Clinical trials: Nervous System Complication
Peripheral Nerve Injuries, Neuroma of Nerve Repair
High-Purity Type I Collagen Nerve Wrapping in Peripheral Nerve Procedures: A Prospective Registry
This prospective multicentre observational registry evaluates early clinical outcomes following the use of High-Purity Type I Collagen (HPTC) as a circumferential nerve wrap during peripheral nerve procedures.
- Conditions
- Peripheral Nerve Injuries, Neuroma of Nerve Repair, Nerve Graft; Complications, Mechanical, Peripheral Nerve Decompression Injury
- Trial name
- NCT07360730
- Testing
- High-Purity Type I Collagen (HPTC) Nerve Wrap
- Where
- 2 sites in India
- Volunteers
- 40 people
- Sponsor
- Adichunchanagiri Institute of Medical Sciences, B G Nagara
Pain, Shoulder, Post Operative Pain
The Role of Neurofeedback Training and Pain Management in Post-operative Shoulder Rehabilitation
The primary aim is to compare the efficacy of neurofeedback training (NFT) and pain management protocol (PMP) in pain reduction, restoration of shoulder function, and improved cognitive performance as the post-operative…
- Trial name
- NCT05948007
- Testing
- Neurofeedback training, Pain management protocol
- Sponsor
- Chang Gung Memorial Hospital
Multiple Sclerosis, Neurogenic Bladder
Vaginal Estriol in Multiple Sclerosis
Study to evaluate the efficiency of vaginal estriol, as a treatment for urogenital symptoms in female patients with RRMS. The secondary objective is to evaluate the potential role of vaginal estriol in re-myelination in RRMS…
- Trial name
- NCT03774407
- Testing
- vaginal estriol
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Texas Tech University Health Sciences Center
Type 2 Diabetes, Osteoporosis
Impact of Screening and Multicomponent Exercise on Fall Rates, Fractures, and Cardiovascular Health in Diabetes
The DIACTIVE study is a randomized controlled trial with a 5- year follow-up designed to evaluate the impact of comprehensive screening and multicomponent interventions on fall prevention, bone health, nerve function and…
- Conditions
- Type 2 Diabetes, Osteoporosis, Diabetic Neuropathies, Fall Prevention
- Trial name
- DiaACTIVE (NCT06745544)
- Testing
- Rhythm- and Multitask-Based Activity (RYMA) and Activities of Daily Living (ADL)
- Where
- Denmark
- Volunteers
- 490 people, healthy volunteers welcome
- Sponsor
- Aalborg University Hospital
Postoperative Pain, Acute, Emergence Delirium
Comparing Ketamine and Fentanyl in Pediatric Tonsillectomy: Pain Control and Emergence Delirium Outcomes (KVFPT)
This study is designed to compare the effectiveness of two medications, ketamine and fentanyl, in managing pain and preventing delirium in children aged 3 to 8 years who are undergoing tonsillectomy and adenoidectomy surgery.
- Trial name
- KVFPT (NCT06630364)
- Testing
- ketamine, fentanyl
- Where
- Turkey (Türkiye)
- Volunteers
- 59 people
- Sponsor
- Medipol University
Intensive Care Unit Delirium, Postoperative Delirium
Role of Natural Light in the Prevention of Delirium After Cardiac Surgery: a Prospective Observational Study With Historical Control
Postoperative delirium is a common complication that usually occurs acutely within the first 24 hours after surgery and resolves within 72 hours; it is common in all medical areas and particularly affects patients over the age of…
- Conditions
- Intensive Care Unit Delirium, Postoperative Delirium, Cardiac Surgery
- Trial name
- iWOnDer (NCT05936944)
- Testing
- Exposure to totally artificial lighting
- Where
- Italy
- Volunteers
- 448 people
- Sponsor
- Azienda Ospedaliero-Universitaria di Parma
Intubation Complication, Hoarseness
Thermosoftening of Double-lumen Tube for Airway Exchanger Catheter
The purpose of this study is to investigate the effect of double-lumen tube thermal-softening before intubation on the success rate of tube exchange by airway exchange catheter.
