
- PARKINSON DISEASE (Disorder), Atypical Parkinsonism, Multiple System Atrophy, Progressive Supranuclear Palsy (PSP)
- Trial name
- BIOMARK-PS (NCT07604883)
- Where
- 2 sites in Poland
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- International Institute of Molecular and Cell Biology in Warsaw
Gastroparesis
Vagal Nerve Stimulation for Gastroparesis
This study is investigating a new form of treatment for a digestive disorder called gastroparesis. Gastroparesis is thought to be caused by a mix of inflammation and neural dysfunction.
- Trial name
- VNS (NCT03120325)
- Testing
- Vagal Nerve Stimulation
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Stanford University
Progressive Supranuclear Palsy (PSP), Healthy Participants
First-in-Human Study for the Safety and Evaluation of Two 4R Tau Ligands as Potential PET Radioligands for Imaging Tau Protein in the Brain
This clinical study is being conducted to learn more about two new imaging drugs, called [18F]ABBV-964i and [18F]ABBV-965i, which are designed to help doctors see changes in the brain related to a condition called Progressive…
- Trial name
- NCT07348276
- Testing
- [18F]ABBV-964i, [18F]ABBV-965i, Lead Candidate
- Where
- United States
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Invicro
Cervical Spinal Cord Injury, Tetraplegia
Testing the Decision Aid: Supporting Patient Decisions About Upper Extremity Surgery in Cervical SCI
Purpose: The objective of this study is to assess a newly created decision support intervention (DSI) or decision aid (DA) for people with spinal cord injury (SCI) to learn about and consider upper extremity reconstructive…
- Trial name
- NCT04995796
- Testing
- Surveys for Research Purposes
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Washington University School of Medicine
Spinal Cord Injury, Paralysis
A Neuroprosthesis for Prolonged Standing After SCI Using Multi-Contact Peripheral Nerve Electrodes
The purpose of this study is to improve the performance of neuroprosthesis for standing after SCI by developing and testing new advanced methods that use multiple contact peripheral nerve electrodes to slow the onset of fatigue…
- Conditions
- Spinal Cord Injury, Paralysis, Tetraplegia, Paraplegia
- Trial name
- NCT01923662
- Testing
- IST-16 (16-Channel implanted stimulator-telemeter
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- VA Office of Research and Development
Bell Palsy
Intradermal Acupuncture and Self-rehabilitation Program in Patients With Severe Bell's Palsy
This study aims to assess the effect of intradermal acupuncture(IA) and guided self-rehabilitation management program(GRMP) (either single or combined) for patients with severe Bell's Palsy.
- Trial name
- NCT06778473
- Testing
- Active Intradermal Acupuncture, Guided self-rehabilitation management program, Health Education
- Where
- China
- Volunteers
- 552 people
- Sponsor
- Zhangjiagang First People's Hospital
Mitochondrial Diseases, Mitochondrial Respiratory Chain Deficiencies
A Phase Ia/Ib, SAD and MAD Study of of KL1333 in Healthy Subjects and Patients With Primary Mitochondrial Disease
This will be a double blind, randomised, placebo controlled, single and multiple oral dose study conducted in 3 parts: Part A, Part B and Part C.
- Conditions
- Mitochondrial Diseases, Mitochondrial Respiratory Chain Deficiencies, MELAS Syndrome, Mitochondrial Myopathies
- Trial name
- NCT03888716
- Testing
- KL1333
- Where
- 2 sites in United Kingdom
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Abliva AB
Unilateral Diaphragmatic Paralysis
Phrenic Nerve Conduction Study to Diagnose Unilateral Diaphragmatic Paralysis
The study aims as the principal objective to compare two approaches to diagnosis unilateral diaphragmatic paralysis: transdiaphragmatic pressure (Pdi) measurement versus phrenic nerve conduction (NPC) study.
- Trial name
- ENMG-DIAPH (NCT04142684)
- Where
- France
- Volunteers
- 28 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Phrenic Nerve Paralysis, Diaphragm Sellae Meningioma
Comparison of Different Approaches for Supraclavicular Block and Their Effects on Diaphragm Muscle Function
Brachial plexus blocks used for anesthesia in upper extremity operations can be performed with interscalene, axillary, supraclavicular and infraclavicular approaches.
- Conditions
- Phrenic Nerve Paralysis, Diaphragm Sellae Meningioma, Complications, Respiratory Complication
- Trial name
- NCT04756050
- Testing
- Bupivacaine HCl 0.5% Injectable Solution, Prilocaine HCl % 2 injectable solution, adrenaline amp 0.5mg
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people
- Sponsor
- Bozyaka Training and Research Hospital
Carpal Tunnel Syndrome, Charcot-Marie-Tooth Disease
Patient Reported Outcomes Measures (PROM) in Carpal Tunnel Therapies in Patients With Inherited Neuropathies
The purpose of this study is to learn about focal compressive median neuropathy at the wrist (Carpal Tunnel Syndrome) and outcomes of therapies (e.g.
- Conditions
- Carpal Tunnel Syndrome, Charcot-Marie-Tooth Disease, Inherited Peripheral Neuropathy
- Trial name
- NCT02788734
- Testing
- Web-based survey
- Where
- United States
- Volunteers
- 333 people
- Sponsor
- University of South Florida
Cubital Tunnel Syndrome, Ulnar Nerve Compression
Randomized Trial of Supercharged End-to-Side Anterior Interosseous Nerve Transfer for Severe Cubital Tunnel Syndrome
Functional motor recovery distal to a peripheral nerve lesion is predicated upon time to reinnervation of the motor end plate and the number of regenerate axons that reach the target.
- Conditions
- Cubital Tunnel Syndrome, Ulnar Nerve Compression, Ulnar Nerve Palsy, Ulnar Nerve Entrapment
- Trial name
- NCT04647058
- Testing
- Cubital tunnel release, Supercharged end-to-side (SETS) nerve transfer
- Where
- 2 sites in United States
- Sponsor
- Brigham and Women's Hospital
Neuropathy, Facial, Bell Palsy
Different Laser Frequencies on Neuropathic Outcomes in Patients With Bell's Palsy
this study was done to compare different laser frequencies on neuropathic outcomes in patients with Bell's palsy.
- Conditions
- Neuropathy, Facial, Bell Palsy, Laser
- Trial name
- NCT07519421
- Testing
- Low-Level Laser Therapy, gallium arsenide diode laser (BTL-5000 laser), high intensity laser treatment
- Where
- Saudi Arabia
- Volunteers
- 104 people
- Sponsor
- Kafrelsheikh University
Cerebral Palsy
Paired Non-invasive VNS in Adolescent Cerebral Palsy Rehabilitation
This is an open-label safety and feasibility trial evaluating the use of paired non-invasive vagus nerve stimulation (VNS) and upper extremity (UE) rehabilitation in the motor impairment reduction of adolescent patients with…
- Trial name
- NCT07394608
- Testing
- Non-invasive taVNS
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Icahn School of Medicine at Mount Sinai