Clinical trials: Neural Tube Defect
Myelomeningocele, Extubation Time
Operating Room Extubation and Postoperative Outcomes in Neonates With Meningomyelocele
Meningomyelocele is one of the most common neural tube defects requiring surgical repair in the neonatal period. Postoperative respiratory complications and the need for prolonged mechanical ventilation are important causes of…
- Conditions
- Myelomeningocele, Extubation Time, Neonatal
- Trial name
- MEROX (NCT07465055)
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Gaziantep City Hospital
Cerebral Palsy, Spina Bifida
Evaluation of the Transitional and Lifelong Care Program
The population cared for in the Transitional and Lifelong Care (TLC) clinic is youth and adults with childhood-onset disability, of which the large majority are adults with brain-based, neurodevelopmental conditions such as…
- Conditions
- Cerebral Palsy, Spina Bifida, Developmental Disability
- Trial name
- NCT05849285
- Testing
- TLC Clinic
- Where
- Canada
- Volunteers
- 410 people
- Sponsor
- Western University, Canada
Petrous Apex Meningioma
Petro-trigeminal Line and Petrous Apex Cephaloceles
cephaloceles are rare lesions of the petrous apex, inconsistently listed as meningoceles or arachnoid cysts. They're consistent with a herniation posterolateral of the Meckel cavum within the petrous apex.
- Trial name
- APEX (NCT05639491)
- Where
- France
- Volunteers
- 209 people
- Sponsor
- University Hospital, Strasbourg, France
Neural Tube Defects (NTDs), Facial Cleft Defect
Genetic Analysis of Neural Tube and Orofacial Cleft Defects in the Irish Population
In a collaborative effort with the Health Research Board, the national organization for medical research in the Republic of Ireland, individuals with neural tube defects (NTDs) or facial cleft defects and their parents will be…
- Conditions
- Neural Tube Defects (NTDs), Facial Cleft Defect, Hereditary Oral Clefts
- Trial name
- NCT00341068
- Where
- United States
- Volunteers
- 7,451 people
- Sponsor
- National Human Genome Research Institute (NHGRI)
Spina Bifida, Neurogenic Bladder
CIC Behavioral Economics in Children With Spina Bifida
The purpose of the study is to develop a comprehensive program to increase early initiation of self-catheterization in children with Spina Bifida. This will be a prospective open label randomized control trial.
- Trial name
- NCT05562713
- Testing
- Present Bias without Loss Aversion, Present Bias with Loss Aversion
- Where
- 2 sites in United States
- Volunteers
- 22 people
- Sponsor
- Duke University
Meningomyelocele/Spina Bifida
the Effects of Platelet-Rich Plasma on Postoperative Complications After Meningomyelocele
Introduction: Meningomyelocele is a common congenital neural tube defect. To reduce complications, early surgery and a multidisciplinary approach is needed.
- Trial name
- NCT05711355
- Testing
- Use of Platelet-Rich Plasma after meningomyelocele sac repair, meningomyelocele sac repair
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Yuzuncu Yil University
Anencephaly, Acrania
Genetics of Spina Bifida and Anencephaly
The goal of this research study is to discover the genetic and environmental factors that contribute to the cause of neural tube defects such as spina bifida and anencephaly.
- Trial name
- NCT00636233
- Where
- United States
- Volunteers
- 10,000 people
- Sponsor
- Duke University
Spinal Cord Injuries, Multiple Sclerosis
A Wheelchair Propulsion Training Program
The overall purpose of this project is to test the feasibility of a manual wheelchair propulsion program which aims to reduce the chance of development of upper limbs pain and injury.
- Conditions
- Spinal Cord Injuries, Multiple Sclerosis, Amputation, Spina Bifida
- Trial name
- HS (NCT04009187)
- Testing
- In-person wheelchair propulsion training program, 30-minute education session
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Washington University School of Medicine
Rheumatologic Conditions (JRA,Lupus), Epilepsy
Coping Skills Training (CST) for Children With Chronic Health Conditions
Purpose of the study The purpose of this study is to pilot an adapted Coping Skills Training (CST) intervention for feasibility and preliminary efficacy with a sample of children 8 to 12 years of age and their parents.
- Conditions
- Rheumatologic Conditions (JRA,Lupus), Epilepsy, Spina Bifida, Asthma
- Trial name
- NCT00359775
- Testing
- Coping Skills Training
- Where
- United States
- Volunteers
- 38 people
- Sponsor
- Children's Hospital and Health System Foundation, Wisconsin
Spina Bifida
Retrograde Colonic Irrigation to Manage Spina Bifida Functional Digestive Sequelae: a Multicenter, Prospective, Randomized Controlled Trial
Spina Bifida is a developmental congenital disorder caused by the incomplete closing of the embryonic neural tube, leading to serious malformations of the nervous system.
