Clinical trials: Nervous System Complication
Arthroscopic Shoulder Surgery
Interscalene Versus Infraspinatus-Teres Minor Blocks for Arthroscopic Shoulder Surgery
This randomized controlled trial aims to compare the effectiveness of interscalene (ISB) and infraspinatus-teres minor (ITM) blocks for postoperative analgesia in patients undergoing elective arthroscopic shoulder surgery.
- Trial name
- ITM-ISB (NCT07253740)
- Testing
- Interscalene Brachial Plexus Block (ISB), Infraspinatus-Teres Minor Block (ITM)
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Ataturk University
Multiple Sclerosis, Urinary Incontinence
Effects of Telerehabilitation-Based Pelvic Floor Muscle Training in People With Multiple Sclerosis
The effectiveness of pelvic floor muscle training on urinary incontinence and sexual function has been known for many years. However, the evaluation of its effectiveness in people with Multiple Sclerosis (MS) has recently begun…
- Trial name
- NCT04758468
- Testing
- Telerehabilitation-based pelvic floor muscle training, Home-based pelvic floor muscle training
- Where
- Turkey (Türkiye)
- Volunteers
- 45 people
- Sponsor
- Dokuz Eylul University
Preterm, Patent Ductus Arteriosus
NeoDoppler: New Ultrasound Technology for Continuous Monitoring of Cerebral Circulation Pilot
Non-invasive tools for monitoring of course of disease are important and necessary in the treatment of pre-term/premature infants and sick neonates.
- Conditions
- Preterm, Patent Ductus Arteriosus, Sepsis, Asphyxia
- Trial name
- CE-NeoDoppler (NCT06646250)
- Testing
- NeoDoppler - CE certified
- Where
- Norway
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- St. Olavs Hospital
Cholelithiasis
Laparo-endoscopic Single Site (LESS) Cholecystectomy Versus Standard LAP-CHOLE
The aim of this study is to assess possible differences between the LESS approach and the standard laparoscopic approach to cholecystectomy.
- Trial name
- LESSCHO (NCT01339325)
- Testing
- Cholecystectomy
- Where
- Italy
- Volunteers
- 180 people
- Sponsor
- San Giovanni Addolorata Hospital
Systemic Lupus Erythematosus, Lupus Nephritis
Fourth-gen CAR T Cells Targeting BCMA/CD19 for Refractory Systemic Lupus Erythematosus (SLE)
This study is a preliminary investigation, with a single-group design, not randomized and transparent, focusing on treatment. Its purpose is to identify the highest dose of BH002 injection (CD19-BCMA CAR-T cells) that patients…
- Conditions
- Systemic Lupus Erythematosus, Lupus Nephritis, Autoimmune Diseases, Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis
- Trial name
- BAH242 (NCT06350110)
- Testing
- CD19- BCMA CAR-T cells
- Where
- China
- Volunteers
- 75 people
- Sponsor
- Essen Biotech
Gender, Postoperative Pain
Acute Postthoracotomy Pain - Impact of Gender
Adequate analgesia in thoracic surgery is essential to prevent severe postoperative complications, especially respiratory problems.
- Conditions
- Gender, Postoperative Pain, Thoracotomy, Analgesia
- Trial name
- NCT03281213
- Testing
- Thoracotomy
- Where
- Austria
- Volunteers
- 346 people, healthy volunteers welcome
- Sponsor
- Medical University of Graz
Restless Legs Syndrome, Kidney Failure, Chronic
Study of Vitamin C, Vitamin E and Their Combination to Treat Restless Legs Syndrome in Hemodialysis Patients
The purpose of this study is to determine whether vitamin C, vitamin E and their combination are effective in the treatment of RLS in hemodialysis patients.
- Trial name
- ShirazUMS (NCT01125033)
- Testing
- Vitamin C & Vitamin E, Vitamin C, Vitamin E
- Where
- Iran
- Volunteers
- 60 people
- Sponsor
- Shiraz University of Medical Sciences
Depth of Anaesthesia, EEG
EEG Monitoring Under Anaesthesia in Children: Towards Personalized Anaesthesia Care
Electroencephalographic recordings (EEG) present an opportunity to monitor changes in human brain electrical activity during changing states of consciousness during general anesthesia.
- Conditions
- Depth of Anaesthesia, EEG, Anesthesia Emergence Delirium
- Trial name
- EEGPAC (NCT04103138)
- Testing
- Sedline EEG sensor placement, Sedline EEG monitoring
- Where
- Singapore
- Volunteers
- 200 people
- Sponsor
- KK Women's and Children's Hospital
Overactive Bladder (OAB)
Impact of Transcutaneous Electrical Nerve Stimulation on the Autonomic Nervous System in the Treatment of Overactive Bladder
The goal of this observational study is to evaluate the impact of Transcutaneous Electrical Nerve Stimulation on the autonomic nervous system in adults women with overactive bladder.
- Trial name
- StimHAV (NCT07781033)
- Testing
- heart rate variability assement
- Volunteers
- 70 people
- Sponsor
- Centre Hospitalier de Roubaix
Obstructive Sleep Apnea, Postoperative Respiratory Complications
A Multicenter Retrospective Analysis of Postoperative Respiratory Complications in Children With Obstructive Sleepapnea
This retrospective observational study aims to evaluate postoperative respiratory complications (PORC) after (adeno)tonsillectomy in children with OSA.
