Clinical trials: Nervous System Disorders
Stroke, Hemiplegia
The Effect of Modified Constraint Induced Movement Therapy on Upper Extremity Function in Stroke Rehabilitation
The purpose of the study is to determine the effect of Modified Constraint-Induced Movement Therapy and trunk restraint contrasted with conventional physical therapy treatment on improving upper extremity function, balance, and…
- Conditions
- Stroke, Hemiplegia, Chronic Stroke Patients
- Trial name
- mCIMT (NCT06692569)
- Testing
- Conventional Physical Therapy, Modified Constraint Induced Movement Therapy
- Where
- Saudi Arabia
- Volunteers
- 34 people
- Sponsor
- University of Jazan
Delirium, Postoperative, Cardiac Disease
Optic Nerve Sheath Diameter is Associated With Postoperative Delirium in Patients Undergoing Open Heart Surgery
Although the incidence of delirium after cardiac surgery is high, it is not sufficiently recognized. The long-term effects of delirium are likely to be underestimated.
- Conditions
- Delirium, Postoperative, Cardiac Disease, Cardiac Valve Disease
- Trial name
- NCT05942183
- Testing
- ONSD
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people
- Sponsor
- Samsun University
Combat Posttraumatic Stess Disorder, Mild Traumatic Brain Injury
Lithium Augmentation for Hyperarousal Symptoms of Post Traumatic Stress Disorder: Pilot Study
The purpose of this study is to explore the effectiveness of adding lithium carbonate (lithium) to treatment for combat-related post traumatic stress disorder in combat veterans.
- Trial name
- NCT01754883
- Testing
- Lithium Carbonate
- Where
- United States
- Sponsor
- VA Eastern Colorado Health Care System
Multiple Sclerosis, Urinary Incontinence (UI)
URINARY INCONTINENCE AND PELVIC FLOOR MUSCLE ACTIVITY IN MULTIPLE SCLEROSIS
This study aims to investigate the relationship between urinary incontinence severity and surface electromyography (EMG) findings in women with multiple sclerosis.
- Trial name
- MS-UI-PFM (NCT07489794)
- Where
- Turkey (Türkiye)
- Volunteers
- 47 people
- Sponsor
- Prof. Dr. Cemil Tascıoglu Education and Research Hospital Organization
Fibromyalgia, Posttraumatic Stress Disorder
Fibromyalgia in Men Suffering From PTSD
Assessing FM and psychiatric state among PTSD, MDD and healthy participants
- Conditions
- Fibromyalgia, Posttraumatic Stress Disorder, Major Depressive Disorder
- Trial name
- NCT00229294
- Volunteers
- healthy volunteers welcome
- Sponsor
- Sheba Medical Center
Alzheimer Disease, Aging
Spatial and Ocular Trajectories for the Early Diagnosis of Alzheimer's Disease.
Spatial navigation is a high-level cognitive function that enables humans to orientate themselves and move around in space by constructing a mental representation of the environment.
- Trial name
- ACTSOMA (NCT06213766)
- Testing
- Cognitive assessment, Questionnaires, Spatial navigation task with eye-tracking.
- Where
- 3 sites in France
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Hospices Civils de Lyon
Multiple Sclerosis, Relapsing-Remitting
Photobiomodulation Therapy in Persons With Multiple Sclerosis
This study will test whether photobiomodulation therapy improves muscle endurance and decreases inflammation in persons with relapsing-remitting multiple sclerosis. We will also investigate mechanisms for any improvements.
- Trial name
- NCT03691766
- Testing
- Photobiomodulation Therapy
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Marquette University
Sleep Apnea, Obstructive
eXciteOSA for Treatment of Moderate Obstructive Sleep Apnea
The objective of this study is to assess the efficacy of the eXciteOSA device amongst a sample of patients with moderate OSA. The study is a multi-center, prospective, open-label, randomized, parallel-arm trial of eXciteOSA…
- Trial name
- ELMO (NCT05252156)
- Testing
- eXciteOSA
- Where
- 7 sites in United States
- Volunteers
- 62 people
- Sponsor
- Signifier Medical Technologies
Orthostatic Hypotension, Orthostatic Intolerance
Orthostatic Intolerance and Hypotension After Administration of Morphine in Patients Prior to Hip or Knee Arthroplasty
Incidence of orthostatic intolerance and orthostatic hypotension after intravenous administration of morphine in patients prior to hip or knee arthroplasty.
- Trial name
- NCT04902222
- Testing
- Morphine
- Where
- Denmark
- Volunteers
- 26 people
- Sponsor
- Copenhagen University Hospital, Hvidovre
Multiple Sclerosis
A Study to Investigate the Safety, Tolerability, Pharmacokinetics, Immunogenicity, and Pharmacodynamics of a New Subcutaneous Formulation of Ocrelizumab in Participants With Multiple Sclerosis
The main purpose of this study is to evaluate the safety and tolerability of the ocrelizumab subcutaneous (SC) test formulation in participants with multiple sclerosis (MS).
