Clinical trials: Nervousness
Dementia, Vascular, Alzheimer Disease
LEAD IT! An App to Enable Persons With Early Stage Dementia to Lead Group Activities for Their Peers
The proposed Phase 2 project will involve the further development and evaluation of LEAD IT!, which is a tablet-based app designed to enable persons with dementia to lead activities for their peers (i.e., other persons with…
- Conditions
- Dementia, Vascular, Alzheimer Disease, Dementia, Mixed
- Trial name
- NCT05516342
- Testing
- LEAD IT! Programming
- Where
- United States
- Volunteers
- 182 people
- Sponsor
- Hopeful Aging
Acute Ischemic Stroke, Transient Ischemic Attack
Imaging and Serological Biomarkers of Autonomic Dysfunction After Ischemic Stroke
The goal of this observational study is to to investigate the prevalence and time course of autonomic dysfunction in acute ischemic stroke patients; to evaluate the influence of lesion location on autonomic dysfunction; to…
- Trial name
- ARIADNE (NCT06740942)
- Where
- Germany
- Volunteers
- 100 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Brain and Central Nervous System Tumors, Unspecified Adult Solid Tumor, Protocol Specific
Calcitriol Plus Carboplatin in Treating Patients With Advanced Solid Tumors
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Calcitriol may help solid tumor cells develop into normal cells.
- Trial name
- NCT00008086
- Testing
- calcitriol, carboplatin
- Where
- United States
- Sponsor
- University of Pittsburgh
Neurofibromatosis Type 1
PASS of Paediatric Patients Initiating Selumetinib
Neurofibromatosis type 1 (NF1) is a rare, autosomal dominant genetic disorder that is caused by germline mutations in the NF1 tumour suppressor gene, which encodes the tumour suppressor protein neurofibromin 1.
- Trial name
- NCT05388370
- Where
- 46 sites in Austria, France and 8 more
- Volunteers
- 124 people
- Sponsor
- AstraZeneca
Migraine Headache
Study in Participants With Acute Migraines Headaches
This is a Phase 2, multicenter, randomized, double-blind, placebo and active comparator-controlled study of LY2590443 in approximately 200 participants with migraines.
- Trial name
- NCT00804973
- Testing
- LY2590443, Sumatriptan
- Where
- 19 sites in United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Eli Lilly and Company
Pediatrics Cancer
A Nurse-led Multicomponent Interventional Protocol to Improve Sleep Quality in Paediatric Oncology Patients
Sleep is essential for a child's development, influencing cognitive function, emotional stability, recovery, and overall well-being.
- Trial name
- NCT07323069
- Testing
- Sleep Hygiene Education, Progressive Muscle Relaxation, Breathing exercises
- Where
- Hong Kong
- Volunteers
- 68 people
- Sponsor
- Chinese University of Hong Kong
Glioblastoma Multiforme, Adult
A Study of Berubicin in Adult Subjects With Recurrent Glioblastoma Multiforme
This is an open-label, multicenter, randomized, parallel, 2-arm, efficacy and safety study. Patients with GBM after failure of standard first line therapy will be randomized in a 2:1 ratio to receive berubicin or lomustine for…
- Trial name
- NCT04762069
- Testing
- Berubicin, Lomustine
- Where
- 48 sites in United States, France and 3 more
- Volunteers
- 252 people
- Sponsor
- CNS Pharmaceuticals, Inc.
Epilepsy, Tumor
High-density EEG in Neurological Disorders
The purpose of the study is to use a new method of high-density electroencephalogram (HD-EEG) recording to map brain areas important for movement, sensation, language, emotion, and cognition.
- Conditions
- Epilepsy, Tumor, Healthy
- Trial name
- NCT04266041
- Testing
- High-density electroencephalogram (HD-EEG)
- Where
- United States
- Volunteers
- 122 people, healthy volunteers welcome
- Sponsor
- Dartmouth-Hitchcock Medical Center
Pituitary Tumor, Cerebrospinal Fluid Leakage
Using Polyglycolic Acid Mesh Prevents Cerebrospinal Fluid Leakage
The papers propose a new method to prevent postoperative cerebrospinal fluid leakage. Doctors use the absorbable polyglycolic acid (PGA) and fibrin glue to repair in surgery, prevent cerebrospinal fluid leakage and reduce the…
- Trial name
- NCT06472505
- Testing
- polyglycolic acid(Neoveil)
- Where
- Taiwan
- Volunteers
- 30 people
- Sponsor
- National Taiwan University Hospital
Primary Mediastinal Large B-cell Lymphoma (PMBCL)
Primary Mediastinal Large B-cell Lymphoma With CNS Involvement
This is a retrospective, multicenter study focused on patients with a known diagnosis of PMLBCL which experienced a CNS relapse during the course of their disease to obtain information about the clinical characteristics, the…
- Trial name
- NCT06024694
- Where
- Italy
- Volunteers
- 45 people
- Sponsor
- IRCCS San Raffaele
Insomnia Due to Mental Disorder
CBT-I as Early Intervention of Mood Disorders
This study aims to investigate the effectiveness of transdiagnostic nurse-administered 4-session group cognitive behavioral therapy for insomnia (CBT-I) plus standard care, compared to standard care alone, for improving sleep and…
- Trial name
- NCT03000894
- Testing
- Cognitive Behavioral Therapy for Insomnia (CBT-I)
- Where
- Hong Kong
- Volunteers
- 200 people
- Sponsor
- The University of Hong Kong
Metastatic Melanoma
Triple BRAFinh/MEKinh /antiPD1 Combined Therapy in Patients With BRAF Mutated Melanoma With Central Nervous System Metastasis
Currently, therapeutic options in BRAF mutated melanoma with brain metastasis occurring after achievement of a good control of extracerebral secondary lesions by a first line combined targeted therapy (TT) are limited.
