Clinical trials: Neuralgia
Trigeminal Neuralgia
A Study of Amifostine for Prevention of Facial Numbness in Radiosurgery Treatment of Trigeminal Neuralgia
Trigeminal neuralgia or tic douloureux is severe, often debilitating, facial pain that significantly impairs the patient's quality of life and health.
- Trial name
- NCT01364259
- Testing
- Amifostine, CyberKnife stereotactic radiosurgery
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- Stanford University
Polyneuropathy, Amyloid, Neuropathic Pain
Screening for the Transthyretin-Related Familial Amyloidotic Polyneuropathy (TTR FAP)
An International, multicenter, epidemiological observational study investigating the prevalence of Transthyretin-Related Familial Amyloidotic Polyneuropathy (TTR-FAP) in participants with small fiber polyneuropathy of no obvious…
- Conditions
- Polyneuropathy, Amyloid, Neuropathic Pain, Cardiac Failure, Orthostatic Hypotension
- Trial name
- TRAP2-1 (NCT01705626)
- Where
- 11 sites in Austria, Hungary and 4 more
- Volunteers
- 500 people
- Sponsor
- CENTOGENE GmbH Rostock
Trigeminal Neuralgia
Magnetic Resonance Imaging Study on Patients With Trigeminal Neuralgia
Up to now, multiplanar reconstruction (MPR) has been widely used to detect the neurovascular compressions (NVC) on the patients with idiopathic trigeminal neuralgia (ITN).
- Trial name
- MRI-TN (NCT02713646)
- Where
- China
- Volunteers
- 55 people
- Sponsor
- First Affiliated Hospital Xi'an Jiaotong University
Sciatica
Comparison of Intravenous Ibuprofen and Paracetamol in Patients With Sciatica Presented to the Emergency Department
Currently, Paracetamol and Ibuprofen are widely used by emergency physicians in Turkey for the pain treatments. The objective of the study was to assess whether intravenous Paracetamol has superior Sciatica pain reduction will…
- Trial name
- NCT02777320
- Testing
- paracetamol, Ibuprofen
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people
- Sponsor
- Pamukkale University
Somatic Pain, Neuropathic Pain
C2-C4 Compartment Block Versus Block of Costagliola, in TEAC
C2-C4 compartment block compared to the Costaiola block, in the control of persistent postoperative pain (somatic and neuropathic) in patients undergoing carotid thromboendarterectomy
- Trial name
- TEAC (NCT03409068)
- Testing
- C2-C4 compartment anesthetic block, Costagliola block
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- San Salvatore Hospital of L'Aquila
Pain, Nociceptive Pain
Radicle Relief 1: A Study of Health and Wellness Products on Pain and Other Health Outcomes
A randomized, blinded, placebo-controlled study assessing the impact of health and wellness products on pain and other health outcomes
- Conditions
- Pain, Nociceptive Pain, Neuropathic Pain
- Trial name
- NCT05589935
- Testing
- Relief Study Product Usage
- Where
- United States
- Volunteers
- 457 people, healthy volunteers welcome
- Sponsor
- Radicle Science
Chronic Pain, Pediatric Disorder
PET/MRI in the Diagnosis of Pediatric Chronic Pain
[18F]FTC-146 is a sigma-1 receptor detector and is an experimental radiotracer. Several studies have implicated involvement of sigma-1 receptors in generation and perpetuation of chronic pain conditions, while others are…
- Conditions
- Chronic Pain, Pediatric Disorder, Neuropathic Pain, Nociceptive Pain
- Trial name
- NCT04435821
- Testing
- [18F]FTC-146
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Stanford University
Pain Management, Quality of Life
Neuroma-Associated Pain Management After Combat-Related Trauma in Ukraine
This multicenter interventional study in Ukraine is designed to compare the effectiveness of cryoablation and radiofrequency ablation in managing neuroma-associated pain following combat-related trauma.
- Conditions
- Pain Management, Quality of Life, Neuroma, Functional Outcome
- Trial name
- NAP-C/R (NCT07416448)
- Testing
- cryoablation, Radiofrequency ablation alone
- Where
- Ukraine
- Volunteers
- 100 people
- Sponsor
- Ukrainian Society of Regional Anesthesia and Pain Therapy
Small Fiber Neuropathy, Primary Sjögren Syndrome
Cutaneous Silent Period Assessment in Primary Sjögren's Syndrome
Primary Sjögren's syndrome (pSS) is a chronic, immune-mediated inflammatory disease mainly characterized by exocrine gland involvement.
- Trial name
- NCT05380804
- Testing
- cutaneous silent period (CSP) measurement
- Where
- Turkey (Türkiye)
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Marmara University
Painful Diabetic Neuropathy (PDN), Diabetic Neuropathies
Efficacy of Topical Lidocaine Gel vs. Oral Duloxetine for Painful Diabetic Peripheral Neuropathy
The goal of this clinical trial is to learn if topical lidocaine gel can effectively reduce pain intensity compared to oral duloxetine in adult patients (aged 30-70 years) with type 2 diabetes suffering from painful diabetic…
- Conditions
- Painful Diabetic Neuropathy (PDN), Diabetic Neuropathies, Type 2 Diabetes
- Trial name
- NCT07800468
- Testing
- Topical Lidocaine 2% Gel, Duloxetine (60 MG)
- Volunteers
- 80 people
- Sponsor
- Wah Medical college , POF hospital
Stroke, Neuropathic Pain
Effect of Early Neuromodulation Coupled With Rehabilitation on the Prevention of Post-stroke Pain
This is a prospective clinical study to evaluate the efficacy of tDCS stimulation, coupled with conventional rehabilitation, on the development of post-stroke neuropathic pain.
