Clinical trials: Nervousness
Menopause
Estrogen and Serotonin on Changing Brain Chemistry
The aim of this study is to examine the effects of estrogen and serotonin on cognition, emotional processing, and brain activation.
- Trial name
- NCT01208324
- Testing
- estrogen patch, Amino acids
- Where
- United States
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Arteriovenous Malformations, Cavernous Angiomas
Influence of MMP on Brain AVM Hemorrhage
Brain vascular malformations, including arteriovenous malformations (AVM), cavernous malformations (CVM) and aneurysms, are a source of life-threatening risk of intracranial hemorrhage. The etiology and pathogenesis are unknown.
- Conditions
- Arteriovenous Malformations, Cavernous Angiomas, Brain Aneurysms
- Trial name
- NCT00783523
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- University of California, San Francisco
Mitochondrial Encephalopathy, Lactic Acidosis and Stroke-Like Episodes (MELAS Syndrome)
A Phase 2b Study of Zagociguat in Patients With MELAS
PRIZM is a Phase 2b randomized, double-blind, placebo-controlled, 3-treatment, 2-period, crossover study evaluating the efficacy and safety of oral zagociguat 15 and 30 mg vs.
- Trial name
- PRIZM (NCT06402123)
- Testing
- zagociguat 15mg, zagociguat 30mg
- Where
- 20 sites in United States, Australia and 4 more
- Volunteers
- 43 people
- Sponsor
- Tisento Therapeutics
Spinal Cord Injuries
Transcutaneous Tibial Nerve Stimulation for Spinal Cord Injury Neurogenic Bladder
The purpose of this study is to determine if electric stimulation to the leg, called transcutaneous tibial nerve stimulation (TTNS), can improve bladder outcomes in acute spinal cord injury.
- Trial name
- TTNS1yr (NCT04350359)
- Testing
- Variable-dose TTNS Protocol 5 x week, Fixed-dose TTNS Protocol, Variable-dose TTNS Protocol 2 x week
- Where
- 2 sites in United States
- Volunteers
- 111 people
- Sponsor
- The University of Texas Health Science Center, Houston
Tinnitus, Pain
Modulating Mechanisms in Patients With Chronic Subjective Tinnitus and/or Chronic Pain
This is a cross-sectional investigation into modulating mechanisms in patients with chronic subjective tinnitus, which will compare 4 patient groups namely chronic tinnitus with chronic pain, chronic tinnitus without chronic…
- Trial name
- NCT05186259
- Testing
- Self-reported signs of central sensitization, Objective signs of central sensitization, Audiological outcome measures (audiometry, tinnitus analysis, uncomfortable loudness) in tinnitus patients with and without pain
- Where
- Belgium
- Volunteers
- 135 people, healthy volunteers welcome
- Sponsor
- University Ghent
Hearing Loss
Lab Evaluation of Novel Hearing Aid Coupling Method
Evaluation of different hearing aid coupling methods including two states of a novel coupling method and two traditional coupling methods.
- Trial name
- NCT05377359
- Testing
- Recordings of Hearing Aids with Open Domes, Recordings of Hearing Aids with Closed Domes, Recordings of Hearing Aids with Novel State 1
- Where
- Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Sonova AG
Stroke; Sequelae
Efficacy of Massage in Stroke Spasticity
Stroke is one of the common diseases in the elderly. It is the third ranking cause of death and affects health care system in our country. One of the most important consequences of stroke is spasticity.
- Trial name
- NCT01448980
- Testing
- Thai Traditional Massage (TTM), Physical therapy program
- Where
- Thailand
- Volunteers
- 396 people
- Sponsor
- Mahidol University
Spasticity as Sequela of Stroke, Spastic Hemiplegia
Modulation of Upper Limb Spasticity Post-Stroke
Stroke is one of the commonest causes of severe disability in adults. Stroke often results in spasticity and motor impairments in the upper limb.
- Conditions
- Spasticity as Sequela of Stroke, Spastic Hemiplegia, Upper Extremity Dysfunction
- Trial name
- NCT05069480
- Testing
- Virtual reality-based training equipment., Traditional physical therapy program
- Where
- Saudi Arabia
- Volunteers
- 38 people
- Sponsor
- Umm Al-Qura University
Obstructive Sleep Apnoea (OSA), Exhaled Breath
Mass Spectral Fingerprinting in Obstructive Sleep Apnoea
To answer the question whether a previously detected breath profile in patients suffering from obstructive sleep apnoea (OSA) can be found in a cohort of patients with suspected OSA using mass spectrometry (validation study).
- Conditions
- Obstructive Sleep Apnoea (OSA), Exhaled Breath, Mass Spectrometry
- Trial name
- NCT02810158
- Where
- Switzerland
- Volunteers
- 150 people
- Sponsor
- University of Zurich
Spinocerebellar Ataxia Type 3
A Pharmacokinetics and Safety Study of BIIB132 in Adults With Spinocerebellar Ataxia 3
The primary objective of this study is to evaluate the safety and tolerability of multiple ascending doses of BIIB132 administered via intrathecal (IT) injection to participants with spinocerebellar ataxia type 3 (SCA3).
