Clinical trials: Nervousness
Alzheimer's Disease
The Clinical Response of Choline Acetyltransferase and Apolipoprotein Epsilon Gene Polymorphisms to Donepezil in Alzheimer's Disease
This study attempts to differentiate the clinical responses of Choline Acetyltransferase and Apolipoprotein Epsilon gene polymorphism to donepezil in Alzheimer's Disease patients.
- Trial name
- NCT00381381
- Testing
- Donepezil
- Where
- 15 sites in South Korea
- Volunteers
- 199 people
- Sponsor
- Eisai Korea Inc.
Brain and Central Nervous System Tumors, Sarcoma
High-Dose Methotrexate in Treating Young Patients With Solid Tumors
RATIONALE: Drugs used in chemotherapy, such as high-dose methotrexate work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing.
- Conditions
- Brain and Central Nervous System Tumors, Sarcoma, Unspecified Childhood Solid Tumor, Protocol Specific
- Trial name
- NCT00513981
- Testing
- leucovorin calcium, methotrexate, mass spectrometry
- Where
- 21 sites in Ireland, United Kingdom
- Volunteers
- 36 people
- Sponsor
- Children's Cancer and Leukaemia Group
Stroke
Urdu Version of National Institutes of Health Stroke Scale: Reliability and Validity Study
The goal of this study was to translate and culturally adapt NIHSS into Urdu language and to evaluate its reliability and validity in Pakistani stroke population.
- Trial name
- NCT05203081
- Where
- Pakistan
- Volunteers
- 225 people
- Sponsor
- Riphah International University
Stroke, Aphasia Following Cerebral Infarction
Combined Aphasia and Robot-Assisted Arm Treatment for Chronic Stroke Survivors
The goal of this clinical trial is to learn if a program that combines language and arm treatment can improve language and movement problems in people with chronic stroke.
- Conditions
- Stroke, Aphasia Following Cerebral Infarction, Hemiparesis After Stroke
- Trial name
- CARAT (NCT07000019)
- Testing
- CARAT: combined aphasia and robot-assisted arm therapy, Robot-assisted arm therapy
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- New York Medical College
Myotonic Dystrophy
Effects of SomatoKine (Iplex)Recombinant Human Insulin-like Growth Factor-1/Recombinant Human Insulin-like Growth Factor-binding Protein-3 (rhIGF-I/rhIGFBP-3) in Myotonic Dystrophy Type 1 (DM1)
The aim of this study is to investigate the safety and feasibility of daily subcutaneous injections of recombinant IGF1 complexed with IGF binding protein 3 (SomatoKine-INSMED) as a treatment for muscle wasting and weakness in…
- Trial name
- NCT00233519
- Testing
- SomatoKine/IPLEX
- Where
- United States
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- University of Rochester
Analgesia, Post Operative Pain
The Analgesic Efficacy of Vitamin B Complex in Critically Ill Obstetrics After Caesarean Section
We aim to investigate the value of vitamin B (B1, B6, B9, B12) on post-cesarean section analgesia in addition to the standard opioid-sparing multimodal regimen to achieve more robust analgesia with minimal side effects.
- Conditions
- Analgesia, Post Operative Pain, Cesarean Section
- Trial name
- NCT06446830
- Testing
- multimodal analgesia and vitamin B, standard multimodal analgesia
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Ain Shams University
Concussion, Mild
Impact of a Paced Breathing Exercise Intervention on Autonomic Nervous System Function After Pediatric Concussion
The goal of this pilot clinical trial is to assess the feasibility of administering a paced breathing exercise intervention program to children and adolescents in the sub-acute period after concussion, and to document the…
- Trial name
- Breathe (NCT06559865)
- Testing
- Breathing exercises
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Exercise Recovery, Physical Performance Parameters
Effects of Pork Protein on Recovery Following Simulated Fireground Activity
The goal of this clinical trial is to learn whether consuming pork-based protein before and after physically demanding simulated firefighting activities can improve recovery, physical performance, and cognitive performance in…
- Conditions
- Exercise Recovery, Physical Performance Parameters, Muscle Damage, Cognition
- Trial name
- PORK-FIRE (NCT07819565)
- Testing
- Pork-Based Protein Ready-to-Eat Meals, Plant-Based Protein Ready-to-Eat Meals, Carbohydrate-Focused Lower-Protein Ready-to-Eat Meals
- Where
- 2 sites in United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Sam Houston State University
Diffuse Midline Glioma (DMG), Glioblastoma
ONC206 for Treatment of Newly Diagnosed, Recurrent Diffuse Midline Gliomas, and Other Recurrent Malignant CNS Tumors
This phase I trial studies the effects and best dose of ONC206 alone or in combination with radiation therapy in treating patients with diffuse midline gliomas that is newly diagnosed or has come back (recurrent) or other…
- Conditions
- Diffuse Midline Glioma (DMG), Glioblastoma, Recurrent Ependymoma, Recurrent Malignant Central Nervous System Neoplasm
- Trial name
- PNOC023 (NCT04732065)
- Testing
- ONC206, Standard of Care Radiation Therapy, Optional Proton (1H) MR spectroscopy (MRS)
- Where
- 7 sites in United States, Netherlands and 1 more
- Volunteers
- 208 people
- Sponsor
- Sabine Mueller, MD, PhD
Meningitis, Meningococcal
Maternal Immunization With MenAfriVac™
The World Health Organization (WHO) recommends that infants receive a single dose of the meningococcal serogroup A-tetanus toxoid conjugate vaccine, MenAfriVac, when they reach at least 9 months of age.
