Clinical trials: Nervous System Complication
Kidney Disease, Chronic, End Stage Renal Disease
The Effect of Exercise on Dialysis Patients' Survival
The purpose of this study is to check if patients' exercise during their dialysis sessions can prevent their early deaths.
- Conditions
- Kidney Disease, Chronic, End Stage Renal Disease, Hemodialysis
- Trial name
- NCT04898608
- Testing
- Intradialytic Exercise
- Where
- 2 sites in Iran
- Volunteers
- 74 people
- Sponsor
- Pardis Specialized Wellness Institute
Amyotrophic Lateral Sclerosis, Renal Insufficiency
Dexpramipexole Renal PK Study
This is a multicenter, open-label, single-dose, PK and safety study in subjects with various stages of renal impairment.
- Trial name
- NCT01424176
- Testing
- Dexpramipexole (dose 1), Dexpramipexole (dose 2)
- Where
- 2 sites in United States
- Volunteers
- 36 people
- Sponsor
- Knopp Biosciences
Delirium, Postoperative
The Impact of Smoking on the Prognosis of Elderly Surgical Patients
Postoperative delirium is a common complication that frequently occurs in elderly patients after surgery. It not only increases the length of hospital stays and healthcare costs but also raises the incidence of postoperative…
- Trial name
- NCT06392308
- Testing
- none intervention
- Where
- China
- Volunteers
- 121 people
- Sponsor
- Affiliated Hospital of Nantong University
Postoperative Delirium, Postoperative Agitation
Emergence Agitation in Paediatric Day Care Surgery
Emergence agitation is a significant and persistent challenge in paediatric anaesthesia, especially in children of preschool age.
- Conditions
- Postoperative Delirium, Postoperative Agitation, Anesthesia, Pain Monitoring
- Trial name
- NCT06571890
- Testing
- Narcotrend bispectral index anaesthesia monitor, Mdoloris Anaesthesia Nociception Monitor
- Where
- Denmark
- Volunteers
- 93 people
- Sponsor
- University of Southern Denmark
Anesthesia, Anesthesia Complication
Optimizing Patient-centred Outcomes Using Opioid Minimization Strategies: The OPUS Anesthesia Pilot Trial
Up to 40% of patients experience suboptimal recovery in the days following major surgery, limiting their return to functional independence.
- Conditions
- Anesthesia, Anesthesia Complication, Surgery, Quality of Life
- Trial name
- OPUS (NCT06884540)
- Testing
- Dexmedetomidine, lidocaine, control group
- Where
- 5 sites in Canada
- Volunteers
- 100 people
- Sponsor
- CHU de Quebec-Universite Laval
Complex Regional Pain Syndromes, Postherpetic Neuralgia
The Comparison of Sympathetic Blockade of Stellate Ganglion Block and Thoracic Paravertebral Block
The purpose of this study is to investigate the effect of ultrasound-guided thoracic paravertebral block (TPVB) when performing sympathetic block for upper limb pain control.
- Conditions
- Complex Regional Pain Syndromes, Postherpetic Neuralgia, Phantom Limb Pain, Chronic Post Surgical Pain
- Trial name
- NCT04876989
- Testing
- US-SGB, US-TPVB
- Where
- South Korea
- Volunteers
- 69 people
- Sponsor
- Seoul National University
Pain, Diabetic Neuropathies
A Phase 2 Study of Tapentadol Extended-Release (JNS024ER) ) in Japanese Participants With Chronic Pain Due to Diabetic Neuropathic Pain or Postherpetic Neuralgia
The purpose of this study is to investigate the efficacy and safety of tapentadol extended-release (ER) tablets in Japanese participants with moderate to severe chronic (lasting a long time) pain due to painful diabetic…
- Conditions
- Pain, Diabetic Neuropathies, Neuralgia, Postherpetic Neuralgia
- Trial name
- NCT01124617
- Testing
- Tapentadol
- Where
- 31 sites in Japan
- Volunteers
- 91 people
- Sponsor
- Janssen Pharmaceutical K.K.
Diabetic Foot Ulcer
Study of Oasis Ultra in Diabetic Foot Ulcers
Many people with diabetes will develop a non-healing diabetic foot ulcer. Many ways are available to try to get a diabetic foot ulcer to heal, including application of Oasis Ultra.
- Trial name
- NCT01835379
- Testing
- Oasis, Standard
- Where
- 16 sites in United States
- Volunteers
- 82 people
- Sponsor
- Healthpoint
Sarcopenia, Sarcopenic Obesity
Effects of Sarcopenia and Sarcopenic Obesity in Complex Abdominal Wall Surgery
The objective of our study is to evaluate the prevalence of sarcopenia and sarcopenic obesity in our surgical population and their relationship in postoperative complications after complex abdominal wall surgery and its influence…
- Conditions
- Sarcopenia, Sarcopenic Obesity, Incisional Hernia
- Trial name
- NCT04690179
- Volunteers
- 150 people
- Sponsor
- Hospital Universitario Ramon y Cajal
Analgesia, Pain, Acute
A Randomized Comparison Between 0.67 mcg/kg, 1 mcg/kg, and 1.33 mcg/kg of Perineural Dexmedetomidine for Ultrasound-Guided Infraclavicular Block
This study will compare three different doses of perineural dexmedetomidine 0.67 mcg/kg, 1 mcg/kg, and 1.33 mcg/kg as adjuvants to local anesthetics for ultrasound-guided infraclavicular brachial plexus blocks (ICBs).
