Clinical trials: Neural Tube Defect, open to volunteers
Spinal Cord Injuries, Cerebral Palsy
Mobile Health Self-Management and Support System for Chronic and Complex Health Conditions
This study will assess the benefits of using mobile health system designed for individuals with chronic and complex health conditions (such as those with Spinal Cord Injury,Cerebral Palsy, Spina Bifida, and Traumatic Brain…
- Conditions
- Spinal Cord Injuries, Cerebral Palsy, Spinal Dysraphism, Brain Injuries
- Trial name
- NCT02592291
- Testing
- MHealth
- Where
- United States
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Spina Bifida, Neurogenic Bowel
Bowel Continence Across the Lifespan in People With Spina Bifida
The goal of this observational study is to learn how different enema programs affect bowel control in children and adults with spina bifida.
- Conditions
- Spina Bifida, Neurogenic Bowel, Bowel Incontinence
- Trial name
- BCALS (NCT07390318)
- Testing
- Retrograde Enema, Antegrade Enema
- Where
- 24 sites in United States
- Volunteers
- 943 people
- Sponsor
- David Chu
Recurrent Adult Tethered Cord Syndrome
A Randomized Controlled Trial for Surgical Treatment of Recurrent Adult Tethered Cord Syndrome
This trial compares detethering surgery and spinal column shortening surgery, two treatments for adults with recurrent tethered cord syndrome (TCS), a neurological disorder where the spinal cord becomes abnormally attached to…
- Trial name
- NCT06197399
- Testing
- Detethering Surgery, Spinal Column Shortening Surgery
- Where
- China
- Volunteers
- 222 people
- Sponsor
- Xuanwu Hospital, Beijing
Myelomeningocele
Cellular Therapy for In Utero Repair of Myelomeningocele - The CuRe Trial
Spina bifida, or myelomeningocele (MMC), is a birth defect that results in paralysis, excess fluid on the brain (hydrocephalus), and impaired ability to urinate and have bowel movements normally.
- Trial name
- CuRe (NCT04652908)
- Testing
- Placental Mesenchymal Stem Cells seeded on a commercially available dural graft extracellular matrix, Untreated contemporaneous cohort
- Where
- United States
- Volunteers
- 55 people
- Sponsor
- University of California, Davis
Spina Bifida
Parenting Program for Young Children With Spina Bifida
The goal of this clinical trial is to test and improve an online program for caregivers of young children with spina bifida. Investigators hope to learn whether the program can improve caregiver stress and positive parenting…
- Trial name
- NCT07915557
- Testing
- Positive Parenting Program
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Phoenix Children's Hospital
Fetal Congenital Abnormalities, Fetoscopy
Fetoscopic Robotic Open Spina Bifida Treatment
Fetal spina bifida is a common birth defect that results in hydrocephalus, motor-, bowel-, bladder- and sexual dysfunction in the child. The condition is progressive in utero.
- Conditions
- Fetal Congenital Abnormalities, Fetoscopy, Fetal Surgery, Robotic Surgical Procedure
- Trial name
- FROST (NCT06907732)
- Testing
- Fetoscopic robotic open spina bifida closure
- Volunteers
- 15 people
- Sponsor
- Mount Sinai Hospital, Canada
Neural Tube Defects, Spina Bifida
Fetoscopic Neural Tube Defect Repair
This is a single-arm prospective study to record maternal and neonatal outcomes on subjects who undergo fetoscopic repair of Neural Tube Defects (NTD) at Oregon Health \& Science University (OHSU).
- Trial name
- NTD (NCT06946563)
- Testing
- Fetoscopic Neural Tube Defect Repair Devices
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Oregon Health and Science University
Spina Bifida
Efficacy of Intravesical Oxybutynin in Children With Neurogenic Bladder Dysfunction
Malformation of the lumbosacral region (spina bifida) affects the innervation of the bladder in children. The usual evolution leads to a neurological bladder with small capacity, poor compliancy and overactivity, exposing to…
- Trial name
- POXIPEN (NCT07027020)
- Testing
- Oxybutynin Hydrochloride
- Where
- 19 sites in France
- Volunteers
- 60 people
- Sponsor
- Central Hospital, Nancy, France
Syringomyelia, Chiari Malformation
Development of a Patient-reported Outcome Measure for Chiari Malformation and Syringomyelia
Chiari malformation corresponds to the herniation of cerebellar tonsils into the foramen magnum resulting in obstruction of cerebrospinal fluid circulation, which may eventually lead to the formation of an intramedullary cavity…
- Trial name
- BCS-score (NCT06011226)
- Testing
- focus groups, questionnaire
- Where
- France
- Volunteers
- 60 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Chiari Malformations
Dynamic MRI and Quantitative MR CSF Flow Studies in Craniovertebral Junction Anomalies
The purpose of this study is to decide which position of the neck affects cerebral spinal fluid (CSF) flow between the spinal cord and the brain.
