Clinical trials: Nervous System Diseases
Subacromial Impingement Syndrome, Shoulder Tendinitis
Subacromial Impingement Syndrome Functional Tests Correlation With Ultrasound Parameters
In this study, among the patients who applied to the Physical Medicine and Rehabilitation outpatient clinic of Muğla Training and Research Hospital and were diagnosed with subacromial impingement by anamnesis and clinical tests…
- Conditions
- Subacromial Impingement Syndrome, Shoulder Tendinitis, Shoulder Bursitis, Shoulder Pain
- Trial name
- NCT06384430
- Testing
- Shoulder functional tests and ultrasound
- Where
- Turkey (Türkiye)
- Volunteers
- 70 people
- Sponsor
- Muğla Sıtkı Koçman University
Stroke
Remediation of the Non-Paretic Arm in Stroke
Stroke survivors with severe contralesional paresis often have substantial control and coordination deficits in the non-paretic arm.
- Trial name
- NCT03062930
- Testing
- Track 1, Track 2
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Milton S. Hershey Medical Center
Central Nervous System Lymphoma, Non-Hodgkin Lymphoma
Secondary Central Nervous System Lymphoma Registry - Charité
The objective of the observation is to collect and document data on treatment strategies for secondary central nervous system lymphoma (SCNSL) in routine clinical practice, whether obtained in the context of clinical trials or…
- Trial name
- NCT05114330
- Where
- Germany
- Volunteers
- 300 people
- Sponsor
- Charite University, Berlin, Germany
Cervical Spinal Cord Injury
Efficacy of a Brain-Computer Interface Controlled Functional Electrical Stimulation Therapy for Spinal Cord Injury Neurorehabilitation
The study's main goal is to determine the efficacy of a therapy with brain-computer interface controlled functional electrical stimulation for neurorehabilitation of spinal cord injury patients' upper limbs.
- Trial name
- NCT05343130
- Testing
- Brain-Computer Interface
- Where
- Mexico
- Volunteers
- 32 people
- Sponsor
- Instituto Nacional de Rehabilitacion
Parkinson Disease
Study to Assess the Safety, Tolerability and Pharmacokinetic Profile of PBF -509 (80 mg, 160 mg and 240 mg) "After Multiple Oral Doses" in Healthy Volunteers
Study to assess the safety and tolerability of three doses of PBF-509 (80 mg, 160 mg and 240 mg) after repeated (8 days) single daily oral dose administration in young male and female healthy subjects.
- Trial name
- NCT02111330
- Testing
- PBF-509
- Where
- 2 sites in Spain
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Stroke, Hemiplegia
CUped: An Approach to Motor Recovery Post-Stroke, Not Compensation
The goal of lower limb rehabilitation after stroke is recovery of independent walking at home and in the community. Few stroke survivors achieve this goal.
- Trial name
- NCT06329765
- Testing
- Exercise with CUped - a motor-assisted, split crank pedaling device and undergo 50 m of gait training.
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Marquette University
X-Linked Adrenoleukodystrophy
Safety, Pharmacokinetics and Pharmacodynamics of NV1205 in Pediatric Male Subjects With Adrenoleukodystrophy
This is a phase I/II, open label dose escalation study of multiple dose levels of NV1205 with a long-term treatment phase.
- Trial name
- NCT03196765
- Testing
- Sobetirome (NV1205)
- Where
- 13 sites in Argentina, Australia and 6 more
- Sponsor
- NeuroVia, Inc.
Developmental Language Disorders, Language Development
Understanding the Predictive Factors and the Neurocognitive Basis of Developmental Language Disorder
For most children, language acquisition might appear like an effortless phenomenon, mostly arising from informal daily interaction with their surrounding people.
- Trial name
- NCT04253600
- Testing
- Risk profile screening questionnaire, Investigation of the neural correlates of DLD using Magnetic Resonance Imagery (MRI), Online investigation of predictive factors associated with DLD and LANCOM app development
- Where
- 2 sites in Belgium
- Volunteers
- 1,500 people, healthy volunteers welcome
- Sponsor
- Université Catholique de Louvain
Parkinson's Disease (PD)
Effect of Two Multiple-dose Regimens of BIA 3-202 on the Pharmacokinetics and Motor Response of Levodopa, and on the Erythrocyte Comt Activity in Parkinson's Disease Patients
The purpose of this study is to determine the effect of two different multiple-dose regimens of nebicapone in comparison to placebo and entacapone 200 mg on the pharmacokinetics of levodopa in Parkinson's Disease (PD) patients.
- Trial name
- NCT02834507
- Testing
- BIA 3-202, Comtan®, Sinemet®
- Volunteers
- 19 people
- Sponsor
- Bial - Portela C S.A.
Tendinopathy
Efficacy of Therapeutic Percutaneous Electrolysis Simple vs Multiple vs Laser Therapy in Supraspinatus Tendinopathy.
Supraspinatus tendinopathy is one of the main pathologies that cause functional alterations in the glenohumeral joint. It reduces the quality of life of the population suffering from this injury.
