Clinical trials: Nervous System Complication
Neurological Complication
Transcranial Doppler, Optic Nerve Envelope Diameter and Quantitative Pupillometry Measurements
Non-invasive neuromonitoring tools such as transcranial doppler, optic nerve envelope diameter measurement and quantitative pupillometry are routinely used in acute brain injured patients as part of multimodal neuromonitoring…
- Trial name
- DOPPLER (NCT05843214)
- Testing
- Non-invasive neuromonitoring evaluation (transcranial doppler, optic nerve envelope diameter and quantitative pupillometry)
- Where
- Reunion
- Volunteers
- 230 people
- Sponsor
- Centre Hospitalier Universitaire de la Réunion
Delirium, Psychomotor Agitation
Acupuncture for the Prevention of Emergence Delirium in Children Undergoing Myringotomy Tube Placement
Myringotomy tube placement is one of the most commonly performed operations in children. Emergence delirium after such procedures is common.
- Trial name
- NCT02383004
- Testing
- Acupuncture
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Oregon Health and Science University
Brain Damage, Postoperative
Evaluation of Neuronal Damage in Patients Undergoing Robot-assisted Laparoscopic Radical Prostatectomy With Biomarkers
Robotic assisted laparoscopic surgery has become an alternative to open or laparoscopic technique in various surgical fields. Robot assisted laparoscopic surgery is preferred by surgeons and patients due to easy accessibility…
- Conditions
- Brain Damage, Postoperative, Surgery-Complications
- Trial name
- NCT05692804
- Testing
- Mini Mental State Examination(MMSE),Montreal Cognitive Assessment ( MoCA),S100B ( protein S100 subunit beta) ,GFAP ( glial fibrillary acidic protein ),NSE ( neuron-specific enolase )
- Where
- Turkey (Türkiye)
- Volunteers
- 59 people, healthy volunteers welcome
- Sponsor
- Akdeniz University
Diabetic Polyneuropathy
A Double-Blind, Placebo-Controlled Study of Fermented Deglycyrrhizinated Licorice Extract
This double-blind, placebo-controlled study evaluated the efficacy of oral α-amylase enzyme replacement therapy in treating early-stage diabetic polyneuropathy (DPN).
- Trial name
- NCT07148804
- Testing
- Fermented Deglycyrrhizinated Licorice, Non-fermented Deglycyrrhizinated Licorice
- Where
- Egypt
- Volunteers
- 83 people, healthy volunteers welcome
- Sponsor
- Helwan University
Ureter Stone
Effectiveness Basket Wires for the Maintenance of Stone and Pneumatic Probe in the Treatment of Ureteral Stones
Patients included in the study included the necessary tests U / A, K, Na, Cr, BUN, CBC, And U / C was checked and anesthesia counseling was done. Patients were prepared for action.
- Trial name
- NCT03980444
- Testing
- Basket of wire, control group, no basket
- Where
- 2 sites in Iran
- Volunteers
- 124 people
- Sponsor
- Mohammad Sadegh Bagheri Baghdasht
Covid19, Myocardial Infarction
Outcomes of Patients Who Survived Treatment on an Intensive Care Unit for COVID-19 in England and Wales
This retrospective cohort study aims to characterise outcomes for patients treated on an intensive care unit (ICU) with COVID-19 in England and Wales, one year after discharge from hospital.
- Conditions
- Covid19, Myocardial Infarction, Stroke, Critical Illness
- Trial name
- OPTIC-19 (NCT04838106)
- Testing
- Not applicable as observational study
- Where
- United Kingdom
- Volunteers
- 319,600 people
- Sponsor
- University of Oxford
Emergence Delirium, Dexmeditomidine
Intravenous Dexmedetomidine for Emergence Delirium in Pediatric Patient
Various pharmacological interventions in peri-operative period have been used in literature to prevent ED which include use of propofol, fentanyl, ketamine, clonidine, midazolam and dexmedetomidine etc (5).