- Conditions
- Obstructive Sleep Apnea, Postoperative Respiratory Complications, Adenotonsillectomy, Child Obesity
- Trial name
- MRA PORC (NCT07305168)
- Where
- 2 sites in Belgium, Hungary
- Volunteers
- 200 people
- Sponsor
- University Hospital, Antwerp
Neuropathy Autonomic, Cardiac Autonomic Neuropathy
Diabetic Neuropathy Rapid Screening Test in Turkish Patients With Type 2 Diabetes: Sudoscan
Neuropathy is a frequently observed complication occurring in 60-70% of diabetic patients throughout their lives. In addition, neuropathy is a severe disease that progresses insidiously; its diagnosis can be delayed due to the…
- Conditions
- Neuropathy Autonomic, Cardiac Autonomic Neuropathy, Type2Diabetes, Diabetic Neuropathy Peripheral
- Trial name
- NCT05299918
- Volunteers
- 437 people
- Sponsor
- Istanbul University
Retinopathy of Prematurity (ROP), Prematurity Complications
Retinopathy of Prematurity - Visual Function and Retinal Structure
Children born prematurely may develop a characteristic retinal disease named retinopathy of prematurity (ROP). This disease could lead to retinal detachment and blindness.
- Conditions
- Retinopathy of Prematurity (ROP), Prematurity Complications, Cerebral Visual Impairment, Visual Field Defect
- Trial name
- NCT07427719
- Where
- Norway
- Volunteers
- 140 people
- Sponsor
- Oslo University Hospital
Sarcoma, Carcinoma
A Clinical Study on Oncolytic Virus Injection (R130 OV) for the Treatment of Advanced Solid Tumors
20 participants are expected to be enrolled for this open，Single-armed clinical trial to evaluate the safety and efficacy of the recombinant herpes simplex virus Ⅰ, R130 in patients with advanced solid tumors.
- Conditions
- Sarcoma, Carcinoma, Digestive Cancer, Breast Cancer
- Trial name
- NCT05961111
- Testing
- Recombinant oncolytic herpes simplex virus type 1 (R130)
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Shanghai Yunying Medical Technology
Voice Alteration, Intubation Complication
Intubation Tube Applications on Voice Performance in Early Postoperative Period
Changes in voice performance in the postoperative period due to trauma suffered during endotracheal intubation or edema occurring in the postoperative period are often observed.
- Trial name
- NCT04011111
- Testing
- Intubation tube and voice analysis
- Where
- Turkey (Türkiye)
- Volunteers
- 88 people
- Sponsor
- Hitit University
Diabetic Neuropathy
Safety and Efficacy Study of QR-333 in Patient's With Symptomatic Diabetic Neuropathy
The purpose of this study is to determine whether QR-333 is safe and effective in the treatment of diabetic neuropathy as compared to placebo.
- Trial name
- NCT00568035
- Testing
- QR-333
- Where
- 19 sites in United States
- Volunteers
- 140 people
- Sponsor
- Quigley Pharma, Inc.
Osteo Arthritis Knee, Analgesia
Comparing Local Anesthesia With and Without iPACK Block
Total knee arthroplasty is an effective surgical intervention for patients with chronic osteoarthritis commonly performed worldwide. Postoperative pain management has been a key focus in patient care for this procedure.
- Conditions
- Osteo Arthritis Knee, Analgesia, Pain, Postoperative
- Trial name
- NCT04635176
- Testing
- Real iPACK block (20 mL of 0.25% bupivacaine, 2.5mcg/mL epinephrine, and 50mcg/mL preservative-free dexamethasone)
- Where
- Canada
- Volunteers
- 10 people
- Sponsor
- University of Calgary
Urinary Bladder, Neurogenic, Urodynamics
Measurement of Bladder Pressure With a Novel External Device, Comparison to Urodynamics Testing
The investigators have developed a novel pressure monitoring device that hooks to standard urinary catheters. The investigators will be testing how the pressure measurements recorded with this device compare to the gold standard…
- Trial name
- NCT03456089
- Testing
- Urodynamics Testing
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Christopher Cooper
Diabetes; Neuropathy, Polyneuropathy (Manifestation)
FOot CAre and Exercises ImplementatioN for People With Diabetes in Primary Care
The main objective of this type 2 hybrid implementation effectiveness trial is to implement a contextually appropriate preventive intervention for 12 weeks face to face group foot and ankle exercises for people with diabetic foot…
- Trial name
- FOCAIN (NCT05639478)
- Testing
- Foot-related exercises
- Where
- Brazil
- Volunteers
- 356 people
- Sponsor
- University of Sao Paulo General Hospital
Caries, Dental
Health Effects of Silver-Mercury Dental Fillings
The purpose of this study is to determine whether there are detectable health effects of low-level mercury exposure (from normal exposure to mercury-containing dental fillings) in the known target organs/systems affected by…
- Trial name
- NCT00066118
- Testing
- Dental amalgam restorations
- Where
- United States
- Volunteers
- 507 people
- Sponsor
- University of Washington
Painful Diabetic Neuropathy, Diabetic Neuropathy, Painful
Extension of Phase 3 Gene Therapy for Painful Diabetic Neuropathy
The purpose of this study is to explore the overall safety profile and durability of efficacy of Engensis (VM202) in painful diabetic peripheral neuropathy.
- Trial name
- NCT04055090
- Testing
- Long-Term Follow-Up of Patients who Received Engensis (VM202)
- Where
- 14 sites in United States
- Volunteers
- 101 people
- Sponsor
- Helixmith Co., Ltd.
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