Clinical trials: Nervous Vagus
Alzheimer Disease (AD)
Alzheimer's Disease Treated With Vagus Nerve Stimulation
The goal of this clinical trial is to evaluate the safety and efficacy of vagus nerve stimulation (VNS) for treating Alzheimer's disease (AD) in patients aged 50-80 years with mild cognitive impairment to moderate Alzheimer's…
- Trial name
- Advant (NCT06923007)
- Testing
- Vagus Nerve Stimulation
- Where
- China
- Volunteers
- 74 people
- Sponsor
- Beijing Municipal Administration of Hospitals
Stroke
Non-invasive Auricular Vagus Nerve Stimulation (taVNS) on Postural Control and Autonomic Responses in Stroke
This randomized controlled trial is conducted to determine the effects of transcutaneous auricular Vagus nerve stimulation (taVNS) on postural control in stroke patients (e.g., improvements in balance, mobility, and functional…
- Trial name
- NCT07629687
- Testing
- Vagus Nerve Stimulation combined with Balance Training Group, Balance Training Group
- Where
- Pakistan
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Riphah International University
SCI - Spinal Cord Injury
Vagus Nerve Stimulation (VNS) in Spinal Cord Injury (SCI) Adaptive Follow-On Study
This study is an open label extension of the SCI EFS clinical trial (NCT04288245) that developed an innovative strategy to enhance recovery of motor and sensory function after neurological injury.
- Trial name
- SCI-AFOS (NCT06351111)
- Testing
- Active VNS
- Where
- 2 sites in United States
- Volunteers
- 20 people
- Sponsor
- The University of Texas at Dallas
Refractory Epilepsy
Effect of Short-term Theta Frequency Stimulation of the Vagus Nerve on Cognition in Patients With Refractory Epilepsy
The purpose of this investigation is data pilot study of the effect of theta frequency stimulation of the vagus nerve on cognitive performance in patients with refractory epilepsy.
- Trial name
- NCT03331939
- Testing
- no stimulation, beta (25-30 Hz), Theta (5 Hz)
- Volunteers
- 2 people
- Sponsor
- University of California, Davis
Giant Axonal Neuropathy (GAN)
Intraneural Administration of scAAV9/JeT-GAN Into the Vagus Nerve for Patients With Giant Axonal Neuropathy (GAN)
Giant axonal neuropathy (GAN) is a rare pediatric disorder caused by autosomal recessive mutations in the GAN gene. GAN is a multisystem, neurodegenerative disorder affecting the peripheral nervous system (PNS), central nervous…
- Trial name
- NCT07543991
- Testing
- scAAV9/JeT-GAN
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- University of Texas Southwestern Medical Center
Presbycusis
Improving Speech in Noise Perception for Individuals With Age-related Hearing Loss
Hearing loss, especially for speech perception in the presence of noise, may lead older individuals to withdraw from social situations.
- Trial name
- NCT07192757
- Testing
- transcutaneous auricular vagus nerve stimulation
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- University of Florida
Neuroinflammation
The White Blood Cell Reactivity Following Surgical Trauma and Associated Regulatory Mechanisms.
The purpose of this study is to describe numerical and functional changes in the white blood cell efter surgical trauma. Further, observed immune cell changes correlate to heart rate variability and cognitive function will be…
- Trial name
- NCT03058328
- Testing
- Cognitive testing, testing of heart rate variability and blood samples
- Where
- Sweden
- Volunteers
- 40 people
- Sponsor
- Karolinska University Hospital
Perinatal Brain Injury
Neuro-MoD: Neuroplasticity With Motor Development
This study is for infants and toddlers between 8 and 24 months old who use one arm and/or hand differently following a perinatal brain injury.
- Trial name
- NCT07738432
- Testing
- Constraint-Induced Movement Therapy (CIMT), Transcutaneous auricular vagus nerve stimulation (taVNS)
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- University of Wisconsin, Madison
Chronic Musculoskeletal Pain, Autonomic Dysfunction
Non-invasive Vagus Nerve Stimulation for Chronic Musculoskeletal Pain
Chronic musculoskeletal (MSK) pain affects an estimated 20-33% of the global population and is frequently associated with autonomic nervous system dysfunction, characterised by symptoms such as orthostatic intolerance…
- Conditions
- Chronic Musculoskeletal Pain, Autonomic Dysfunction, Dysautonomia
- Trial name
- RESTORE-MSK (NCT07409363)
- Testing
- Active Vagus Nerve Stimulation
- Where
- United Kingdom
- Volunteers
- 12 people
- Sponsor
- University of Leeds
Drug-Refractory Epilepsy
Rechargeable Implantable Vagus Nerve Stimulation System for Drug-Refractory Epilepsy
To evaluate the performance of automatic stimulation mode of a new rechargeable implantable vagus nerve stimulation system for drug-refractory epilepsy
- Trial name
- NCT05993117
- Testing
- G114R VNS system
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Beijing Pins Medical Co., Ltd
Voice Change, Hypocalcemia
The Use of Dexamethasone in Total Thyroidectomy to Improve Voice Outcome and Hypocalcaemia
Thyroidectomy is a standard procedure for benign and malignant pathologies of the thyroid gland. Each year, some 100 total thyroidectomies are performed in Kowloon East Cluster, Hospital Authority, Hong Kong.
