Clinical trials: Nervous Vagus
Tourette Syndrome, Chronic Tic Disorder
Transcutaneous Auricular Vagus Nerve Stimulation for Chronic Tic Disorders/Tourette's Syndrome in Children and Adolescents
The objective of this trial is to evaluate the effect of transcutaneous auricular vagus nerve stimulation compared to sham stimulation in improving chronic tic disorder or Tourette's syndrome in children and adolescents.
- Trial name
- NCT07854665
- Testing
- Transcutaneous auricular vagus nerve stimulation
- Where
- China
- Volunteers
- 124 people
- Sponsor
- The First Affiliated Hospital of Zhejiang Chinese Medical University
Stroke, Ischemic, Hemiplegia
Evaluation of Noninvasive Vagus Nerve Stimulation on Functional Status in Ischemic Stroke
In this study, the effectiveness of vagus nerve stimulation in patients with right and left hemiparesis will be compared with each other and with the sham application.
- Conditions
- Stroke, Ischemic, Hemiplegia, Hemiparesis;Poststroke/CVA
- Trial name
- NCT05809037
- Testing
- transcutaneous auricular vagus nerve stimulation
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Istanbul Physical Medicine Rehabilitation Training and Research Hospital
Vagus Nerve Diseases, Long COVID
Vagus Stimulation in Female Long COVID Patients.
The aim of the present pilot study is to investigate the acceptance, feasibility and implementation of the vagus nerv stimulation in Long COVID patients.
- Conditions
- Vagus Nerve Diseases, Long COVID, Long Covid19, Post-COVID-19 Syndrome
- Trial name
- Vagus (NCT05918965)
- Testing
- transcutaneous electrical vagal neurostimulation
- Where
- Austria
- Volunteers
- 45 people
- Sponsor
- Medical University of Vienna
Recurrent Laryngeal Nerve Injuries
CRANIO-CAUDAL AND LATERAL APPROACH FOR RECURRENT LARYNGEAL NERVE
The recurrent laryngeal nerve (RLN) dissection should be performed cranio-caudally in TOETVA approach.The aim of this study was to compare the cranio-caudal and lateral approach for RLN dissection in regard with the rates of LOS…
- Trial name
- NCT04379804
- Testing
- Lateral approach, Cranio-caudal approach
- Where
- Turkey (Türkiye)
- Volunteers
- 198 people, healthy volunteers welcome
- Sponsor
- Istanbul University
Stroke
Non-invasive VNS in Stroke Recovery
To evaluate feasibility and effectiveness of non-invasive VNS to enhance stroke recovery
- Trial name
- NOVUS (NCT06761404)
- Testing
- taVNS
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- The Methodist Hospital Research Institute
Vagus Nerve Stimulation, Stroke
Vagal Nerve Stimulation To Enhance Cognition and Learning
The purpose of this study is to find out whether pairing vagus nerve stimulation (VNS) with cognitive training can improve memory and language learning in people who have previously used VNS therapy for movement rehabilitation…
- Conditions
- Vagus Nerve Stimulation, Stroke, Cognitive Assessment, Language Acquisition
- Trial name
- NCT07719387
- Testing
- VNS for Cognition
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Stony Brook University
Epilepsy
Vagus Nerve Stimulation Clinical Outcomes Measured Prospectively in Patients Stimulated
Vagus Nerve Stimulation (VNS) Therapy has been approved marked for the treatment of epilepsy since 1994. This post-market study is designed to follow the clinical course and outcomes for patients with refractory seizures treated…
- Trial name
- V-COMPAS (NCT01281293)
- Where
- 20 sites in United States, Belgium and 3 more
- Volunteers
- 124 people
- Sponsor
- Cyberonics, Inc.
Neuropathic Pain, Radiotherapy Side Effect
Efficacy and Safety of Transcutaneous Auricular Vagus Nerve Stimulation on Radiotherapy-Related Neuropathic Pain
This multi-center, randomized, double-blind, sham-controlled trial aims to investigate the effect and safety of TaVNS in treating radiotherapy-related neuropathic pain.
- Trial name
- RELAX (NCT05543239)
- Testing
- Transcutaneous Auricular Vagus Nerve Stimulation(TaVNS)
- Where
- 4 sites in China
- Volunteers
- 116 people
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Lung Cancer, Vagus Nerve Injuries
Vagus Nerve Preservation and Chronic Cough in Non-small Cell Lung Cancer Surgery
Lung cancer is the leading cause of cancer death worldwide. Surgical resection is the main treatment for resectable non-small-cell lung cancer (NSCLC), and lobectomy with systemic mediastinal lymph node dissection is the standard…
- Conditions
- Lung Cancer, Vagus Nerve Injuries, Cough
- Trial name
- NCT04923412
- Testing
- Pulmonary branch of vagus nerve preserved, Pulmonary branch of vagus nerve not preserved
- Where
- South Korea
- Volunteers
- 214 people
- Sponsor
- Seoul National University Bundang Hospital
Otorhinolaryngologic Diseases
Reconstruction Implant Bone After Removal Using Porous Titanium Prosthesis
This trial will study the reconstruction of the anterior part of the mandible and the adjacent soft tissue parts by a mandibular prosthesis made in porous titanium, associated or not, to a latissimus dorsi or pectoral flap, to…
- Trial name
- NCT00213837
- Testing
- Mandibular prosthesis made of a new highly biointegratable material
- Where
- France
- Volunteers
- 7 people
- Sponsor
- University Hospital, Strasbourg, France
Prader-Willi Syndrome
A Clinical Evaluation of Non-Invasive Vagus Nerve Stimulation for Temper Outbursts in People With PWS
The goal of the VNS4PWS clinical study is to test the efficacy, safety, and acceptability of transcutaneous vagus nerve stimulation (tVNS) treatment in people with PWS.
