Clinical trials: Nervous System Complication
Cramps, Chronic Kidney Disease(CKD)
Prevalence and Severity of Cramps in Chronic Kidney Disease Patients
Cramps are a frequent and severe complication in CKD patients. Their characteristics : triggering factors, associated factors, are not well known. There is no recognized effective treatment.
- Trial name
- CRAMéREIN (NCT06737094)
- Where
- France
- Volunteers
- 250 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Preterm Infant, Brain Injuries
Cerebral Regional Tissue Oxygen Saturation to Guide Oxygen Delivery in Preterm Neonates During Immediate Transition
The aim of the COSGOD Phase III trial is to examine, if it is possible to increase survival without cerebral injury in preterm neonates <32 weeks of gestation by monitoring the cerebral tissue oxygen saturation in addition to…
- Conditions
- Preterm Infant, Brain Injuries, Birth Hypoxia
- Trial name
- COSGOD (NCT03166722)
- Testing
- Control group, Study group
- Where
- 12 sites in Austria, Canada and 5 more
- Volunteers
- 655 people
- Sponsor
- Medical University of Graz
Bladder Cancer, Brain and Central Nervous System Tumors
High-dose ICE With Amifostine
The purpose of the study is to evaluate the combination of amifostine and high dose chemotherapy with blood stem cell support. Amifostine is a druf developed to protect normal tissues against the toxicities of chemotherapy and…
- Conditions
- Bladder Cancer, Brain and Central Nervous System Tumors, Carcinoma of Unknown Primary, Extragonadal Germ Cell Tumor
- Trial name
- NCT00003657
- Testing
- filgrastim, Amifostine, Carboplatin
- Where
- 3 sites in United States
- Volunteers
- 24 people
- Sponsor
- Dana-Farber Cancer Institute
Breast Cancer, Cardiovascular Complications
Potential Biomarkers for Bevacizumab-Induced High Blood Pressure in Patients With Solid Tumor
RATIONALE: Studying samples of blood and urine in the laboratory from patients with cancer receiving bevacizumab may help doctors learn more about changes that occur in DNA and identify biomarkers related to high blood pressure.
- Conditions
- Breast Cancer, Cardiovascular Complications, Colorectal Cancer, Fallopian Tube Cancer
- Trial name
- NCT01096381
- Testing
- laboratory biomarker analysis, questionnaire administration
- Where
- 2 sites in United States
- Volunteers
- 8 people
- Sponsor
- Vanderbilt-Ingram Cancer Center
Postoperative Delirium
Predictors of Postoperative Delirium After Transcatheter Aortic Valve Implantation
Patients undergoing transcatheter aortic valve implantation (TAVI) have distinctive characteristics: they are old, frail, with several co-morbidities and take multiple medications.
- Trial name
- NCT02585128
- Testing
- Delirium assessment, MMSE (Mini Mental State Examination), Barthel index
- Where
- Switzerland
- Volunteers
- 201 people
- Sponsor
- Cardiocentro Ticino
Coronary Disease, Cardiovascular Diseases
Cardiac and Renal Disease Study (CARDS)
To examine the epidemiology of renal disease and its relationship to cardiovascular disease.
- Conditions
- Coronary Disease, Cardiovascular Diseases, Cerebrovascular Accident, Heart Failure
- Trial name
- NCT00049907
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Obesity, Morbid, Postoperative Pain
Study of the Effect of the Drug Gabapentin on Postoperative Pain and Incidence of Postoperative Nausea and Vomiting
The purpose of this research study is to evaluate the drug gabapentin (Neurontin®) for its ability to reduce postoperative pain, the need for morphine-like pain medication, and the severity and frequency of postoperative nausea…
- Conditions
- Obesity, Morbid, Postoperative Pain, Postoperative Nausea and Vomiting
- Trial name
- NCT00886236
- Testing
- Gabapentin
- Where
- United States
- Volunteers
- 62 people
- Sponsor
- Medical University of South Carolina
C.Surgical Procedure; Cardiac, Acute Kidney Injury
Portal Flow Pulsatility as a Risk Factor for Acute Kidney Injury After Cardiac Surgery
The purpose of this study is to evaluate the possible association between portal vein flow pulsatility and acute kidney injury after cardiac surgery.
- Conditions
- C.Surgical Procedure; Cardiac, Acute Kidney Injury, Postoperative Complications, Right-Sided Heart Failure
- Trial name
- PP-AKI (NCT02831907)
- Testing
- Cardiac surgery
- Where
- Canada
- Volunteers
- 146 people
- Sponsor
- Montreal Heart Institute
Sphingolipidoses, Enzyme Deficiency
SPL Insufficiency Syndrome (SPLIS)/NPHS14: a SPLIS Observational Study and Patient Registry (International)
This protocol aims to gather information about sphingosine phosphate lyase insufficiency syndrome (SPLIS), also known as NPHS14, and to create a SPLIS patient registry.
