Clinical trials: Nervous System Complication
Pain
ADVANCE: Assessment for Defining Variability in Anesthesia Through Novel Clinical EEG
The present study is designed to compare prospectively whether sBIS, sEMG, or CVI variability (brain monitoring) can be used to predict unwanted intraoperative responses (high blood pressure, fast heart rate, tearing, etc.) to…
- Trial name
- CVI (NCT00689130)
- Where
- 4 sites in United States, Spain
- Volunteers
- 120 people
- Sponsor
- Medtronic - MITG
Post Operative Pain
Parent Nurse Controlled Analgesic in Pediatric Patients With Developmental Delay
The purpose of this study is to compare, the safety, efficacy and level of parent and nurse satisfaction with three methods of opioid administration post-operatively in children (4-18 years of age) with developmental delay.
- Trial name
- PNCA (NCT00743730)
- Testing
- Pain and standard side effect management for PNCA with basal method., Pain and standard side effect management with PNCA without basal, Pain and standard side effect management with IV on an as needed basis method.
- Where
- United States
- Volunteers
- 94 people
- Sponsor
- Medical College of Wisconsin
Breast Feeding, Analgesia Obstetrical
Intravenous Dexmedetomidine for Cesarean Section
Nervous, anxiety, fear and other psychological reactions always appears in parturients during cesarean section. This study intends to investigate the effectiveness and safety of dexmedetomidine combined with butorphanol tartrate…
- Conditions
- Breast Feeding, Analgesia Obstetrical, Postoperative Pain
- Trial name
- NCT03065530
- Testing
- Normal Saline, Dexmedetomidine 0.03ug/kg/h, Dexmedetomidine 0.05ug/kg/h
- Where
- China
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Preterm, Sensory Disorder
Mother-to-infant Bonding and Prematurity Are Associated With Sensory Processing at 12 Months of Age
Establishing a strong bond between mother and infant is crucial for fostering healthy relationships in the future. This research sought to investigate the correlation between mother-to-infant bonding and sensory processing, as…
- Conditions
- Preterm, Sensory Disorder, Attachment Disorder
- Trial name
- NCT06232811
- Testing
- Assessment
- Where
- Turkey (Türkiye)
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Gazi University
Anesthesia, Conduction, Arthroplasty, Replacement, Knee
Concentration Effect of Local Anesthetics on Femoral Nerve Block Efficiency
US-guided femoral nerve block is used effectively in post-operative pain management in the surgical treatment of the lower extremity.
- Conditions
- Anesthesia, Conduction, Arthroplasty, Replacement, Knee, Pain, Postoperative, Anesthesia and Analgesia
- Trial name
- NCT03623230
- Testing
- Ultrasound Guided Femoral Nerve Block, Dressing, Bupivacaine 0.25% Injectable Solution
- Where
- Turkey (Türkiye)
- Volunteers
- 63 people
- Sponsor
- Bozyaka Training and Research Hospital
Microvascular Disease, Microvascular Complications
Test of Reproducibility of [15O]H20-PET Assessment of Brain Perfusion
In the aging population, ischemic heart disease, stroke and dementia are increasingly prevalent. Diagnosis and treatment of the former two i.e., large-vessel coronary heart disease and endovascular thrombectomy of the brain in…
- Conditions
- Microvascular Disease, Microvascular Complications, Diabetes Mellitus Type 2, Cerebral Hypoperfusion
- Trial name
- SVAT (NCT06624267)
- Testing
- PET
- Where
- Denmark
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- University Hospital Bispebjerg and Frederiksberg
Hypothermia; Anesthesia, Agitation, Emergence
Evaluation of The Relationship Between Perioperative Hypothermia and Emergence Agitation
The main aim of our study was to investigate the relationship between perioperative hypothermia and postoperative emergence agitation.
- Conditions
- Hypothermia; Anesthesia, Agitation, Emergence, Postoperative Complications, Hypothermia Following Anesthesia
- Trial name
- NCT06543134
- Testing
- surgery, sedation scale
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Kocaeli City Hospital
Delirium, Postoperative Cognitive Dysfunction
Prevention of Early Postoperative Decline
The purpose of this trial is to determine whether using a brain training program in the time leading up to as well as after heart surgery will reduce confusion and cognitive loss that can occur after surgery.
- Trial name
- PEaPoD (NCT02908464)
- Testing
- Lumosity
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- Beth Israel Deaconess Medical Center
Colorectal Cancer, Oncologic Complications
The SaVe Project-Sarcopenia and Vertigo in Aging Patients With Colorectal Cancer
The goal of this clinical trial is to learn about the cause of dizziness and decline in walking ability in in older adults ≥65 years during chemotherapy treatment for colorectal cancer.
- Conditions
- Colorectal Cancer, Oncologic Complications, Comprehensive Geriatric Assessment, Vestibular Rehabilitation
- Trial name
- SaVe (NCT05710809)
- Testing
- Targeted specialized physical group-based exercise and Comprehensive Geriatric Assessement
- Where
- 2 sites in Denmark
- Volunteers
- 150 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Ischemic Stroke
Remote Ischaemic Conditioning in Endovascular Recanalization for Proximal Anterior Circulation Occlusion Study
Ischaemic stroke causes significant morbidity and mortality and is a leading cause of disability within an ageing United Kingdom (UK) population.