- Trial name
- OCARINA 3 (NCT07667322)
- Testing
- Ocrelizumab Co-formulated With rHuPH20
- Where
- 12 sites in United States, Brazil and 2 more
- Volunteers
- 75 people
- Sponsor
- Hoffmann-La Roche
Narcolepsy, Cataplexy
Cardiovascular Variability and Heart Rate Arousal Response in Idiopathic Hypersomnia
Autonomic nervous system dysfunction has been described in narcolepsy with cataplexy affecting the sympathetic function. In this study the investigators analyzed whether altered diurnal and nocturnal cardiovascular control is…
- Trial name
- NCT02913651
- Testing
- Polysomnography
- Where
- France
- Volunteers
- 33 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Epilepsy
A Multicenter, Open-Label Study To Investigate The Safety And Pharmacokinetics Of Lacosamide In Children With Partial Seizures
The purpose of this study was to evaluate the safety and pharmacokinetics of LCM syrup in children ages from 1 month to 17 years with uncontrolled partial seizures when added to 1 to 3 other antiepileptic drugs (AEDs).
- Trial name
- NCT00938431
- Testing
- Lacosamide
- Where
- 21 sites in United States, Belgium and 1 more
- Volunteers
- 47 people
- Sponsor
- UCB Pharma
Nerve Transfer
Nerve Transfers for Restoration of Hand Function in Cervical Spinal Cord Injury: Effects and Influencing Factors
The goal of this observational study is to learn about influencing factors on the clinical outcomes of nerve transfers used to restore hand function in patients with cervical spinal cord injury (CSCI).
- Trial name
- NCT06596629
- Where
- Netherlands
- Volunteers
- 19 people
- Sponsor
- Roessingh Research and Development
Shift-Work Sleep Disorder, Insomnia
Fire Fighter Fatigue Management Program: Operation Healthy Sleep
Firefighters work some of the most demanding schedules known under highly stressful and demanding conditions. The need to work frequent extended shifts and long work weeks leads to acute and chronic partial sleep deprivation as…
- Conditions
- Shift-Work Sleep Disorder, Insomnia, Restless Leg Syndrome, Obstructive Sleep Apnea
- Trial name
- NCT01988129
- Testing
- Sleep disorders education and screening
- Where
- United States
- Volunteers
- 1,189 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Gaucher Disease, Type 1
Study of Gene-Activated® Human Glucocerebrosidase (GA-GCB) ERT Compared With Imiglucerase in Type I Gaucher Disease
Gaucher disease is a rare lysosomal storage disorder caused by the deficiency of the enzyme glucocerebrosidase (GCB). Due to the deficiency of functional GCB, glucocerebroside accumulates within macrophages leading to cellular…
- Trial name
- NCT00553631
- Testing
- velaglucerase alfa, imiglucerase
- Where
- 11 sites in United States, Argentina and 7 more
- Volunteers
- 34 people
- Sponsor
- Shire
Stroke, Walking, Difficulty
To Develop a Walking Exercise Program for Non-ambulatory Stroke Survivors
The goal of this clinical trial is to test a gait (walking) training program in non-ambulatory (unable to walk) chronic stroke survivors.
- Conditions
- Stroke, Walking, Difficulty, Cardiovascular Injury
- Trial name
- NCT06247553
- Testing
- Gait Training, Leg Cycling Exercise
- Where
- United States
- Volunteers
- 72 people
- Sponsor
- University of Kansas Medical Center
Hydrocephalus, Normal Pressure
MRI-Volumetry in the Evaluation of Shunt Treatment for Hydrocephalus
This randomized, double-blinded, cross-over study aim to evaluate the effects of shunt treatment in idiopathic normal pressure hydrocephalus (iNPH) by measuring cerebral ventricular volume and clinical symptoms at different shunt…
- Trial name
- NCT04599153
- Testing
- Ventriculoperitoneal shunt opening pressure setting
- Where
- Sweden
- Volunteers
- 36 people
- Sponsor
- Uppsala University
Sleep Apnea, Diabetes
Hyperglycemic Profiles in Obstructive Sleep Apnea: Effects of PAP Therapy
This is a randomized control trial in people with diabetes and obstructive sleep apnea who will be randomly assigned for 3 months to PAP therapy along with healthy lifestyle and sleep education or healthy lifestyle and sleep…
- Trial name
- HYPNOS (NCT02454153)
- Testing
- REMStar Positive Airway Pressure, LifeStyle Counseling
- Where
- United States
- Volunteers
- 184 people
- Sponsor
- Johns Hopkins University
Obstructive Sleep Apnea
Adherence to Health Coaching with Wearable Devices: Enhancing Patient Engagement and Outcomes
The goal of this clinical trial is to learn how integrating health and wellness coaching (HWC) with Continuous Positive Airway Pressure (CPAP) therapy affects adherence to treatment and overall health outcomes in individuals with…
- Trial name
- NCT06525337
- Testing
- STANDARDCARE (STAND) group, CONTROL (CON) group
- Where
- 2 sites in United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Coastal Carolina University
Pain, Chronic, Sleep Disturbance
Alpha Entrainment for Pain and Sleep (Extension)
Long-term pain affects one-third of the United Kingdom population and can be very disabling. People experiencing long-term pain often suffer from disturbed sleep because of their pain symptoms, and disturbed sleep can then make…
- Trial name
- NCT05699837
- Testing
- Audio or visual alpha (10Hz) stimulation
- Where
- 2 sites in United Kingdom
- Volunteers
- 19 people
- Sponsor
- University of Manchester
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