- Trial name
- SPLIS-OSPRI (NCT04885179)
- Testing
- no intervention
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Anesthesia Emergence Delirium
Dexmedetomidine Versus Ketamine Versus Magnesium Sulfate for the Prevention of Emergence Agitation Following Sevoflurane Induced Anesthesia in Cardiac Catheterization in Pediatrics
Emergence agitation (EA) is a post-operative behavioral disturbance was first reported in early 1960s. EA is a term used to describe non purposeful restlessness and agitation, thrashing, crying or moaning, disorientation and…
- Trial name
- NCT06077539
- Testing
- Dexmedetomidine, Ketamine, Magnesium
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Cairo University
Electroacupuncture, Acupuncture
Effect of Electroacupuncture on Sensitive Symptoms of Distal Diabetic Peripheral Neuropathy
This is a controlled clinical trial with the aim to study the effects of electroacupuncture on neuropathic pain reduction, quality of life and changes in sensory and motor nerve conduction velocity in patients with type 2…
- Conditions
- Electroacupuncture, Acupuncture, Diabetic Polyneuropathy, Diabetic Peripheral Neuropathy
- Trial name
- EA&DPN (NCT05521737)
- Testing
- Electroacupuncture
- Where
- Mexico
- Volunteers
- 200 people
- Sponsor
- Instituto Mexicano del Seguro Social
Delirium, Postoperative
Effectiveness of Delirium Care Protocol After Cardiac Surgery
This study was conducted as a quasi-experimental study to determine the effectiveness of the postoperative delirium prevention, diagnosis and intervention protocol in patients monitored in the intensive care unit after cardiac…
- Trial name
- NCT06268119
- Testing
- training nurses and caring for patients to prevent, diagnose, and intervene in postoperative delirium.
- Where
- Turkey (Türkiye)
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Gonul Kara Soylemez
Malignant Neoplasm, Leukemia, Lymphocytic, Chronic, B-Cell
Project to Improve Communication About Serious Illness - Pilot Study
This two-year pilot study will test whether a one-page "Jumpstart Form" will affect goals-of-care discussions in the hospital. This form will be provided to clinicians and will include patient-specific information about…
- Conditions
- Malignant Neoplasm, Leukemia, Lymphocytic, Chronic, B-Cell, Lung Disease Chronic, Congestive Heart Failure
- Trial name
- PICSI-P (NCT03746392)
- Testing
- Jumpstart Intervention
- Where
- 2 sites in United States
- Volunteers
- 150 people
- Sponsor
- University of Washington
End Stage Renal Disease
CoQ10 and Exercise for Mitochondrial Dysfunction in Advance Kidney Disease
Frailty and sarcopenia are modifiable risk factors for morbidity and mortality in patients with ESRD. Exercise is the recommended intervention to prevent frailty and sarcopenia, however, many clinical trials have shown limited…
- Trial name
- NCT05422534
- Testing
- CoQ10, HB-HIIT, Observational
- Where
- 2 sites in United States
- Volunteers
- 156 people
- Sponsor
- Vanderbilt University Medical Center
Postamputation Pain
Alcohol Neurolysis and Capsaicin for Postamputation Pain (PAP)
Postamputation pain is a complex condition that includes phantom limb pain (PLP), stump pain and residual limb pain (RLP), the latter of which may be referred from joints, the spine and inflamed bursa and tendons.
- Trial name
- NCT07443553
- Testing
- Injection of alcohol near neuroma, Lidocaine 2% injection, Injection of capsaicin 150 mcg per mL if relief with lidocaine 2%
- Where
- Ukraine
- Volunteers
- 120 people
- Sponsor
- Northwestern University
Hyponatremia Symptomatic, Osmotic Demyelination Syndrome
International Multi-center Retrospective Study of Patients With Serum Sodium ≤110 mmol/L to Determine the Relationship Between Osmotic Demyelination Syndrome (ODS) and Rapid Correction of Hyponatremia
Electronic medical records dating back as far as available for each center to identify patients admitted to the hospital with a serum sodium ≤110 mmol/l.
- Conditions
- Hyponatremia Symptomatic, Osmotic Demyelination Syndrome, Cerebral Edema
- Trial name
- PRONATREOUS (NCT07576036)
- Testing
- Hypertonic 3% saline
- Where
- United States
- Volunteers
- 800 people
- Sponsor
- Rochester General Hospital
Vulvodynia, Vestibulodynia
Somatocognitive Therapy in Treatment of Provoked (Localized) Vestibulodynia - Randomized Clinical Trial (ProLoVe Study)
This is a two-arm randomized clinical trial assessing effectiveness of somatocognitive therapy versus treatment as usual for provoked vestibulodynia (PVD).
- Trial name
- ProLoVe (NCT04613713)
- Testing
- Somatocognitive physiotherapy, Treatment as usual
- Where
- Norway
- Volunteers
- 128 people
- Sponsor
- Oslo Metropolitan University
Low Anterior Resection Syndrome, Rectal Cancer Surgery
Transanal Irrigation for Low Anterior Resection Syndrome
The preservation surgery of the anal sphincter muscle has become the standard procedure in the treatment of rectal cancer and, thanks to advancements in surgical techniques, can now be performed for tumors located closer to the…
- Conditions
- Low Anterior Resection Syndrome, Rectal Cancer Surgery, Insomnia
- Trial name
- TraLARS (NCT06796296)
- Testing
- Transanal Irrigation (TAI)
- Where
- South Korea
- Volunteers
- 94 people
- Sponsor
- Seoul National University Hospital
Bladder Disease, Bladder, Neurogenic
Deceased Donor Bladder or Combined Kidney-bladder Transplantation: a Phase 0 First-in-human Study
The goal of this clinical trial is to demonstrate the feasibility of bladder transplantation in patients with terminal bladder diseases who would benefit from a new bladder or a combined kidney and bladder transplant.
- Conditions
- Bladder Disease, Bladder, Neurogenic, Bladder Cancer, Kidney Failure
- Trial name
- NCT06337942
- Testing
- Bladder Transplantation, Combined Kidney and Bladder Transplantation
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- University of California, Los Angeles
Postoperative Pain, Narcotic Use
Postoperative Opt-In Narcotic Treatment Study
pills go unused, generating waste and leaving an opportunity for misuse and abuse. In a recent study, researchers let patients choose what medications to go home with after surgery.
- Conditions
- Postoperative Pain, Narcotic Use, Analgesia, Endocrine Surgery
- Trial name
- POINT (NCT04710069)
- Testing
- POINT
- Where
- United States
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles