Clinical trials: Neural Injury
Traumatic Brain Injury
Relationship Between Attention and Emotional Regulation Post-Traumatic Brain Injury (TBI)
The purpose of this pilot study is to investigate the relationship between attention and emotional function post-Traumatic Brain Injury (TBI) in an effort to better understand the cognitive mechanisms of emotional processing in…
- Trial name
- NCT01681589
- Testing
- Transcranial Direct Current Stimulator (TDCS), Control Group, Healthy Control Group
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- NYU Langone Health
Spinal Cord Injury
Improving Motor Function After Spinal Cord Injury
The goals of this study are to examine the physiology of Central Nervous System pathways contributing to the control of upper and lower extremity movements after SCI, and to promote the recovery of extremity movements by using…
- Trial name
- NCT01915095
- Testing
- rTMS, Training, Motor Task
- Where
- 3 sites in United States
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Spinal Cord Injuries
Neural Facilitation of Movements in People With SCI
Spinal cord injury leads to long-lasting paralysis and impairment. Re-enabling movement of paralyzed areas is challenging and more information is needed about neurological recovery.
- Trial name
- NCT05354206
- Testing
- Electrophysiology assessment - corticospinal tract, Electrophysiology assessment - reticulospinal tract, Training with some stimulation
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Brain Injury
Neural Bases of Cognitive Rehabilitation for Brain Injury
Some of the most common and disabling consequences of brain injury are deficits in cognition, such as difficulty with sustained attention, memory, organization, and goal management.
- Trial name
- NCT01120756
- Testing
- Goal-oriented attentional self-regulation, Brain Health Education
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Spinal Cord Injury
Neural Adaptation After Tendon Transfer and Training in Tetraplegia
The number of people in the United States who have survived SCI is estimated to be approximately 273,000 persons. Around 50% of the injuries are to the cervical spine resulting in tetraplegia.
- Trial name
- NCT02768103
- Testing
- task-based training
- Where
- United States
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Mandible; Deformity, Surgical Healing
LLLT Effects on Inferior Alveolar Nerve (IAN) Recovery Post-orthognathic Surgery
Low-level laser therapy (LLLT) is a well-studied technique that has been shown to improve recovery time and reduce pain and swelling in patients undergoing surgery, including orthognathic surgery, and has no known negative…
- Conditions
- Mandible; Deformity, Surgical Healing, Orthognathic Surgery, Nerve Injury
- Trial name
- NCT04910074
- Testing
- Low-level laser therapy, Dummy LLLT
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Albert Einstein College of Medicine
Depression, Anxiety
Neural Changes Associated With a Mindfulness-based Intervention for Young Adults With Childhood Maltreatment
Childhood trauma is remarkably prevalent, and it has long lasting impact on mental health and neural development. This trial aims to see whether the 8-week mindfulness based intervention can reduce stress related psychological…
- Conditions
- Depression, Anxiety, PTSD, Trauma, Psychological
- Trial name
- NCT02447744
- Testing
- Mindfulness based intervention
- Where
- United States
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Brain Diseases, Metabolic, Inborn, Urea Cycle Disorder
Neurologic Injuries in Adults With Urea Cycle Disorders
Urea cycle disorders (UCDs) are a group of rare inherited metabolism disorders. The purpose of this study is to evaluate how UCD-related neurologic injuries affect adults with one of the most common types of UCD.
- Conditions
- Brain Diseases, Metabolic, Inborn, Urea Cycle Disorder, Ornithine Transcarbamylase Deficiency
- Trial name
- NCT00472732
- Where
- 2 sites in United States
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Andrea Gropman
PTSD
Neural Circuits in Women With Abuse and Posttraumatic Stress Disorder
The purpose of this study was to assess the effects of the medication paroxetine on symptoms of posttraumatic stress disorder (PTSD) and the brain in women with a history of PTSD related to childhood abuse.
- Trial name
- NCT01681849
- Testing
- Paroxetine, Positron Emission Tomography (PET) Imaging
- Where
- United States
- Volunteers
- 91 people, healthy volunteers welcome
- Sponsor
- Emory University
Post-Traumatic Stress Disorder
Cannabinoid Control of Fear Extinction Neural Circuits in Post-traumatic Stress Disorder
The goal of this study is to look at how a type of drug called cannabinoids are related to the processing of fear signals, the experience of emotions and fear, and the pattern of activity in the brain that is involved in these…
- Trial name
- NCT02069366
- Testing
- Dronabinol
- Where
- United States
- Volunteers
- 86 people, healthy volunteers welcome
- Sponsor
- Wayne State University
Surgical Complication, Paresthesia
Trial of Bilateral Sagittal Split Osteotomy Induced Paresthesia Using Ultrasonic vs. Reciprocating Saw Instrumentation
The aim of this prospective study is to analyze the postoperative paresthesias experienced in patients who undergo bilateral sagittal split osteotomies (BSSO) using an ultrasonic saw, versus a reciprocating saw.
- Conditions
- Surgical Complication, Paresthesia, Fracture, Nerve Injury
- Trial name
- NCT05205616
- Testing
- Sonopet ultrasonic saw, Reciprocating saw
- Where
- 2 sites in United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco