Clinical trials: Neural Tube Defect
Obesity, Neural Tube Defects
Folate Metabolism in Normal Weight and Obese Women of Child-bearing Age
The purpose of this study is to determine if there is a difference in the short term response in serum folate after a single dose of folic acid in normal weight and obese women of childbearing age.
- Trial name
- NCT01743196
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- University of Georgia
Spina Bifida, Cerebral Palsy
The Impact of Community-based Wellness Programs on The Triple Aim
People with disabilities experience a staggering incidence of secondary conditions that can result in death or negatively impact their health, participation in the community, and quality of life.
- Conditions
- Spina Bifida, Cerebral Palsy, Spinal Cord Injury, Traumatic Brain Injury
- Trial name
- NCT02938130
- Testing
- Wellness Programs
- Where
- United States
- Volunteers
- 119 people
- Sponsor
- University of Pittsburgh
Neurogenic Bladder, Tethered Spinal Cord Syndrome
Urological Deterioration in Secondary Tethered Cord Syndrome and Clue to Detect It
Secondary tethered cord syndrome (STCS) has been diagnosed with signs of progressive deterioration in urological or neuroorthopedic systems following primary tethering surgery.
- Trial name
- NCT04483570
- Testing
- Redo-tethering operation
- Volunteers
- 54 people
- Sponsor
- Seoul National University Hospital
Chiari Malformation Type I, Syringomyelia
Abnormality of the Central Canal of the Spinal Cord in Syringomyelia in a Patient With a Basal Skull Malformation
The aim of this study is to analyze the association between a deformity of the cranial portion of the central spinal canal and syringomyelia in patients with a Chiari-type malformation of the craniocervical junction.
- Trial name
- SYRCANAL (NCT07720206)
- Testing
- MRI
- Where
- France
- Volunteers
- 50 people
- Sponsor
- University Hospital, Bordeaux
Thoracolumbar; Spina Bifida
3D-printed Module-assisted Minimally Invasive Lumbar Pedicle Screw Placement
To explore the accuracy of 3D printed module assisted minimally invasive lumbar pedicle screw placement using Quandrant system, and verify its feasibility of reducing error rate of screw placement and postoperative complications.
- Trial name
- NCT02970578
- Testing
- 3D printed module
- Volunteers
- 36 people
- Sponsor
- The Affiliated Hospital of Putian University
Spina Bifida Aperta, Acquired Traumatic Spinal Cord Injury
Self-esteem and Neuro-urological Follow-up in Patients With Spina Bifida or Spinal Cord Injury
With improved life expectancy over the last fifty years, spina bifida has become a disease of the adult. One of the major stakes for these patients is the preservation of a regular follow-up of uro-nephrologicals risk factors and…
- Trial name
- ESTIME (NCT01606618)
- Where
- 16 sites in France
- Volunteers
- 111 people
- Sponsor
- Rennes University Hospital
Spina Bifida, Urothelial Neoplasm
Urothelium Tissue Engineering Using Biopsies From Transurethral Resection of Prostate
Different clinical conditions can require urinary bladder augmentation or replacement. Tissue engineered bladder has been clinically evaluated but is not recommended due to diverse side effects.
- Conditions
- Spina Bifida, Urothelial Neoplasm, Bladder, Neurogenic, Bladder Exstrophy
- Trial name
- IMOPU (NCT03698721)
- Testing
- Transurethral Resection of Prostate
- Volunteers
- 365 people
- Sponsor
- Central Hospital, Nancy, France
Cerebral Palsy, Stroke
Reliability of the Melbourne Assessment
The aim of the study is to investigate the reliability of the Melbourne Assessment.
- Conditions
- Cerebral Palsy, Stroke, Traumatic Brain Injury, Meningomyelocele
- Trial name
- NCT02595411
- Where
- Switzerland
- Volunteers
- 30 people
- Sponsor
- University Children's Hospital, Zurich
Physical Activity
Daily Physical Activity in Myelomeningocele
Obesity is getting more common and challenging to treat in children and adolescents with myelomeningocele. Therefore, it is becoming more important to determine daily physical activity in these patients.
- Trial name
- NCT04186338
- Testing
- Omnidirectional accelerometer monitor (3x3 cm and 16 g, Actical®, Philips Respironics)
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Marmara University
Spina Bifida, Myelomeningocele
Fetoscopic NEOX Cord 1K® Spina Bifida Repair
To fetoscopically use cryopreserved human umbilical cord allografts, named NEOX Cord 1K®, as a spinal cord cover of spina bifida defects.
