Clinical trials: Nervous System Disorders
Age-related Hearing Loss, Cognitive Decline
Study of Cognitive Reserve Disorder Affecting Depression in Aged Related Hearing Loss Via Rest State EEG
In this study, patients with aged-related hearing loss with depression and without depression were evaluated by audiometry (pure tone audiometry and speech audiometry), cognitive function assessment (MMSE scale for simple mental…
- Conditions
- Age-related Hearing Loss, Cognitive Decline, Depression
- Trial name
- NCT05892731
- Testing
- with depression, without depression
- Where
- China
- Volunteers
- 44 people
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Muscle Fatigue (C23.888.592.612.612), Muscle Weakness or Atrophy
A Biomechanical Study of Collaborative FES on Lower Limb Motor Function in the Elderly
This study will first conduct a precise assessment of the differences in muscle coordination among the elderly through muscle synergy analysis; then, based on this, it will extract abnormal synergy patterns and muscle activation…
- Trial name
- NCT07245602
- Testing
- Collaborative Functional Electrical Stimulation, Traditional functional electrical stimulation
- Volunteers
- 30 people
- Sponsor
- Chen Xuan
Deep Learning
Automated Detection and Diagnosis of Pathological DRGs in PHN Patients Using Deep Learning and Magnetic Resonance
Here, this study aimed to develop an automated system for detecting and diagnosing lesion DRGs in PHN patients based on deep learning.
- Trial name
- NCT06274502
- Testing
- YOLOv8
- Where
- 2 sites in China
- Volunteers
- 41 people
- Sponsor
- Huazhong University of Science and Technology
Progressive Supranuclear Palsy, Brain Diseases
Personalized Parkinson Project PSP Cohort
There is an urgent need for the development of digital progression biomarkers, which are sensitive to detect small, but potentially clinically relevant changes in the disease course.
- Conditions
- Progressive Supranuclear Palsy, Brain Diseases, Neurodegenerative Diseases, Movement Disorders
- Trial name
- PPP-PSP (NCT05501431)
- Testing
- Verily Study Watch
- Where
- Netherlands
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Chronic Fatigue Syndrome
Transcutaneous Vagus Nerve Stimulation as a Complementary Therapy to Exercise in Chronic Fatigue
Chronic fatigue is enhanced by adapted physical activity (APA) programs. Patients consulting on St Etienne hospital and suffering from fibromyalgia and long Covid benefit from a 4-6 week APA program, with 2 sessions per week.
- Trial name
- PAF-tVNS (NCT06170645)
- Testing
- APA program, Active transcutaneous VNS
- Where
- France
- Volunteers
- 60 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Hyperandrogenism, Metabolic Cardiovascular Syndrome
Phlebotomy and Polycystic Ovary Syndrome
AIMS To study the effects of the decrease in iron tissue depots after scheduled bloodletting on insulin sensitivity, carbohydrate metabolism, classic and non-classic cardiovascular risk factors in patients with functional…
- Trial name
- NCT02460445
- Testing
- Phlebotomy, ethinylestradiol, Cyproterone Acetate
- Where
- Spain
- Volunteers
- 37 people
- Sponsor
- Manuel Luque Ramírez
Cervical Cancer, Endometrial Cancer
Epidural Analgesia or Patient-Controlled Analgesia in Treating Patients Who Have Undergone Surgery for Gynecologic Cancer
RATIONALE: Giving pain medication into the space between the wall of the spinal canal and the covering of the spinal cord or giving it into a vein may help lessen pain caused by cancer surgery.
- Conditions
- Cervical Cancer, Endometrial Cancer, Fallopian Tube Cancer, Ovarian Cancer
- Trial name
- NCT00295945
- Testing
- fentanyl citrate, hydromorphone hydrochloride, ropivacaine hydrochloride
- Where
- United States
- Volunteers
- 240 people
- Sponsor
- University of California, San Francisco
Sarcopenia
Increase of Handgrip Strength After the Use of Removable Partial Dentures.
A common goal of the health professions is to keep the elderly functional, preventing sarcopenia and frailty. Is there an association between handgrip strength in partially edentulous elderlies after completing their dentition…
- Trial name
- NCT04606745
- Where
- Chile
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Comisión Nacional de Investigación Científica y Tecnológica
Radiculopathy, Musculoskeletal Diseases
Clinical Effectiveness of High-Intensity Laser Therapy in Patients With Cervical Radiculopathy:
This investigation aims to investigate the effect of high intensity laser therapy on radicular symptoms, neuropathic pain, cervical range of motion and quality of life in patients with cervical radiculopathy compared to cervical…
- Conditions
- Radiculopathy, Musculoskeletal Diseases, Cervical Pain, Cervical Radicular Pain
- Trial name
- NCT04734977
- Testing
- High-intensity laser therapy (HILT), Therapeutic Exercise
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people
- Sponsor
- Afyonkarahisar Health Sciences University
Post Herpetic Neuralgia
Efficacy, Tolerability, and Safety of NXN-462 in Patients With Post-Herpetic Neuralgia
The purpose of this study is to investigate whether NXN-462, a selective nNOS inhibitor, is effective in reducing pain levels in patients with post-herpetic neuralgia.
