Clinical trials: Nervous System Neoplasms
Cancer, Alzheimer Disease
Implement and Test Visual Consent Template and Process
The investigators plan to conduct a stepped wedge randomized control trial to implement and test the consent template and process in three studies. Randomization will occur at the research coordinator/research team level.
- Trial name
- NCT06804837
- Testing
- Visual consent, Standard consent
- Where
- 3 sites in United States
- Volunteers
- 266 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Tinnitus
Sub-chronic Neurostimulation Delivered in the Middle Ear for Tinnitus Suppression
The objectives of this study are to evaluate the safety and efficacy of applying electrical stimulation on the promontorium (EPS) for the suppression of tinnitus in a sub-chronic stimulation regimen.
- Trial name
- NCT01549145
- Testing
- Nimbus Multifunctional Stimulator
- Where
- Israel
- Volunteers
- 14 people
- Sponsor
- EstimME Ltd.
Fertility Issues
Assessing the Fertility Status of Men With Spinal Muscular Atrophy (SMA)
This study will aim to assess the fertility status of men with Spinal Muscular Atrophy (SMA) not on disease-modifying therapies. Participants will: 1.
- Trial name
- NCT06194539
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- Bar-Chama, Natan, M.D.
Neuropathic Pain, Radiotherapy Side Effect
Efficacy and Safety of Transcutaneous Auricular Vagus Nerve Stimulation on Radiotherapy-Related Neuropathic Pain
This multi-center, randomized, double-blind, sham-controlled trial aims to investigate the effect and safety of TaVNS in treating radiotherapy-related neuropathic pain.
- Trial name
- RELAX (NCT05543239)
- Testing
- Transcutaneous Auricular Vagus Nerve Stimulation(TaVNS)
- Where
- 4 sites in China
- Volunteers
- 116 people
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Sarcoma
Ifosfamide or Doxorubicin in Treating Patients With Advanced or Metastatic Soft Tissue Sarcoma
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. It is not yet known whether ifosfamide or doxorubicin is more effective for advanced or metastatic soft…
- Trial name
- NCT00003212
- Testing
- doxorubicin hydrochloride, ifosfamide
- Where
- 23 sites in Belgium, Denmark and 8 more
- Volunteers
- 780 people
- Sponsor
- European Organisation for Research and Treatment of Cancer - EORTC
Pediatric Cancer
Virtual Reality on Pain, Fear and Emotional Experience During Port Needle Insertion
In pediatric hematology-oncology patients, the need for a central venous catheter may arise in some cases to provide treatment. Totally implanted vascular access devices are known as "ports," and port catheters are commonly used…
- Trial name
- NCT06605339
- Testing
- Virtual Reality
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- Dokuz Eylul University
Brain Neoplasms, Malignant, Metastasis
CEST- Glucose Enhanced MRI for Metastatic Brain Tumours
This project will compare two MRI contrast agents in metastatic brain tumours in humans. More specifically, the investigators will compare the tumour contrast obtained using glucose versus the current standard gadolinium-based…
- Trial name
- NCT02796729
- Testing
- Magnetic resonance imaging, Gadovist (Gadobutrol), 50% dextrose solution
- Where
- Canada
- Volunteers
- 3 people, healthy volunteers welcome
- Sponsor
- British Columbia Cancer Agency
Brain and Central Nervous System Tumors, Lymphoma
Rebeccamycin Analogue in Treating Children With Solid Tumors or Non-Hodgkin's Lymphoma
Phase II trial to study the effectiveness of rebeccamycin analogue in treating children who have solid tumors or non-Hodgkin's lymphoma.
- Conditions
- Brain and Central Nervous System Tumors, Lymphoma, Neuroblastoma, Retinoblastoma
- Trial name
- NCT00006102
- Testing
- becatecarin
- Where
- 226 sites in United States, Australia and 5 more
- Volunteers
- 200 people
- Sponsor
- National Cancer Institute (NCI)
Brain and Central Nervous System Tumors
Monoclonal Antibody Therapy in Treating Patients With Recurrent Gliomas
RATIONALE: Monoclonal antibodies can locate tumor cells and either kill them or deliver tumor-killing substances to them without harming normal cells.
- Trial name
- NCT00002753
- Testing
- iodine I 131 monoclonal antibody 81C6
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Duke University
Breast, Breast Cancer
Self Reported Pain in Women While Undergoing Treatment for Non-metastatic Breast Cancer
The overall purpose of this study is to investigate whether younger subjects report pain with pegfilgrastim (or biosimilar substitution) more often and/or at higher levels (greater intensity) than older subjects.This study will…
- Trial name
- NCT04174742
- Testing
- pegfilgrastim
- Where
- 2 sites in United States
- Volunteers
- 115 people
- Sponsor
- Wake Forest University Health Sciences
Brain Tumors, Quality of Life
Acceptance and Commitment Therapy for Neuro-Oncology Wellbeing
Background. Survivors of childhood brain tumours have the poorest health-related quality of life of all cancer survivors due to the multiple physical and psychological sequelae of brain tumours and their treatment.