- Trial name
- IRRICO (NCT02361450)
- Testing
- Retrograde Colonic Irrigation, Usual Care
- Where
- 6 sites in France
- Volunteers
- 34 people
- Sponsor
- Rennes University Hospital
Lower Urinary Tract Symptoms
Impact of Probiotics on Urinary Symptoms in Spinal Cord Injury SCI and SB
As a collaborative effort between MedStar National Rehabilitation Hospital (NRH)/MedStar Health Research Institute (MHRI), Children's National Medical Center (CNMC) Department of Urology, Children's Research Institute (CRI)…
- Trial name
- NCT02748317
- Testing
- Lactobacillus rhamnosus GG
- Where
- 2 sites in United States
- Volunteers
- 96 people
- Sponsor
- Medstar Health Research Institute
Myelomeningocele, Pregnancy
Evaluation of Hysterotomy Site After Open Fetal Surgery
This study is to review how the uterus heals after having open fetal surgery. Open fetal surgery causes a scar perhaps two: one from the open fetal surgery and a second from delivery by cesarean section; rarely, the same area of…
- Trial name
- Hysterotomy (NCT02493062)
- Testing
- Sonohysterogram
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- St. Louis University
Spina Bifida, Latex Allergy
Yulex Glove Prospective Study in Spina Bifida
This study is to evaluate the safety of Yulex gloves when used by individuals who have documented allergy to natural rubber latex from Hevea brasiliensis.
- Trial name
- NCT01133288
- Testing
- Yulex gloves
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Hugo W. Moser Research Institute at Kennedy Krieger, Inc.
Neural Tube Defects, Anemia
Post T-plant Infusion of Allogeneic Cytokine Induced Killer (CIK) Cells as Consolidative Therapy in Myelodysplastic Syndromes/Myeloproliferative Disorders
Allogeneic stem cell transplantation (transplant of blood cells from another individual) is a treatment option for patients with myelodysplasia or myeloproliferative Disorders.
- Conditions
- Neural Tube Defects, Anemia, Leukemia, Myeloid, Bone Marrow Transplant Failure
- Trial name
- NCT01392989
- Testing
- CIK cells, Cyclosporine, Mycophenolate Mofetil
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- Everett Meyer
Myelomeningocele, Bladder, Neurogenic
Effect of Botulinum Toxin in Neurogenic Bladders in Children With Myelomeningocele
The purpose of this study is to examine how injection of botulinum toxin in the bladder affects bladder function. The trial is carried out in children born with malformation of the spinal cord and subsequent overactive bladders.
- Trial name
- NCT00175123
- Testing
- Botulinum A toxin
- Where
- Denmark
- Volunteers
- 30 people
- Sponsor
- University of Aarhus
Bone Loss, Spinal Cord Injuries
Intervention on Bone Health in Wheelchair Users
The low mechanical loading of bones among wheelchair users leads to an increased risk of bone fractures and associated complications due to low bone mineral density (BMD).
- Conditions
- Bone Loss, Spinal Cord Injuries, Cerebral Palsy, Spina Bifida
- Trial name
- BoneWheel (NCT05615402)
- Testing
- Bone-specific strength training, Nutrition optimalisation
- Where
- Norway
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Norwegian School of Sport Sciences
Tethered Cord Syndrome
Surgical Management and Outcome of Tethered Cord Syndrome
The aim of this study is to assess surgical management and outcome of Tethered cord syndrome
- Trial name
- NCT05579795
- Testing
- Detethering of the spinal cord
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Assiut University
Neural Tube Defect
Open Myelomeningocele Repair With High Maternal BMI
Spina bifida is a neurological abnormality characterized by an opening in the skin and exposure of the spinal cord on the back of the baby at the time of birth.
- Trial name
- NCT03044821
- Testing
- Open-Uterus Fetal Repair
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Baylor College of Medicine
Arnold-Chiari Malformation, Posterior Fossa Tumors
Efficacy of Acetaminophen in Posterior Fossa Surgery
Uncontrolled pain after posterior fossa surgery and associated negative side effects of conventional opioid therapy causes significant morbidity and mortality in infants and children.
- Trial name
- NCT02532322
- Testing
- IV acetaminophen, normal saline
- Where
- United States
- Sponsor
- Children's National Research Institute
Neurogenic Bladder, Spina Bifida
Comparing Urinary Tract Infections in Children With Spina Bifida Using Two Types of Catheters for Catheterization
The primary aim of this study was to determine if using the SpeediCath hydrophilic catheter would reduce the incidence of symptomatic urinary tract infections (UTI)in children with spina bifida who perform clean intermittent…
- Trial name
- NCT01263392
- Testing
- Intermittent catheterization
- Where
- 4 sites in Canada
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- University of Alberta