- Trial name
- NCT05813106
- Testing
- Dexmedetomidine Hydrochloride, normal saline
- Where
- Saudi Arabia
- Volunteers
- 60 people
- Sponsor
- Security Forces Hospital
Trigeminal Neuralgia, Microvascular Decompression Surgery
Post-Operative Trigeminal Pain After Microvascular Decompression for Trigeminal Neuralgia
The goal of this observational study is to learn about the long-term effects of microvascular decompression (MVD) in patients with trigeminal neuralgia (TN).
- Conditions
- Trigeminal Neuralgia, Microvascular Decompression Surgery, Post-operative Pain
- Trial name
- NCT07216547
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Rutgers, The State University of New Jersey
Infertility, Miscarriage
Preimplantation Genetic Diagnosis (PGD) by Array Comparative Genome Hybridization (CGH) and Blastocyst Biopsy
This study evaluates the effect of single embryo transfer (SET) with and without array CGH for the evaluation of the complete chromosome complement of the blastocyst. Patients will be allocated at random into two groups.
- Trial name
- NCT01332643
- Testing
- Preimplantation Genetic Diagnosis
- Where
- Peru
- Volunteers
- 120 people
- Sponsor
- Reprogenetics
Diabetic Neuropathies, Painful, Diabetic Neuropathy Peripheral
Posterior Tibial Nerve PRF for Diabetic Neuropathic Pain
This study aimed to evaluate the efficacy of ultrasound (US)-guided posterior tibial nerve pulsed radiofrequency (PTN PRF) in the treatment of painful diabetic peripheral neuropathy (DPNP) refractory to conservative treatments.
- Trial name
- NCT06463015
- Testing
- ultrasound-guided posterior tibial nerve pulsed radiofrequency
- Where
- Turkey (Türkiye)
- Volunteers
- 55 people
- Sponsor
- Diskapi Teaching and Research Hospital
Brain Metastasis, Radiation Therapy Complication
A Clinical Trial on Whole-brain Radiotherapy With Temozolomide Concurrent Chemotherapy or Avoidance of Hippocampus for Patients of Brain Metastases
The purpose of this study is to evaluate the effects on neurocognitive function of whole-brain radiotherapy (WBRT) with/without TMZ concurrent chemotherapy or avoidance of hippocampus for patients of brain metastases, as well as…
- Trial name
- NCT02832635
- Testing
- TMZ, WBRT with avoidance of hippocampus, WBRT without avoidance of hippocampus
- Where
- 10 sites in China
- Volunteers
- 256 people
- Sponsor
- Sun Yat-sen University
Advanced Malignant Solid Neoplasm, Ann Arbor Stage III Hodgkin Lymphoma
Tazemetostat in Treating Patients With Relapsed or Refractory Advanced Solid Tumors, Non-Hodgkin Lymphoma, or Histiocytic Disorders With EZH2, SMARCB1, or SMARCA4 Gene Mutations (A Pediatric MATCH Treatment Trial)
This phase II Pediatric MATCH trial studies how well tazemetostat works in treating patients with brain tumors, solid tumors, non-Hodgkin lymphoma, or histiocytic disorders that have come back (relapsed) or do not respond to…
- Conditions
- Advanced Malignant Solid Neoplasm, Ann Arbor Stage III Hodgkin Lymphoma, Ann Arbor Stage III Non-Hodgkin Lymphoma, Ann Arbor Stage IV Hodgkin Lymphoma
- Trial name
- NCT03213665
- Testing
- Tazemetostat
- Where
- 117 sites in United States, Puerto Rico
- Volunteers
- 20 people
- Sponsor
- National Cancer Institute (NCI)
Type 2 Diabetes, Coronary Heart Disease
NMR Metabolomics-Based Risk Assessment and Stratified Digital Health Interventions in Middle-Aged Adults (PREMAP)
PREMAP invites residents of the Eloisa region (South Savo, Finland) turning 45, 50, or 55 years of age in 2026 to undergo a blood-based NMR metabolomics risk assessment for five interlinked cardio-renal-metabolic conditions (type…
- Conditions
- Type 2 Diabetes, Coronary Heart Disease, Myocardial Infarction, Cerebrovascular Disease
- Trial name
- PREMAP (NCT07820800)
- Testing
- Digital health interventions
- Where
- Finland
- Volunteers
- 1,400 people, healthy volunteers welcome
- Sponsor
- University of Eastern Finland
Diabetic Foot, Diabetic Neuropathies
Placenta Derived Stem Cells for Treating of Chronic Ulcers and Neuropathy
This is an initial dose escalation safety and exploratory efficacy study to treat two groups of subjects with critically sized diabetic wounds and diabetic neuropathy using placental-derived stem cells (PDSC) transplanted by…
- Conditions
- Diabetic Foot, Diabetic Neuropathies, Diabetic Foot Ulcer
- Trial name
- PDSC (NCT06373809)
- Testing
- Transplantation of Placenta Derived Stem Cells
- Where
- 2 sites in Nicaragua
- Volunteers
- 20 people
- Sponsor
- Michael H Carstens
Diabetic Neuropathies
Differences In The Severity Of Diabetic Neuropathy Based On Electromyography In Type 2 Diabetes Mellitus Patients With And Without Comorbidities
The goal of this clinical trial is to learn the differences severity level of diabetic neuropathy based on electromyelography in type II diabetic patient with and without comorbidities. The main questions of this study: 1.
