Clinical trials: Nervous System Complication
Diabetic Neuropathy
The Balance Control Mechanism of DPN Patients
This study will evaluate the balance ability of DPN (diabetic peripheral neuropathy)patients, which will help us to understand the relationship between peripheral and central nervous system, in order to early diagnosis and…
- Trial name
- NCT02606747
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Geheng Yuan
Spinal Cord Injury, Neurogenic Bladder
Multifaceted Treatment of Catheter-related Urinary Tract Infection
The specific objective of this clinical trial is to demonstrate that a multifaceted approach for treatment for catheter-related urinary tract infection (UTI) in patients with spinal cord injury is effective and feasible.
- Conditions
- Spinal Cord Injury, Neurogenic Bladder, Urinary Tract Infection
- Trial name
- NCT00732238
- Testing
- Shortened course of antibiotic therapy, Standard Therapy
- Where
- United States
- Volunteers
- 61 people
- Sponsor
- US Department of Veterans Affairs
Postoperative Delirium (POD), Perioperative Neurocognitive Disorders
Ortopod CZ Pilot Study
ORTOPOD PILOT STUDY is a non-randomized, non-interventional clinical study that addresses the issue of perioperative neurocognitive disorder (deterioration of cognitive functions in the preoperative and perioperative period) and…
- Trial name
- ORTOPODCZ (NCT06869876)
- Where
- Czechia
- Volunteers
- 75 people
- Sponsor
- Tomas Bata Hospital, Czech Republic
End Stage Renal Disease, Chronic Kidney Disease
Different Doses of Oral Melatonin Supplements in Chronic Kidney Disease (CKD)-Associated Sleep Disorders
The study will evaluate the safety and efficacy of melatonin supplementation in CKD and ESRD patients with sleep disorders to reduce sleep latency times, the number of apnea/hypopneic episodes, and prolong duration in rapid eye…
- Conditions
- End Stage Renal Disease, Chronic Kidney Disease, Sleep Disorder
- Trial name
- NCT01922999
- Testing
- Melatonin
- Where
- United States
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- Southeast Renal Research Institute
Subarachnoid Hemorrhage, Acute Kidney Injury
A Low ChloridE hyperTonic Solution for Brain Edema
This pilot study will compare the two hypertonic solutions currently used for subarachnoid hemorrhage (SAH) - related complications and to determine if the reduction of chloride load is safer, and as efficacious as the classic…
- Trial name
- ACETATE (NCT03204955)
- Testing
- Sodium chloride /sodium acetate (16.4%), Sodium chloride (23.4%), PlasmaLyte
- Where
- United States
- Volunteers
- 59 people
- Sponsor
- Emory University
Deglutition Disorders
Prevalence, Risk Factors and Complications of Oropharyngeal Dysphagia in Stroke Patients
Oropharyngeal dysphagia (OD) is a common morbidity after stroke that disrupts swallowing physiology. The investigators aimed at evaluating the prevalence of oropharyngeal dysphagia (OD) after stroke and analysing the risk factors…
- Trial name
- Marato-11 (NCT03147755)
- Testing
- No intervention
- Volunteers
- 395 people
- Sponsor
- Pere Clave
Sleep Apnea, Obstructive, Child
Effect of CPAP and Adenotonsillectomy in Upper Airway Volume of Children With OSAS
Obstructive sleep apnea syndrome (OSAS) in children has high prevalence and severe complications, and its first line of treatment (adenotonsillectomy) has risk of complications.
- Conditions
- Sleep Apnea, Obstructive, Child, Continuous Positive Airway Pressure, Adenoidectomy
- Trial name
- NCT03169491
- Testing
- Continuous positive airway pressure (CPAP)
- Where
- Mexico
- Volunteers
- 150 people
- Sponsor
- Instituto Nacional de Enfermedades Respiratorias
Delirium, Surgery-Complications
Mitigating Delirium With Fluvoxamine Treatment for Non-Cardiac Surgery
The investigation will establish biological plausibility and infrastructure required for a multisite clinical trial evaluating the re-purposing of fluvoxamine to mitigate postoperative delirium risk in geriatric patients…
- Trial name
- MD FluNCS (NCT06969287)
- Testing
- Fluvoxamine
- Where
- United States
- Volunteers
- 46 people
- Sponsor
- Washington University School of Medicine
Painful Diabetic Neuropathy
The Benefits of Astaxanthin as Add on Therapy in the Management of Painful Diabetic Neuropathy Patient
Diabetes is one of the main health care problemsworldwide with 5% average increased number of cases every year. According to International Diabetes Federation the prevalence of people with diabetes reached the number of 425…
- Trial name
- NCT04689984
- Testing
- Standard therapy, Astaxanthin
- Where
- Indonesia
- Volunteers
- 60 people
- Sponsor
- Duta Wacana Christian University
Cancer
Cyproheptadine in Preventing Weight Loss in Children Receiving Chemotherapy for Cancer
RATIONALE: Cyproheptadine hydrochloride may prevent weight loss caused by cancer or cancer treatment. It is not yet known whether cyproheptadine is more effective than a placebo in preventing weight loss in young patients…
- Trial name
- NCT01132547
- Testing
- cyproheptadine hydrochloride
- Where
- 14 sites in United States
- Volunteers
- 22 people
- Sponsor
- University of South Florida
Dental Anxiety, Sedation Complication
Remimazolam in the Extraction of Impacted Wisdom Teeth
Benzodiazepines, represented by midazolam, are often used for sedation in outpatient surgery in dentistry. However, midazolam has the problems of slow consciousness recovery and long recovery time, which brings trouble to the…
- Conditions
- Dental Anxiety, Sedation Complication, Anterograde Amnesia
- Trial name
- NCT05350085
- Testing
- Remimazolam besylate, Midazolam
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Peking Union Medical College Hospital
Urinary Incontinence
A Comparison of Tolterodine and Placebo Treatments on Nocturnal Frequency and Sleep Quality in Women After Menopause.
