Clinical trials: Nervous Vagus
Spinal Cord Injuries
Auricular Vagus Nerve Stimulation (aVNS) in Chronic Spinal Cord Injuries (SCI)
The purpose of this research is to test if Auricular Vagal Nerve Stimulation (aVNS) is safe in persons with spinal cord injury (SCI).
- Trial name
- NCT06588608
- Testing
- auricular nerve stimulation (aVNS)
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- University of Miami
Airway Obstruction, Vocal Cord Paralysis
Total Versus Partial Arytenoidectomy in Bilateral Vocal Fold Paralysis
Total arytenoidectomy is claimed to increase risk of aspiration and cause more voice loss than other operations performed for bilateral vocal fold paralysis (BVFP). However, objective evidence for such conclusion is lacking.
- Trial name
- NCT01824849
- Testing
- Total arytenoidectomy, Partial arytenoidectomy
- Where
- Turkey (Türkiye)
- Volunteers
- 20 people
- Sponsor
- Hacettepe University
Chemotherapy Induced Peripheral Neuropathy
Self-applied taVNS for CIPN
The purpose of this study is to determine the feasibility of using a portable device at home to self-administer transcutaneous auricular vagus nerve stimulation (taVNS).
- Trial name
- NCT07596030
- Testing
- Transcutaneous Auricular Vagus Nerve Stimulation (taVNS)
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- University of Miami
Thyroid Cancer, Recurrent Laryngeal Nerve Injuries
Effect of Reversed Tracking Method for Identification of EBSLN in Thyroid Surgery
The feasibility and effectiveness of Reversed Tracking Method for the identification and protection of extralaryngeal nerve branches in thyroid surgery were analyzed.
- Trial name
- NCT03680222
- Testing
- Reversed Tracking Method
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Fujian Medical University
Parkinson Disease
Balance Exercise and Vagus Nerve Stimulation on Weight-shifting Control and Ambulation in Parkinson Disease and Anxiety
Postural balance and anxiety are the two critical factors for reducing independence and quality of life in patients with Parkinson's disease (PD). Anxiety would deteriorate balance and gait dysfunction.
- Trial name
- NCT06476912
- Testing
- weight-shifting exercise
- Where
- Taiwan
- Volunteers
- 94 people
- Sponsor
- National Taiwan University Hospital
Drug-Resistant Epilepsy, Epilepsy
Ultrasound-Guided Intermediate Cervical Plexus Block for Postoperative Analgesia in Vagus Nerve Stimulation Surgery
This retrospective cohort study evaluated the medical records of adult patients who underwent vagus nerve stimulator (VNS) implantation under general anesthesia for drug-resistant epilepsy at Fırat University Hospital between…
- Conditions
- Drug-Resistant Epilepsy, Epilepsy, Postoperative Pain
- Trial name
- NCT07689617
- Testing
- Ultrasound-guided intermediate cervical plexus block, Bupivacaine
- Where
- Turkey (Türkiye)
- Volunteers
- 76 people
- Sponsor
- Firat University
Vocal Fold Palsy, Dysphagia
Universal Screening for Vocal Fold Motion Impairment in Children Undergoing Congenital Cardiac Surgery
The purpose of this study is to determine how often heart or chest surgery in children leads to problems with the movement of the vocal folds.
- Conditions
- Vocal Fold Palsy, Dysphagia, Congenital Heart Disease in Children
- Trial name
- NCT03882450
- Testing
- Flexible fiberoptic laryngoscopy, Laryngeal ultrasonography
- Where
- United States
- Volunteers
- 94 people
- Sponsor
- Emory University
Tinnitus
Vagus Nerve Stimulation (VNS) Paired With Tones for Tinnitus
Assess the safety and efficacy of VNS paired with tones for tinnitus using a randomized, controlled, parallel study design.
- Trial name
- NCT01962558
- Testing
- VNS Treatment, VNS Control
- Where
- 3 sites in United States
- Volunteers
- 30 people
- Sponsor
- MicroTransponder Inc.
Epilepsy
TMS as a Tool for the Evaluation of Neuromodulatory Effects of Transcutaneous Vagus Nerve Stimulation
Transcutaneous vagus nerve stimulation (tVNS) has been investigated as a potential treatment for epilepsy with inconsistent results.
- Trial name
- NCT05639387
- Testing
- actual tVNS
- Where
- Belgium
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University Ghent
Chronic Cluster Headache
Prevention and Acute Treatment of Chronic Cluster Headache Compared to Standard of Care
Subjects enrolled into this 10 week study will for the first two weeks document the number of cluster headaches and the means of treating (medication) of these attacks. Subjects will then be randomized to into either two groups.
- Trial name
- NCT01701245
- Testing
- GammaCore
- Where
- 10 sites in Belgium, Germany and 2 more
- Volunteers
- 97 people
- Sponsor
- ElectroCore INC
Migraine
Non-Invasive Neurostimulation For the Relief of Symptoms Associated With Migraine
The purpose of this pilot study is to assess feasibility and clarify the design of future study(ies) to support marketing approval of the GammaCore™ device for the treatment and/or prevention of migraine symptoms.