- Trial name
- DISNEY-T2DM (NCT06573684)
- Testing
- Electromyography
- Where
- Indonesia
- Volunteers
- 78 people
- Sponsor
- Universitas Diponegoro
Breast Cancer, Ovarian Neoplasm
Omega-3 Fatty Acid in Treating Pain in Patients With Breast or Ovarian Cancer Receiving Paclitaxel
Paclitaxel, a widely used chemotherapeutic agent, is associated with several well-known side effects including neuropathy (weakness, numbness and pain) and generalized body aches.
- Conditions
- Breast Cancer, Ovarian Neoplasm, Pain
- Trial name
- NCT01821833
- Testing
- Omega-3 fatty acid, Paclitaxel
- Where
- 2 sites in United States
- Volunteers
- 60 people
- Sponsor
- New Mexico Cancer Research Alliance
Acne, Bites
Implementation of a Minor Ailment Service in Community Pharmacy Practice
Self-care and self-medication are commonly the treatments of choice for the management of minor ailments. Minor ailments can be treated through community pharmacy using a Minor Ailment Service (MAS).
- Conditions
- Acne, Bites, Burns, Cold
- Trial name
- INDICA+PRO (NCT05247333)
- Testing
- Minor ailment service
- Where
- Spain
- Volunteers
- 20,987 people
- Sponsor
- Universidad de Granada
Renal Function Disorder, Postoperative Delirium
Conscious Sedation for Transcatheter Aortic Valve Implantation
Aortic valve stenosis is the heart valve disease with the highest prevalence among the elderly, and may lead to heart failure. Until recently, the only definitive treatment was surgical replacement (SAVR).
- Conditions
- Renal Function Disorder, Postoperative Delirium, Adverse Event, Death
- Trial name
- NCT05462938
- Testing
- Continuous infusion of propofol, Continuous infusion of dexmedetomidine
- Where
- Greece
- Volunteers
- 65 people
- Sponsor
- University of Ioannina
Diabetic Neuropathy
Less Neuropathy After Yoga- Managing Diabetic Neuropathy With Yoga
The long-term goal is to identify and establish effective mind-body interventions (as an aspect of complementary and alternative medicine) to improve health and Quality of Life (QoL) for people with disabilities.
- Trial name
- LeNY (NCT02659007)
- Testing
- yoga
- Volunteers
- 15 people
- Sponsor
- Colorado State University
Rheumatoid Arthritis (RA, Osteoporosis
Generative AI Impact on Rheumatoid Arthritis Complications Diagnosis
Generative AI (GenAI) based on large language models (LLMs) is expected to improve the diagnosis and treatment of autoimmune diseases.
- Conditions
- Rheumatoid Arthritis (RA, Osteoporosis, Osteoarthritis, Interstitial Lung Disease
- Trial name
- NCT07301892
- Testing
- Generative AI prediction report for RA complications
- Where
- China
- Volunteers
- 57 people
- Sponsor
- Guang'anmen Hospital of China Academy of Chinese Medical Sciences
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.