- Trial name
- NCT05510466
- Where
- France
- Volunteers
- 18 people
- Sponsor
- University Hospital, Montpellier
Brain Edema, Brain Tumor
XERECEPT® (hCRF) for Patients Requiring Dexamethasone to Treat Edema Associated With Brain Tumors
The purpose of this study is to compare the safety and efficacy of XERECEPT® to dexamethasone (Decadron) a common treatment for symptoms of brain swelling (edema).
- Trial name
- NCT00088166
- Testing
- hCRF
- Where
- 34 sites in United States, Canada
- Volunteers
- 200 people
- Sponsor
- Celtic Pharma Development Services
Trisiomy 21 (Down Syndrome)
Vitamins and Minerals for Children With Downs Syndrome
The trial aimed to examine the effects of supplementation with antioxidants and folinic acid on the health, growth and psychomotor development of children with Down syndrome.
- Trial name
- NCT00378456
- Testing
- Antioxidants- (Vitamins A,C,E Selenium and Zinc), Folinic acid, Vitamins A,C,E Selenium and Zinc and Folinic acid.
- Where
- 3 sites in United Kingdom
- Sponsor
- Institute of Child Health
Low Intensity Ultrasound Pulsarions
Focused Ultrasound Neuromodulation for Treatment of Temporal Lobe Epilepsy
The aim of the proposed study is to assess the feasibility of using the BrainSonix BX Pulsar 1002 low-frequency and Low-Intensity Focused Ultrasound Pulsations (LIFUP) in human subjects suffering from intractable temporal lobe…
- Trial name
- LIFUP (NCT03657056)
- Testing
- BX Pulsar 1002
- Sponsor
- Massachusetts General Hospital
Mild Cognitive Impairment (MCI)
Enhancing Attention in Elderly Using a Brain-Computer-Interface
Cognitive reserve refers to the brain's ability to maintain cognitive performance despite age-related changes or neuropathology.
- Trial name
- NCT07441122
- Testing
- transcranial electrical stimulation, Mindfulness Meditation
- Where
- 2 sites in United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Texas at Austin
Craniocerebral Trauma
Pilot Study of the Use of a Portable Cranial Scanner in Intensive Care for Cerebro-injured Patients
Cerebral scans are a key examination in the management of serious brain-injured patients in intensive care, and are often repeated in the initial phase.
- Trial name
- ESPER (NCT05891522)
- Testing
- portable scanner, fixed scanner
- Where
- France
- Volunteers
- 46 people
- Sponsor
- Rennes University Hospital
Abnormality, Respiratory System, Autonomic Nervous System
Effects of Deployment Exposures on Cardiopulmonary and Autonomic Function
Following deployment to Operations Enduring and Iraqi Freedom and Operation New Dawn (OEF/OIF/OND), Veterans report breathing problems, difficulty exercising and other symptoms.
- Trial name
- AirHzds (NCT01754922)
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Pain, Muscle Rigidity
Investigation on a Topical Cosmetic Pain Lotion (Egyfil) for Stiffness and Pain Relief
The application of a novel topical formulation for the treatment of muscular pain and stiffness (Egyfil), containing hyaluronic acid, SH-Polypeptide-6 and SH-Oligopeptide-1, is investigated to evaluate efficacy and safety in 26…
- Trial name
- NCT05711953
- Testing
- Egyfil Pain Lotion
- Where
- Italy
- Volunteers
- 26 people
- Sponsor
- Contrad Swiss SA
Brain Tumors
[F-18]Fluoro-DOPA PET Imaging of Brain Tumors in Children
The first phase of the study will investigate if there is increased uptake of [F-18]FDOPA in pediatric brain tumors when compared to normal brain tissue.
- Trial name
- NCT00556153
- Testing
- [F-18]Fluoro-DOPA PET, a diagnostic radiopharmaceutical
- Sponsor
- Children's Hospital Medical Center, Cincinnati
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