- Conditions
- Analgesia, Pain, Acute, Upper Extremity Surgery, Nerve Block
- Trial name
- NCT07249827
- Testing
- dexmedetomidine (perineural) 0.67 mcg/kg, dexmedetomidine (perineural) 1 mcg/kg, dexmedetomidine (perineural) 1.33 mcg/kg
- Where
- Canada
- Volunteers
- 69 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Muscle Weakness, Critical Illness
Translation and Validation of the Intensive Care Unit Mobility Scale (IMS)
Intensive care unit acquired weakness (ICUAW) is a common issue in critically ill patients. Early mobilization can reduce the occurrence of ICUAW. This requires a standardized procedure based on validated scales.
- Conditions
- Muscle Weakness, Critical Illness, Mechanical Ventilation Complication, Early Mobilization
- Trial name
- TAVIMS (NCT05591950)
- Where
- Germany
- Volunteers
- 100 people
- Sponsor
- Charite University, Berlin, Germany
Anal Cancer, Cervical Cancer
Vaccine Therapy in Treating Patients With Advanced or Recurrent Cancer
RATIONALE: Vaccines made from certain human papillomaviruses may be able to help the body to kill more tumor cells. PURPOSE: Phase II trial to study the effectiveness of human papillomavirus vaccine therapy in treating patients…
- Conditions
- Anal Cancer, Cervical Cancer, Esophageal Cancer, Head and Neck Cancer
- Trial name
- NCT00019110
- Testing
- human papillomavirus 16 E7 peptide, synthetic human papillomavirus 16 E6 peptide
- Where
- 6 sites in United States
- Sponsor
- National Cancer Institute (NCI)
Somatosensory Perception Following Lower Limb Amputation
Spinal Cord Stimulation (SCS) for Amputees
The purpose of this study is to investigate how leg amputee patients can feel sensations with neuromodulation while they are using a prosthetic leg.
- Trial name
- NCT04490382
- Testing
- 32 channel external stimulator
- Sponsor
- Duke University
Postoperative Delirium
Postoperative Delirium in Elderly Patients Undergoing Major Non-Cardiac Surgery in Singapore
The primary aim of this study is to investigate the incidence, risk factors and sequelae of postoperative delirium in elderly patients undergoing major non-cardiac surgery in Singapore.
- Trial name
- NCT04330950
- Testing
- Neurocognitive tests
- Where
- 4 sites in Singapore
- Volunteers
- 98 people
- Sponsor
- National University Hospital, Singapore
Sleep Disorder, Polycystic Ovarian Syndrome (PCOS)
Association Between Polycystic Ovary Syndrome and Sleep Quality: A Questionnaire-Based Study
This cross-sectional study enrolled 310 women with PCOS (Rotterdam criteria) at a tertiary referral center between September 2025 and January 2026.
- Trial name
- PMOS (NCT07898423)
- Where
- Turkey (Türkiye)
- Volunteers
- 290 people
- Sponsor
- Tepecik Training and Research Hospital
Urinary Retention, Stroke, Complication
Electroacupuncture on Post-stroke Urinary Retention
This study aimed to evaluate the effectiveness of adjuvant electroacupuncture therapy for the post-stroke patients with urinary retention under conventional treatments, compared with sham electroacupuncture.
- Trial name
- NCT02472288
- Testing
- Electroacupuncture (EA)
- Where
- 3 sites in South Korea
- Volunteers
- 25 people
- Sponsor
- Kyunghee University
Emergence Delirium
The PREVENT AGITATION Trial II - Children ≤1 Year
Emergence agitation is a clinical condition in which the child experiences a variety of behavioural disturbances including crying, thrashing, and disorientation during early awakening from anaesthesia.
- Trial name
- NCT05091242
- Testing
- Clonidine, Sodium chloride
- Where
- 2 sites in Australia, Denmark
- Volunteers
- 336 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Emergence Agitation
Comparison of Emergence Agitation Between Remimazolam With Flumazenil and Propofol-based Total Intravenous Anesthesia in Patients Undergoing Nasal Surgery
Participants will be randomly assigned to receive general anesthesia with either remimazolaml-based total intravenous anesthesia reversed with flumazenil or propofol-based total intravenous anesthesia.
- Trial name
- NCT07265050
- Testing
- Remimazolam with Flumazenil, Propofol
- Volunteers
- 204 people
- Sponsor
- Seoul National University Hospital
Pectus Excavatum, Pain, Postoperative
Sub-Paraspinal Block in Nuss Patients. A Pilot Project
The purpose of this pilot study was to evaluate effectiveness of a novel regional anesthesia technique developed at the investigators institution, as part of a quality improvement initiative, to assist with multilevel thoracic…
- Trial name
- NCT02169297
- Testing
- Ultrasound-guided Sub-Paraspinal Block, PCA only
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Nemours Children's Clinic
Amputation, Neuroma Amputation
Effect of Prophylactic TMR and RPNI on Neuroma and Phantom Limb Pain
The purpose of this study is to analyze the efficacy of novel interventions in post-amputation surgical care (specifically Targeted Muscle Reinnervation and Regenerative Peripheral Nerve Interface) on post-amputation pain and…
- Conditions
- Amputation, Neuroma Amputation, Phantom Limb Pain, Residual Limbs
- Trial name
- NCT05344261
- Testing
- Targeted Muscle Re-innervation, Regenerative Peripheral Nerve Interface, Standard Post-Amputation Surgical Care
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
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