- Conditions
- Spina Bifida, Myelomeningocele, Myeloschisis
- Trial name
- NCT04243889
- Testing
- NEOX Cord 1K
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- The University of Texas Health Science Center, Houston
Chiari Malformation
Duragen Versus Duraguard in Chiari Surgery
The study evaluates two materials used for duraplasty of the posterior cranial fossa in treatment of Chiari malformation. One material (DuraGen) is a non-suturable collagen matrix that is applied over the defect if brain…
- Trial name
- NCT00741858
- Testing
- Duragen duraplasty, Duraguard duraplasty
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- University of Illinois Chicago
Spinal Cord Injuries, Cerebral Palsy
Mobile Health Self-Management and Support System for Chronic and Complex Health Conditions
This study will assess the benefits of using mobile health system designed for individuals with chronic and complex health conditions (such as those with Spinal Cord Injury,Cerebral Palsy, Spina Bifida, and Traumatic Brain…
- Conditions
- Spinal Cord Injuries, Cerebral Palsy, Spinal Dysraphism, Brain Injuries
- Trial name
- NCT02592291
- Testing
- MHealth
- Where
- United States
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Spina Bifida, Myelomeningocele
tSCS in Children With Spina Bifida
A single-center, open-label, investigational pilot trial to explore potential effects of transcutaneous spinal cord stimulation on leg muscle strength and walking in children with myelomeningocele.
- Trial name
- NCT07615686
- Testing
- Transcutaneous stimulator
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Bailey Petersen
Chiari Malformation Type I, Proprioceptive Disorders
Investigation of the Effects of Exercise on Patients With Chiari Malformation
Chiari Malformation (CM) is a posterior brain anomaly caused by the displacement of the brain stem and cerebellum into the cervical spinal canal.
- Conditions
- Chiari Malformation Type I, Proprioceptive Disorders, Coordination and Balance Disturbances, Syringomyelia
- Trial name
- NCT04220541
- Testing
- Motor learning based exercise
- Where
- Turkey (Türkiye)
- Volunteers
- 16 people
- Sponsor
- Hacettepe University
Fetal Surgery, Myelomeningocele
Fetal Surgery Interview Study: Parental Perceptions of Fetal Surgery
Open maternal-fetal surgery is currently used on fetuses with myelomeningocele (MMC). Fetoscopic or minimal access fetal surgery is also being used to treat fetuses with congenital diaphragmatic hernia (CDH).
- Conditions
- Fetal Surgery, Myelomeningocele, Congenital Diaphragmatic Hernia
- Trial name
- NCT03788122
- Testing
- In-depth interview
- Where
- 2 sites in Belgium, United Kingdom
- Volunteers
- 40 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Myelomeningocele, Neurogenic Bladder
Efficacy of Contrast Enhanced Voiding Urosonography for Urodynamic Studies
The investigators will assess the feasibility of replacing fluoroscopy/iodinated contrast with ultrasound/sulfur hexafluoride lipid-type A microspheres during routine urodynamic studies.
- Conditions
- Myelomeningocele, Neurogenic Bladder, Tethered Cord Syndrome, Bladder, Neurogenic
- Trial name
- NCT04738539
- Testing
- Contrast Enhanced Voiding Urosonography with Urodynamic Testing, Urodynamic Testing
- Where
- United States
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Neural Tube Defects (NTDs)
First-Trimester Screening of Open Neural Tube Defects Using Biometrics and Maternal Serum Markers
Open neural tube defects are congenital malformations associated with significant morbidity. Early detection during the first trimester remains a key challenge.
- Trial name
- BIMAS (NCT07864142)
- Where
- France
- Volunteers
- 100 people
- Sponsor
- University Hospital, Strasbourg, France
Open Spina Bifida, Myelomeningocele
Fetoscopic Open Spina Bifida Repair Using the SAFER Technique
Children submitted to fetoscopic in utero myelomeningocele repair using the SAFER (Skin-over-biocellulose for Anternatal FEtoscopic Repair) technique will evaluate at 30 months or more, regarding ambulation, neurodevelopment…
- Conditions
- Open Spina Bifida, Myelomeningocele, Meningomyelocele, Chiari Malformation With Spina Bifida
- Trial name
- NCT04356703
- Testing
- Neuropsicomotor developmental test
- Where
- Brazil
- Volunteers
- 30 people
- Sponsor
- Hospital Israelita Albert Einstein
Atlantoaxial Dislocation, Chiari Malformation
Clinical Study of the Treatment of Chiari Malformation Combined With Type II Skull Base Depression
The research background of this study is that Chiari malformation (CM) is a congenital malformation in the foramen magnum region, often associated with syringomyelia, basilar depression, odontoid dislocation and other…
- Conditions
- Atlantoaxial Dislocation, Chiari Malformation, Basilar Invagination
- Trial name
- NCT05754554
- Testing
- Atlas occipital decompression lateral joint release combined with occipital-neck fusion, Simple FMD with Outer Dural Delamination
- Where
- China
- Volunteers
- 64 people
- Sponsor
- Southern Medical University, China
Premature Infants, Cerebral Palsy
Interrater Reliability of Infant Motor Profile
The aim of this study is to assess risky infants (or diagnosed infants) with Infant Motor Profile, and analyze interrater and intrarater reliability of this test.
- Conditions
- Premature Infants, Cerebral Palsy, Down Syndrome, Metabolic Disorders
- Trial name
- IMP (NCT03188107)
- Testing
- Video based assessment
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Abant Izzet Baysal University