Clinical trials: Nervous Vagus
Healthy, Activity, Motor
Comparison of the Effectiveness of Exercise and Vagus Therapy in Healthy Individuals
Objective: Sympathetic activity starts to increase during exercise. At the end of the exercise, while sympathetic activation decreases, parasympathetic activity increases.
- Conditions
- Healthy, Activity, Motor, Sleep, Stress, Physiological
- Trial name
- NCT04832347
- Testing
- Exercise, Vagus Nerve Stimulation
- Where
- Turkey (Türkiye)
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Sinop University
Postural Orthostatic Tachycardia Syndrome
Vagus Nerve Stimulation in Treatment of Postural Orthostatic Tachycardia Syndrome
Postural orthostatic tachycardia (POTS) is characterized by abnormalities in the autonomic nervous system in the body. The autonomic nervous system controls and regulates body functions such as heart rate, breathing, digestion…
- Trial name
- POTS (NCT03930914)
- Testing
- Parasym (TM) Transcutaneous Electrical Nerve Stimulation (TENS) Device
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- University of Oklahoma
Fibromyalgia
taVNS Treatment for Fibromyalgia
In this research study we want to learn more about if transcutaneous electrical nerve stimulation (TENS), a safe electrical stimulation tool, can relieve Fibromyalgia pain.
- Trial name
- NCT04777500
- Testing
- Auricular transcutaneous electrical nerve stimulation device
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Massachusetts General Hospital
Prader-Willi Syndrome
Effects of Transcutaneous Vagus Nerve Stimulation on Emotion Regulation and Executive Functioning in Prader-Willi Syndrome
The STIM-PRADER study aims to assess the effectiveness of auricular vagal neuromodulation therapy (aVNT) on emotional, behavioral, and cognitive domains impaired in Prader-Willi Syndrome (PWS).
- Trial name
- STIM-PRADER (NCT06720571)
- Testing
- Auricular vagal neuromodulation therapy (aVNT)
- Where
- 4 sites in France
- Volunteers
- 24 people
- Sponsor
- University of Bordeaux
Postural Orthostatic Tachycardia Syndrome (POTS), Post-acute COVID-19 Syndromes
Effects of Auricular Vagus Nerve Stimulation Combined With Slow-paced Breathing on Individuals With Postural Orthostatic Tachycardia Syndrome.
This study investigates a non-pharmacological treatment approach for Postural Orthostatic Tachycardia Syndrome (POTS), a disorder of the autonomic nervous system characterized by an excessive increase in heart rate upon standing.
- Trial name
- NCT06996314
- Testing
- TVNS + Slow-Paced Breathing (TVNS+SDB), TVNS without Breathing Training (TVNS+NB)
- Volunteers
- 100 people
- Sponsor
- Ali Kapan
Venous Canulation Pain, Nervous Vagus
Effect of Cold Application to Different Side Neck Region on Venous Cannulation Pain
Intravenous (iv) cannulation is one of the most common applications performed by anesthesiologists in and outside the operating room. It is necessary to provide vascular access before any anesthetic procedure.
- Conditions
- Venous Canulation Pain, Nervous Vagus, Left Side, Right Side
- Trial name
- NCT06253299
- Testing
- marble stone
- Where
- Turkey (Türkiye)
- Volunteers
- 140 people
- Sponsor
- Samsun University
Parkinson Disease
Balance Exercise and Vagus Nerve Stimulation on Weight-shifting Control and Ambulation in Parkinson Disease and Anxiety
Postural balance and anxiety are the two critical factors for reducing independence and quality of life in patients with Parkinson's disease (PD). Anxiety would deteriorate balance and gait dysfunction.
- Trial name
- NCT06476912
- Testing
- weight-shifting exercise
- Where
- Taiwan
- Volunteers
- 94 people
- Sponsor
- National Taiwan University Hospital
Methylene Blue, Recurrent Laryngeal Nerve Injuries
Methylene Blue Spray for Identification of Recurrent Laryngeal Nerve and Parathyroid Gland
Thyroidectomy is the procedure by which surgeons treat various thyroid diseases and is considered the commonest endocrinal surgery. Yet, it carries a risk for intraoperative complications.
- Conditions
- Methylene Blue, Recurrent Laryngeal Nerve Injuries, Parathyroid Gland
- Trial name
- NCT05113628
- Testing
- methylene blue identification
- Where
- Egypt
- Volunteers
- 80 people
- Sponsor
- Zagazig University
Migraine
Compare the Effectiveness of nVNS and TENS on Pain and Quality of Life in Patients of Migraine
Migraine is a genetically influenced complex neurological disorder characterized by episodes of moderate-to-severe headaches, typically unilateral and frequently accompanied by nausea and heightened sensitivity to light and…
- Trial name
- NCT07055776
- Testing
- non-invasive vagus nerve stimulation (nVNS), non-invasive transcutaneous electrical nerve stimulation (TENS)
- Where
- Pakistan
- Volunteers
- 72 people
- Sponsor
- Superior University
Chronic Inflammatory Demyelinating Polyneuropathy
Non-invasive Vagus Nerve Stimulation (nVNS) in Pediatric Chronic Inflammatory Demyelinating Polyneuropathy (CIDP)
Participants will be requested to deliver non-invasive vagus nerve stimulation (nVNS) two times per day, at least five days per week.