- Trial name
- VNS4PWS (NCT06144645)
- Testing
- tVNS, intermittent stimulation, tVNS, continuous stimulation
- Where
- 18 sites in United States
- Volunteers
- 102 people
- Sponsor
- Foundation for Prader-Willi Research
Refractory Epilepsy
Clinical Trial of Vagus Nerve Stimulation for Treatment of Refractory Epilepsy
Evaluate the long-term clinical effectiveness and safety of the PINS vagus nerve stimulator to patients with refractory epilepsy.
- Trial name
- VNSRE (NCT02378792)
- Testing
- Vagus Nerve Stimulation
- Where
- 5 sites in China
- Volunteers
- 300 people
- Sponsor
- Beijing Pins Medical Co., Ltd
Postural Orthostatic Tachycardia Syndrome (POTS), Post-acute COVID-19 Syndromes
Effects of Auricular Vagus Nerve Stimulation Combined With Slow-paced Breathing on Individuals With Postural Orthostatic Tachycardia Syndrome.
This study investigates a non-pharmacological treatment approach for Postural Orthostatic Tachycardia Syndrome (POTS), a disorder of the autonomic nervous system characterized by an excessive increase in heart rate upon standing.
- Trial name
- NCT06996314
- Testing
- TVNS + Slow-Paced Breathing (TVNS+SDB), TVNS without Breathing Training (TVNS+NB)
- Volunteers
- 100 people
- Sponsor
- Ali Kapan
Recurrent Laryngeal Nerve Palsy, Postoperative Dysphonia
Post Thyroidectomy Echographic Method for Study of Vocal Fold Motion
One of the major risks of endocrine surgery is recurrent nerve palsy (RNP), leading to vocal folds (VF) immobility. It happens in 5% of cases, leading to high morbidity: dysphonia, aspirations, impossibility to work.
- Trial name
- VOCALE (NCT03976011)
- Testing
- Transcutaneous Laryngeal Ultrasonography
- Where
- 5 sites in France
- Volunteers
- 500 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Burn Injury
Effect of Non-Invasive Vagus Nerve Stimulation in Burn Patients
This study will evaluate the effects of non-invasive vagus nerve stimulation (nVNS) in adults with burn injuries. Burn patients may experience anxiety, poor sleep quality, pain, itching, and changes in autonomic nervous system…
- Trial name
- NCT07566871
- Testing
- Non-Invasive Vagus Nerve Stimulation, Conventional Physiotherapy
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Fenerbahce University
Subarachnoid Hemorrhage, Aneurysmal
Safety and Efficacy of Non-invasive Vagus Nerve Stimulation in the Treatment of Headache in Subarachnoid Hemorrhage
This is a single site, randomized, sham-controlled, double blinded pilot study assessing the feasibility, safety, tolerability, and efficacy of non-invasive VNS (nVNS), gammaCore, in the treatment of headache in subarachnoid…
- Trial name
- VANQUISH (NCT04126408)
- Testing
- gammaCore
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Northwell Health
Healthy Volunteers
Effect of Recording Duration on Heart Rate Variability During taVNS
This study aims to evaluate how different heart rate variability (HRV) recording durations reflect autonomic nervous system responses during transcutaneous auricular vagus nerve stimulation (taVNS) in healthy adults.
- Trial name
- taVNS-HRV (NCT07526415)
- Testing
- Transcutaneous Auricular Vagus Nerve Stimulation
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Sinop University
Fibromyalgia Syndrome
Transcutaneous Vagus Nerve Stimulation for Pain and Autonomic Dysfunction in Fibromyalgia (RESET-FMS)
Fibromyalgia syndrome (FMS) is a chronic pain condition characterized by widespread pain, fatigue, sleep disturbances, cognitive symptoms, and autonomic dysfunction, significantly impairing quality of life.
- Trial name
- RESET-FMS (NCT07682090)
- Testing
- Transcutaneous Vagus Nerve Stimulation
- Where
- Italy
- Volunteers
- 80 people
- Sponsor
- University of Roma La Sapienza
Parkinson Disease, Idiopathic, Constipation
Ameliorating Effects and Mechanisms of TaVNS on Constipation in PD Patients.
The investigators intend to conduct a randomized, double-blind, sham-stimulation-controlled experiment, incorporating various clinical scales, gastrointestinal electrogram, and high-resolution anorectal manometry (HRAM), to…
- Trial name
- NCT06623591
- Testing
- active Transcutaneous auricular vagus nerve stimulation
- Volunteers
- 30 people
- Sponsor
- Kezhong Zhang
Autonomic Nervous System Imbalance
Vagus Nerve Stimulation for Autonomic Nervous System Activity
There are no generally accepted values for transcutaneous vagus nerve stimulation (taVSS application parameters (amplitude, frequency, intensity, duration, side) yet, therefore there are heterogeneous applications in studies.
- Trial name
- NCT05906940
- Testing
- Transcutaneous Vagus Nerve Stimulation
- Where
- Turkey (Türkiye)
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Bahçeşehir University