Clinical trials: Nervous System Complication
Solid Tumors, Advanced Cancer
APL-101 Study of Subjects With NSCLC With c-Met EXON 14 Skip Mutations and c-Met Dysregulation Advanced Solid Tumors
To assess: efficacy of APL-101 as monotherapy for the treatment of NSCLC harboring MET Exon 14 skipping mutations, NSCLC harboring MET amplification, solid tumors harboring MET amplification, solid tumors harboring MET fusion…
- Conditions
- Solid Tumors, Advanced Cancer, Renal Cancer, Gastric Cancer
- Trial name
- SPARTA (NCT03175224)
- Testing
- APL-101 Oral Capsules
- Where
- 35 sites in United States, Australia and 9 more
- Volunteers
- 497 people
- Sponsor
- Apollomics Inc.
Peripheral Neuropathy, Diabetic Neuropathies
Focal Vibrations and Neuropathic Pain in Diabetic Peripheral Neuropathy
Most of the literature found on whole body vibrations(WBV) instead of focal muscle vibrations (FMV) in diabetic peripheral neuropathy patients.
- Trial name
- NCT05322746
- Testing
- Focal muscle vibration
- Where
- Pakistan
- Volunteers
- 96 people
- Sponsor
- Riphah International University
Phantom Limb, Motor Activity
The Effects of Targeted Phantom Motor Execution on Phantom Limb Control
Lower limb amputations account for more than 85% of all amputations. In Canada, it has been reported that transtibial amputation (TTA) is the most common level of amputation.
- Conditions
- Phantom Limb, Motor Activity, Amputation Stump, Amputation
- Trial name
- NCT05247827
- Testing
- Targeted phantom limb motor execution (exercise)
- Where
- Canada
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Saskatchewan
Quality of Life (QOL), Patient-Reported Outcome Measures (PROMs)
Validation of the EQ-5D-Y-3L and EQ-5D-Y-5L for Paediatric Patients in China
The goal of this observational study is to validate the EQ-5D-Y-3L and EQ-5D-Y-5L in measuring health-related quality of life (HRQoL) for paediatric patients with different health conditions in China.
- Conditions
- Quality of Life (QOL), Patient-Reported Outcome Measures (PROMs), Pneumonia Childhood, Neuroblastoma (NB)
- Trial name
- NCT06873672
- Where
- China
- Volunteers
- 360 people
- Sponsor
- RenJi Hospital
Postoperative Delirium, Postoperative Cognitive Dysfunction
The Caffeine, Postoperative Delirium, and Change in Outcomes After Surgery (CAPACHINOS-2) Study
The objective of this study is to test the effects of caffeine on neurocognitive and clinical recovery after major surgery. Specifically, this trial tests the primary hypothesis that caffeine will reduce the incidence of…
- Conditions
- Postoperative Delirium, Postoperative Cognitive Dysfunction, Mild Cognitive Impairment
- Trial name
- NCT05574400
- Testing
- Dextrose Water, Caffeine citrate
- Where
- United States
- Volunteers
- 250 people
- Sponsor
- University of Michigan
Breast Neoplasm Female, Pain, Postoperative
Effectiveness of Ultrasound Guided PECS Block on Opioid Consumption and Patient Satisfaction Through Adequate Pain Control Following Breast Cancer Surgery.
Breast cancer is the most common and leading cause of cancer deaths among females worldwide. Patients undergoing modified radical mastectomy (MRM) are associated with moderate to severe acute postoperative pain and shoulder…
- Conditions
- Breast Neoplasm Female, Pain, Postoperative, Pain, Analgesia
- Trial name
- NCT04343807
- Testing
- PECS Block, Control Group
- Where
- Pakistan
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Aga Khan University
Strabismus
Prevention of Complications of Eye Surgery
This study was designed to investigate pre-operatively measured parameters of various anaesthetic regimes, iris color, sex, age, surgical time, severity of Marcus-Gunn Pupil (MGP), type of mechanical stimulation of eye, and…
- Trial name
- ocr (NCT00478907)
- Testing
- KETAMINE, PROPOFOL, THIOPENTAL
- Where
- Iran
- Volunteers
- 300 people
- Sponsor
- Isfahan University of Medical Sciences
Pain Management, Postoperative Acute Pain
Effect of Sedation After Ultrasound-Guided Spinal Anesthesia on Back Pain
This study will evaluate whether giving sedation before spinal anesthesia, when performed with ultrasound guidance, reduces the risk of developing back pain after surgery.
- Conditions
- Pain Management, Postoperative Acute Pain, Chronic Back Pain
- Trial name
- NCT07198412
- Testing
- Ultrasound-guided spinal anesthesia, Midazolam plus ultrasound-guided spinal anesthesia, Landmark-guided spinal anesthesia
- Where
- Egypt
- Volunteers
- 180 people
- Sponsor
- Benha University
Emergence Agitation, Emergence Delirium, Anesthesia
Efficacy of Ultrasound-guided Greater Auricular Nerve Block in Preventing Postoperative Emergence Agitation in Pediatric Patients Undergoing Microscopic Middle Ear Surgery.
