Clinical trials: Neurally Mediated Syncope
Syncope, Vasovagal, Neurally-Mediated
Clinical Trial for the Prevention of Vasovagal Syncope
The main question in the study is whether people taking fludrocortisone are less likely to faint than people taking an inactive pill called a placebo. Fludrocortisone is a drug that stimulates the body to retain salt and water.
- Trial name
- NCT00118482
- Testing
- fludrocortisone acetate
- Where
- 14 sites in United States, Canada
- Volunteers
- 213 people
- Sponsor
- University of Calgary
Syncope, Vasovagal
Compression Stockings for Treating Vasovagal Syncope Trial
Syncope, a sudden, transient loss of consciousness (TLOC), is a common inconvenience of daily function and quality of life (QoL).
- Trial name
- COMFORTS II (NCT05086679)
- Testing
- Compression Stockings with 25-30 mm Hg pressure, Compression stockings with up to <=10 mm Hg pressure, Lifestyle modification
- Where
- Iran
- Volunteers
- 268 people
- Sponsor
- Tehran Heart Center
Vasovagal Syncope
Assessment of Midodrine in the Prevention of Vasovagal Syncope: The Prevention of Syncope Trial IV
About 20% of adults faint recurrently. These patients are often highly symptomatic, have problems with employment and driving and have reduced quality of life.
- Trial name
- POST 4 (NCT01456481)
- Testing
- midodrine hydrochloride
- Where
- 17 sites in United States, Canada and 1 more
- Volunteers
- 134 people
- Sponsor
- Dr. Bob Sheldon
Neurally Mediated Syncope
Italian Cardioneuroablation Study for Neurocardiogenic Syncope Patients
Multicenter Italian interventional "proof of efficacy" clinical trial that aims to evaluate the incidence of asystolic pauses and heart rate in patients with CNS who performed severe CNA identified through asystolic pauses…
- Trial name
- ItalianCNA (NCT05751330)
- Testing
- Transcatheter ablation of cardiac ganglionated plexi
- Where
- 2 sites in Italy
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Policlinico Casilino ASL RMB
Syncope, Vasovagal, Bradycardia
National Registry of Cardioneuroablation in Recurrent Reflex Syncope
This registry aims to collect patient data on cardioneuroablation for vasovagal syncope from multiple centers in France. The aim is to evaluate success rates, compare techniques and help institutions set up their own…
- Conditions
- Syncope, Vasovagal, Bradycardia, Heart Arrest
- Trial name
- CANVAS-R (NCT06159764)
- Testing
- Cardioneuroablation
- Where
- 14 sites in France
- Volunteers
- 50 people
- Sponsor
- University Hospital, Bordeaux
Vasovagal Reaction
Prevention of Vasovagal Reactions in First-time Blood Donors Using a Combined PSYchological and Physiological Approach
The prevention of vasovagal reactions (VVR) occurring during or after donation is a major issue for the French Blood Establishment (EFS), firstly to guarantee the safety of donors but also to retain them, as this reaction is one…
- Trial name
- PREDONPSY (NCT06014346)
- Testing
- Psychological strategy, Physiological strategy
- Where
- France
- Volunteers
- 5,320 people, healthy volunteers welcome
- Sponsor
- Hospices Civils de Lyon
Syncope
Effect of Psychotherapy on Quality of Life and Recurrence of Events in Patients With Recurrent Vasovagal Syncope: A Randomized Pilot Study
Recurrent vasovagal syncope although presenting a benign prognosis in terms of survival, is associated with significant impairment of quality of life.
- Trial name
- NCT04252729
- Testing
- Psychotherapy
- Where
- Brazil
- Volunteers
- 10 people
- Sponsor
- Mauricio Ibrahim Scanavacca
Obstructive Sleep Apnea, Vasovagal Syncope
Clinical Association Between Obstructive Sleep Apnea, Facial Pigmentation, and Vasovagal Symptoms.
The goal of this prospective cohort study is to study patients referred for sleep study by in-lab polysomnography in the Jordan University Hospital and the Jordan Hospital or with an at-home sleep study kit.
- Conditions
- Obstructive Sleep Apnea, Vasovagal Syncope, Smoking, Acanthosis Nigricans
- Trial name
- VasOSA (NCT06331819)
- Testing
- In-lab polysomnography, Continuous positive airway pressure, Home sleep study device
- Where
- Jordan
- Volunteers
- 200 people
- Sponsor
- Jordan Collaborating Cardiology Group
Blood Donors
Addressing Fear and Risk of Vasovagal Reactions Among High School Donors
In this study, high school donors will be asked about their blood donation-related fears prior to their donation. Half of the donors reporting fear will be assigned to a brief coping skills intervention.
- Trial name
- NCT03835299
- Testing
- Fear Intervention
- Where
- United States
- Volunteers
- 4,035 people
- Sponsor
- Ohio University
Circulatory Collapse, Circulatory Failure
Suspension Syndrome
Suspension syndrome refers to a potentially life-threatening condition that can occur in unconscious persons after prolonged suspension in a harness.
