Clinical trials: Nervous System Disorders
Amyotrophic Lateral Sclerosis (ALS)
Remotely Supervised tDCS for Slowing ALS Disease Progression
Most ALS care is centered on patient support and symptom management, making rehabilitation an integral aspect for slowing disease progression, prolonging life span, and increasing quality of life.
- Trial name
- NCT04866771
- Testing
- Transcranial Direct Current Stimulation (tDCS)
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- University of Illinois Chicago
Stroke, Upper-limb Paresis
Automatic Versus Intentional Movement Exercises to Enhance Arm Functions After Stroke
Many patients retain upper-limb motor impairment following stroke. Most conventional rehabilitation techniques are aimed to improve motor intentional movement by repeated exercises.
- Trial name
- AUTOTAB (NCT01565044)
- Testing
- motor training
- Where
- France
- Volunteers
- 26 people
- Sponsor
- Hospices Civils de Lyon
Vestibular Function Tests
Computerized Rotational Head Impulse Test-Vertical (crHIT-vertical)
The purpose of this research study is to test whether a Computerized Rotational Head Impulse Test-Vertical (crHIT-vertical) is able to reliably evaluate the vertical semicircular canals in patients with vestibular dysfunctions.
- Trial name
- NCT04087044
- Testing
- Computerized Rotational Head Impulse Test ( crHIT)-Vertical
- Where
- 3 sites in United States
- Volunteers
- 186 people, healthy volunteers welcome
- Sponsor
- Neurolign
Alzheimer Disease, Late Onset, Cognitive Impairment
Effects of Personalized Music Listening in Advanced Alzheimer's
Recent functional imaging studies have facilitated a better understanding of the neuroplasticity mechanisms underlying the strong and multifaceted effects of music on brain development.
- Trial name
- NCT06765434
- Testing
- Music ( Dmitri Shostakovich's Jazz Waltz Suite), Music( Personalized music)
- Where
- Turkey (Türkiye)
- Volunteers
- 54 people
- Sponsor
- Okan University
Episodic Migraine
A Study Evaluating the Effectiveness of AMG 334 Injection in Preventing Migraines in Adults Having Failed Other Therapies
The purpose of this study is to determine if AMG 334 is effective in treating migraines in patients who have failed other preventive migraine treatments.
- Trial name
- NCT03096834
- Testing
- AMG334 (70 mg) Pre-Filled Syringe (PFS)
- Where
- 59 sites in Australia, Austria and 14 more
- Volunteers
- 246 people
- Sponsor
- Novartis Pharmaceuticals
Multiple Sclerosis, Pelvic Floor Dysfunction
Relationship Between Pelvic Floor Dysfunctions and Lower Limb Strength and Activation in MS Patients
we aim to investigate the relationship between pelvic floor dysfunctions, core endurance, hip external rotation muscle strength, and tibialis posterior and tibialis anterior muscle activation in patients diagnosed with MS
- Trial name
- NCT06777134
- Testing
- Assessment of pelvic floor dysfunction, The Quality of Life Assessment, Core endurance assessment
- Where
- Turkey (Türkiye)
- Volunteers
- 73 people
- Sponsor
- Berivan Beril Kılıç
Multiple Sclerosis
Observational Study for Assessment of the Effect of Fampyra on the Manual Function of Persons With Multiple Sclerosis
Multiple Sclerosis (MS) is the most common chronic neurological disease affecting young adults, with onset usually at age 20-40 years. Women are affected 3-4 times more than men.
- Trial name
- NCT01547234
- Where
- Israel
- Volunteers
- 47 people
- Sponsor
- Carmel Medical Center
Stroke, Seizures
Epilepsy Watch After Vascular Events: Frequency, Outcomes, and Risk Markers
This research aims to determine the frequency of seizures in patients following a stroke, identify risk factors associated with post-stroke seizures, and characterize EEG changes linked to these seizures.
- Conditions
- Stroke, Seizures, EEG Power Spectra, Serum Biomarkers
- Trial name
- EY-WAVEFORMS (NCT06922734)
- Where
- Slovenia
- Volunteers
- 602 people, healthy volunteers welcome
- Sponsor
- University Medical Centre Maribor
Stroke
F@ce 2.0 a Mobile Phone-supported and Family-centred Rehabilitation Intervention After Stroke in Uganda
The purpose of the present proposal is to implement and evaluate a new model for mobile phone supported and family-centred rehabilitation intervention (F@ce 2.0) with regard to functioning in activities in daily living and…
- Trial name
- NCT04337034
- Testing
- Mobile phone supported and family-centred rehabilitation, Information and blood pressure measurement
- Where
- 3 sites in Uganda
- Volunteers
- 98 people
- Sponsor
- Karolinska Institutet
S100B, Neutrophils/Lymphocytes Ratio
Protein S100B Versus Neutrophils/Lymphocytes Ratio in Early Prediction of Brain Injury
The study aimed to evaluate the role of Protein S100B versus the neutrophil-to-lymphocyte ratio (NLR) as an early predictor biomarker and the value of amplitude-integrated electroencephalography (aEEG) as an early predictor and…
- Conditions
- S100B, Neutrophils/Lymphocytes Ratio, Prediction, Brain Injury
- Trial name
- NCT07093723
- Testing
- S100B Protein, Neutrophils to Lymphocytes ratio
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Tanta University
Fibromyalgia
Investigation of AVACEN Thermal Exchange System for Fibromyalgia Pain
Hypothesis: Daily use of the AVACEN Thermal Exchange System for 4 weeks will show improved Fibromyalgia pain and functioning markers, as assessed by biomarkers and clinical and psychological assessment.