- Trial name
- NCT01748877
- Testing
- NXN-462
- Where
- 25 sites in United States, Canada
- Volunteers
- 188 people
- Sponsor
- NeurAxon Inc.
Acquired Brain Injury
Exploring the Use of the Cognitive Orientation to Daily Occupational Performance Approach (CO-OP) With Children, Teenagers and Young Adults With Executive Functions Deficits Following Severe Acquired Brain Injury
Acquired brain injury (ABI) in childhood are the cause of disabling motor, cognitive and behavioural disorders, with severe consequences on the later development of autonomy and learning, with long-term repercussions on…
- Trial name
- REFECO-OP (NCT04560777)
- Testing
- CO-OP intervention
- Where
- 2 sites in France
- Volunteers
- 12 people
- Sponsor
- Hopitaux de Saint-Maurice
Epilepsy
HOPE-Epilepsy Trial
This a multi-center study to examine whether supplementation with omega 3 fatty acids will reduce seizure frequency in patients with epilepsy .
- Trial name
- HOPE-Epilepsy (NCT01744275)
- Testing
- Omega 3 fatty acids, corn oil
- Where
- Brazil
- Volunteers
- 370 people, healthy volunteers welcome
- Sponsor
- Hospital do Coracao
Cirrhosis, Hepatic Encephalopathy
Brain Energy Metabolism in Patients With Chronic Liver Disease and Impaired Central Nervous System
The purpose of the current study is to look into the pathogenesis of a severe medical condition causing acute episodes on the central nervous system as seen in majority of patients with liver cirrhosis.
- Trial name
- NCT00424957
- Where
- Denmark
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Alzheimer Disease, Dementia
Care Coordination System for People With Dementia
Dementia, a chronic disease of aging, is characterized by progressive cognitive decline that interferes with independent functioning.
- Conditions
- Alzheimer Disease, Dementia, Dementia Alzheimers
- Trial name
- NCT04308512
- Testing
- Active Nili device, Passive Nili system
- Where
- United States
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Bijan Najafi, PhD
Cervicogenic Headache, Central Sensitization
Central Sensitization and Neuropathic Pain in Cervicogenic Headache
Cervicogenic headache is a type of secondary headache that originates from the structures of the neck and can spread toward the head and facial regions.
- Conditions
- Cervicogenic Headache, Central Sensitization, Neuropathic Pain
- Trial name
- NCT07292181
- Testing
- Clinical assessment with standardized questionnaires
- Where
- Turkey (Türkiye)
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Gulseren Demir Karakilic
Physical Disability, CP (Cerebral Palsy)
Evaluating the Impacts of a Single Session of Robot Assisted Gait Training With a Trexo
Early use of robotic gait trainers have shown many benefits, however why these benefits occur and how to maximize them is unknown.
- Conditions
- Physical Disability, CP (Cerebral Palsy), Developmental Disability
- Trial name
- NCT06407219
- Testing
- Robot Assisted Gait Training
- Where
- Canada
- Volunteers
- 50 people
- Sponsor
- University of Calgary
Pain, Anxiety
Virtual Reality During the Removal of Chest Drains in Critically-ill Patients
Appropriate pain and anxiety management of critically-ill patients during bedside procedures remains a big challenge. Clinical Practice Guidelines recommend preemptive analgesia or non-pharmacological interventions, such as…
- Trial name
- NCT05332119
- Testing
- VR glasses, Control group
- Where
- Spain
- Volunteers
- 98 people
- Sponsor
- Gemma Via Clavero
Obstructive Sleep Apnea (OSA), Sleep Apnea - Obstructive
Clinical Trial of the Cryosa System for the Treatment of Obstructive Sleep Apnea (OASIS)
The objective of this study is to evaluate the safety and effectiveness of the Cryosa System when used as intended to perform the Cryosa Procedure.
- Conditions
- Obstructive Sleep Apnea (OSA), Sleep Apnea - Obstructive, OSA
- Trial name
- (OASIS) (NCT07720219)
- Testing
- Cryosa Procedure
- Volunteers
- 130 people
- Sponsor
- Cryosa, Inc.
Sleep Apnea, Obstructive
Mandibular Advancement Device on Sleep Quality in Obstructive Sleep Apnea Patients
Sleep is an important factor that influences long-term quality of life with known health consequences. Obstructive sleep apnea, the most prevalent disease that disturbs sleep, is considered a public health problem.
- Trial name
- DAMOSA (NCT06169228)
- Testing
- mandibular advancement
- Where
- Spain
- Volunteers
- 50 people
- Sponsor
- Instituto de Investigación Sanitaria de la Fundación Jiménez Díaz
Stroke
Hybrid Robot+FES Stroke Rehabilitation
The investigators have developed a novel robot-guided stretching under intelligent control and combine it with active movement training, which helped increase joint ROM, reduce spasticity and joint stiffness, increase muscle…
- Trial name
- NCT04550728
- Testing
- Ankle robot training group, Ankle robot training and functional electrical stimulation(FES) group
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of Maryland, Baltimore
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