- Trial name
- NCT03746665
- Testing
- meningococcal serogroup A conjugate vaccine
- Where
- The Gambia
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- London School of Hygiene and Tropical Medicine
GHD
A Study to Investigate the Safety and Efficacy of Once-weekly PEG-somatropin (GenSci004) in Children With Growth Hormone Deficiency
The purpose of this Phase 3 study is to evaluate the safety and efficacy of once-weekly GenSci004 over 108 weeks in children with GHD aged from 6 months to 17 years old, inclusive.
- Trial name
- ESCALATE (NCT06024967)
- Testing
- PEG-somatropin
- Volunteers
- 180 people
- Sponsor
- Changchun GeneScience Pharmaceutical Co., Ltd.
Pericardial Effusion, Inflammatory Response After Surgery
Anesthesia Management, Inflammatory Response and Recovery After Non-intubated VATS Pericardial Window
Non-intubated video-assisted thoracoscopic surgery (NIVATS) is performed under spontaneous ventilation and avoids tracheal intubation and one-lung mechanical ventilation.
- Conditions
- Pericardial Effusion, Inflammatory Response After Surgery, Postoperative Complications, Procedural Sedation and Analgesia
- Trial name
- RNIVATS (NCT07800767)
- Testing
- Systemic opioid-based analgesia during NIVATS, Thoracic regional analgesia during NIVATS
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people
- Sponsor
- Koşuyolu Kartal Heart Training and Research Hospital
Insomnia Disorder, Circadian Rhythm Sleep Disorder
The Sleep Clinic Outcome and Practice Study
The goal of this clinical trial is to explore the outcome and practice treatment for sleep-wake disturbances in a Sleep Clinic. The main questions it aims to answer are: What is the practice (timing and duration of treatment…
- Trial name
- SUP (NCT06669507)
- Testing
- Chronotherapy, Cognitive Behavioral Therapy for Insomnia
- Where
- Norway
- Volunteers
- 3,400 people, healthy volunteers welcome
- Sponsor
- St. Olavs Hospital
Headache, Migraine, Migraine
Mind and Body Approaches to Pain Reduction in Youth With Migraine
The overarching objective of this protocol is to identify and understand the neural and pain processing mechanisms by which youth with migraine improve in response to preventive treatment.
- Conditions
- Headache, Migraine, Migraine, Migraine Disorders, Headache
- Trial name
- NCT03472092
- Testing
- Cognitive Behavioral Therapy (CBT), Amitriptyline, Biofeedback-Assisted Relaxation Training (BART)
- Where
- United States
- Volunteers
- 132 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Sacro Iliac Joint Pain, Low Back Pain
Effectiveness Of Alcohol Addition In Ultrasound-Guided Periarticular Sacroiliac Joint Injection
The aim of this work is to evaluate the efficacy of adding alcohol to local anesthetics and steroids to provide pain relief in patients with sacroiliac joint pain.
- Conditions
- Sacro Iliac Joint Pain, Low Back Pain, Alcohol Induced Neurolysis
- Trial name
- NCT07151027
- Testing
- sacroiliac joint injection
- Where
- Egypt
- Volunteers
- 54 people
- Sponsor
- Fayoum University
Primary Dysmenorrhea
Application of Electrical Neurostimulation Transcutaneous in Patients With Primary Dysmenorrhea.
The present study aims to verify the analgesic potential of a new methodological proposal for application for transcutaneous electrical nerve stimulation (TENS interactive) using patients with primary dysmenorrhoea and compare it…
- Trial name
- NCT02205970
- Testing
- TENS
- Volunteers
- 124 people
- Sponsor
- Universidade Federal de Sao Carlos
Obstructive Sleep Apnea, Comorbid Insomnia and Sleep Apnea
Does the Timing of Insomnia Therapy (CBT-i) Impact the Usage and Compliance of Upper Airway Stimulation (UAS) Treatment of Obstructive Sleep Apnea (OSA)
Obstructive sleep apnea, or OSA, affects over 1 billion adults worldwide. OSA is one of many sleep disorders. Individuals can suffer from more than one sleep disorder at a time.
- Conditions
- Obstructive Sleep Apnea, Comorbid Insomnia and Sleep Apnea, Insomnia
- Trial name
- CBT-i and UAS (NCT07838870)
- Testing
- Digital Cognitive Behavioral Therapy (CBT-i)-COAST
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Thomas Kaffenberger
Hydrocephalus, Normal Pressure
A Study Comparing Shunt Placement Versus Endoscopic Third Ventriculostomy in the Treatment of Hydrocephalus
The main purpose of this study is to compare two types of treatment of hydrocephalus: placement of a ventriculoperitoneal (VP) shunt versus an endoscopic third ventriculostomy (ETV).
- Trial name
- NCT01115270
- Testing
- Non-invasive measures
- Where
- United States
- Volunteers
- 196 people
- Sponsor
- University of California, Los Angeles
Pregnancy, Analgesia
An Observational Study of Post-cesarean Delivery Respiratory Patterns Using a Non-invasive Minute Ventilation Monitor (Exspiron ™ System)
The purpose of this study is to evaluate the breathing patterns of women who undergo cesarean delivery with spinal or epidural morphine for post-operative pain control in the first day after surgery.
- Conditions
- Pregnancy, Analgesia, Respiratory Depression, Obstructive Sleep Apnea
- Trial name
- NCT02903173
- Where
- United States
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Duke University
Migraine
A Real-world, Prospective Observational Study of Rimegepant ODT for the Acute Treatment of Migraine Attacks in Adults.
This study aims at characterizing the effectiveness of rimegepant as an acute migraine treatment in a real world setting on two aspects: Consistency of response to rimegepant across multiple attacks Effectiveness of rimegepant in…
- Trial name
- CONFIDENCE (NCT06467370)
- Where
- United States
- Volunteers
- 467 people
- Sponsor
- Pfizer
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