- Conditions
- Stroke, Neuropathic Pain, Central Post Stroke Pain
- Trial name
- ENADA (NCT07202455)
- Testing
- Active tDCS
- Where
- 2 sites in France
- Volunteers
- 60 people
- Sponsor
- University Hospital, Clermont-Ferrand
Failed Back Surgery Syndrome, Limb Ischemia
Evaluation of Online Tool (E-TOOL SCS) in Spinal Cord Stimulaion
This observational multicenter study aims to evaluate the reliability and validity of the e-tool for selecting patients eligible for SCS for chronic pain caused by one of the four etiologies listed above in the experience of…
- Conditions
- Failed Back Surgery Syndrome, Limb Ischemia, Neuropathic Pain, Complex Regional Pain Syndromes
- Trial name
- E-TOOLSCS (NCT06229015)
- Where
- Italy
- Volunteers
- 80 people
- Sponsor
- Istituti Clinici Scientifici Maugeri SpA
Pain, Pain, Neuropathic
Local and Widespread Hypoalgesic Effects of Neurodynamic Mobilization in Healthy Controls
Background \& Significance Pain is the primary reason many patients seek care from healthcare professionals who utilize various manual therapy techniques.
- Trial name
- NCT03674489
- Testing
- Neurodynamic Slider Mobilization, Neurodynamic Tensioner Mobilization
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Brenau University
Diabetic Neuropathies, Polyneuropathies
Neuropathic Pain Management
This is a prospective, randomized, double blind, comparative, experimental controlled Phase 3 clinical trial to assess the efficacy, safety and superiority of F0343 (gabapentin combined with B vitamins) compared to gabapentin…
- Trial name
- M-F0434 (NCT01263132)
- Testing
- F0434, Gabapentin
- Where
- Mexico
- Volunteers
- 104 people
- Sponsor
- Merck KGaA, Darmstadt, Germany
Atypical Facial Pain, Persistent Idiopathic Facial Pain
Efficacy and Safety of ATNC05 in Treatment of Atypical Facial Pain
The purpose of the study is to test the efficacy of ATNC05 in the treatment of Atypical Facial Pain (AFP), also known as Persistent Idiopathic Facial Pain (PIFP).
- Conditions
- Atypical Facial Pain, Persistent Idiopathic Facial Pain, Atypical Trigeminal Neuralgia, Neuropathic Orofacial Pain
- Trial name
- AFP (NCT01920087)
- Testing
- ATNC05
- Where
- United States
- Sponsor
- Allodynic Therapeutics, Inc
Diabetic Neuropathy, Pain
Diabetic Neuropathy Topical Treatment
Comparative study of efficacy and safety of ketamine, clonidine, mixture of both and placebo in patients with diabetic neuropathic pain
- Trial name
- NCT00661063
- Testing
- ketamine, vehicle gel, ketamine + clonidine
- Where
- Brazil
- Volunteers
- 200 people
- Sponsor
- Irmandade da Santa Casa de Misericordia de Sao Paulo
Chronic Pain
Plasma Concentration of Ketamine and Norketamine .
Oral ketamine is increasingly used by doctors to both reduce the amount of narcotic pain medication consumed and to improve chronic pain management in difficult cases.
- Trial name
- NCT02016664
- Testing
- Ketamine
- Where
- Canada
- Volunteers
- 12 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Piriformis Syndrome, Lumbar Radiculopathy
Investigation of the Presence of Piriformis Syndrome Accompanying Lumbar Radiculopathy
Piriformis syndrome is a neuromuscular disorder that is characterized by piriformis muscle tenderness, hip, and leg pain, and may be accompanied by compression or irritation of the sciatic nerve under the piriformis muscle.
- Trial name
- NCT05392933
- Testing
- Ultrasound guided piriformis muscle lidocaine injection
- Where
- Turkey (Türkiye)
- Volunteers
- 39 people
- Sponsor
- Istanbul University - Cerrahpasa
Neuropathic Pain
Chronic Unilateral Lumbar Radicular Pain
Chronic neuropathic lumbar pain is among one of the most widespread complaints of patients.Many approaches have been attempted to target chronic pain, with varying efficacy and risks.
- Trial name
- NCT06092749
- Testing
- Transgrade technique (TG), Interlaminar technique (IL)
- Where
- Egypt
- Volunteers
- 80 people
- Sponsor
- Ain Shams University
Neuralgia, Postherpetic
A Research Study to Evaluate the Safety and Effectiveness of MK0686 for the Treatment of Postherpetic Neuralgia (Also Known as PHN or Post Shingles Pain) (0686-005)
The purpose of this Study is to test the Safety and Effectiveness of MK0686 in relieving neuropathic (chronic) pain as experienced by patients with Postherpetic Neuralgia (Also Know as PHN or Post Shingles Pain).
- Trial name
- NCT00282763
- Testing
- MK0686
- Volunteers
- 12 people
- Sponsor
- Merck Sharp & Dohme LLC