- Conditions
- Intubation Complication, Hoarseness, Sore Throat
- Trial name
- NCT03846713
- Testing
- non-thermosoftening, thermosoftening
- Where
- South Korea
- Volunteers
- 102 people
- Sponsor
- Seoul National University Hospital
Sarcopenia, ESRD (End Stage Renal Disease)
Serum Insulin-like Growth Factor-1 to Albumin Ratio as a Biomarker for Sarcopenia Severity in End-Stage Renal Disease Patients on Hemodialysis
Sarcopenia is a prevalent and serious complication among patients with End-Stage Renal Disease (ESRD) receiving maintenance dialysis, characterized by progressive loss of skeletal muscle mass, strength, and physical function.
- Trial name
- NCT07586956
- Volunteers
- 110 people
- Sponsor
- Sohag University
Bladder Cancer, Breast Cancer
Physician-Initiated Stop-Smoking Program for Patients Receiving Treatment for Early-Stage Cancer
RATIONALE: Physician-initiated smoking cessation strategies may be effective in getting early-stage cancer patients to quit smoking.
- Conditions
- Bladder Cancer, Breast Cancer, Colorectal Cancer, Head and Neck Cancer
- Trial name
- NCT00002520
- Testing
- nicotine, Usual Care
- Where
- United States
- Volunteers
- 434 people
- Sponsor
- Eastern Cooperative Oncology Group
Postoperative Delirium
PROSEVO Trial (Propofol-Sevoflurane Delirium Target Trial Emulation)
The results of this study have significant implications for clinical practice and guideline development. The current European guideline on postoperative Delirium prevention (ESAIC 2024) explicitly identifies a lack of large…
- Trial name
- NCT07612579
- Where
- 2 sites in Germany
- Volunteers
- 100,000 people
- Sponsor
- Charite University, Berlin, Germany
Restless Legs Syndrome, End-Stage Renal Disease
A Sleep Laboratory Study to Investigate the Safety and Efficacy of the Rotigotine Skin Patch in Subjects With Restless Legs Syndrome and End-Stage Renal Disease Requiring Hemodialysis
This is a sleep laboratory study to evaluate the efficacy and safety of Rotigotine in subjects with Restless Legs Syndrome and End-Stage Renal Disease requiring hemodialysis.
- Trial name
- NCT01537042
- Testing
- Rotigotine
- Where
- 15 sites in United States, Austria and 4 more
- Volunteers
- 30 people
- Sponsor
- UCB BIOSCIENCES GmbH
Pediatric, Neuropathic Pain
Amputations in Childhood and Neuropathic Pain
This observational study aims to assess the presence of neuropathic pain in children and adolescents who underwent limb amputation during childhood.
- Conditions
- Pediatric, Neuropathic Pain, Phantom Limb Pain, Amputation
- Trial name
- NAPE (NCT07401966)
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Hopitaux de Saint-Maurice
Delirium
The Prevention of Delirium and Complications Associated With Surgical Treatments Multi Center Clinical Trial
Delirium is a medical term or condition that includes a temporary inability to focus attention and to think clearly. Delirium occurs commonly (10% to 70%) in patients older than 60 undergoing large surgeries.
- Trial name
- PODCAST (NCT01690988)
- Testing
- Ketamine (0.5 mg/kg), Ketamine (1 mg/kg)
- Where
- United States
- Volunteers
- 746 people
- Sponsor
- Washington University School of Medicine
Anesthesia Intubation Complication
Muscle Relaxants on Efficacy of LMA Insertion
The use of laryngeal mask airway (LMA) is increasing in pediatric anesthesia because it provides lesser direct mechanical stimulation of the airway due to being placed above the larynx.