- Trial name
- AVACEN: TES (NCT01619579)
- Testing
- AVACEN Thermal Exchange System
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- Avacen, Inc.
Brain Neoplasm, Intracranial Pressure Increase
Non-invasive Intracranial Pressure Monitoring in Brain Tumor Patients
This research protocol focuses on the pre- and post-operative evaluation of ICP using non-invasive methods, particularly in the context of surgery for brain tumor removal.
- Trial name
- NCT07286396
- Testing
- Ocular Sonography
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Tanta University
Glioblastoma Multiforme, Brain Tumor
Safety of BBB Disruption Using NaviFUS System in Recurrent Glioblastoma Multiforme (GBM) Patients
This study is to evaluate the safety and find the tolerated ultrasound dose of transient opening of the blood-brain barrier (BBB) by using the NaviFUS System in recurrent GBM patients.
- Conditions
- Glioblastoma Multiforme, Brain Tumor, Glioblastoma, Glioma
- Trial name
- NCT03626896
- Testing
- NaviFUS System
- Where
- Taiwan
- Volunteers
- 6 people
- Sponsor
- NaviFUS Corporation
C.Surgical Procedure, Stress
Music Therapy as an Adjunct in CIED Lead Extraction Procedures
The study will investigate possible effects of music therapy as an adjunct in an invasive cardiac procedure where infected or broken pacemaker leads, or leads from implantable cardioverter-defibrillators are removed from inside…
- Conditions
- C.Surgical Procedure, Stress, Pain, Procedural, Anxiety
- Trial name
- MATH (NCT04172662)
- Testing
- Facilitated Music Listening
- Where
- Norway
- Volunteers
- 68 people
- Sponsor
- Oslo University Hospital
Tardive Dyskinesia
Efficacy, Safety, and Tolerability of NBI-1065890 Versus Placebo in Adults With Tardive Dyskinesia
The primary objective of this study is to evaluate the efficacy of NBI-1065890 compared with placebo for the treatment of tardive dyskinesia (TD) in adult participants.
- Trial name
- NCT07365462
- Testing
- NBI-1065890
- Where
- 18 sites in United States
- Volunteers
- 100 people
- Sponsor
- Neurocrine Biosciences
Tarlov Cysts
Case Report of Nerve Root Sleeve Reinforcement and Reconstruction and Sacral Canal Plasty for the Treatment of Sacral Canal
A retrospective study of the changes in the VAS scores and imaging examinations after the reconstruction and reinforcement of nerve root sleeves and caudal angioplasty for the treatment of sacral cysts from August 2017 to January…
- Trial name
- NCT04960462
- Testing
- nerve root sleeve reinforcement
- Where
- China
- Volunteers
- 24 people
- Sponsor
- Peking University Third Hospital
Gaucher Disease
Nutritional Status of Gaucher Disease Patients
This cross-sectional study aims to evaluate the nutritional status of patients with Gaucher disease attending Assiut University Children's Hospital using anthropometric measurements and body composition analysis.
- Trial name
- NCT07845188
- Volunteers
- 84 people
- Sponsor
- Assiut University
Stroke, Acute, Stroke, Ischemic
Personalized Patient and Caregiver Education After Stroke
This is a randomized pilot trial to evaluate the impact of a customizable stroke education app (vs standard of care discharge education) on patient satisfaction and education retention.
- Conditions
- Stroke, Acute, Stroke, Ischemic, Stroke
- Trial name
- MyStroke (NCT05118503)
- Testing
- Customized education, Standard of care discharge education
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- University of Pennsylvania
Hip Fractures, Stroke
Accuracy Activity Monitors for Inhospital Activity Monitoring of Geriatric Patients
The focus of this study will be to determine the accuracy of the MOX, the Axivity and Fitbit, Empatica and Chill+ activity monitors (with both custom-made and available algorithms) for the classification of lying, sitting…
- Conditions
- Hip Fractures, Stroke, Abdominal Injury
- Trial name
- NCT04865627
- Testing
- activity monitor
- Where
- Belgium
- Volunteers
- 20 people
- Sponsor
- KU Leuven
Alzheimer's Disease, Dementia
A Study of Acupuncture for Patients With Behavioural and Psychological Symptoms of Dementia
The purpose of the study is to evaluate the safety and tolerability of acupuncture for patients with BPSD \& healthy volunteers.
- Trial name
- NCT01055561
- Testing
- Acupuncture
- Where
- China
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Chengdu University of Traditional Chinese Medicine
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