- Conditions
- Brain Tumors, Quality of Life, Brain Tumor, Pediatric
- Trial name
- ACT NOW (NCT04722237)
- Testing
- Acceptance and Commitment Therapy
- Where
- United Kingdom
- Volunteers
- 72 people
- Sponsor
- Nottingham University Hospitals NHS Trust
Ischemic Stroke, Mild
ProUrokinase for Mild Ischemic Cerebrovascular Events (PUMICE)
The purpose of this study is to investigate the safety and efficacy of rhPro-UK (35mg) versus standard medical treatment in acute mild ischemic stroke within 4.5 hours of symptom onset.
- Conditions
- Ischemic Stroke, Mild, Thrombosis
- Trial name
- PUMICE (NCT05507645)
- Testing
- Recombinant Human Prourokinase for Injection (rhPro-UK), standard medical treatment
- Where
- 89 sites in China
- Volunteers
- 1,446 people
- Sponsor
- Beijing Tiantan Hospital
Pain, Acute, Vocal Fold Polyp
Patient Augmented Reality and Vibratory Array Otorhinolaryngology Procedures
In-office procedures (IOPs) are a cost-effective, and safe alternative to many operating room procedure, with benefits such as reduced anesthesia risk.
- Conditions
- Pain, Acute, Vocal Fold Polyp, Vocal Cord Paralysis, Laryngeal Neoplasms
- Trial name
- PARVA (NCT06227039)
- Testing
- Vibroacoustic stimulation on, Augmented Reality on, Vibroacoustic stimulation off
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Breast Cancer, Chronic Fatigue Syndrome
Monitoring of Chronic Conditions in Breast Cancer
REBECCA-1 is an observational study. Clinical research is undergoing a revolutionary change. The use of electronic patient records (EHR), digital registers, smartphones etc will create "real-world data" (RWD) that provides great…
- Trial name
- REBECCA-1 (NCT05587777)
- Where
- Norway
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Helse Stavanger HF
Cachexia, Neoplasms
Cancer-associated Muscle Mass - Molecular Factors and Exercise Mechanisms
Muscle mass loss is a common adverse effect of cancer. Muscle mass loss occurs with or without reduction in body weight. Cancer cachexia (CC) is the involuntary loss of body weight of >5% within 6 months and it occurs in 50-80%…
- Conditions
- Cachexia, Neoplasms, Exercise, Metabolism
- Trial name
- PANACEA (NCT05307367)
- Testing
- Exercise training
- Where
- Denmark
- Volunteers
- 144 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Myasthenia Gravis, Thymoma
The Role of the Thymus in Myasthenia Gravis
Although the association between thymic hyperplasia / thymoma and autoimmune myasthenia gravis has been known for some time, the question of causality remains uncertain.
- Trial name
- NCT01102192
- Where
- Germany
- Volunteers
- 20 people
- Sponsor
- Charite University, Berlin, Germany
Brain Metastases
Toronto BNB Pilot Study
As treatments improve and patients live longer with cancer, even after it has spread to the brain, efforts to improve quality of life are growing.
- Trial name
- NCT02082587
- Where
- 3 sites in Canada
- Volunteers
- 39 people
- Sponsor
- University Health Network, Toronto
Cushing's Disease, Cushing's Syndrome
Compassionate Use of CORLUX® (Mifepristone) in the Treatment of Signs and Symptoms of Endogenous Cushing's Syndrome
This is a compassionate use study. In addition to providing compassionate use access to mifepristone, objectives of the study will be to evaluate the safety and utility of mifepristone in the treatment of the signs and symptoms…
- Trial name
- NCT01371565
- Testing
- Mifepristone
- Where
- 5 sites in United States
- Volunteers
- 4 people
- Sponsor
- Corcept Therapeutics
Auto-immune Encephalitis, Epilepsy
Antibodies Causing Epilepsy Syndromes: The ACES Study.
The Antibodies Causing Epilepsy Syndromes (ACES) Study is a observational cohort study focusing on detection of auto-immune epilepsy in patients with epilepsy of unknown origin.
- Trial name
- ACES (NCT02802475)
- Testing
- vena punction
- Where
- 8 sites in Netherlands
- Volunteers
- 582 people
- Sponsor
- Erasmus Medical Center
Childhood Central Nervous System Choriocarcinoma, Childhood Central Nervous System Embryonal Tumor
Combination Chemotherapy in Treating Young Patients With Advanced Solid Tumors
This phase I trial is studying the side effects and best dose of oxaliplatin when given together with leucovorin and fluorouracil in treating young patients with advanced solid tumors.
- Conditions
- Childhood Central Nervous System Choriocarcinoma, Childhood Central Nervous System Embryonal Tumor, Childhood Central Nervous System Germ Cell Tumor, Childhood Central Nervous System Germinoma
- Trial name
- NCT00281944
- Testing
- oxaliplatin, fluorouracil, leucovorin calcium
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- National Cancer Institute (NCI)