- Trial name
- NCT05160558
- Testing
- BIIB132
- Where
- 20 sites in United States, Germany and 4 more
- Volunteers
- 8 people
- Sponsor
- Biogen
Digestive System Disease, Urologic Diseases
Low-dose Droperidol for Prevention of Postoperative Delirium in Elderly Patients After Non-cardiac Surgery
The aim of this multicenter, prospective, randomized, double-blind and large sample study is to explore the preventive effect of low-dose droperidol on POD in elderly patients after non-cardiac surgery, providing new approach for…
- Conditions
- Digestive System Disease, Urologic Diseases, Gynecological Disease, Orthopedic Surgery
- Trial name
- NCT05401058
- Testing
- Droperidol Injection, Saline
- Where
- 9 sites in China
- Volunteers
- 797 people
- Sponsor
- RenJi Hospital
Traumatic Brain Hemorrhage
SAFETY: Stabilization Points to Third Hospital Line Assessment oF the Impact of the usE of Infrascanner Model 2500 to Provide Decision Support for Diagnosis/Screening of Traumatic Brain InjurY in Ukraine
The Infrascanner model 2500 is a handheld, noninvasive device that is FDA-cleared to detect traumatic intracranial hematomas. FDA clearance K200203 was issued in 2020, K211617 added pediatric age group to the IFU in 2022, and…
- Trial name
- SAFETY (NCT07014748)
- Testing
- Handheld brain hematoma detector
- Where
- 4 sites in United States, Ukraine
- Volunteers
- 600 people
- Sponsor
- InfraScan, Inc.
Multiple Sclerosis
Retrospective Cohort Study of Rebif® Use in Pediatric Multiple Sclerosis (MS) Subjects (REPLAY)
The aim of this retrospective study is to review and describe safety, tolerability and efficacy of Rebif® (subcutaneous interferon [IFN]-beta-1a) in children and adolescents, using information already recorded in medical records.
- Trial name
- REPLAY (NCT01207648)
- Testing
- Rebif®
- Where
- 18 sites in United States, Argentina and 6 more
- Volunteers
- 307 people
- Sponsor
- EMD Serono
Obstructive Sleep Apnea
Titration of Oral Appliance Therapy: a Prospective, Randomized Cross-over Trial.
In this prospective randomized cross-over trial, 3 different titration procedures will be compared: 1. titration of the mandibular advancement device (MAD) in the home setting based on both the physical limits of the patient's…
- Trial name
- NCT03716648
- Testing
- DISE-assisted titration, PSG-guided titration, subjective titration
- Where
- Belgium
- Volunteers
- 10 people
- Sponsor
- University Hospital, Antwerp
Diabetic Neuropathy, Painful
A Study To Evaluate Pregabalin In Patients With Painful Diabetic Peripheral Neuropathy (DPN)
A study of pregabalin efficacy and safety in a racially and culturally diverse group of subjects with painful diabetic peripheral neuropathy (DPN).
- Trial name
- NCT00156078
- Testing
- pregabalin
- Where
- 35 sites in Argentina, Brazil and 17 more
- Volunteers
- 450 people
- Sponsor
- Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
Obstructive Sleep Apnea, Obesity
Consequences of Obstructive Sleep Apnea on Respiratory Function Following Weight-loss Surgery
The investigators propose to compare two different treatments, continuous positive airway pressure (CPAP) versus breathing of atmospheric pressure, in subjects with obstructive sleep apnea (OSA)recovering from weight loss surgery…
- Trial name
- NCT01697878
- Testing
- CPAP followed by atmospheric pressure, Atmospheric pressure followed by CPAP
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- Massachusetts General Hospital
Tinnitus
Study of Application of Transcutaneous Trigeminal Nerve Stimulation and Sound Fusion Stimulation on Tinnitus
This study aims to evaluate the efficacy of applying transcutaneous trigeminal nerve stimulation (NUEYNE-T30, NUEYNE-T100) and sound fusion stimulation on tinnitus.
- Trial name
- NCT05291078
- Testing
- A transcutaneous trigeminal nerve stimulator: High Frequency, A transcutaneous trigeminal nerve stimulator: Low Frequency, Sound Therapy
- Where
- South Korea
- Volunteers
- 25 people
- Sponsor
- Nu Eyne Co., Ltd.
Non-verbal Learning Disorder, Autism Spectrum Disorder
Natural Treatments for the Management of Emotional Dysregulation in Youth With Non-verbal Learning Disability (NVLD) and/or Autism Spectrum Disorders (ASD)
This study consists of a 6-week, open-label, randomized clinical trial study to compare efficacy and tolerability of the natural treatments omega-3 fatty acids, inositol, and N-acetylcysteine (NAC) in the treatment of mood…
- Conditions
- Non-verbal Learning Disorder, Autism Spectrum Disorder, Autism
- Trial name
- NCT03757585
- Testing
- Open-label Treatment with Omega-3 Fatty Acids + Inositol, Open-label Treatment with N-acetylcysteine
- Where
- United States
- Volunteers
- 54 people
- Sponsor
- Massachusetts General Hospital
Brain Metastases, Radiosurgery
Hippocampal-Sparing Stereotactic Radiosurgery Treatment of Brain Metastases Using CyberKnife
This phase II clinical trial involves the use of hippocampal-sparing together with stereotactic radiosurgery (SRS) for the treatment of brain metastases.
- Trial name
- HiSparCK (NCT05177185)
- Testing
- Hippocampal-sparing, Stereotactic radiosurgery
- Volunteers
- 70 people
- Sponsor
- Ottawa Hospital Research Institute
Traumatic Brain Injury, Upper Extremity
Transcutaneous Auricular Vagus Nerve Stimulation to Improve Upper Extremity Recovery After Traumatic Brain Injury
Upper extremity weakness, impaired coordination, reduced dexterity, and limited arm and hand use may continue after TBI. Repetitive, task-specific rehabilitation may improve function, but recovery can remain incomplete.
- Trial name
- taVNS (NCT07867015)
- Testing
- taVNS, FTP
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Craig Hospital
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