This study is being done to compare frequency of urination during the night when women take tolterodine tablets vs. when they take placebo tablets.
- Trial name
- NCT00323635
- Testing
- tolterodine
- Where
- 2 sites in United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Diabetic Peripheral Neuropathic Pain (DPN), Diabetic Neuropathies
Cannabidiol for the Treatment of Diabetic Peripheral Neuropathy: Pilot Study
The "Cannabidiol for the Treatment of Diabetic Peripheral Neuropathy: Pilot study (CBD-DPN1)" is a double-blinded, placebo-controlled, crossover pilot study evaluating the efficacy of Cannabidiol (CBD) and full-spectrum CBD…
- Trial name
- CBD-DPN1 (NCT07298408)
- Testing
- Cannabidiol (CBD) oral solution, Full-Spectrum CBD hemp extract oral solution
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Florida A&M University
Deafness, Kidney Diseases
Endolymphatic Sac Tumors in a Population of Patients With Von Hippel-Lindau Disease:The Natural History and Pathobiology, and a Prospective Non-Randomized Clinical Trial of Hearing Preservation Surgery in Patients With Early Stage Endolymphatic Sac Tumors
The von Hippel Lindau (VHL) gene has recently been identified as the genetic defect resulting in a syndrome of multiple neoplasias.
- Conditions
- Deafness, Kidney Diseases, Kidney Neoplasms, Neoplasms
- Trial name
- NCT00001668
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Parkinson's Disease
An Extension of Istradefylline in Parkinson's Disease Patients Who Have Completed Studies 6002-EU-007, 6002-US-013 or 6002-US-018
This is a 1-year, open-label, long-term safety extension for patients who have completed prior istradefylline studies 6002-EU-007, 6002-US-013 or 6002-US-018.
- Trial name
- NCT00199368
- Testing
- Istradefylline ( KW-6002)
- Where
- United States
- Volunteers
- 1,100 people
- Sponsor
- Kyowa Kirin, Inc.
Alopecia Areata, Depressive Episode
The Epidemiology, Management, and the Associated Burden of Related Conditions in Alopecia Areata
This study series consists of four related studies and aims to explore and describe many important elements of alopecia areata over three key areas: (1) the current epidemiology of alopecia areata, (2) the prevalence and…
- Conditions
- Alopecia Areata, Depressive Episode, Recurrent Depressive Disorder, Anxiety Disorders
- Trial name
- NCT04239521
- Testing
- Exposure of interest (studies 2 & 3).
- Where
- United Kingdom
- Volunteers
- 51,955 people
- Sponsor
- Momentum Data
Pain, Postoperative
Erector Spinae Plane Block for Post-thoracotomy Pain
Post-thoracotomy pain is one of the most severe forms of post-operative pain. Among the most common techniques for the management of post-thoracotomy pain, there are the intercostal nerve block, and a recently described block…
- Trial name
- NCT04013815
- Testing
- erector spinae plane block with ropivacaine, Intercostal nerve block with ropivacaine
- Where
- Italy
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Roma La Sapienza
Brain Damage, Postoperative Cognitive Dysfunction
Liver Transplant Does it Affect the Brain
Neuronal damage caused by neuroinflammation in patients undergoing major surgery is the most determinant factor of postoperative cognitive disfunction (POCD).
- Conditions
- Brain Damage, Postoperative Cognitive Dysfunction, Neuron Specific Enolase, Glial Fibrillary Acidic Protein
- Trial name
- NCT04368052
- Testing
- Mini Mental Test (MMT), S-100 beta, Neuron specific enolase and Glial fibrillary acidic protein
- Where
- Turkey (Türkiye)
- Volunteers
- 33 people
- Sponsor
- Ege University
Diabetes Complications, Diabetic Neuropathies
Development and Testing of a New Generation of Diabetic Footwear
This particular trial is looking to compare the effectiveness of two types of foot bed/ sole materials used within diabetic footwear.
- Trial name
- DiaBSmart (NCT01816906)
- Testing
- Footwear :PU, Footwear: MCP
- Where
- India
- Volunteers
- 82 people
- Sponsor
- Staffordshire University
Diabetic Neuropathies
A Trial Of [S,S]-Reboxetine In Patients With Chronic Painful Diabetic Peripheral Neuropathy.
This is a trial to investigate the effectiveness and safety of [S,S]-Reboxetine in relieving chronic peripheral pain suffered by patients with diabetes.
- Trial name
- NCT00625833
- Testing
- [S,S]-Reboxetine
- Where
- 56 sites in United States, Czechia and 4 more
- Volunteers
- 330 people
- Sponsor
- Pfizer
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