- Trial name
- NCT05732883
- Testing
- Dexamethasone, Normal saline
- Where
- Hong Kong
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Tseung Kwan O Hospital, Hong Kong
Dry Eye Disease, Dry Eye
Neurological Dry Eye Study Stimulating Both Lacrimal and Vagus Nerves
This is a study on neurological dry eye disease, focusing on a patented over-the-counter supplement supporting tear production neurologically, including the lacrimal and vagus nerves.
- Trial name
- NCT06271005
- Testing
- NeuroTears
- Volunteers
- 75 people
- Sponsor
- Genetic Disease Investigators
Temporomandibular Joint Disorders, Pain
A Combined Treatment of Manual Therapy and Nervous Vagus Stimulation in Patients With Myogenic Temporomandibular Disorders
Temporomandibular disorders (TMD) are one of the most important Public Health issues in the world and its incidence has increased over the years.
- Trial name
- NCT05272488
- Testing
- Manual therapy and vagus nerve stimulation, Manual therapy
- Where
- 3 sites in Spain
- Volunteers
- 60 people
- Sponsor
- University of Alcala
Consciousness Disorders, Brain Injury
Paired Vagus Nerve Stimulation in Mobilization of Patients With Prolonged Disorders of Consciousness
Prolonged disorders of consciousness (pDOC) are defined as DOC lasting >1 year post injury for patients with Traumatic Brain Injury (TBI) and >3 months post injury for patients with non-TBI and at present there are limited…
- Conditions
- Consciousness Disorders, Brain Injury, Altered Level of Consciousness
- Trial name
- NCT06930716
- Testing
- Transcutaneous vagus nerve stimulation (taVNS), Physical therapy using Hocoma, Standard of Care
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Ischemic Stroke
Combined taVNS and tDCS in Subacute Stroke Patients
Ischemic stroke, the most prevalent neurological disorder, is treated with medication and thrombectomy but with limited success, especially in chronic stages where traditional rehabilitation is the primary option.
- Trial name
- NCT06244914
- Testing
- tDCS stimulation, taVNS stimulation
- Where
- Taiwan
- Volunteers
- 80 people
- Sponsor
- National Cheng-Kung University Hospital
Unilateral Vocal Cord Paralysis, Central Auditory Processing Disorder
Early UVFP Management Based on Neurological Evidences (ION-UVFP) - Preliminary Study
The purpose of this preliminary study is to help clarify our hypotheses for the longitudinal study by investigating the relationship between vocal cord paralysis and central auditory processes and thus the interpretation of…
- Trial name
- NCT03966183
- Where
- Belgium
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Cliniques universitaires Saint-Luc- Université Catholique de Louvain
Stroke, Motor Rehabilitation
Wether VNS in Early Stage (3 Months) is Safe and More Beneficial for Post-stroke Motor Rehabilitation
Upper-extremity impairment after stroke remains a major therapeutic challenge and a target of neuromodulation treatment efforts. In previous study, Vagus nerve stimulation was constricted to patients 9 months after stroke.
- Trial name
- NCT06938243
- Testing
- Vagus Nerve Stimulation in early stage, Vagus Nerve Stimulation in late stage
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Qilu Hospital of Shandong University
Healthy, Activity, Motor
Comparison of the Effectiveness of Exercise and Vagus Therapy in Healthy Individuals
Objective: Sympathetic activity starts to increase during exercise. At the end of the exercise, while sympathetic activation decreases, parasympathetic activity increases.
- Conditions
- Healthy, Activity, Motor, Sleep, Stress, Physiological
- Trial name
- NCT04832347
- Testing
- Exercise, Vagus Nerve Stimulation
- Where
- Turkey (Türkiye)
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Sinop University
Epilepsy, Sudden Cardiac Death
Optimization of VNS in Epileptic Patients to Induce Cardioprotection
This study is a non-randomized, prospective study in patients with a diagnosis of epilepsy and previously implanted FDA approved Vagus Nerve Stimulation (VNS) devices.
- Trial name
- NCT04387435
- Testing
- A change or titration in the current or frequency settings of the VNS therapy system.
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- University of California, Los Angeles
Migraine
Compare the Effectiveness of nVNS and TENS on Pain and Quality of Life in Patients of Migraine
Migraine is a genetically influenced complex neurological disorder characterized by episodes of moderate-to-severe headaches, typically unilateral and frequently accompanied by nausea and heightened sensitivity to light and…
- Trial name
- NCT07055776
- Testing
- non-invasive vagus nerve stimulation (nVNS), non-invasive transcutaneous electrical nerve stimulation (TENS)
- Where
- Pakistan
- Volunteers
- 72 people
- Sponsor
- Superior University