- Trial name
- NCT01532830
- Testing
- n-VNS
- Where
- 3 sites in United States
- Volunteers
- 30 people
- Sponsor
- ElectroCore INC
Postural Orthostatic Tachycardia Syndrome (POTS)
Tragus Stimulation for POTS Treatment
Postural Tachycardia Syndrome (POTS) is a form of dysautonomia characterized by an abnormal cardiovascular response to orthostatic challenges.
- Trial name
- TREAT-POTS (NCT07163130)
- Testing
- Transcutaneous auricular vagus nerve stimulation
- Volunteers
- 24 people
- Sponsor
- Aristotle University Of Thessaloniki
Postoperative Cognitive Dysfunction, Postoperative Delirium
Effects of Perioperative Transauricular Vagus Nerve Electrical Stimulation on POD, POCD and CPSP
Postoperative delirium (POD) and postoperative cognitive dysfunction (POCD) occur in 11-51% of patients after surgery, and its prevalence increases with age.
- Conditions
- Postoperative Cognitive Dysfunction, Postoperative Delirium, Chronic Post Operative Pain
- Trial name
- NCT05439707
- Testing
- transaricular vagus nerve stimulation, fake transaricular vagus nerve stimulation
- Where
- China
- Volunteers
- 600 people
- Sponsor
- Xuzhou Central Hospital
Benign Multinodular Goiter, Thyroidectomy
Intraoperative Methylene Blue Spray for the Identification and Preservation of Vital Structures in Thyroidectomy
This randomized controlled trial aims to evaluate the efficacy of intraoperative methylene blue (MB) spray in improving the identification and preservation of the recurrent laryngeal nerve (RLN) and parathyroid glands (PGs)…
- Conditions
- Benign Multinodular Goiter, Thyroidectomy, Recurrent Laryngeal Nerve Injury, Hypoparathyroidism
- Trial name
- NCT07395388
- Testing
- Intraoperative topical methylene blue spray, Conventional Dissection
- Where
- Pakistan
- Volunteers
- 136 people
- Sponsor
- Services Hospital, Lahore
Stroke, Upper Extremity Paresis
Transcutaneous Vagus Nerve Stimulation for Motor Recovery After Stroke
This study will evaluate the safety and effectiveness of Respiratory-gated Auricular Vagal Afferent Nerve Stimulation (RAVANS) for improving motor recovery after stroke.
- Trial name
- NCT03292159
- Testing
- Active RAVANS concurrent with arm motor training, Inactive RAVANS concurrent with arm motor training
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Massachusetts General Hospital
Spinal Cord Injuries, Upper Extremity Paresis
Targeted Plasticity Therapy for Upper Limb Rehabilitation in Spinal Cord Injuries
Texas Biomedical Device Center at UT Dallas has developed an innovative strategy to enhance recovery of motor and sensory function after neurological injury termed targeted plasticity therapy (TPT).
- Trial name
- NCT04288245
- Testing
- Active Vagus Nerve Stimulation
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Baylor Research Institute
Autonomic Nervous System Modulation, Pain Perception
Pain Perception and the Autonomic Nervous System
In this study, we want to investigate how pain processing and sensation are related to a certain part of the nervous system, the so-called autonomic nervous system.
- Conditions
- Autonomic Nervous System Modulation, Pain Perception, Pain Sensitivity, Central Sensitization
- Trial name
- NCT06667895
- Testing
- respiratory gated taVNS, random burst stimulation, continuous stimulation
- Where
- Switzerland
- Volunteers
- 146 people, healthy volunteers welcome
- Sponsor
- Schweinhardt Petra
Multiple Sclerosis
Noninvasive Vagal Nerve Stimulation
Growing evidence suggests that vagal nerve stimulation (VNS) may be novel and effective in the management of the symptom burden of multiple sclerosis (MS) potentially by reducing inflammation and emotional distress, therefore…
- Trial name
- VANISH-MS (NCT06816004)
- Testing
- Remotely Supervised Transcranial Direct Current Stimulation (RS - tDCS), Remotely Supervised Transcutaneous Auricular Vagus Nerve Stimulation (RS - taVNS), Remotely Supervised Transcutaneous Cervical Vagus Nerve Stimulation (RS - tcVNS)
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- NYU Langone Health
Widspread Chronic Pain, Fibromyalgia
The Effect of Vagus Nerve Stimulation on Pain and Functional Activities in Individuals With Chronic Widespread Pain
The goal of this clinical trial is to examine the effect of vagus nerve stimulation (VNS) on chronic, widespread pain in adults.
- Trial name
- NCT07080749
- Testing
- Vagal nerve stimulation through deep exhalation exercise, Vagal nerve stimulation through ear electrical stimulation, No intervention (observational study)
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of North Georgia
Subarachnoid Haemorrhage From Cerebral Aneurism Rupture
Investigating the Tolerability and Feasibility of tVNS Following aSAH
After a subarachnoid haemorrhage, complications are common and increase the overall rate of disability and death from the condition.
- Trial name
- tVNS in aSAH (NCT06374693)
- Testing
- Transcutaneous Vagus Nerve Stimulation
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- Sheffield Teaching Hospitals NHS Foundation Trust