- Trial name
- NCT07695792
- Testing
- Simple electrolysis percutaneous, Multifiliar Electrolysis percutaneus, Laser
- Where
- Spain
- Volunteers
- 90 people
- Sponsor
- Universidad Pontificia de Salamanca
Postoperative Confusion
Automated Visual Monitoring for Improving Patient Safety (VIPSafe)
After an operation many patients are in a confused mental status at the intensive care unit. In this status they possibly fall out of their bed or pull out endotracheal tubes or central venous catheters accidentally.
- Trial name
- VIPSafe (NCT01317407)
- Where
- Germany
- Volunteers
- 100 people
- Sponsor
- Staedtisches Klinikum Karlsruhe
Migraine, Headaches
Effect on Migraine Frequency of Combined Anti-oxidant Therapy: The MIGRANT Study.
Migraine affects 15% of Western Australians and is a leading cause of suffering and disability in our community (1,2). Research suggests that inflammation of the brain's coverings (meninges) by nerve cell inflammation and the…
- Trial name
- MIGRANT (NCT02629536)
- Testing
- N-acetyl cysteine 600 mg, VitE 250 IU, VitC 500 mg tablet
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University of Notre Dame Australia
Parkinson Disease
Post-Physical Therapy Extension of In-Home Dynamic Standing Table Use in Parkinson Disease
When postural imbalance and gait difficulties emerge in subjects with Parkinson disease, patients are typically referred for a number of physical therapy sessions.
- Trial name
- NCT03045211
- Testing
- Dynamic Standing Table
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- University of Michigan
Stroke
Effects of Task-Based Mirror Therapy for Post-stroke Shoulder-Hand Syndrome
The study aims to determine the effects of task-based mirror therapy on edema, pain and upper limb motor function with shoulder-hand syndrome in post stroke patients.
- Trial name
- NCT07428811
- Testing
- Task based mirror therapy, Conventional exercises
- Where
- 2 sites in Pakistan
- Volunteers
- 34 people
- Sponsor
- Riphah International University
Pain, Knee Osteoarthritis
A Study to Evaluate the Efficacy and Safety of CG5503 Prolonged Release (PR) in Subjects With Moderate to Severe Chronic Pain Due to Osteoarthritis of the Knee
The purpose of this study is to evaluate whether tapentadol (CG5503) prolonged-release (PR) tablets at doses of 100-250 mg twice daily provide a better pain relief in patients with moderate to severe chronic pain due to…
- Trial name
- NCT00486811
- Testing
- Tapentadol ER (100 to 250 mg twice daily), Oxycodone CR (20 to 50 mg twice daily)
- Where
- 100 sites in Austria, Croatia and 11 more
- Volunteers
- 990 people
- Sponsor
- Grünenthal GmbH
Sleep Deprivation, Performance
Impact of Sleep Deprivation and Caffeine in Medical Professionals
While the negative impact of sleep deprivation on cognitive processing and the partial reversal of this phenomenon by caffeine are well known, the types of cognitive processing previously studied have been limited to simple…
- Trial name
- NCT04273841
- Testing
- Military Energy Gum
- Where
- United States
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- Walter Reed Army Institute of Research (WRAIR)
Mild Cognitive Impairment, Alzheimer Disease
Behavioral Change Following Alzheimer's Disease (AD) Biomarker Disclosure
The proposed project will assess long-term changes to health/lifestyle, advanced planning, and research engagement that Black and White patients with Amnestic Mild Cognitive Impairment (aMCI) make following disclosure of positron…
- Conditions
- Mild Cognitive Impairment, Alzheimer Disease, Amnestic Mild Cognitive Disorder
- Trial name
- SHARED III (NCT05584241)
- Testing
- Diagnostic Disclosure Protocol, Biomarker Disclosure Protocol
- Where
- United States
- Volunteers
- 102 people
- Sponsor
- University of Michigan
Motor Activity
The Reliability of the Nine Hole Peg Test in Patients With Multiple Sclerosis
The main aim of the project is to establish inter-rater reliability, internal variability and variability of results got in two different ways of the Nine Hole Peg Test administered according to the new Czech extended version…
- Trial name
- NCT05012241
- Testing
- Nine Hole Peg Test
- Where
- 2 sites in Czechia
- Volunteers
- 33 people
- Sponsor
- Charles University, Czech Republic
Parkinson Disease
Studying Movement Control in Parkinson's Disease Using Closed Loop Deep Brain Stimulation
Parkinson's disease is a common, disabling, progressive condition characterised by severe problems with movement for which medical treatment in the longer term can be unsatisfactory.
- Trial name
- NCT02585154
- Testing
- Deep Brain Stimulation applied through custom built external stimulator (Little et al., 2013, 2015), closed-loop Deep Brain Stimulation applied through custom built external stimulator (Little et al., 2013, 2015), Deep Brain Stimulation off
- Where
- 2 sites in United Kingdom
- Volunteers
- 30 people
- Sponsor
- University of Oxford
Shoulder Pain
The Effectiveness of Massage Therapy in Patients With Shoulder Pain
The goal of this clinical trial is to evaluate the effectiveness of massage in pain reduction and its influence on the range of motion of the shoulder complex in SP. The main questions it aims to answer are: 1.
- Trial name
- NCT06520254
- Testing
- Massage therapy
- Where
- Poland
- Volunteers
- 30 people
- Sponsor
- Wroclaw University of Health and Sport Sciences