- Trial name
- RICE PAC (NCT03152799)
- Testing
- RIPC Remote Ischaemic Pre-Conditioning
- Volunteers
- 60 people
- Sponsor
- University College, London
Bladder Cancer, Brain and Central Nervous System Tumors
Lapatinib and Paclitaxel in Treating Patients With Advanced Solid Tumors
RATIONALE: Drugs used in chemotherapy, such as paclitaxel, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing.
- Conditions
- Bladder Cancer, Brain and Central Nervous System Tumors, Breast Cancer, Esophageal Cancer
- Trial name
- NCT00313599
- Testing
- lapatinib, paclitaxel
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- University of California, San Francisco
Fibromyalgia
Safety Study of DS-5565 for Treatment of Fibromyalgia Pain in Subjects With Chronic Kidney Disease
DS-5565 (mirogabalin) is being studied as treatment for fibromyalgia (FM) pain. Because it is excreted through the kidneys, people who have reduced kidney function will not process the drug as well as with those with normal…
- Trial name
- NCT02496884
- Testing
- DS-5565
- Where
- 39 sites in United States, Bulgaria and 6 more
- Volunteers
- 56 people
- Sponsor
- Daiichi Sankyo
Emergence Delirium
AGItated Patients Management: intraNASAL Midazolam vs Intramuscular Loxapine
This study is a non-inferiority phase III randomized trial evaluating the effect of intranasal midazolam versus intramuscular loxapine on the rapid tranquilization of agitated patient in emergency department.
- Trial name
- AGINASAL (NCT05324852)
- Testing
- Intranasal midazolam, Intramuscular loxapine
- Where
- France
- Volunteers
- 1 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Delirium, Postoperative, Surgical Procedure
Polish Validation 4AT Tool
Delirium is a phenomenon which affects patients with various disorders and representing various age groups. Screening instruments make it possible to diagnose the condition at an early stage and to prevent its development.
- Trial name
- NCT04563858
- Testing
- Validation
- Where
- Poland
- Volunteers
- 444 people
- Sponsor
- Andrzej Frycz Modrzewski Krakow University
Phantom Limb Pain
Virtual Reality for Phantom Limb Pain
This study will develop a virtual reality-based treatment for phantom limb pain among Veterans and test it against the most established behavioral therapy for phantom limb pain, mirror therapy.
- Trial name
- NCT02784548
- Testing
- Virtual Reality
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- VA Office of Research and Development
Drug/Agent Toxicity by Tissue/Organ, Leukemia
Growth Factor to Prevent Oral Mucositis in Patients With Hematologic Cancer
RATIONALE: Keratinocyte growth factor may prevent symptoms of mucositis in patients receiving radiation therapy and chemotherapy.
- Conditions
- Drug/Agent Toxicity by Tissue/Organ, Leukemia, Lymphoma, Multiple Myeloma and Plasma Cell Neoplasm
- Trial name
- NCT00004132
- Testing
- filgrastim, palifermin, cyclophosphamide
- Where
- United States
- Sponsor
- Jonsson Comprehensive Cancer Center
Agitation
The Effect of Intravenous Fentanyl Prior the End of Surgery on Emergence Agitation in Paediatric Patients After General Anesthesia
The propose of this study is to determine the effect of intravenous fentanyl prior the end of surgery on the incidence and severity of EA in pediatric patient.
- Trial name
- NCT01440114
- Testing
- fentanyl, NSS
- Where
- Thailand
- Volunteers
- 144 people
- Sponsor
- Prince of Songkla University
Carcinomas, Amyloidosis
B-Receptor Signaling in Cardiomyopathy
We hope to determine the importance of different genes (including B receptors) in anthracycline-induced cardiomyopathy. This has important benefits to patients exposed to anthracyclines, as this could help determine whether…
- Conditions
- Carcinomas, Amyloidosis, Anal Cancer, Anemia
- Trial name
- NCT01135849
- Where
- United States
- Volunteers
- 99 people
- Sponsor
- Daniel Bernstein
Cancer, All Types, Cancer of Liver
The PIONEER Initiative: Precision Insights On N-of-1 Ex Vivo Effectiveness Research Based on Individual Tumor Ownership (Precision Oncology)
The PIONEER Initiative stands for Precision Insights On N-of-1 Ex vivo Effectiveness Research. The PIONEER Initiative is designed to provide access to functional precision medicine to any cancer patient with any tumor at any…
- Conditions
- Cancer, All Types, Cancer of Liver, Cancer of Stomach, Cancer of Head and Neck
- Trial name
- PIONEER (NCT03896958)
- Where
- United States
- Volunteers
- 1,000 people
- Sponsor
- SpeciCare
Pain, Procedural, Pain, Postoperative
The Effect of Vibration and Cold on Pain and Anxiety Associated With Chest Tube Removal Following CABG
Removal of chest tubes after coronary artery bypass graft (CABG) surgery can cause severe pain and anxiety, which may negatively affect the recovery process.
- Conditions
- Pain, Procedural, Pain, Postoperative, Coronary Artery Bypass Surgery, Chest Tubes
- Trial name
- CABG (NCT06217263)
- Testing
- Vibration device, Vibration device&Cold application pack
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 93 people
- Sponsor
- Istanbul University - Cerrahpasa
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