- Trial name
- NCT00795080
- Testing
- Dynamic cervical MRI scans
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Postoperative Neurogenic Lower Urinary Tract Dysfunction Secondary to Tethered Cord Syndrome
Effectiveness of Electrical Pudendal Nerve Stimulation for Neurogenic Lower Urinary Tract Dysfunction in Pediatric Tethered Cord Syndrome Post-Surgery
The goal of this prospective observational study is to evaluate whether the addition of electrical pudendal nerve stimulation (EPNS) to standard conservative treatment can improve bladder function in pediatric patients with…
- Trial name
- NCT07062133
- Testing
- Electrical pudendal nerve stimulation, Conventional conservative treatment
- Where
- China
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Shanghai Institute of Acupuncture, Moxibustion and Meridian
Spina Bifida
Motor Imagery-Supported Thoracic Expansion in Children With Spina Bifida
This study will investigate whether adding motor imagery to thoracic expansion exercises can improve respiratory function in children with spina bifida.
- Trial name
- NCT07846202
- Testing
- Thoracic Expansion Exercises, Motor Imagery-Supported Thoracic Expansion Exercises
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Karabuk University
Myelomeningocele, Spina Bifida
Transcutaneous Spinal Stimulation for Children and Youth With Spina Bifida
A study to use transcutaneous spinal cord stimulation to characterize sensorimotor deficits in a pediatric population of individuals with spina bifida.
- Trial name
- NCT06918119
- Testing
- Transcutaneous stimulation
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Mayo Clinic
Muscle Weakness, Problems Moving Their Arms and Legs
Toward Ubiquitous Lower Limb Exoskeleton Use in Children and Young Adults
People with cerebral palsy (CP), muscular dystrophy (MD), spina bifida, or spinal cord injury often have muscle weakness, and problems moving their arms and legs.
- Trial name
- NCT06998134
- Testing
- Extension assist knee ankle foot orthosis (EA-KAFO)
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- National Institutes of Health Clinical Center (CC)
Spina Bifida
Autologous Human Umbilical Cord Tissue Patch for Postnatal Closure of Open Neural Tube Defects
The purpose of this study is to determine the impact of an autologous umbilical cord patch for dural closure on the repair of open neural tube defect.
- Trial name
- NCT06929572
- Testing
- Autologous umbilical cord patch
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- The University of Texas Health Science Center, Houston
Spinal Cord Injuries, Spina Bifida
Downstream Effects of Personalized 'Top-down' Participation-based Interventions Among Youth With Physical Disabilities
Participation in community-based activities is essential to the health and well-being of youth with physical disabilities; yet, it is extremely restricted.
- Conditions
- Spinal Cord Injuries, Spina Bifida, Musculoskeletal Disorder, Juvenile Arthritis
- Trial name
- NCT05784285
- Testing
- Engagement in a 8-week community-based activity program
- Where
- Canada
- Volunteers
- 150 people
- Sponsor
- McGill University
Spina Bifida
Evaluation of muLtimodal and Non-invasive SPINa Bifida Neurovessels During Prospective Follow-up
The aim of the study is to investigate known urinary biomarkers in order to determine whether they can be predictive of a risk of damage to the upper urinary tract and therefore the kidneys in patients with spina bifida.
- Trial name
- SPINLESS (NCT06041334)
- Testing
- Collection of a urine sample, Magnetic Resonance Imaging of the bladder
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Rennes University Hospital
Spina Bifida, Fecal Incontinence
Enema Device for Children With Spina Bifida
The International Center for Colorectal and Urogenital Care at Children's Hospital Colorado treats patients who suffer from many different colorectal issues such as anorectal malformation, Hirschsprung disease, and severe…
- Trial name
- NCT05253196
- Testing
- Use of the foley catheter assistive device
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Colorado, Denver
Folate Deficiency, Neural Tube Defects
Folic Acid Salt Study (FISFA Zambia)
Question: How effective is fortified iodized salt with folic acid (FISFA) in increasing serum and red blood cell folate in non-lactating, non-pregnant women of reproductive age in the country of Zambia who do not have active food…
- Trial name
- NCT06734611
- Testing
- Fortified Iodized Salt with Folic Acid (FISFA)
- Where
- 2 sites in United States, Zambia
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Chiari Malformation Type I
Health-related Quality of Life in Chiari Malformation Type 1 - A National Cross-Sectional Patient Survey
The goal of this observational survey study is to investigate factors that may affect the health-related quality of life (HRQoL) in adults with Chiari malformation type 1 (CM1).
- Trial name
- NCT07818122
- Where
- Sweden
- Volunteers
- 1,004 people
- Sponsor
- Karolinska Institutet