This study is designed to evaluate the effectiveness of ultrasound-guided greater auricular nerve block (GAN) on the reduction of emergence agitation (EA) occurrence and EA severity in children who are receiving general…
- Conditions
- Emergence Agitation, Emergence Delirium, Anesthesia, Emergence From Anesthesia, Emergence Delirium
- Trial name
- NCT07435675
- Testing
- ultrasound-guided greater auricular nerve block (GANB)
- Where
- Egypt
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- Fayoum University
Colorectal Cancer (MSI-H), Postoperative Delirium (POD)
POD Risk for Colorectal Cancer Surgery
Postoperative delirium is a common complication after colorectal cancer surgery that hinders recovery. This observational study hypothesizes that a simple, practical risk tool can be developed by combining preoperative clinical…
- Trial name
- NCT07597330
- Where
- China
- Volunteers
- 590 people
- Sponsor
- LanZhou University
Pain, Postoperative, Post Operative Swelling
Effect Of Autologous Platelet Rich Fibrin On Post-Operative Complications And Healing Following The Extraction
As post-operative pain, infection inflammation and infections are the main complications after the surgical extraction of the lower third molar the aim of this study is to compare the healing effects of PRF administered…
- Conditions
- Pain, Postoperative, Post Operative Swelling, Trismus, Soft Tissue Healing
- Trial name
- PRF (NCT06609967)
- Testing
- application of PRF, application of conventional surgicel
- Where
- Pakistan
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Dow University of Health Sciences
Myocardial Infarction, Stroke
Using AtorVASTatin to Prevent VAscular Inflammatory OccLUSion in the Critically Ill
Patients are admitted to the critical care unit of the hospital because of medical conditions that have a high likelihood of causing severe problems with blood flow, breathing, or brain function.
- Conditions
- Myocardial Infarction, Stroke, Renal Failure
- Trial name
- VASTVALUS (NCT01073800)
- Testing
- atorvastatin 80 mg per os daily
- Where
- Canada
- Volunteers
- 100 people
- Sponsor
- University of Alberta
Amputation, Phantom Limb
Ambulatory Continuous Peripheral Nerve Blocks for Treatment of Post-Amputation Phantom Limb and Stump Pain
Research study to determine if putting local anesthetic-or numbing medication-through one or two tiny tube(s) placed next to the nerves that go to an amputated limb will decrease phantom limb and/or stump pain.
- Conditions
- Amputation, Phantom Limb, Stump Pain
- Trial name
- NCT00667264
- Testing
- perineural ropivacaine
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- University of California, San Diego
Diabetic Neuropathy
Safety, Tolerability, Pharmacokinetics and Preliminary Efficacy of AV411 in Neuropathic Pain
The purpose of this study is to determine the safety, tolerability and pharmacokinetics of AV411 after single and multiple doses in patients with chronic neuropathic pain due to diabetes.
- Trial name
- NCT00576277
- Testing
- AV411
- Where
- 2 sites in Australia
- Volunteers
- 36 people
- Sponsor
- Avigen
Small-Fiber Neuropathy, Chronic Kidney Disease
Small-fiber Neuropathy in Chronic Kidney Disease
Neurological dysfunction is a common complication of late stage chronic kidney disease (CKD) and peripheral nerve system is often involved in such complication.
- Trial name
- NCT01078857
- Testing
- Skin biopsy
- Where
- Taiwan
- Volunteers
- 120 people
- Sponsor
- National Taiwan University Hospital
Apnoea, Prematurity
Automated Apnoea Detection in Preterms on Non-invasive Ventilation
The aim of this study is to monitor the frequency of apnoeas (pauses in breathing) on various methods of non-invasive respiratory support that are detected by an automated machine-learning (ML) model based on diaphragmatic…
- Trial name
- NCT07794007
- Testing
- Diaphragmatic electromyography
- Volunteers
- 30 people
- Sponsor
- King's College Hospital NHS Trust
Pain, Postoperative, Pain, Acute
Parecoxib in Total Knee Arthroplasty
Early mobilization and rehabilitation can be difficult after total knee arthroplasty (TKA) due to a high incidence of moderate to severe postoperative pain.
- Conditions
- Pain, Postoperative, Pain, Acute, Analgesia, Analgesic Nephropathy
- Trial name
- NCT05924412
- Testing
- Intravenous study drug, Intravenous saline solution
- Where
- Chile
- Volunteers
- 40 people
- Sponsor
- University of Chile
Phantom Limb Pain
Incidence and Factors Affecting the Development and Outcome of Phantom Limb Pain (PLP) - A Single-centre Prospective Cohort Study.
Phantom limb pain (PLP), defined as pain felt in the missing portion of the amputated limb following amputation, occurs in a significant percentage of patients who undergo limb amputation and it is among the most difficult…
- Trial name
- NCT05005481
- Testing
- NIL intervention
- Where
- Singapore
- Volunteers
- 67 people, healthy volunteers welcome
- Sponsor
- Singapore General Hospital
Diabetic Neuropathy
The Effect of Random Vibrations on Perception and Balance
The purpose of this study is to investigate the effects of vibrating insoles on vibration perception threshold (VPT) and balance of people with diabetic neuropathy.
- Trial name
- NCT02989831
- Testing
- Vibrating insoles 'on'
- Volunteers
- 40 people
- Sponsor
- University Medical Center Groningen
Episiotomy, Episiotomy Wound
Active Oxygen and Negative Ion Sanitary Pads for Episiotomy Pain, Healing, and Postpartum Symptoms
This study is to assess the impact of sanitary pads infused with active oxygen and negative ions on episiotomy pain, wound healing, and postpartum physical symptoms in primiparous women.
- Conditions
- Episiotomy, Episiotomy Wound, Postpartum Complication, Postpartum Recovery
- Trial name
- NCT07487974
- Testing
- Active Oxygen and Negative Ion Sanitary Pad, Standard Postpartum Sanitary Pad
- Where
- Turkey (Türkiye)
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- KTO Karatay University
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