- Trial name
- LMA_MR (NCT03487003)
- Testing
- rocuronium, saline
- Where
- South Korea
- Volunteers
- 128 people
- Sponsor
- Daegu Catholic University Medical Center
Postoperative Recovery, Postoperative Delirium
The Effect of Desflurane Versus Sevoflurane on Postoperative Recovery
Patients over the age of 65 years are at increased risk for developing delirium and cognitive complications in the immediate postoperative period after noncardiac surgeries, resulting in increased morbidity and mortality.
- Conditions
- Postoperative Recovery, Postoperative Delirium, Difference in Pharmakokinetics of Volatile Anesthetics
- Trial name
- RAPID (NCT05331027)
- Testing
- Desflurane, Sevoflurane
- Where
- Austria
- Volunteers
- 190 people
- Sponsor
- Medical University of Vienna
Emergence Agitation
Effect of Dexmedetomedine in Subtenon's Block on Emergence Agitation in Pediatric Strabismus Surgery
The study is conducted to evaluate the effects of dexmedetomedine in subtenon's block in conjunction to general anesthesia under sevoflurane anesthesia on emergence agitation, intraoperative hemodynamic stability, postoperative…
- Trial name
- NCT04485273
- Testing
- Laryngeal Mask Airway, Sevoflurane, Subtenon's Block
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Sameh Fathy
Postoperative Delirium, Postoperative Neurocognitive Disorder
Correlation Analysis of POD and pNCD in Elderly Spinal Surgery Patients
This study is a prospective cohort study to investigate the differences in serum indexes between elderly spinal surgery patients with postoperative delirium (POD) who either develop or do not develop long-term postoperative…
- Conditions
- Postoperative Delirium, Postoperative Neurocognitive Disorder, Spinal Surgery
- Trial name
- NCT06466083
- Testing
- no intervention
- Where
- China
- Volunteers
- 165 people
- Sponsor
- Xuanwu Hospital, Beijing
Apnea, Obstructive Sleep, Pregnancy Complications
Sleep Apnea Syndrome in Obese Women During Pregnancy
Excess weight or obesity is associated with an increased risk of health disorders: high blood pressure, diabetes, cardiovascular risks, dyslipidemia and sleep apneas.
- Conditions
- Apnea, Obstructive Sleep, Pregnancy Complications, Pre-Eclampsia, Obesity
- Trial name
- NCT03509805
- Testing
- polysomnography
- Where
- France
- Volunteers
- 89 people, healthy volunteers welcome
- Sponsor
- University Hospital, Lille
Parkinson's Disease
A Study of Istradefylline (KW-6002) for the Treatment of Parkinson's Disease
The purpose of this study is to evaluate the efficacy of 40 mg a day of istradefylline (KW-6002) for reducing the percentage of awake time spent in the OFF state in patients with advanced Parkinson's disease treated with levodopa.
- Trial name
- NCT00199394
- Testing
- Istradefylline (KW-6002)
- Where
- United Kingdom
- Volunteers
- 405 people
- Sponsor
- Kyowa Kirin Co., Ltd.
Elective Coronary Artery Bypass Grafting (CABG) Surgery, Coronary Artery Disease
Sleep-disordered Breathing and Perioperative Atrial Fibrillation in Cardiac Surgery
In patients undergoing elective coronary artery bypass grafting (CABG) surgery, coronary artery disease, sleep-disordered breathing (SDB), atrial fibrillation (AF) perioperative atrial fibrillation and complications will be…
- Conditions
- Elective Coronary Artery Bypass Grafting (CABG) Surgery, Coronary Artery Disease, Sleep-disordered Breathing (SDB), Atrial Fibrillation
- Trial name
- CONSIDER-AF (NCT02877745)
- Testing
- Stratification, no intervention
- Where
- Germany
- Volunteers
- 1,200 people
- Sponsor
- Michael Arzt
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