- Conditions
- Circulatory Collapse, Circulatory Failure, Syncope, Vasovagal, Neurally-Mediated, Orthostatic Hypotension
- Trial name
- NCT02726776
- Testing
- Suspension in a harness, Climbing
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Institute of Mountain Emergency Medicine
Vasovagal Syncope
Assessment of Stroke Volume and Cardiac Output in Response to Varying Heart Rates
The investigators will seek to determine the effects of different heart rates on both stroke volume and cardiac output using non-invasive hemodynamic assessments.
- Trial name
- Pacing_SV (NCT03446326)
- Testing
- Pacing
- Where
- Canada
- Volunteers
- 25 people
- Sponsor
- University of Calgary
Syncope
BAsel Syncope EvaLuation (BASEL IX) Study
Syncope is a major health problem. In the emergency department (ED), the management of patients with syncope still remains a clinical challenge because underlying diseases and prognosis can be extremely various.
- Trial name
- NCT01548352
- Where
- 15 sites in United States, Argentina and 7 more
- Volunteers
- 3,500 people
- Sponsor
- University Hospital, Basel, Switzerland
Syncope, Vasovagal
Different Catheter Ablation Strategy in Vasovagal Syncope
This study is a prospective, single-center randomized controlled clinical trial. patients with refractory vasovagal syncope were randomly divided into two groups according to the proportion of 1:1.
- Trial name
- NCT05573178
- Testing
- cardiac ganglion plexus ablation(cardioneuroablation)
- Where
- 2 sites in China
- Volunteers
- 80 people
- Sponsor
- China National Center for Cardiovascular Diseases
Vasovagal Syndrome VVS, Cardioinhibitory Carotid Sinus Syndrome CSS
POLish Registry of CArdioneuroablation and CArdioneuromodulation
The multicentre observational study POL-CA involves a wide spectrum of patients with a history of syncopy. The study recruits patients with diagnosed vasovagal syndrome, cardioinhibitory carotid sinus syndrome, symptomatic sinus…
- Conditions
- Vasovagal Syndrome VVS, Cardioinhibitory Carotid Sinus Syndrome CSS, Symptomatic Sinus Bradycardia SB or Atrioventricular Block AV, Postural Orthostatic Tachycardia Syndrome POTS
- Trial name
- POL-CA (NCT07196397)
- Testing
- cardioneuroablation, SN sparing hybrid ablation, Cardiac sympathetic denervation
- Where
- Poland
- Volunteers
- 1,000 people
- Sponsor
- SABAMED Medical Center Ltd.
POTS - Postural Orthostatic Tachycardia Syndrome
Postural Tachycardia Syndrome and Vasovagal Syncope in Relation to Serum Electrolytes and Adrenal Insufficiency
The present study aims to: 1. Estimate the prevalence of Postural Tachycardia Syndrome and vasovagal syncope among adults patients attend the Internal Medicine Clinic and ICU in period from 11/2022 to 10/2023 2.
- Trial name
- NCT05695755
- Testing
- ECHO, Serum electrolytes
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Assiut University
Orthostatic Hypotension, Reflex Syncope
Data Collection - Of Syncope Tilt Table Testing Study
To characterize the impact of orthostatic hypotension (OH) and reflex syncope on signals measured using a wearable cardiac monitor prototype device.
- Trial name
- COST3 (NCT03721393)
- Testing
- Wearable heart monitor
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Boston Scientific Corporation
Syncope, Vasovagal, Pain Intensity
Safety/Efficacy Study of Local Anesthetic Prior to Femoral Artery Sheath Removal
This randomized controlled trial will examine the impact of local anesthetic on the frequency of vasovagal reactions and the patients perception of pain during femoral arterial sheath removal after percutaneous coronary…
- Trial name
- NCT00465439
- Testing
- Subcutaneous Lidocaine 2% (Xylocaine) without epinephrine
- Where
- Canada
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- Hamilton Health Sciences Corporation
Postural Tachycardia Syndrome (POTS), Vasovagal Syncope (VVS)
Northera Improves Postural Tachycardia Syndrome (POTS) and Postural Vasovagal Syncope (VVS)
Vasovagal syncope (VVS, simple faint) is the most common cause of transient loss of consciousness and represents the acute episodic form of orthostatic intolerance (OI).
- Conditions
- Postural Tachycardia Syndrome (POTS), Vasovagal Syncope (VVS), Fainting
- Trial name
- NCT02558972
- Testing
- Northera (Droxidopa)
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- New York Medical College
Reflex Syncope
Cardioneuroablation: Comparison of Right Versus Left Atrial Approach in Patients With Reflex Syncope
Introduction. Reflex vaso-vagal syncope (VVS) is the most frequent cause of transient loss of consciousness and it's treatment remains a challenge.
- Trial name
- ROMAN2 (NCT05225532)
- Testing
- Radiofrequency ablation
- Where
- Poland
- Volunteers
- 40 people
- Sponsor
- Centre of Postgraduate Medical Education
Reflex Syncope
Cardioneuroablation in Reflex Syncope (CARDIOSYRE Trial)
Background: Reflex syncope is a disease of benign etiology but in severe cases it can be disabling and it carries a risk of severe trauma.
- Trial name
- CARDIOSYE (NCT05513755)
- Testing
- cardioneuroablation
- Where
- Spain
- Volunteers
- 92 people
- Sponsor
- Fundación de investigación HM