- Trial name
- NCT03772717
- Testing
- Non-invasive vagus nerve stimulation (nVNS), Standard of care treatment
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Emory University
Presbycusis
Improving Speech in Noise Perception for Individuals With Age-related Hearing Loss
Hearing loss, especially for speech perception in the presence of noise, may lead older individuals to withdraw from social situations.
- Trial name
- NCT07192757
- Testing
- transcutaneous auricular vagus nerve stimulation
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- University of Florida
Children With Cerebral Palsy
The Effect of Nervus Vagus Stimulation on Spasticity, Autonomic Function, Motor Function and Quality of Life in Children With Spastic Cerebral Palsy
Introduction: Cerebral palsy (CP) is a heterogeneous neurodevelopmental syndrome affecting muscle tone, motor skills, and movement due to brain injury during developmental stages.
- Trial name
- NCT07165665
- Testing
- Bobath (Neurodevelopmental Treatment) approach, Non-invasive transcutaneous auricular vagus nerve stimulation (taVNS)
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Pamukkale University
Chronic Tension-Type Headache, Episodic Tension-Type Headache
Treatment of Tension Headache Using Soft Tissue Techniques VS Vagus Stimulation Techniques.
A treatment based on manual therapy and vagus nerve stimulation is more effective than manual therapy only to reduce frequency, intensity and pressure pain threshold in patients with tension type headache.
- Trial name
- NCT05097300
- Testing
- Suboccipital inhibition, Ischemic pressure, Passive stretching
- Where
- 2 sites in Spain
- Volunteers
- 42 people
- Sponsor
- Lucia Trullenque Espallargas
Migraine
Non-Invasive Neurostimulation For the Relief of Symptoms Associated With Migraine
The purpose of this pilot study is to assess feasibility and clarify the design of future study(ies) to support marketing approval of the GammaCore™ device for the treatment and/or prevention of migraine symptoms.
- Trial name
- NCT01532830
- Testing
- n-VNS
- Where
- 3 sites in United States
- Volunteers
- 30 people
- Sponsor
- ElectroCore INC
Gastrointestinal Diseases, Autonomic Nervous System Disease
Relationship of Cervical Region Tension With Vagal Function
The increase in the tension of the soft tissues around a nerve restricts the movement, affects the function of the nerve, and makes the nerve vulnerable to entrapment.
- Trial name
- NCT05325879
- Testing
- VAGUS-NDT
- Where
- Turkey (Türkiye)
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Hacettepe University
Chronic Migraine
Non-Invasive Neurostimulation for the Prevention of Chronic Migraine
The purpose of this multi-center, prospective, double-blind, randomized, sham-controlled pilot study is to study feasibility and collect preliminary clinical data related to the safety and clinical benefits of daily use of…
- Trial name
- NCT01667250
- Testing
- GammaCore Active Device
- Where
- 6 sites in United States
- Volunteers
- 59 people
- Sponsor
- ElectroCore INC
Stroke, Upper Limb Deficits
VNS During Rehabilitation for Improved Upper Limb Motor Function After Stroke
The primary study objectives are to assess the safety and feasibility of the therapy, including the surgical intervention and stimulation, as well as to provide information on the appropriateness of the study test measures…
- Trial name
- NCT02243020
- Testing
- Vagus Nerve Stimulation (VNS)
- Where
- 3 sites in United States
- Volunteers
- 17 people
- Sponsor
- MicroTransponder Inc.
Stroke, Ischemic Cerebrovascular Accident
Vagus Nerve Stimulation on Improving Sleep in Inpatient Rehab for Post-Acute Stroke
The goal of this clinical trial is to learn if a device which provides vagal nerve stimulation, applied to the tragus of the ear via an ear clip, can improve sleep in individuals recovering from stroke while they are treated in a…
- Conditions
- Stroke, Ischemic Cerebrovascular Accident, Ischemic Stroke, Vagal Nerve Stimulation
- Trial name
- NCT07858656
- Testing
- transauricular Vagal Nerve Stimulation
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- Casa Colina Hospital and Centers for Healthcare
HIV Associated Polyneuropathy
Auricular Vagus Nerve Stimulation Mechanisms for HIV-Associated Peripheral Neuropathy
This study looks at a non-invasive ear stimulation treatment to better understand nerve pain in people living with HIV. The study aims to assess how the body and nervous system respond to this treatment, including changes in…
- Trial name
- NCT07822932
- Testing
- Transcutaneous Auricular Vagus Nerve Stimulation (AVNS)
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- University of Miami
Temporomandibular Joint Dysfunction Syndrome, Autonomic Nervous System Imbalance
The Effect of Vagus Nerve Stimulation on Temporomandibular Joint Dysfunction
Temporomandibular joint dysfunction (TMD) is a broad clinical picture involving the TMJ and its disc, masticatory musculature, ligament tissue, and autonomic nervous system (ANS).
- Trial name
- NCT05500716
- Testing
- Auricular Non-Invazive Vagus Nerve Stimulation + Traditional Rehabilitation Program for TMD, Traditional Rehabilitation Program
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- Alper Percin